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| 1 | Surgery for inflammatory bowel disease显示文摘Despite the new and ever expanding array of medications for the treatment of inflammatory bowel disease (IBD), there are still clear indications for operative management of IBD and its complications. We present an overview of indications, procedures, considerations, and controversies in the surgical therapy of IBD. | John M Hwang Madhulika G Varma | 2008 | World Journal of Gastroenterology2008，14，17： | 13 |
| 2 | Subcurative radiation significantly increases cell proliferation, invasion, and migration of primary glioblastoma multiforme in vivo显示文摘Tumor cell proliferation, infiltration, migration, and neovascularization are known causes of treatment resistance in glioblastoma multiforme(GBM). The purpose of this study was to determine the effect of radiation on the growth characteristics of primary human GBM developed in a nude rat. Primary GBM cells grown from explanted GBM tissues were implanted orthotopically in nude rats. Tumor growth was confirmed by magnetic resonance imaging on day 77(baseline) after implantation. The rats underwent irradiation to a dose of 50 Gy delivered subcuratively on day 84 postimplantation(n = 8), or underwent no radiation(n = 8). Brain tissues were obtained on day 112(nonirradiated) or day 133(irradiated). Immunohistochemistry was performed to determine tumor cell proliferation(Ki-67) and to assess the expression of infiltration marker(matrix metalloproteinase-2, MMP-2) and cell migration marker(CD44). Tumor neovascularization was assessed by microvessel density using von-Willebrand factor(vWF) staining. Magnetic resonance imaging showed well-developed, infiltrative tumors in 11 weeks postimplantation. The proportion of Ki-67-positive cells in tumors undergoing radiation was(71 ± 15)% compared with(25 ± 12)% in the nonirradiated group(P = 0.02). The number of MMP-2-positive areas and proportion of CD44-positive cells were also high in tumors receiving radiation, indicating great invasion and infiltration. Microvessel density analysis did not show a significant difference between nonirradiated and irradiated tumors. Taken together, we found that subcurative radiation significantly increased proliferation, invasion, and migration of primary GBM. Our study provides insights into possible mechanisms of treatment resistance following radiation therapy for GBM. | Adarsh Shankar Sanath Kumar Asm Iskander Nadimpalli RS Varma Branislava Janic Ana deCarvalho Tom Mikkelsen Joseph A Frank Meser M Ali Robert A Knight Stephen Brown Ali S Arbab | 2014 | Chinese Journal of Cancer2014，33，3： | 5 |
| 3 | Sildenafil- mediated neovascularization and protection against myocardial ischaemia reperfusion injury in rats : role of VEGF/angiopoietin-1 显示文摘 | Koneru S Varma Penumathsa S Thirunavukkarasu M | 2008 | J Cell Mol Med2008，12，6： | 1 |
| 4 | Enhanced food sterilization through inclination of the container wails and geometry modifications显示文摘 | VARMA M N KANNAN A | 2005 | Intemafional Journal of Heat and Mass Transfer2005，48，18： | 1 |
| 5 | Strain improvement of Penicillium janthinellum NCIM 1171 for increased cellulase production显示文摘 | Adsul M G Bastawde K B Varma A J | 2007 | Bioresource Technology2007，98，： | 1 |
| 6 | Strain inthe medial collateral ligament of the human knee under single and combined loads 显示文摘 | Hull M L Bems G S Varma H Patterson H A | 1996 | Journal of Biomechanics1996，29，： | 1 |
| 7 | Seismic behavior and modeling of high-strength composite concrete-filled steel tube (CFT) beam-columns 显示文摘 | Varma A H Ricles J M Sause R Lu L W | 2002 | Journal of Constructional Steel Research2002，58，5678： | 1 |
| 8 | CFD studies on natural convective heating of canned food in conical and cylindrical containers显示文摘 | VARMA M N KANNAN A | 2006 | Joumal of Food Engineering2006，77，4： | 1 |
| 9 | Quantum molecular lensing of femtosecond laser optical/plasma filaments显示文摘 | Varma S Chen Y H Milchberg H M | | 0，，： | 1 |
| 10 | Design and analysis of electro - hydraulic draft control system 显示文摘 | Ayers P D Varma K V Karim M N | 1989 | Transaction of the ASAE1989，32，6： | 1 |
| 11 | Management of adult idiopathic thrombocytopenic purpura显示文摘 | NAKHOUL IN KOZUCH P VARMA M | 2006 | Clin Adv2006，4，： | 1 |
| 12 | Oxidation of cellulose under controlled conditions显示文摘 | VARMA A J KULKARMI M P | 2002 | Polymer Degradation and Stability2002，77，1： | 1 |
| 13 | Creep and fatigue behaviour of a near a IMI 834 titanium alloy显示文摘 | SATYANARAYANA D V V VARMA V K NAGALAKSHMI G SRINWASA RAO M K | 2007 | Metals Materials and Processes2007，19，14： | 1 |
| 14 | Triterpenoids and phthalates ester of Moghania macrophylla stem-bark 显示文摘 | Varma R S Parthasarathy M R | 1976 | Curr Sci1976，45，22： | 1 |
| 15 | Retinol blinding protein 4 expression in humans relationship to insulin resistance, in flammation, and response to pioglitazone 显示文摘 | Yao-Borengasser A Varma V Bodies A M | 2007 | Clin Endocrinol Metab2007，92，7： | 1 |
| 16 | Design and analysis of electro-hydraulic draft control system显示文摘 | Ayers P D Varma K V Karim M N | 1989 | Transactions of the ASAE1989，32，6： | 1 |
| 17 | A triphasic ceramic- coated porous bydroxyapatite for tissue engineering application 显示文摘 | Nair M B Suresh Babu S Varma H K | 2008 | Acta Biomater2008，4，1： | 1 |
| 18 | Laparoscopic colonic resection for rectosigmoid colonic tumours: a retrospective analysis and comparison with open resection 显示文摘 | Prakash K Varma D Rajan M | 2010 | Indian Journal of Surgery2010，72，4： | 1 |
| 19 | Overexpression of the Ba- cillus thuringiensis (Bt) Cry2Aa2 protein in chloroplasts con- fers resistance to plants against susceptible and Bt-resistant in- sects 显示文摘 | Kota M Daniell H Varma S | 1999 | Proceedings of the National Academy of Sciences USA1999，96，5： | 1 |
| 20 | Establishment of mouse as an animal model for study of diabetic cataracts : biochemical studies显示文摘 | Hegde KR Henein M G Varma S D | 2003 | Diabetes Obes Metab2003，5，2： | 1 |
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