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| 1 | An experimental validation of genomic selection in octoploid strawberry显示文摘The primary goal of genomic selection is to increase genetic gains for complex traits by predicting performance of individuals for which phenotypic data are not available.The objective of this study was to experimentally evaluate the potential of genomic selection in strawberry breeding and to define a strategy for its implementation.Four clonally replicated field trials,two in each of 2 years comprised of a total of 1628 individuals,were established in 2013–2014 and 2014–2015.Five complex yield and fruit quality traits with moderate to low heritability were assessed in each trial.High-density genotyping was performed with the Affymetrix Axiom IStraw90 single-nucleotide polymorphism array,and 17479 polymorphic markers were chosen for analysis.Several methods were compared,including Genomic BLUP,Bayes B,Bayes C,Bayesian LASSO Regression,Bayesian Ridge Regression and Reproducing Kernel Hilbert Spaces.Cross-validation within training populations resulted in higher values than for true validations across trials.For true validations,Bayes B gave the highest predictive abilities on average and also the highest selection efficiencies,particularly for yield traits that were the lowest heritability traits.Selection efficiencies using Bayes B for parent selection ranged from 74%for average fruit weight to 34%for early marketable yield.A breeding strategy is proposed in which advanced selection trials are utilized as training populations and in which genomic selection can reduce the breeding cycle from 3 to 2 years for a subset of untested parents based on their predicted genomic breeding values. | Salvador A Gezan Luis F Osorio Sujeet Verma Vance M Whitaker | 2017 | Horticulture Research2017，4，1： | 6 |
| 2 | Pathological abnormalities in splenic vasculature in non-cirrhotic portal hypertension:Its relevance in the management of portal hypertension显示文摘BACKGROUND Portal hypertension(PH)is associated with changes in vascular structure and function of the portosplenomesenteric system(PSMS).This is referred to as portal hypertensive vasculopathy.Pathological abnormalities of PSMS has been described in the literature for cirrhotic patients.Raised portal pressure and hyperdynamic circulation are thought to be the underlying cause of this vasculopathy.In view of this,it is expected that pathological changes in splenic and portal vein similar to those reported in cirrhotic patients with PH may also be present in patients with non-cirrhotic PH(NCPH).AIM To investigate pathological abnormalities of splenic vein in patients with NCPH,and suggest its possible implications in the management of PH.METHODS A prospective observational study was performed on 116 patients with NCPH[Extrahepatic portal vein obstruction(EHPVO):53 and non-cirrhotic portal fibrosis(NCPF):63]who underwent proximal splenorenal shunt(PSRS),interposition shunt or splenectomy with devascularization in JIPMER,Pondicherry,India,a tertiary level referral center,between 2011-2016.All patients were evaluated by Doppler study of PSMS,computed tomography portovenogram and upper gastrointestinal endoscopy.An acoustic resonance forced impulse(ARFI)scan and abdomen ultrasound were done for all cases to exclude cirrhosis.Intraoperative and histopathological assessment of the harvested splenic vein was performed in all.The study group was divided into delayed and early presentation based on the median duration of symptoms(i.e.108 mo).RESULTS The study group comprising of 116 patients[77(66%)females and 39(34%)males]with NCPH had a median age of 22 years.Median duration of symptoms was 108 mo.The most common presentation in both EHPVO and NCPF patients was upper gastrointestinal bleeding(hematemesis and melena).The ARFI scan revealed a median score of 1.2(1.0-1.8)m/s for EHPVO and 1.5(0.9-2.8)m/s for NCPF.PSRS was performed in 84 patients(two of whom underwent interposition PSRS using a 10 mm Dacron graft);splenoadrenal shunt in 9;interposition mesocaval shunt in 5;interposition 1st jejunal to caval shunt in 1 patient and devascularization with splenectomy in 17 patients.Median presplenectomy portal pressure was 25(range:15-51)mm Hg.In 77%cases,the splenic vein was abnormal upon intraoperative assessment.Under macroscopic examination,wall thickening was observed in 108(93%),venous thrombosis in 32(28%)and vein wall calcification in 27(23%)cases.Upon examination under a surgical magnification loupe,21(18%)patients had intimal defects in the splenic vein.Histopathological examination of veins was abnormal in all cases.Medial hypertrophy was noted in nearly all patients(107/116),while intimal fibrosis was seen in 30%.Ninety one percent of patients with intimal fibrosis also had venous thrombosis.Vein wall calcification was found in 22%,all of whom had intimal fibrosis and venous thrombosis.The proportion of patients with pathological abnormalities in the splenic vein were significantly greater in the delayed presentation group as compared to the early presentation group.CONCLUSION Pathological changes in the splenic vein similar to those in cirrhotic patients with PH are noted in NCPH.We recommend that PH in NCPH be treated as systemic and pulmonary hypertension equivalent in the gastrointestinal tract,and that early aggressive therapy be initiated to reduce portal pressure and hemodynamic stress to avoid potential lethal effects. | Shahana Gupta Biju Pottakkat Surendra Kumar Verma Raja Kalayarasan Sandip Chandrasekar A Ajith Ananthakrishna Pillai | 2020 | World Journal of Gastrointestinal Surgery2020，12，1： | 3 |
| 3 | 14 Years of Eosinophilic Esophagitis: Clinical Features and Prognosis显示文摘 | Jonathan M Spergel Terri F Brown-Whitehorn Janet L Beausoleil James Franciosi Michele Shuker Ritu Verma Chris A Liacouras | 2009 | Journal of Pediatric Gastroenterology and Nutrition2009，，1： | 2 |
| 4 | 显示文摘 | Verma A Saxena A K Dube D C | 2003 | J Magn Magn Mater2003，263，： | 1 |
| 5 | Proline biosynthesis and osmoregulation in plants显示文摘 | Delauney A J Verma D P S | 1993 | The Plant Journal1993，4，2： | 1 |
| 6 | Mode of initiation and ablation of velatricular fibrillation storms in patients with ischemic cardiomyopathy 显示文摘 | Marrouche NF Verma A Wazni O | 2004 | J Am Coll Cardiol2004，43，9： | 1 |
| 7 | Optimizing care of heart failure after acute MI with an aldosterone receptor antagonist显示文摘 | VERMA A SOLOMEN S D | 2007 | Curr Heart Fail Rep2007，4，4： | 1 |
| 8 | Meteor-s WSDI a scalable P2P infrastructure of registries for semantic publication and discovery of web services 显示文摘 | Verma K Sivashanmugam K Sheth A | 2005 | Journal of Information Technology and Management2005，6，1： | 1 |
| 9 | Anticoagulation in patients with mechanical valves during pregnancy 显示文摘 | Geelani MA Singh S Verma A | 2005 | Asian Cardiovasc Thorac Ann2005，13，1： | 1 |
| 10 | Targeting Axl and Mer Kinases in Cancer显示文摘 | Verma A Warner SL Vankayalapati H | 2011 | Mol Cancer Ther2011，10，10： | 1 |
| 11 | Serum Thl and Th2 cytokine balance in patients of superficial transi?tional cell carcinoma of bladder pre-and post-intravesical com?bination immunotherapy显示文摘 | AGARWAL A AGRAWAL U VERMA S | 2010 | Immunopharmacol Immunotoxi?co]2010，32，2： | 1 |
| 12 | Hypoxia-inducible Factor 1 Activation by Aerobic Glycolysis Implicates the Warburg Effect in Carcinogenesis 显示文摘 | Lu H Forbes R A Verma A | 2002 | J Biol Chem2002，277，23： | 1 |
| 13 | Synthesis of PEDOT:PSS(poly(3,4-ethylenedioxythiophene/poly(4-styrene sulfonate/ngps(nanographitic platelets) nanocomposites as chemiresistive sensors for detection of nitroaromatics显示文摘 | Rattan S Singhal P Verma A L | | 0，，10： | 1 |
| 14 | Expression and purification of recombinant antigens of Mycobacterium tuberculosis for application in serodiagnosis显示文摘 | Kulshrestha A Gupta A Verma N | | 0，，01： | 1 |
| 15 | Piriformospora indica ,a cultivable plant-growth promoting root endoplryte显示文摘 | Varma A Verma S Sudha A | 1999 | Applied and Environmental Microbiology1999，65，6： | 1 |
| 16 | A randomized trial of intra- venous n-acetylcysteine to prevent contrast induced nephrepathy in acute coronary syndromes 显示文摘 | Jaffery Z Verma A White C J | 2012 | Catheter Cardiovasc Interv2012，79，6： | 1 |
| 17 | Proline biosynthesis and osmoregulationin plants显示文摘 | Delauney A J Verma D P S | 1993 | Plant Journal1993，4，： | 1 |
| 18 | Carbon monoxide: a putative neural messenger 显示文摘 | Verma A Hirsch D J Glatt C E | 1993 | Science1993，259，： | 1 |
| 19 | Proline biosynthesis and osmreyulation in plants 显示文摘 | Verma D PS | 1995 | plant J1995，108，： | 1 |
| 20 | Short-and long-termsuccess ofsubstrate-based mapping and ablation of ventriculartachycardia in arr-hythmogenic right ventricular dysplsia显示文摘 | Verma A Killcaslan F SchweikertRA | 2005 | Circulation2005，111，24： | 1 |
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