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| 1 | Modulatory effects of estrogen in two murine models of experimental colitis显示文摘 | Verd E F Deng Y Bercik P Collins S M | 2002 | Am J Physiol Gastrointest Liver Physiol2002，283，： | 1 |
| 2 | The high-quality draft genome of peach (Prunus persica) identifies unique patterns of genetic diversity,domestication and genome evolution显示文摘 | The International Peach Genome Iniative Verde I Abbott A G Scalabrin S Jung S Shu S Marroni F Zhebentyayeva T Dettori M T Grimwood J Cattonaro F Zuccolo A Rossini L Jenkins J Vendramin E Meisel L A Decroocq V Sosinski B Prochnik S Mitros T Policriti A Cip | | 0，，： | 1 |
| 3 | Control of microtubule dynamics and length by cyclin A-and cyclin B-dependent kinase in Xenopus egg extracts显示文摘 | Verde F Dogterom M Stelzer E | 1992 | Cell Biol J1992，118，： | 1 |
| 4 | Visceral hyperalgesia and intestinal dysmotility in a mouse model of postinfective gut dysfunction显示文摘 | Bercík P Wang L Verdú E F | 2004 | Gastroenterology2004，127，： | 1 |
| 5 | Renal biopsy in very elderly patients :data from the Spanish Registry of Glomerulonephritis 显示文摘 | Verde E Quiroga B Rivera F | 2012 | Am J Nephrol2012，35，： | 1 |
| 6 | Visceral hyperalgesia and intestinal dysmotility in a mouse model of postinfective gutdysfunction显示文摘 | Bercìk P Wang L Verdú E F | 2004 | Gastroenterology2004，127，： | 1 |
| 7 | Control of microtubule dynamics and length by cyclin A-and cyclin B-dependent kinases in Xenopus egg extracts显示文摘 | Verde F Dogterom M Stelzer E | 1992 | Cell Biol1992，118，： | 1 |
| 8 | Sequential protocol with urinary-FSH/recombinant-FSH versus standard protocol with recombinant-FSH in women of advanced age undergoing IVF 显示文摘 | Colacurci N Caprio F La Verde E | 2014 | Gynecol Endocrinol2014，30，10： | 1 |
| 9 | Lactobacillus paracasei normalizes muscle hypercontractility in a murine model of postinfective gut dysfunction 显示文摘 | VERDE F BERC K P BERGONZELLI G E | 2004 | Gastroenterology2004，127，： | 1 |
| 10 | Urinary clusterin,cystatin C,beta2-microglobulin and total protein as markers to detect drug-induced kidney injury显示文摘 | Dieterle F Perentes E Cordier A Roth DR Verdes P Grenet O | 2010 | Nat Biotechnol2010，28，5： | 1 |
| 11 | Effect of Aspergillus niger prolyl endopeptidase in patients with celiac disease on a long-term gluten-free diet显示文摘BACKGROUND The gluten-free diet(GFD)has limitations,and there is intense research in the development of adjuvant therapies.AIM To examine the effects of orally administered Aspergillus niger prolyl endopeptidase protease(AN-PEP)on inadvertent gluten exposure and symptom prevention in adult celiac disease(CeD)patients following their usual GFD.METHODS This was an exploratory,double-blind,randomized,placebo-controlled trial that enrolled CeD patients on a long-term GFD.After a 4-wk run-in period,patients were randomized to 4 wk of two AN-PEP capsules(GliadinX;AVI Research,LLC,United States)at each of three meals per day or placebo.Outcome endpoints were:(1)Average weekly stool gluten immunogenic peptides(GIP)between the run-in and end of treatments and between AN-PEP and placebo;(2)celiac symptom index(CSI);(3)CeD-specific serology;and(4)quality of life.Stool samples were collected for GIP testing by ELISA every Tuesday and Friday during run-ins and treatments.RESULTS Forty patients were randomized for the intention-to-treat analysis,and three were excluded from the per-protocol assessment.Overall,628/640(98.1%)stool samples were collected.GIP was undetectable(<0.08μg/g)in 65.6%of samples,and no differences between treatment arms were detected.Only 0.5%of samples had GIP concentrations sufficiently high(>0.32μg/g)to potentially cause mucosal damage.Median GIP concentration in the AN-PEP arm was 44.7%lower than in the run-in period.One-third of patients exhibiting GIP>0.08μg/g during run-in had lower or undetectable GIP after AN-PEP treatment.Compared with the run-in period,the proportion of symptomatic patients(CSI>38)in the AN-PEP arm was significantly lower(P<0.03).AN-PEP did not result in changes in specific serologies.CONCLUSION This exploratory study conducted in a real-life setting revealed high adherence to the GFD.The AN-PEP treatment did not significantly reduce the overall GIP stool concentration.However,given the observation of a significantly lower prevalence of patients with severe symptoms in the AN-PEP arm,further clinical research is warranted. | Juan Pablo Stefanolo Verónica Segura Martina Grizzuti Abel Heredia Isabel Comino Ana Florencia Costa Roberto Puebla María Paz Temprano Sonia Isabel Niveloni Gabriel de Diego María E Oregui Edgardo Gustavo Smecuol Mauricio C de Marzi Elena F Verdú Carolina Sousa Julio César Bai | 2024 | World Journal of Gastroenterology2024，30，11： | 0 |
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