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| 1 | Megacolon in adulthood after surgical treatment of Hirschsprung's disease in early childhood显示文摘Hirschsprung's disease (HD) is a disorder associated with congenital malformation of the enteric nervous system with segmental aganglionosis. Prevailing therapy includes a resection of the affected part of the bowel. However, patients often do not obtain complete functional improvement after surgical treatment. We present the case of a 25-year-old woman who had surgical treatment of HD in early childhood. After that procedure she had clinical features of constipation for years in the end,passing of stool once a week, requiring laxatives and enemas. We diagnosed an incomplete resection of the aganglionic bowel via rectal biopsy and resected the remaining aganglionic segment. Two months after surgery the patient's bowel function improved to a frequency of 1-4 stools per day. We conclude that regular follow-up is required to identify HD patients with persistent alterations of bowel function after surgery. In patients presenting with constipation, recognition of a remaining aganglionic segment or other alterations of the enteric nervous system should be aimed at in an early stage. | Christoph R.Werner Gisela Stoltenburg-Didinger Henning Weidemann Christoph Benckert Marco Schmidtmann Ivo R.van der Voort Viola Andresen Burghard F.Klapp Peter Neuhaus Bertram Wiedenmann Hubert Mnnikes | 2005 | World Journal of Gastroenterology2005，11，36： | 3 |
| 2 | Gender-dependent association of CTLA4 polymorphisms with resolution of hepatitis C virus infection显示文摘 | Eckart Schott Heiko Witt Holger Hinrichsen Konrad Neumann Viola Weich Alexandra Bergk Juliane Halangk Tobias Müller Sebastian Tinjala Gero Puhl Peter Neuhaus Bertram Wiedenmann Thomas Berg | 2006 | Journal of Hepatology2006，，3： | 2 |
| 3 | Serotonin type 3 receptor subunit gene polymorphisms associated with psychosomatic symptoms in irritable bowel syndrome:A multicenter retrospective study显示文摘BACKGROUND Single-nucleotide polymorphisms(SNPs)of the serotonin type 3 receptor subunit(HTR3)genes have been associated with psychosomatic symptoms,but it is not clear whether these associations exist in irritable bowel syndrome(IBS).AIM To assess the association of HTR3 polymorphisms with depressive,anxiety,and somatization symptoms in individuals with IBS.METHODS In this retrospective study,623 participants with IBS were recruited from five specialty centers in Germany,Sweden,the United States,the United Kingdom,and Ireland.Depressive,anxiety,and somatization symptoms and sociodemographic characteristics were collected.Four functional SNPs—HTR3A c.-42C>T,HTR3B c.386A>C,HTR3C c.489C>A,and HTR3E c.*76G>A—were genotyped and analyzed using the dominant and recessive models.We also performed separate analyses for sex and IBS subtypes.SNP scores were calculated as the number of minor alleles of the SNPs above.The impact of HTR3C c.489C>A was tested by radioligand-binding and calcium influx assays.RESULTS Depressive and anxiety symptoms significantly worsened with increasing numbers of minor HTR3C c.489C>A alleles in the dominant model(F_(depressive)=7.475,P_(depressive)=0.006;F_(anxiety)=6.535,P_(anxiety)=0.011).A higher SNP score(range 0-6)was linked to a worsened depressive symptoms score(F=7.710,P-linear trend=0.006)in IBS.The potential relevance of the HTR3C SNP was corroborated,showing changes in the expression level of 5-HT3AC variant receptors.CONCLUSION We have provided the first evidence that HTR3C c.489C>A is involved in depressive and anxiety symptoms in individuals with IBS.The SNP score indicated that an increasing number of minor alleles is linked to the worsening of depressive symptoms in IBS. | Sabrina Berens Yuanjun Dong Nikola Fritz Jutta Walstab Mauro D'Amato Tenghao Zheng Verena Wahl Felix Boekstegers Justo Lorenzo Bermejo Cristina Martinez Stefanie Schmitteckert Egbert Clevers Felicitas Engel Annika Gauss Wolfgang Herzog Robin Spiller Miriam Goebel-Stengel Hubert Mönnikes Viola Andresen Frieling Thomas Jutta Keller Christian Pehl Christoph Stein-Thöringer Gerard Clarke Timothy G Dinan Eamonn M Quigley Gregory Sayuk Magnus Simrén Jonas Tesarz Gudrun Rappold Lukas van Oudenhove Rainer Schaefert Beate Niesler | 2022 | World Journal of Gastroenterology2022，28，21： | 2 |
| 4 | Magnetic behavior of Ca2 NiWO6 double-perovskite 显示文摘 | Peza C A Lourialeb J Viola M C | 2007 | Physiea B2007，398，： | 1 |
| 5 | Transgenic potato plants with strongly decreases expression of pyrophosphate:fructose-6-phosphate phosphotransferase show no visible phenotype and only minor changes in metabolic fluxes in their tubers显示文摘 | Hajirezaei M R Sonnewald U Viola R | 1994 | Planta1994，192，： | 1 |
| 6 | Robust real-time face detection 显示文摘 | Viola P Jones M | 2004 | International Journal of Computer Vision2004，57，2： | 1 |
| 7 | Molecular stability of chemically modified collagen triple helices显示文摘 | Giudici G Viola M | 2003 | Federation of Eu ropean Biochemical Societies2003，547，3： | 1 |
| 8 | Robust real time face detection 显示文摘 | VIOLA P JONES M J | 2004 | International Journal of Computer Vision2004，57，2： | 1 |
| 9 | Ras p21 expression in the progression of breast cancer显示文摘 | FROMOWITZ F B VIOLA M V CHAO S | 1987 | Hum Pathol1987，18，： | 1 |
| 10 | Fast and Robust Classification using Asymmetric AdaBoost and a Detector Cascade 显示文摘 | Viola P Jones M | 2001 | IEEE Transactions on Pattern Analysis and Machine Intelligence2001，18，3： | 1 |
| 11 | Autonomic modulator and QT in-terval dispersion in hypertensive subjects withanxiety显示文摘 | Piccirillo G Viola E Nocco M | 1999 | Hypertension1999，34，： | 1 |
| 12 | Distinct kinetics of cytokine production and cytolysis in effector and memory T cells after viral infection显示文摘 | Bachmann M Bamer M Viola A | 1999 | Eur J Immunol1999，29，1： | 1 |
| 13 | Multi-modal volume registration by maximization of mutual infcrmation显示文摘 | Wells W M Ⅲ Viola P Atsumi H | 1996 | Med Image Anal1996，3，1： | 1 |
| 14 | Robust real-time face detection显示文摘 | Viola P Jones M | 2004 | International Journal of ComputerVision2004，57，2： | 1 |
| 15 | Alignment by maximization of mutual information显示文摘 | P A Viola W M Wells III | 1997 | International Journal of Computer Vision1997，24，2： | 1 |
| 16 | Multi-modal Volume Registration by Maximization of Mutual Information显示文摘 | Well W M Viola P Atsumi H | 1996 | Medical Image Analysis1996，1，1： | 1 |
| 17 | Robust real-time face detection显示文摘 | VIOLA P JONES M J | 2004 | International Journal of Computer Vision2004，57，2： | 1 |
| 18 | Robust Real-Time Face Detection 显示文摘 | VIOLA P JONES M | 2004 | International Journal of Computer Vision2004，57，2： | 1 |
| 19 | Robust real-time object detection显示文摘 | VIOLA P JONES M | 2001 | International Journal of Computer Vision2001，4，： | 1 |
| 20 | Alighment by maximization of mutual information显示文摘 | Viola P William M Wells Ⅲ | 1997 | International Journal of Computer Vision Computer Vision1997，24，2： | 1 |
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