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| 1 | NEW METHOD OF SIMULATING CONCENTRATED DRAIN HOLES IN SEEPAGE CONTROL ANALYSIS显示文摘In this paper, based upon the basic solution of sink, the approximate solution of single drain hole in finite elements is derived by use of the superposition principle. Then, the theoretical solution is extended to the case of some drain holes in one finite element, and the method is used in seepage control analysis with quick convergence and high accuracy. On the other hand, if the positions of the drain holes are changed, only some control factors of drain holes are changed, but the finite element grid need not to be reformed. Therefore, the method is more suitable in optimal research of seepage control. | Zhan Mei li, Su Bao yu , Liu Jun yong, Shen Zhen zhong College of Water Conservancy and Hydropower Engineering, Hohai University, Nanjing 210098, P.R.China (Received Aug.1, 1998) | 1999 | Journal of Hydrodynamics1999，11，3： | 22 |
| 2 | Impact of meteorological factors on the incidence of childhood hand,foot,and mouth disease(HFMD)analyzed by DLNMs-based time series approach显示文摘Background:Hand,foot,and mouth disease(HFMD)has become an emerging infectious disease in China in the last decade.There has been evidence that meteorological factors can influence the HFMD incidence,and understanding the mechanisms can help prevent and control HFMD.Methods:HFMD incidence data and meteorological data in Minhang District,Shanghai were obtained for the period between 2009 and 2015.Distributed lag non-linear models(DLNMs)were utilized to investigate the impact of meteorological factors on HFMD incidence after adjusting for potential confounders of long time trend,weekdays and holidays.Results:There was a non-linear relationship between temperature and HFMD incidence,the RR of 5th percentile compared to the median is 0.836(95%CI:0.671-1.042)and the RR of 95th percentile is 2.225(95%CI:1.774-2.792),and the effect of temperature varied across age groups.HFMD incidence increased with increasing average relative humidity(%)(RR=1.009,95%CI:1.005-1.015)and wind speed(m/s)(RR=1.197,95%CI:1.118-1.282),and with decreasing daily rainfall(mm)(RR=0.992,95%CI:0.987-0.997)and sunshine hours(h)(RR=0.966,95%CI:0.951-0.980).Conclusions:There were significant relationships between meteorological factors and childhood HFMD incidence in Minhang District,Shanghai.This information can help local health agencies develop strategies for the control and prevention of HFMD under specific climatic conditions. | Hongchao Qi Yue Chen Dongli Xu Hualin Su Longwen Zhan Zhiyin Xu Ying Huang Qianshan He Yi Hu Henry Lynn Zhijie Zhang | 2018 | Infectious Diseases of Poverty2018，7，1： | 17 |
| 3 | Complement C3 activation regulates the production of tRNA-derived fragments Gly-tRFs and promotes alcohol-induced liver injury and steatosis显示文摘Complement is known to play a role in alcoholic fatty liver disease (AFLD), but the underlying mechanisms are poorly understood, thereby constraining the development of a rational approach for therapeutic intervention in the complement system. C3 deficiency has been shown to impart protective effects against ethanol-induced hepatic steatosis and inflammation. Here we demonstrate a protection effect in wild-type mice by treatment with CR2-Crry, a specific inhibitor of C3 activation. The expression of glycine transfer (t) RNA-derived fragments (Gly-tRFs) is upregulated in ethanol-fed mice and inhibition of Gly-tRFs in vivo decreases chronic ethanol feeding-induced hepatosteatosis without affecting inflammation. The expression of Gly-tRF was downregulated in C3-deficient or CR2-Crry-treated mice, but not in C5-deficient mice;Gly-tRF expression was restored by the C3 activation products C3a or Asp (C3a-des-Arg) via the regulation of CYP2E1. Transcriptome profiling of hepatic tissues showed that Gly-tRF inhibitors upregulate the expression of sirtuin1 (Sirt1) and subsequently affect downstream lipogenesis and β-oxidation pathways. Mechanistically, Gly-tRF interacts with AGO3 to downregulate Sirt1 expression via sequence complementarity in the 3′ UTR. Notably, the expression levels of C3d, CYP2E1 and Gly-tRF are upregulated, whereas Sirt1 is decreased in AFLD patients compared to healthy controls. Collectively, our findings suggest that C3 activation products contribute to hepatosteatosis by regulating the expression of Gly-tRF. Complement inhibition at the C3 activation step and treatment with Gly-tRF inhibitors may be potential and precise therapeutic approaches for AFLD. | Fudi Zhong Zhigao Hu Keqing Jiang Biao Lei Zhan Wu Guandou Yuan Hongliang Luo Chunqiang Dong Bo Tang Chaowen Zheng Shuai Yang Yonglian Zeng Zhenya Guo Shuiping Yu Huizhao Su Guo Zhang Xiaoqiang Qiu Stephen Tomlinson Songqing He | 2019 | Cell Research2019，29，7： | 14 |
| 4 | LUCC and its impact on run-off yield in the Bai River catchment—upstream of the Miyun Reservoir basin显示文摘Aims The Miyun Reservoir is the most important drinking water source for Beijing—the capital of China with a population of more than 16 million.Since the 1980s,the inflow to the reservoir has been decreasing,which seriously threatens the security of water use in Beijing.Our goal was to analyze the impact of land use and cover change(LUCC)on run-off yield in the upstream of the Miyun Reservoir.Methods In this study,the Soil andWater Assessment Tool(SWAT)was used to simulate the impacts of LUCC on the run-off yield in the Bai River catchment—upstream of the Miyun Reservoir basin in northern China.The investigation was conducted using two 6-year historical streamflow records:from 1986 to 1991 and from 2000 to 2005.A split sample procedure was used for model calibration and validation.The data from 1986 to 1988 and from 2000 to 2002 were used for calibration,while those from 1989 to 1991 and from 2003 to 2005 for validation.The SWAT calibration was based on monthly measured discharge at Zhangjiafen station at the catchment outlet from Bai River catchment.Additionally,the influence of LUCC on the surface run-off was distinguished from that of climate change on the surface runoff through SWAT scenarios modeling,the twoway analysis of variance(ANOVA),and the rainfall–run-off double-mass analysis in the Bai River catchment.Important Findings We found that the SWAT model could be used successfully to accurately simulate run-off yield and different LUCC patterns affecting water quantity in this catchment.During calibraion for the two periods the simulated monthly run-off satisfactorily matched the observed values,with the Nash–Sutcliffe coefficient>0.9 and 0.7 and a coefficient of determination of 0.9 and 0.65 at the outlet station(Zhangjiafen station),while during validation for the two periods the obtained values were 0.85,0.65 and 0.9,0.65,respectively.During the period of 1986–91,both the SWAT scenarios modeling and the analysis of the two-way ANOVA method showed that LUCC and climate change had some impact on run-off,and the impact of climate change was more significant than that of LUCC.Compared with the period during 1986–91,the run-off yield in the period during 2000–05 significantly decreased.The obtained results from the rainfall–run-off double-mass analysis indicate that since 1998 LUCC has had an increasing influence on the run-off,while the response of the run-off to rainfall has been decreasing.Since 1998,the LUCC has been a major driving force for run-off change in Bai River catchment. | Chesheng Zhan Zongxue Xu Aizhong Ye Hongbo Su | 2011 | Journal of Plant Ecology2011，4，1： | 12 |
| 5 | The Development of A Fluorescence Polarization Immunoassay for Aflatoxin Detection显示文摘A fluorescence polarization immunoassay(FPIA)was developed for the analysis ofaflatoxins(AFs)using an anti-aflatoxin B1(AFB1)monoclonal antibody and a novel fluorescein-labeled AFB1tracer.The FPIA showed an IC50 value of 23.33ng/mL with a limit of detection of 13.12 ng/mL for AFB1.The cross-reactivities of AFB1,AFB2,AFG1,AFG2,AFM1,and AFM2 with the antibody were100%,65.7%,143%,23.5%,111.4%,and 2%,respectively.The group-specificity of anti-AFB1mAb indicated that the FPIA could potentially be used in a screening method for the detection of total AFs,albeit not AFG2 and AFM2.The total time required for analyzing 96 samples in one microplate was less than 5 min.This study demonstrates the potential usefulness of the FPIA as a rapid and simple technique for monitoring AFs. | SHENG Ya Jie EREMIN Sergei MI Tie Jun ZHANG Su Xia SHEN Jian Zhong WANG Zhan Hui | 2014 | Biomedical and Environmental Sciences2014，27，2： | 10 |
| 6 | Oncogenic AURKA-enhanced N6-methyladenosine modification increases DROSHA mRNA stability to transactivate STC1 in breast cancer stem-like cells显示文摘RNase III DROSHA is upregulated in multiple cancers and contributes to tumor progression by hitherto unclear mechanisms.Here,we demonstrate that DROSHA interacts withβ-Catenin to transactivate STC1 in an RNA cleavage-independent manner,contributing to breast cancer stem-like cell(BCSC)properties.DROSHA mRNA stability is enhanced by N6-methyladenosine(m^(6)A)modification which is activated by AURKA in BCSCs.AURKA stabilizes METTL14 by inhibiting its ubiquitylation and degradation to promote DROSHA mRNA methylation.Moreover,binding of AURKA to DROSHA transcript further strengthens the binding of the m^(6)A reader IGF2BP2 to stabilize m^(6)A-modified DROSHA.In addition,wild-type DROSHA,but not an m^(6)A methylation-deficient mutant,enhances BCSC stemness maintenance,while inhibition of DROSHA m^(6)A modification attenuates BCSC traits.Our study unveils the AURKA-induced oncogenic m^(6)A modification as a key regulator of DROSHA in breast cancer and identifies a novel DROSHA transcriptional function in promoting the BCSC phenotype. | Fei Peng Jie Xu Bai Cui Qilan Liang Sai Zeng Bin He Hong Zou Manman Li Huan Zhao Yuting Meng Jin Chen Bing Liu Shasha Lv Peng Chu Fan An Zifeng Wang Junxiu Huang Yajing Zhan Yuwei Liao Jinxin Lu Lingzhi Xu Jin Zhang Zhaolin Su Zhiguang Li Fangjun Wang Eric W-FLam Quentin Liu | 2021 | Cell Research2021，31，3： | 9 |
| 7 | An Improved Approach to Delay-dependent Robust Stabilization for Uncertain Singular Time-delay Systems显示文摘In this paper, delay-dependent stability analysis and robust stabilization for uncertain singular time-delay systems are addressed. By using Jensen integral inequality, an improved delay-dependent criterion of admissibility for singular time-delay systems is proposed in terms of linear matrix inequality (LMI). Our new proposed criterion is less conservative and the numerical complexity is smaller than the existing ones. Based on this criterion, a state feedback controller is designed to ensure that the uncertain singular time-delay system is admissible. Finally, three numerical examples are employed to illustrate the effectiveness of the proposed method. | Xin Sun Qing-Ling Zhang Chun-Yu Yang Zhan Su Yong-Yun Shao | 2010 | International Journal of Automation and computing2010，7，2： | 7 |
| 8 | Discrete and continuum modeling of granular flow in silo discharge显示文摘 | Tian Tian Jinglin Su Jinhui Zhan Shujun Geng Guangwen Xu Xiaoxing Liu | 2018 | Particuology2018，16，1： | 6 |
| 9 | Vegetation changes in the agricultural-pastoral areas of northern China from 2001 to 2013显示文摘Climate change and human activity have resulted in increasing change of vegetation growth globally. Numerous studies have been conducted on extreme climate events and analyses of ecological environment evolution. However, such studies have placed little emphasis on vegetation change and spatial variation in this type of ecotone. Accordingly, this study analyzed the changes in vegetation type and growth using the 16-d composite MOD13A1 product with 1-km resolution and MOD12Q1 product with 1-km resolution. We used the mean, maximum, standard deviation normalized-difference vegetation index(NDVI) values, and the rate of change(ROC) of NDVI value to explain vegetation changes within the studied ecotone. Our results showed that significant vegetation type and growth changes have occurred in the study area. From 2001 to 2013, for example, with the exception of 2001, 2004 and 2009, a certain extent of grassland area was converted to cropland. Drought severity index(DSI) results indicate that there exists drought in 2001, 2004 and 2009. Such temporal changes in cropland and grassland area confirmed the ecological vulnerability of the ecotone. At the same time, vegetation varied spatially from west to east and from south to north. The mean, maximum and standard deviation NDVI values were all sorted in descending order based on differences in latitude and longitude, as follows: NDVI_(2013)>NDVI_(2009)>NDVI_(2004)>NDVI_(2001) | SU Wei YU De-yong SUN Zhong-ping ZHAN Jun-ge LIU Xiao-xuan LUO Qian | 2016 | Journal of Integrative Agriculture2016，15，5： | 6 |
| 10 | Aescin-induced reactive oxygen species play a pro-survival role in human cancer cells via ATM/AMPK/ULK1-mediated autophagy显示文摘Aescin, a natural mixture of triterpene saponins, has been reported to exert anticancer effect. Recent studies show that aescin increases intracellular reactive oxygen species (ROS) levels. However, whether the increased ROS play a role in the anticancer action of aescin remains to be explored. In this study, we demonstrated that aescin (20-80 μg/mL) dose-dependently induced apoptosis and activated mammalian target of rapamycin (mTOR)-independent autophagy in human hepatocellular carcinoma HepG2 cells and colon carcinoma HCT 116 cells. The activation of autophagy favored cancer cell survival in response to aescin, as suppression of autophagy with ATG5 siRNAs or 3-methyladenine (3-MA), a selective inhibitor of autophagy, promoted aescin-induced apoptosis in vitro, and significantly enhanced the anticancer effect of aescin in vivo. Meanwhile, aescin dose-dependently elevated intracellular ROS levels and activated Ataxia-telangiectasia mutated kinase/AMP-activated protein kinase/UNC-51-like kinase-1 (ATM/AMPK/ULK1) pathway. The ROS and ATM/AMPK/ULK1 pathway were upstream modulators of the aescin-induced autophagy, as N-acetyl-L-cysteine (NAC) or ATM kinase inhibitor (KU-55933) remarkably suppressed aescin-induced autophagy and consequently promoted aescin-induced apoptosis, whereas overexpression of ATG5 partly attenuated NAC-induced enhancement in aescin-induced apoptosis. In conclusion, this study provides new insights into the roles of aescin-mediated oxidative stress and autophagy in cancer cell survival. Our results suggest that combined administration of the antioxidants or autophagic inhibitors with aescin might be a potential strategy to enhance the anticancer effect of aescin. | Bin Li Guo-liang Wu Wei Dai Gang Wang Hao-yuan Su Xue-ping Shen Rui Zhan Jia-ming Xie Zhong Wang Zheng-hong Qin Quan-gen Gao Gen-hai Shen | 2018 | Acta Pharmacologica Sinica2018，39，12： | 5 |
| 11 | Delay-dependent Stability Analysis and Stabilization of Discrete-time Singular Delay Systems显示文摘 | SUN Xin ZHANG Qing-Ling YANG Chun-Yu SHAO Yong-Yun SU Zhan | 2010 | 自动化学报2010，36，10： | 5 |
| 12 | Dexmedetomidine mitigates isoflurane-induced neurodegeneration in fetal rats during the second trimester of pregnancy显示文摘Dexmedetomidine has significant neuroprotective effects. However, whether its protective effects can reduce neurotoxicity caused by isoflurane in fetal brain during the second trimester of pregnancy remains unclear. In this study, timed-pregnancy rats at gestational day 14 spontaneously inhaled 1.5% isoflurane for 4 hours, and were intraperitoneally injected with dexmedetomidine at dosages of 5, 10, 20, and 20 μg/kg 15 minutes before inhalation and after inhalation for 2 hours. Our results demonstrate that 4 hours after inhaling isoflurane, 20 μg/kg dexmedetomidine visibly mitigated isoflurane-induced neuronal apoptosis, reversed downregulation of brain-derived neurotrophic factor expression, and lessened decreased spatial learning and memory ability in adulthood in the fetal rats. Altogether, these findings indicate that dexmedetomidine can reduce neurodegeneration induced by isoflurane in fetal rats during the second trimester of pregnancy. Further, brain-derived neurotrophic factor participates in this process. | Zhi-yuan Su Qing Ye Xian-bao Liu Yu-zhong Chen Hong Zhan Shi-yuan Xu | 2017 | Neural Regeneration Research2017，12，8： | 5 |
| 13 | A Fuzzy PID Algorithm for a Novel Miniature Spherical Robots with Three-dimensional Underwater Motion Control显示文摘We proposed and developed a small bionic amphibious spherical robot system for tasks such as coastal environment monitoring and offshore autonomous search and rescue.Our third-generation bionic small amphibious spherical robots have many disadvantages,such as the lack of maneuverability and a small operating range.It is difficult to accomplish underwater autonomous motion control with these robots.Therefore,we proposed a fourth-generation amphibious spherical robot.However,the amphibious spherical robot developed in this project has a small and compact design,with limited sensors and external sensing options.This means that the robot has weak external information collection capabilities.We need to make the real time operation of the robot's underwater motion control system more reliable.In this paper,we mainly used a fuzzy Proportional-Integral-Derivative(PID)control algorithm to design an underwater motion control system for a novel robot.Moreover,we compared PID with fuzzy PID control methods by carrying out experiments on heading and turning bow motions to verify that the fuzzy PID is more robust and exhibits good dynamic performance.We also carried out experiments on the three-dimensional(3D)motion control to validate the design of the underwater motion control system. | Liwei Shi Yao Hu Shuxiang Su Shuxiang Guo Huiming Xing Xihuan Hou Yu Liu Zhan Chen Zan Li Debin Xia | 2020 | Journal of Bionic Engineering2020，17，5： | 4 |
| 14 | Fluorescence polarization immunoassay for salinomycin based on monoclonal antibodies显示文摘A fluorescence polarization immunoassay(FPIA) for the determination of salinomycin(SAL) was developed by using anti-SAL monoclonal antibodies(mAb).Fluorescein labeled SAL(tracer) was synthesized by the N-hydroxysuccinimide active ester method and purified using thin layer chromatography(TLC).The developed FPIA for SAL had a dynamic range from 0.60 to 2193 ng/mL with an IC50 value of 33.2 ng/mL and a detection limit(LOD) of 0.08 ng/mL.No significant cross-reactivities were observed with other drugs but 67.6% with narasin. | Wang, Zhan Hui Cheng, Lin Li Shi, Wei Min Zhang, Su Xia Shen, Jian Zhong | 2010 | Science China Chemistry2010，53，3： | 4 |
| 15 | Glycosyltransferases and non-alcoholic fatty liver disease显示文摘Non-alcoholic fatty liver disease(NAFLD) is the most common form of chronic liver disease and its incidence is increasing worldwide. However, the underlying mechanisms leading to the development of NAFLD are still not fully understood. Glycosyltransferases(GTs) are a diverse class of enzymes involved in catalyzing the transfer of one or multiple sugar residues to a wide range of acceptor molecules. GTs mediate a wide range of functions from structure and storage to signaling, and play a key role in many fundamental biological processes. Therefore, it is anticipated that GTs have a role in the pathogenesis of NAFLD. In this article, we present an overview of the basic information on NAFLD, particularly GTs and glycosylation modification of certain molecules and their association with NAFLD pathogenesis. In addition, the effects and mechanisms of some GTs in the development of NAFLD are summarized. | Yu-Tao Zhan Hai-Ying Su Wei An | 2016 | World Journal of Gastroenterology2016，22，8： | 4 |
| 16 | Preparation and luminescence properties of orange-red Ba3Y4O9:Sm3+phosphors显示文摘A novel orange-red emitting Ba_3 Y_4 O_9:Sm^(3+) phosphors were prepared by a high temperature solidstate reaction in air. X-ray diffraction(XRD), photoluminescence spectra, fluorescence decay and temperature-dependent emission spectra were utilized to characterize the structure and luminescence properties. The results show that the excitation spectrum includes a series of linear peaks at350, 367, 382, 410, 424, 445, 470 and 495 nm, respectively. Under 410 nm excitation, the emission peaks were located at 574 nm(~4 G_(5/2)-~6 H_(5/2)), 608 nm(~4 G_(5/2)-~6 H_(7/2)),659 nm(~4 G_(5/2)-~6 H_(9/2)) and722 nm(~4 G_(5/2)-~6 H_(11/2)), respectively. The concentration quenching occurs when x equals 0.08 for Ba_3 Y_(4-x)O_9:xSm^(3+) phosphor and its mechanism is ascribed to the dipole-dipole interaction. The chromaticity coordinates of Ba_3 Y_(3.92)O_9:0.08 Sm^(3+) phosphor are in the orange-red region. The temperature-dependent study shows that this phosphor has excellent luminescence thermal-stability.And the luminescence intensity of Ba_3 Y_(3.92)O_9:0.08 Sm^(3+) phosphor at 473 K only declines by about25.75% of its initial intensity. The experimental data indicate that Ba_3 Y_4 O_9:Sm^(3+) phosphor may be promising as an orange-red emitting phosphor for white light emitting diodes. | Jiayu Li Ran Pang Zhan Yu Liyan Liu Haiyan Wu Huimin Li Lihong Jiang Su Zhang Jing Feng Chengyu Li | 2018 | Journal of Rare Earths2018，36，7： | 3 |
| 17 | Estimating the impact of land use change on surface energy partition based on the Noah model显示文摘陆地使用在表面精力分区上有重要影响,是众所周知的。在地区性的气候变化的上下文与陆地使用变化从网络发光(NR ) 学习理智的热流动(SHF ) 和潜伏的热流动(LHF ) 的分区的演变趋势是重要的。在这份报纸,我们学习了精力分区的反应用挪亚模型打使用。首先,在 2003 和 2005 之间的 SHF 和 LHF 的挪亚模型模拟结果包括地从 Changbai 山车站, Xilinhot 车站,和 Yucheng 车站用观察数据被验证。学习领域表示陆地使用的三种不同类型变化:过多的采伐森林,草地退化恶化,和地下水水平分别地衰退。学习时期随后通过 2034 从 2015 被扩大,使用四张投射陆地使用地图并且强迫从普林斯顿(2000-2004 ) 的数据。模拟结果证明在陆地使用变换期间, LHF 的年度一般水准去10.7%,上升10.1%,并且为 Changbai 山,内部蒙古,和北中国车站去11.5%,分别地当 SHF 的年度一般水准上升10.6%时,去10.1%,并且为三个区域去11.3%[出版摘要] | Shaohui CHEN Hongbo SU Jinyan ZHAN | 2014 | Frontiers of Earth Science2014，8，1： | 3 |
| 18 | Electropolishing of titanium alloy under hydrodynamic mode显示文摘Titanium(Ti) alloys are widely used in aerospace industry due to the low density and high corrosion resistance. However, machining and polishing remain great challenges because of the hardness and chemical stability. With a home-made electrochemical machining workstation, cyclic voltammetry is performed at a wide potential range of [0 V, 20 V] to record the details of passivation and depassivation processes under a hydrodynamic mode. The results show that the thickness of viscous layer formed on the alloy surface plays a crucial effect on the electropolishing quality. The technical parameters, including the mechanical motion rate, polishing time and electrode gap, are optimized to achieve a surface roughness less than 1.9 nm, which shows a prospective application in the electrochemical machining of Ti and it alloys. | Pei Huang Junhui Lai Lianhuan Han Fang-Zu Yang Li-Min Jiang Jian-Jia Su Zhao-Wu Tian Zhong-Qun Tian Dongping Zhan | 2016 | Science China Chemistry2016，59，11： | 3 |
| 19 | Prognosis of 153 patients with decompensated hepatitis B virus-related cirrhosis is improved after 3-year continuous lamivudine treatment显示文摘 | CHEN Guang-cheng YU Tao MIN Xiao-hui ZHAO Li-na QING Qing YUAN Yu-hong SU Hong ZHAN Jun HUANG Kai-hong CHEN Qi-kui | 2013 | Chinese Medical Journal2013，，8： | 3 |
| 20 | Blood pressure variability and baroreflex sensitivity are not different in spontaneously hypertensive rats and stroke-prone spontaneously hypertensive rats显示文摘瞄准:表明并且比较血压(BP ) 的血液动力学的显型,血压可变性(BPV ) 和在基因高血压的老鼠的 baroreflex 敏感(BRS ) 。方法:BP 用一种计算机化的技术在有意识的、自由地动人的老鼠连续地被记录。BPV 在 1-h 经期期间被表示为 beat-to-beat BP 价值的标准偏差。BRS 被在脱羟肾上腺素的静脉注射生产的 BP 响应举起测量心经期延伸决定。结果:体重和心时期不在 15 个星期岁时在自发地高血压的老鼠(SHR ) 和击容易的自发地高血压的老鼠(SHR-SP ) 之间是不同的。BP 水平比 SHR 在 SHR-SP 是显著地更高的,而在 BPV 和 BRS 没有有效差量。份量上,分别地,收缩、心脏舒张、吝啬的 BP 被 36.9% , 42.9% 和 39.5% 显著地与 SHR (P 0.05 ) 相比在 SHR-SP 提高。结论:BPV 和 BRS 没在 SHR 和 SHR-SP 与 BP 改变同时被改变。 | Lin-shu ZHAN Yun-feng GUAN Ding-feng SU Chao-yu MIAO | 2005 | Acta Pharmacologica Sinica2005，26，8： | 3 |
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