|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Diagnosis and treatment of hepatocellular carcinoma: An update显示文摘Hepatocellular carcinoma(HCC) is one of the most common malignancies leading to high mortality rates in the general population; in cirrhotic patients, it is the primary cause of death. The diagnosis is usually delayed in spite of at-risk population screening recommendations, i.e., patients infected with hepatitis B or C virus. Hepatocarcinogenesis hinges on a great number of genetic and molecular abnormalities that lead to tumor angiogenesis and foster their dissemination potential. The diagnosis is mainly based on imaging studies such as computed tomography and magnetic resonance, in which lesions present a characteristic classical pattern of early arterial enhancement followed by contrast medium 'washout' in late venous phase. On occasion, when imaging studies are not conclusive, biopsy of the lesion must be performed to establish the diagnosis. The Barcelona Clinic Liver Cancer staging method is the most frequently used worldwide and recommended by the international guidelines of HCC management. Currently available treatments include tumor resection, liver transplant, sorafenib and locoregional therapies(alcoholization, radiofrequency ablation, chemoembolization). The prognosis of hepatocarcinoma is determined according to the lesion's stage and in cirrhotic patients, on residual liver function. Curative treatments, such as liver transplant, are sought in patients diagnosed in early stages; patients in more advanced stages, were not greatly benefitted by chemotherapy in terms of survival until the advent of target molecules such as sorafenib. | Javier Tejeda-Maldonado Ignacio García-Juárez Jonathan Aguirre-Valadez Adrián González-Aguirre Mario Vilatobá-Chapa Alejandra Armengol-Alonso Francisco Escobar-Penagos Aldo Torre Juan Francisco Sánchez-ávila Diego Luis Carrillo-Pérez | 2015 | World Journal of Hepatology2015，7，3： | 22 |
| 2 | Exploratory study on microRNA profiles from plasma-derived extracellular vesicles in Alzheimer’s disease and dementia with Lewy bodies显示文摘Background:Because of the increasing life expectancy in our society,aging-related neurodegenerative disorders are one of the main issues in global health.Most of these diseases are characterized by the deposition of misfolded proteins and a progressive cognitive decline.Among these diseases,Alzheimer’s disease(AD)and dementia with Lewy bodies(DLB)are the most common types of degenerative dementia.Although both show specific features,an important neuropathological and clinical overlap between them hampers their correct diagnosis.In this work,we identified molecular biomarkers aiming to improve the misdiagnosis between both diseases.Methods:Plasma extracellular vesicles(EVs)-from DLB,AD and healthy controls-were isolated using size-exclusion chromatography(SEC)and characterized by flow cytometry,Nanoparticle Tracking Analysis(NTA)and cryo-electron microscopy.Next Generation Sequencing(NGS)and related bibliographic search was performed and a selected group of EV-associated microRNAs(miRNAs)was analysed by qPCR.Results:Results uncovered two miRNAs(hsa-miR-451a and hsa-miR-21-5p)significantly down-regulated in AD samples respect to DLB patients,and a set of four miRNAs(hsa-miR-23a-3p,hsa-miR-126-3p,hsa-let-7i-5p,and hsamiR-151a-3p)significantly decreased in AD respect to controls.The two miRNAs showing decreased expression in AD in comparison to DLB provided area under the curve(AUC)values of 0.9 in ROC curve analysis,thus suggesting their possible use as biomarkers to discriminate between both diseases.Target gene analysis of these miRNAs using prediction online tools showed accumulation of phosphorylation enzymes,presence of proteasome-related proteins and genes involved in cell death among others.Conclusion:Our data suggest that plasma-EV associated miRNAs may reflect a differential profile for a given dementia-related disorder which,once validated in larger cohorts of patients,could help to improve the differential diagnosis of DLB versus AD. | Ana Gámez-Valero Jaume Campdelacreu Dolores Vilas Lourdes Ispierto Ramón Reñé RamiroÁlvarez MPilar Armengol Francesc E.Borràs Katrin Beyer | 2019 | Translational Neurodegeneration2019，8，1： | 4 |
| 3 | New genes emerging for colorectal cancer predisposition显示文摘Colorectal cancer(CRC)is one of the most frequent neoplasms and an important cause of mortality in the developed world.This cancer is caused by both genetic and environmental factors although 35%of the variation in CRC susceptibility involves inherited genetic differences.Mendelian syndromes account for about5%of the total burden of CRC,with Lynch syndrome and familial adenomatous polyposis the most common forms.Excluding hereditary forms,there is an important fraction of CRC cases that present familial aggregation for the disease with an unknown germline genetic cause.CRC can be also considered as a complex disease taking into account the common diseasecommom variant hypothesis with a polygenic model of inheritance where the genetic components of common complex diseases correspond mostly to variants of low/moderate effect.So far,30 common,low-penetrance susceptibility variants have been identified for CRC.Recently,new sequencing technologies including exomeand whole-genome sequencing have permitted to add a new approach to facilitate the identification of new genes responsible for human disease predisposition.By using whole-genome sequencing,germline mutations in the POLE and POLD1 genes have been found to be responsible for a new form of CRC genetic predisposition called polymerase proofreading-associated polyposis. | Clara Esteban-Jurado Pilar Garre Maria Vila Juan José Lozano Anna Pristoupilova Sergi Beltrán Anna Abulí Jenifer Muoz Francesc Balaguer Teresa Ocaa Antoni Castells Josep M Piqué Angel Carracedo Clara Ruiz-Ponte Xavier Bessa Montserrat Andreu Luis Bujanda Trinidad Caldés Sergi Castellví-Bel | 2014 | World Journal of Gastroenterology2014，20，8： | 3 |
| 4 | 实体器官移植患者中热带病和地方性感染病的流行状况显示文摘 | Martín-Dávila P Fortún J López-Vélez R 康悦 吴菊芳 | 2010 | 中国感染与化疗杂志2010，10，3： | 3 |
| 5 | Initial experience with EUS-guided cholangiopancreatography for biliary and pancreatic duct drainage: a Spanish national survey显示文摘 | Juan J. Vila Manuel Pérez-Miranda Enrique Vazquez-Sequeiros Monder Abu-Suboh Abadia Antonio Pérez-Millán Ferrán González-Huix Joan Gornals Julio Iglesias-Garcia Carlos De la Serna José R. Aparicio José C. Subtil Alberto álvarez Felipe de la Morena Jesús G | 2012 | Gastrointestinal Endoscopy2012，，6： | 2 |
| 6 | Perspectives of the potential implications of wine polyphenols on human oral and gut microbiota显示文摘 | T. Requena M. Monagas M.A. Pozo-Bayón P.J. Martín-álvarez B. Bartolomé R. del Campo M. ávila M.C. Martínez-Cuesta C. Peláez M.V. Moreno-Arribas | 2010 | Trends in Food Science & Technology2010，，7： | 2 |
| 7 | Levels of anti-Inflammatory cytokines and neurological worsening in acute ischemic stroke显示文摘 | Vila N Castillo J Davalos A | 2003 | Stroke2003，34，3： | 1 |
| 8 | Neutron Irradiation Effects on Optical Absorption of KU1 and KS-4V Quartz Glasses and Infrasi1301显示文摘 | Leon M Marti n P Vila R | 2009 | Fusion Engineering and Design2009，84，71819110111： | 1 |
| 9 | Proinflammatory cytokines and ealy neurological worsening in ischemic artoke显示文摘 | Vila N Castilo J Davalos A | 2000 | Stroke2000，31，10： | 1 |
| 10 | Proinflammatory cy-tokines and early neurological worsening in ischemicstroke显示文摘 | Vila N Castillo J Davalos A | 2000 | Stroke2000，31，10： | 1 |
| 11 | Impairment of hepatic stat-3 activation and reduction of PPAR alpha activity in fructose-fed rats显示文摘 | Roglans N Vila L Farre M | 2007 | Hepatology2007，45，： | 1 |
| 12 | Proinflammatorycytokines and early neurological worsening in ischemicstroke显示文摘 | VILA N CASTILLO J DAVALOS A | 2000 | Stroke2000，31，10： | 1 |
| 13 | Liver transplantation in patients with portal vein thrombosis显示文摘 | Gerardo Manzanet Fernando Sanjuán Paco Orbis Rafael López ángel Moya Manuel Juan Juanjo Vila Josep Asensi Pedro Sendra José Ru??z Mart??n Prieto José Mir | 2001 | Liver Transplantation2001，，2： | 1 |
| 14 | Analysis of mortality and risk factors associated with native valve endocarditis in drug users: The importance of vegetation size显示文摘 | Pilar Martín-Dávila Enrique Navas Jesús Fortún Jose Luis Moya Javier Cobo Vicente Pintado Carmen Quereda Manuel Jiménez-Mena Santiago Moreno | 2005 | American Heart Journal2005，，5： | 1 |
| 15 | Agenetic approach to ischemic stroke therapy显示文摘 | Vila N | 2004 | Cerebrorasc Dis2004，1，2： | 1 |
| 16 | Levels of anti inflammatory cytokines and neurological worsening in acute ischemic stroke显示文摘 | Vila N Castillo J Divalos A | 2003 | Stroke2003，34，： | 1 |
| 17 | Proinflammatory cytokines and early neurological worsening in ischemic stroke显示文摘 | Vila N Castillo J Davalos A | 2000 | Stroke2000，31，10： | 1 |
| 18 | Proinflammatory cytokines and early neurological worsening in ischemicstroke显示文摘 | Vila N Castillo J DavalosA | 2000 | Stroke2000，31，10： | 1 |
| 19 | Plasma homocysteine levels in patients withischemic cerebral infarction 显示文摘 | VILA N DEULOFEU R CHAMORRO A | 1998 | Med Clin (Barc)1998，110，： | 1 |
| 20 | Proinflammatory cytokines and early neurological wersing in ischemic stroke显示文摘 | Vila N Castillo J Davalos A | 2003 | Stroke2003，34，10： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员