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| 1 | Household air pollution and lung cancer in China:a review of studies in Xuanwei显示文摘Over half of the world's population is exposed to household air pollution from the burning of solid fuels at home. Household air pollution from solid fuel use is a leading risk factor for global disease and remains a major public health problem, especially in low- and mid-income countries. This is a particularly serious problem in China, where many people in rural areas still use coal for household heating and cooking. This review focuses on several decades of research carried out in Xuanwei County, Yunnan Province, where household coal use is a major source of household air pollution and where studies have linked household air pollution exposure to high rates of lung cancer. We conducted a series of case-control and cohort studies in Xuanwei to characterize the lung cancer risk in this population and the factors associated with it. We found lung cancer risk to vary substantially between different coal types, with a higher risk associated with smoky(i.e., bituminous) coal use compared to smokeless(i.e., anthracite) coal use. The installation of a chimney in homes resulted in a substantial reduction in lung cancer incidence and mortality. Overall, our research underscores the need among existing coal users to improve ventilation, use the least toxic fuel, and eventually move toward the use of cleaner fuels, such as gas and electricity. | Wei Jie Seow Wei Hu Roel Vermeulen H.Dean Hosgood III George S.Downward Robert S.Chapman Xingzhou He Bryan A.Bassig Christopher Kim Cuiju Wen Nathaniel Rothman Qing Lan | 2014 | Chinese Journal of Cancer2014，33，10： | 15 |
| 2 | Total Replacement of Fish Oil with Vegetable Oils in the Diet of Juvenile Jade Perch Scortum barcoo Reared in Recirculating Aquaculture Systems显示文摘 | Stijn Van Hoestenberghe Ivo Roelants Daniel Vermeulen Bruno Maria Goddeeris | 2013 | Journal of Agricultural Science and Technology(B)2013，3，5： | 10 |
| 3 | Glutamate reduces experimental intestinal hyperpermeability and facilitates glutamine support of gut integrity显示文摘AIM:To assess whether glutamate plays a similar role to glutamine in preserving gut wall integrity.METHODS:The effects of glutamine and glutamate on induced hyperpermeability in intestinal cell lines were studied.Paracellular hyperpermeability was induced in Caco2.BBE and HT-29CL.19A cell lines by adding phorbol-12,13-dibutyrate(PDB) apically,after which the effects of glutamine and glutamate on horseradish peroxidase(HRP) diffusion were studied.An inhibitor of glutamate transport(L-trans-pyrrolidine-2,4-dicarboxylic acid:trans-PDC) and an irreversible blocker(acivicin) of the extracellular glutamine to glutamate converting enzyme,γ-glutamyltransferase,were used.RESULTS:Apical to basolateral HRP flux increased significantly compared to controls not exposed to PDB (n=30,P<0.001).Glutamine application reduced hyperpermeability by 19%and 39%in the respective cell lines.Glutamate application reduced hyperpermeability by 30%and 20%,respectively.Incubation of HT29CL.19A cells with acivicin and subsequent PDB and glutamine addition increased permeability levels.Incubation of Caco2.BBE cells with trans-PDC followed by PDB and glutamate addition also resulted in high permeability levels.CONCLUSION:Apical glutamate-similar to glutaminecan decrease induced paracellular hyperpermeability.Extracellular conversion of glutamine to glutamate and subsequent uptake of glutamate could be a pivotal step in the mechanism underlying the protective effect of glutamine. | Mechteld AR Vermeulen Jeffrey de Jong Mathijs J Vaessen Paul AM van Leeuwen Alexander PJ Houdijk | 2011 | World Journal of Gastroenterology2011，17，12： | 9 |
| 4 | Neuroanatomy of lower gastrointestinal pain disorders显示文摘Chronic abdominal pain accompanying intestinal inflammation emerges from the hyperresponsiveness of neuronal,immune and endocrine signaling pathways within the intestines,the peripheral and the central nervous system.In this article we review how the sensory nerve information from the healthy and the hypersensitive bowel is encoded and conveyed to the brain.The gut milieu is continuously monitored by intrinsic enteric afferents,and an extrinsic nervous network comprising vagal,pelvic and splanchnic afferents.The extrinsic afferents convey gut stimuli to second order neurons within the superficial spinal cord layers.These neurons cross the white commissure and ascend in the anterolateral quadrant and in the ipsilateral dorsal column of the dorsal horn to higher brain centers,mostly subserving regulatory functions.Within the supraspinal regions and the brainstem,pathways descend to modulate the sensory input.Because of this multiple level control,only a small proportion of gut signals actually reaches the level of consciousness to induce sensation or pain.In inflammatory bowel disease(IBD)and irritable bowel syndrome(IBS)patients,however,long-term neuroplastic changes have occurred in the brain-gut axis which results in chronic abdominal pain.This sensitization may be driven on the one hand by peripheral mechanisms within the intestinal wall which encompasses an interplay between immunocytes,enterochromaffin cells,resident macrophages,neurons and smooth muscles.On the other hand,neuronal synaptic changes along with increased neurotransmitter release in the spinal cord and brain leads to a state of central wind-up.Also life factors such as but not limited to inflammation and stress contribute to hypersensitivity.All together,the degree to which each of these mechanisms contribute to hypersensitivity in IBD and IBS might be diseaseand even patient-dependent.Mapping of sensitization throughout animal and human studies may significantly improve our understanding of sensitization in IBD and IBS.On the long run,this knowledge can be put forward in potential therapeutic targets for abdominal pain in these conditions. | Wim Vermeulen Joris G De Man Paul A Pelckmans Benedicte Y De Winter | 2014 | World Journal of Gastroenterology2014，20，4： | 7 |
| 5 | 腹部手术后是否应用鼻胃管?——近期文献的分析显示文摘在许多医疗中心,腹部手术后在胃肠(GI)功能尚未完全恢复前预防性使用鼻胃管(NGI)已是一个诊疗常规。在腹部手术中使用鼻胃管可使术野有更好显露也已成为广泛共识。但在二十世纪80—90年代,许多临床试验却对是否常规使用鼻胃管提出了新的争议。1995年,Cheatham等在对截止到1993年所公开发表的文献所做的分析中显示: | 刘军麟 Vermeulen H Storm-Versloot MN Busch OR | 2008 | 中华普通外科学文献(电子版)2008，2，2： | 4 |
| 6 | Myostatin gene promoter:structure,conservation and importance as a target for muscle modulation显示文摘Myostatin(MSTN) is one of the key factors regulating myogenesis. Because of its role as a negative regulator of muscle mass deposition, much interest has been given to its protein and, in recent years, several studies have analysed MSTN gene regulation. This review discusses the MSTN gene promoter, focusing on its structure in several animal species, both vertebrate and invertebrate. We report the important binding sites considering their degree of phylogenetic conservation and roles they play in the promoter activity. Finally, we discuss recent studies focusing on MSTN gene regulation via promoter manipulation and the potential applications they have both in medicine and agriculture. | Carla Vermeulen Carvalho Grade Carolina Stefano Mantovani Lúcia Elvira Alvares | 2019 | Journal of Animal Science and Biotechnology2019，10，2： | 4 |
| 7 | Optical frequency synthesizer with an integrated erbium tunable laser显示文摘Optical frequency synthesizers have widespread applications in optical spectroscopy,frequency metrology,and many other fields.However,their applicability is currently limited by size,cost,and power consumption.Silicon photonics technology,which is compatible with complementary-metal-oxide-semiconductor fabrication processes,provides a low-cost,compact size,lightweight,and low-power-consumption solution.In this work,we demonstrate an optical frequency synthesizer using a fully integrated silicon-based tunable laser.The synthesizer can be self-calibrated by tuning the repetition rate of the internal mode-locked laser.A 20 nm tuning range from 1544 to 1564 nm is achieved with~10−13 frequency instability at 10 s averaging time.Its flexibility and fast reconfigurability are also demonstrated by fine tuning the synthesizer and generating arbitrary specified patterns over time-frequency coordinates.This work promotes the frequency stability of silicon-based integrated tunable lasers and paves the way toward chip-scale lowcost optical frequency synthesizers. | Ming Xin Nanxi Li Neetesh Singh Alfonso Ruocco Zhan Su Emir Salih Magden Jelena Notaros Diedrik Vermeulen Erich P.Ippen Michael R.Watts Franz X.Kartner | 2019 | Light(Science & Applications)2019，8，1： | 2 |
| 8 | Reassessment of the accuracy of traditional sperm characteristics and adenosine triphosphate (ATP) in estimating the fertilizing potential of human semen in vivo显示文摘 | Comhaire F H Vermeulen L Schoonjans F | 1987 | Int J Androl1987，，10： | 2 |
| 9 | Adenosine triphosphate in human semen: a quantitative estimate of fertilizing potential显示文摘 | Comhaire F H Vermeulen L Ghedira K | 1983 | Fertil Steril1983，40，： | 2 |
| 10 | 评估饮用水中化学物暴露与健康结局:认识和研究需求现状显示文摘[背景]安全的饮用水对于健康至关重要。虽然在全球范围内,微生物污染仍然是饮用水相关疾病发病率和死亡率的最主要原因,但在供水中的化学物也可能导致疾病,而其中一些的人体健康结局的证据有限或缺乏。[目的]旨在总结当前人们对这一问题的了解状况,找出认识差距,并为与饮用水中化学物相关的流行病学研究提供建议。[讨论]评估饮用水中化学物暴露与健康结局十分具有挑战性。暴露通常为低浓度,在水中测量是通常是不够的,化学物以混合物形式存在,暴露时间通常很长,可能涉及多个暴露途径,而能够反映相应暴露阶段的有效生物标志却很少。此外,相对风险的幅度具有变小趋势。[结论]研究应该包括:设计良好的流行病学研究,涵盖能够比较污染程度并具有足够样本量的地区;结合生物分析并整合复杂混合物影响的污染物产生综合评价;足够水中测量次数,以评估地理和时间变异性;有关导致暴露的个人生活习惯的详细信息(例如,摄入、淋浴、游泳和饮食);生物样本的采集,以测量相关的生物标志;先进的统计模型,以评估暴露和相对风险,并应考虑解决测量误差的方法。最后,纳入早期生物效应和遗传易感性的分子标志对于了解化学物作用机制是必不可少的。需要评估大量新出现的污染物的风险和人类暴露,但这些知识仍然缺乏。 | Cristina M.Villanueva Manolis Kogevinas Sylvaine Cordier Michael R.Templeton Roel Vermeulen John R.Nuckols Mark J.Nieuwenhuijsen Patrick Levallois 汪源 张伊人 何蓉 金泰廙 | 2014 | 环境与职业医学2014，31，8： | 2 |
| 11 | Pattern of alpha- and betacatenin and E-cadherin expression in colorectal adenomas and carcinomas显示文摘 | Van der Wurff AA Vermeulen SJ | 1997 | J Pathol1997，182，3： | 2 |
| 12 | Fish bioaccumulation and biomarkers in environmental risk assessment: a review显示文摘 | Ron van der Oost Jonny Beyer Nico P.E Vermeulen | 2002 | Environmental Toxicology and Pharmacology2002，，2： | 2 |
| 13 | Eco-industrial park initiatives in the USA and the Netherlands: first lessons显示文摘 | R.R. Heeres W.J.V. Vermeulen F.B. de Walle | 2004 | Journal of Cleaner Production2004，，8： | 2 |
| 14 | Importance of adapted digestion conditions to simulate in vitro lipid digestion of broilers in different life stages显示文摘In vitro digestion studies demonstrate large potential to gain more and quicker insights into the underlying mechanisms of feed additives,allowing the optimization of feed design.Unfortunately,current in vitro digestion models relevant for broiler chickens lack sufficient description in terms of protocols and standardisation used.Furthermore,no distinction is made between the different life phases of these animals(starter,grower,and finisher).Hence,our research aimed to establish adapted in vitro digestion conditions,corresponding to the 3 life phases in broilers,with specific focus on lipid digestion.The effect of 3 different bile salt concentrations of 2,10,and 20 mM,and 3 different lipase activities of 5,20,and 100 U/mL,on in vitro lipid digestion kinetics were evaluated using a full factorial design.These values were selected to represent starter,grower,and finisher birds,respectively.Our findings showed that the extent of lipid digestion was mainly influenced by lipase activity.The rate of lipid digestion was affected by an interplay between bile salt concentration and lipase activity,due to possible lipase inhibition at certain bile salt concentrations.Overall,this work resulted in 3 in vitro lipid digestion models representative for starter,grower,and finisher birds.In conclusion,this research showed the impact of adapted in vitro digestion conditions on lipid digestion kinetics and thus the need for these conditions relevant for each life phase of broilers. | Daphne Michels Sarah H.E.Verkempinck Agnese Panozzo Karen Vermeulen Marc E.Hendrickx Liesbet Thijs Tara Grauwet | 2023 | Animal Nutrition2023，，1： | 2 |
| 15 | Gamma knife radiosurgery for the treatment oftrigeminal neuralgia 显示文摘 | Vermeulen S Posewitz A | 1998 | Stereotact Funct Neurosurg1998，70，1： | 1 |
| 16 | Design of a High-precision 3D-coordinate measuring machine显示文摘 | | 1997 | CIPR Ann1997，47，1： | 1 |
| 17 | A paradigm for gene regulation: inflammation,NF-kappaB and PPAR显示文摘 | Vanden BW Vermeulen L Delerive P | 2003 | Adv Exp Med Biol2003，544，： | 1 |
| 18 | Biphasic sarcomatoid carcinoma (carcinosarcoma) of the renal pelvis with heterologous chondrogenic differentiation 显示文摘 | Vermeulen P Hoekx L Colpaert C | 2000 | Virchows Arch2000，437，： | 1 |
| 19 | International expansion through start-up or acquisition:a learning perspective显示文摘 | Barkema H G & Vermeulen F | 1998 | Academy of ManagementJournal1998，，41： | 1 |
| 20 | Perimesencephalic hemorrhage: a nonaneurysmal and benign form of subarachnoid hemorrhage 显示文摘 | van GIJN J van DONGEN K J VERMEULEN M | 1985 | Neurology1985，35，4： | 1 |
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