|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | A comparison of the relative efficiency of ICSI and extended culture with epididymal sperm versus testicular sperm in patients with obstructive azoospermia显示文摘This is a retrospective cohort study comparing blastocyst transfer outcomes following intracytoplasmic sperm injection utilizing epididymal versus testicular sperm for men with obstructive azoospermia.All cases at a single center between 2012 and 2016 were included.Operative approach was selected at the surgeon’s discretion and included microepididymal sperm aspiration or testicular sperm extraction.Blastocyst culture was exclusively utilized prior to transfer.The primary outcome was live birth rate.Secondary outcomes included fertilization rate,blastulation rate,euploidy rate,and implantation rate.A mixed effects model was performed.Seventy-six microepididymal sperm aspiration cases and 93 testicular sperm extraction cases were analyzed.The live birth rate was equivalent(48.6%vs 50.5%,P=0.77).However,on mixed effects model,epididymal sperm resulted in a greater likelihood of fertilization(adjusted OR:1.37,95%CI:1.05–1.81,P=0.02)and produced a higher blastulation rate(adjusted OR:1.41,95%CI:1.1–1.85,P=0.01).As a result,the epididymal sperm group had more supernumerary blastocysts available(4.3 vs 3,P<0.05).The euploidy rate was no different.Pregnancy rates were no different through the first transfer cycle.However,intracytoplasmic sperm injection following microepididymal sperm aspiration resulted in a greater number of usable blastocysts per patient.Thus,the true benefit of epididymal sperm may only be demonstrated via a comparison of cumulative pregnancy rates after multiple transfers from one cohort. | Scott J Morin Brent M Hanson Caroline R Juneau Shelby A Neal Jessica N Landis Richard T Scott Jr James M Hotaling | 2020 | Asian Journal of Andrology2020，22，2： | 2 |
| 2 | Biomarker-guided sequential targeted therapies to overcome therapy resistance in rapidly evolving highly aggressive mammary tumors显示文摘组合指向的治疗在由堵住治疗癌症是更有效的绕过机制或导致的合成致命性。然而,他们的临床的申请被抵抗和毒性妨碍。遇见这重要挑战,我们用 ErbB2-overexpressing/PTEN-low 开发了并且测试各种各样的指向的治疗的指导 biomarker 的顺序的应用程序的一个新奇概念,高度好攻击的乳癌作为我们的模型。惊人地,从遗传上设计的鼠标与 intratumoral 异质从病人和乳房的肿瘤在两 PTEN-low/trastuzumab-resistant 乳癌支撑了 ErbB2 和下游的小径驱动器 trastuzumab 抵抗的激活。尽管 lapatinib 开始禁止了 trastuzumab 抵抗的鼠标肿瘤,肿瘤由激活表明由量的蛋白质数组出现的网络的 PI3K/mTOR 绕过抑制。有趣地,小径也是的 mTOR 的激活在 neoadjuvant 观察了表明 lapatinib 抵抗的对待 lapatinib 的病人。Trastuzumab + lapatinib 抵抗被一个 PI3K/mTOR 双 kinase 禁止者(BEZ235 ) 的顺序的申请有效地没有重要毒性克服。然而,我们的 p-RTK 数组分析证明 BEZ235 治疗在遗传上设计的老鼠肿瘤导致了增加的 ErbB2 表示和 phosphorylation,导致 BEZ235 抵抗并且在 3-D,然而并非 2-D,文化。机械学地,我们作为 BEZ235 抵抗的新奇机制识别了 ErbB2 蛋白质稳定和激活,它被随后的治疗与 lapatinib + BEZ235 联合颠倒。显著地, biomarker 指导的指向的治疗的这个顺序的应用程序在很快发展加倍的抵抗的肿瘤改变忍受极其好攻击的肿瘤的鼠标的寿命。使用的这条根本上新奇的途径有效地在一个顺序的顺序罐头指向了治疗目标和改编在在治疗期间发展抵抗的癌症的发信号的网络。 | Ozgur Sahin Qingfei Wang Samuel W Brady Kenneth Ellis Hai Wang Chia-Chi Chang Qingling Zhang Preety Priya Rui Zhu Stephen T Wong Melissa D Landis William J Muller Francisco J Esteva Jenny Chang Dihua Yu | 2014 | Cell Research2014，24，5： | 2 |
| 3 | Explicit and implicit perception of illusory contours in unilateral spatial neglect: behavioural and anatomical correlates of preattentive grouping mechanisms 显示文摘 | Vuilleumier P Valenza N Landis T | 2001 | Neuropsychologia2001，39，6： | 1 |
| 4 | Glutathione S-transi'erase P1 polymorphism (Ile105Val) predicts cumulative neuropathy in patients receiving oxalipla- tin-based chemotherapy 显示文摘 | Lecomte T Landi B Beaune P | 2006 | Clin Cancer Res2006，12，10： | 1 |
| 5 | Cognitive changes at high altitude in healthy climbers and in climbers developing acute mountain sickness显示文摘 | M Landis T Casey J | 1991 | Aviat Space Environ Med1991，62，4： | 1 |
| 6 | Cancer statistics, 1999 显示文摘 | Landis SH Murray T Bolden S | 1999 | CA Cancer J Clin1999，49，1： | 1 |
| 7 | Akinetic mutism in bilateral necrotizing leucoencephalopathy after radiation andchemotherapy: electrophysiological and auto psy findings显示文摘 | Gutling E Landis T Kleihes P | 1992 | J Neurol1992，239，： | 1 |
| 8 | Semantic paralexia:A release of right hemispheric function from left hemispheric control显示文摘 | Regard M Graves R | 1983 | Neuropsychologia1983，21，： | 1 |
| 9 | Development differ-ences in the comprehension of semantic relations显示文摘 | Landis T Herrmann D Chaffin R | 1987 | Zeitschrift für Psychologie mit Zeitschrift für Angewandte Psychologie1987，195，2： | 1 |
| 10 | Cancer statistics,1998显示文摘 | LANDIS S H MURRAY T BOLDEN S | 1998 | CA Cancer J Clin1998，48，1： | 1 |
| 11 | Level-of-service model for pedestrians at signalized intersections显示文摘 | Petritsch T A Landis B W Mcleod P S | 2005 | Transportation Research Record2005，，1939： | 1 |
| 12 | Bitemporal hypoperfusion in transient global amnesia ^(99m)Tc-HM-PAOSPECT and neuropsychological findings during and after an attack 显示文摘 | Stillhard G Landis T Schiess R et ol | 1990 | Neurol Neurosurg Psychiatry1990，53，： | 1 |
| 13 | A study on the frequency of olfactory dysfunction显示文摘 | LANDIS B N KONNERTH C G HUMMEL T | 2004 | Laryngoscope2004，114，： | 1 |
| 14 | Vertebral artery hypoplasia:apredisposing factor for posterior circulation stroke?显示文摘 | Perren F Poglia D Landis T | 2007 | Neurology2007，68，1： | 1 |
| 15 | Predators suppress Aphis glycines Matsumura population growth in soybean 显示文摘 | Fox T B Landis D A Cardoso F F | 2004 | Environ Entomo12004，33，： | 1 |
| 16 | Cancer statistics 1998显示文摘 | Murray T Bolden S | 1998 | Cancer1998，48，1： | 1 |
| 17 | Cancer statistics, 1999 显示文摘 | Landis SH Murray T Bolden S | 1999 | CA Cancer J Clin1999，49，1： | 1 |
| 18 | X-ray microtomographic studies of pore structure and permeability in Portland cement concrete 显示文摘 | LU S LANDIS E N KEANE D T | 2006 | Mater Struct2006，39，61： | 1 |
| 19 | Design,theory and measurement of a polarization insensitive absorber for terahertz imaging显示文摘 | Landy N I Bingham C M Tyler T | | 0，，： | 1 |
| 20 | MicroRNA expression dif- ferentiates histology and predicts survival of lung cancer 显示文摘 | Landi M T Zhao Y Rotunno M | 2010 | Clinical Cancer Research2010，16，2： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员