|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Stem cell therapy in the management of shoulder rotator cuff disorders显示文摘Rotator cuff tears are frequent shoulder problems that are usually dealt with surgical repair. Despite improved surgical techniques, the tendon-to-bone healing rate is unsatisfactory due to difficulties in restoring the delicate transitional tissue between bone and tendon. It is essential to understand the molecular mechanisms that determine this failure. The study of the molecular environment during embryogenesis and during normal healing after injury is key in devising strategies to get a successful repair. Mesenchymal stem cells(MSC) can differentiate into different mesodermal tissues and have a strong paracrine, anti-inflammatory, immunoregulatory and angiogenic potential. Stem cell therapy is thus a potentially effective therapy to enhance rotator cuff healing. Promising results have been reported with the use of autologous MSC of different origins in animal studies: they have shown to have better healing properties, increasing the amount of fibrocartilage formation and improving the orientation of fibrocartilage fibers with less immunologic response and reduced lymphocyte infiltration. All these changes lead to an increase in biomechanical strength. However, animal research is still inconclusive and more experimental studies are needed before human application. Future directions include expanded stem cell therapy in combination with growth factors or different scaffolds as well as new stem cell types and gene therapy. | Maria Valencia Mora Miguel A Ruiz Ibán Jorge Díaz Heredia Raul Barco Laakso Ricardo Cuéllar Mariano García Arranz | 2015 | World Journal of Stem Cells2015，7，4： | 6 |
| 2 | Selection of patients with hepatocellular carcinoma for livertransplantation:Past and future显示文摘The aim of liver transplantation(LT) for hepatocellular carcinoma(HCC) is to ensure a rate of disease-free survival similar to that of patients transplanted due to benign disease. Therefore, we are forced to adopt strict criteria when selecting candidates for LT and prioritizing patients on the waiting list(WL), to have clarified indications for bridging therapy for groups at risk for progression or recurrence, and to establish certain limits for downstaging therapies. Although the Milan criteria(MC) remain the standard and most employed criteria for indication of HCC patients for LT by far, in the coming years, criteria will be consolidated that take into account not only data regarding the size/volume and number of tumors but also their biology. This criteria will mainly include the alpha fetoprotein(AFP) values and, in view of their wide variability, any of the published logarithmic models for the selection of candidates for LT. Bridging therapy is necessary for HCC patients on the WL who meet the MC and have the possibility of experiencing a delay for LT greater than 6 mo or any of the known risk factors for recurrence. It is difficult to define single AFP values that would indicate bridging therapy(200, 300 or 400 ng/m L); therefore, it is preferable to rely on the criteria of a French AFP model score > 2. Other single indications for bridging therapy include a tumor diameter greater than 3 cm, more than one tumor, and having an AFP slope greater than 15 ng/m L per month or > 50 ng/m L for three months during strict monitoring while on the WL. When considering the inclusion of patients on the WL who do not meet the MC, it is mandatory to determine their eligibility for downstaging therapy prior to inclusion. The upper limit for this therapy could be one lesion up to 8 cm, 2-3 lesions with a total tumor diameter up to 8 cm, or a total tumor volume of 115 cm^3. Lastly, liver allocation and the prioritization of patients with HCC onthe WL should take into account the recently described HCC model for end-stage liver disease, which considers hepatic function, HCC size and the number and the log of AFP values. This formula has been calibrated with the survival data of non-HCC patients and produces a dynamic and more accurate assessment model. | Arturo Soriano Aranzazu Varona Rajesh Gianchandani Modesto Enrique Moneva Javier Arranz Antonio Gonzalez Manuel Barrera | 2016 | World Journal of Hepatology2016，8，1： | 6 |
| 3 | Genetic relationships among Spanish sheep using microsatellites显示文摘 | Arranz J J Bayon Y San Primitivo F | 1998 | Animal Genetics1998，29，6： | 2 |
| 4 | Polymorphisms of the 5-HT2c receptor and leptin genes are associated with antipsychotie drug-induced weight gain in Caucasian subjects with a first-episode psychosis 显示文摘 | Templeman LA Reynolds GP Arranz B | 2005 | Pharmacogenetics and Genomics2005，15，4： | 1 |
| 5 | Comparison between free radical scavenging capacity and oxidative stability of nut oils显示文摘 | Arranz S Cert R P6rez - Jim6nez J | 2008 | Food Chemistry2008，110，4： | 1 |
| 6 | Allelic association analysis of the 5 - HT2C receptor gene in bipolar affective disorder 显示文摘 | Gutierrez B Fananas L Arranz M J | 1996 | Neurosci Lett1996，212，1： | 1 |
| 7 | Governance structures in R&D networks: An analysis in the European context 显示文摘 | ARRANZ N ARROYABE J C F D | 2007 | Technological Forecasting and Social Change2007，74，5： | 1 |
| 8 | Sex hormone binding globulin stimulates chorionic gonadotrophin secretion from human cytotro- phoblasts in culture 显示文摘 | Queipo G Deas M Arranz C | 1998 | Hum Reprod1998，13，5： | 1 |
| 9 | Differences in the expression of the ASIP gene are involved in the recessive black coat colour pattern in sheep: evidence from the rare Xalda sheep breed显示文摘 | Royo L J Alvarez I Arranz J J | 2008 | Animal Genetics2008，39，3： | 1 |
| 10 | Genetic relationships among Spanish sheep using microsatellites 显示文摘 | Arranz J J Bayon Y Li K | 1998 | AnimalGenetics1998，29，6： | 1 |
| 11 | 5-HT2A receptor T102C polymorphism and schizophrenia显示文摘 | Arranz M J Lin M W Powell J | 1996 | Lancet1996，347，9018： | 1 |
| 12 | Changes in phenolic content of tomato products during storage显示文摘 | Vallverdú-Queralt A Arranz S Medina-Remón A | 2011 | J Agric Food Chem2011，59，17： | 1 |
| 13 | The Kinase Aktl controls macrophage response to lipopolysaccharide by regulating mieroRNAs 显示文摘 | Androulidaki A Iliopoulos D Arranz A | 2009 | Immunity2009，31，2： | 1 |
| 14 | Alterations in the ex-pression of p53, KLF4, and p21 in neuroendocrine lung tumors显示文摘 | Naranjo GJ Bernal JF Arranz PG | 2014 | Arch Pathol Lab Med2014，138，7： | 1 |
| 15 | Primary renal lymphoma:report of 3 cases and review of the literature显示文摘 | Arranz Arijia JA Carrion JR Garcia FR | 1994 | Am J Nephrol1994，14，2： | 1 |
| 16 | Expression profiles of genes in- volved in the mouse nuclear factor-kappa B signal transduction pathway are modulated by mangiferin显示文摘 | Leiro J Arranz JA Yanez M | 2004 | International Journal of Immunophar- macology2004，4，6： | 1 |
| 17 | Bilateral popliteal aneurysm as a result of vascular type Ⅳ entrapment in a young patient:a report of an exceptional case显示文摘 | Lopez Garcia D Arranz M A Tagarro S | 2007 | J Vasc Surg2007，46，5： | 1 |
| 18 | Bilateral popliteal aneu- rysm as a result of vascular type IV entrapment in a young patient: a report of an exceptional case显示文摘 | L6pez Garcia D Arranz MA Tagarro S | 2007 | J Vase Surg2007，46，5： | 1 |
| 19 | Effect of formal contracts, rela- tional norms and trust on performance of joint re- search and development projects显示文摘 | Arranz N Arroyabe J | 2012 | British Journal of Management2012，23，4： | 1 |
| 20 | Seasonal and Pandemic A(H1N1 )2009 influenza vaccination coverage and attitudes among health-care workers in a Spanish University Hospital 显示文摘 | V~rseda S Restrepo MA Arranz E | 2010 | Vaccine2010，28，30： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员