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| 1 | Recurrent aggressive mesenteric desmoid tumor successfully treated with sorafenib: A case report and literature review显示文摘BACKGROUND Desmoid tumors(DT) are locally advanced but histologically benign monoclonal neoplasms that can occur from any musculoaponeurotic structure. The aim of this report is to analyze a rare clinical case of an aggressive intra-abdominal DT successfully treated with sorafenib.CASE SUMMARY A 36-year-old man presented with increasing colicky abdominal pain and a selfpalpable mass in his left abdomen. Fourteen years earlier he was diagnosed with a large intra-abdominal tumor, which adhered to the left colonic flexure, part of the major gastric curvature and the spleen. Subsequent exploratory laparotomy revealed a voluminous mass in the epigastrium, arising from the posterior surface of the stomach and invading the superior mesenteric vessels, transverse mesocolon and the small bowel mesentery. As the tumor was unresectable, a jejunojejunal bypass was performed. Traditional therapeutic interventions proved insufficient, and the patient was started on sorafenib with a subsequent fulldisease response.CONCLUSIONDT's pathogenesis has been associated with mutations in the adenomatous polyposis coli(APC) gene or beta-catenin gene CTNNB1, sex steroids or previous surgical trauma. Local treatment modalities, such as surgery or radiotherapy, are implemented in aggressively progressing or symptomatic patients. Sorafenib is a hopeful therapeutic option against DTs, while several pharmacological agents have been successfully used. | Aikaterini Mastoraki Dimitrios Schizas Chrysovalantis Vergadis Leon Naar Alexios Strimpakos Michail G Vailas Natasha Hasemaki George Agrogiannis Theodore Liakakos Nikolaos Arkadopoulos | 2019 | World Journal of Clinical Oncology2019，10，4： | 4 |
| 2 | Aktl and Akt2 protein kinases differentially contribute to macrophage polarization 显示文摘 | Arranz A Doxaki C Vergadi E | 2012 | Proc Natl Acad Sci U S A2012，109，24： | 1 |
| 3 | Pulmonary microRNA profiling in a mouse model of ventilator - induced lung injury 显示文摘 | Vaporidi K Vergadi E Kaniaris E | 2012 | Am J Physiol Lung Cell Mol Physiol2012，303，3： | 1 |
| 4 | Early macrophage recruitment and ahernative activation are critical for the later development of hypoxia-induced pulmonary hypertension 显示文摘 | Vergadi E Chang MS Lee C | 2011 | Circulation2011，123，18： | 1 |
| 5 | Aktl and Akt2 protein kinases differentially contribute to macrophage polarization显示文摘 | Arranz A Doxaki C Vergadi E | 2012 | Proc Nat Acad Scie USA2012，109，24： | 1 |
| 6 | Pulmonary mi- croRNA profiling in a mouse model of ventilator - induced lung in- jury显示文摘 | VAPORIDI K VERGADI E KANIAR1S E | 2012 | Am J Physiol Lung Cell Mol Physiol2012，303，3： | 1 |
| 7 | Early macrophage recruitment and ahcrnative activation are critical for the later development of hypoxia-induced pulmonary hyper- tension 显示文摘 | Vergadi E Chang MS Lee C | 2011 | Circulation2011，123，18： | 1 |
| 8 | Aktl and Akt2 protein kinases differentially contribute to macrophage polarization 显示文摘 | ARRANZ A DOXAKI C VERGADI E | 2012 | Proc Nail Acad Sci L S A2012，109，24： | 1 |
| 9 | Exosomes Mediate the Cytoprotective Action of Mesenchymal Stromal Cells on Hypoxia-Induced Pulmonary Hypertension显示文摘 | Changjin Lee S. Alex Mitsialis Muhammad Aslam Sally H. Vitali Eleni Vergadi Georgios Konstantinou Konstantinos Sdrimas Angeles Fernandez-Gonzalez Stella Kourembanas | 2012 | Circulation2012，，22： | 1 |
| 10 | Aktl and Akt2 protein kinases differentially contribute to macrophage polarization 显示文摘 | Arranz A Doxaki C Vergadi E et aI | 2012 | Proc Natl Acad Sci U S A2012，109，24： | 1 |
| 11 | Genetic and pharmacologic inhibition of Tpl2 kinase is protective in a mouse model of ventilator-induced lung injury显示文摘 | Kaniaris E Vaporidi K Vergadi E | 2014 | Intensive Care Med Exp2014，2，1： | 1 |
| 12 | Akt2 deficiency protects from acute lung injury via alternative macrophage activation and miR-146a induction in mice显示文摘 | VergadiE VaporidiK TheodorakisEE | 2014 | J Immunol2014，192，1： | 1 |
| 13 | Pulmonary mi- croKNA profiling in a mouse model of ventilator-induced lung in- jury显示文摘 | VAPORIDI K VERGADI E KANIARIS E | 2012 | Am J Physiol Lung Cell Mol Physiol2012，303，3： | 1 |
| 14 | Pulmonary microRNA profiling in a mouse model of ventilator-induced lung injury显示文摘 | Vaporidi K Vergadi E Kaniaris E | | 0，，3： | 1 |
| 15 | Current evidence for the management of paediatrie parapneumonie effusions显示文摘 | Paraskakis E Vergadi E Chatzimichael A | 2012 | Curt Med Res Opin2012，28，7： | 1 |
| 16 | Exosomes Mediate the Cytoprotective Action of Mesenchymal Stromal Cells on Hypoxia-Induced Pulmonary Hypertension显示文摘 | Changjin Lee S. Alex Mitsialis Muhammad Aslam Sally H. Vitali Eleni Vergadi Georgios Konstantinou Konstantinos Sdrimas Angeles Fernandez-Gonzalez Stella Kourembanas | 2012 | Circulation2012，，22： | 1 |
| 17 | Akt1 and Akt2 protein kinases differentially contribute to macrophage polarization显示文摘 | Alicia Arranz Christina Doxaki Eleni Vergadi Yeny Martinez de la Torre Katerina Vaporidi Eleni D. Lagoudaki Eleftheria Ieronymaki Ariadne Androulidaki Maria Venihaki Andrew N. Margioris Efstathios N. Stathopoulos Philip N. Tsichlis Christos Tsatsanis | 2012 | Proceedings of the National Academy of Sciences2012，，24： | 1 |
| 18 | Early macrophage re- cruitment and alternative activation are critical for the later de- velopment ofhypoxia-induced pulmonary hypertension 显示文摘 | Vergadi E Chang MS Lee C | 2011 | Cir- culation2011，123，18： | 1 |
| 19 | Abnormal gait and hypoglycorrhachia in a toddler with seizures显示文摘Introduction:Glucose transporter type 1(Glut1)deficiency syndrome is a treatable neurometabolic disorder characterized by seizures,developmental delay,and hypoglycorrhachia.Due to the rareness and non-specific clinical manifestations,it is usually mis-or underdiagnosed.Case presentation:We report the case of a toddler who presented with afebrile epileptic seizures and abnormal gait.Brain imaging and electroencephalogram were normal.Further investigation of the cerebrospinal fluid revealed hypoglycorrhachia that was the clue to the diagnosis of Glut1 deficiency syndrome and the initiation of treatment with ketogenic diet.Conclusion:Our case highlights the importance of lumbar puncture while investigating a child with epileptic seizures and abnormal gait or developmental delay,in order not to miss treatable neurometabolic conditions,such as Glut1 deficiency syndrome. | Maria Angeli Eleni Vergadi Georgios Niotakis Maria Raissaki Emmanouil Galanakis | 2022 | Pediatric Investigation2022，6，1： | 0 |
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