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| 1 | Influences of Ivabradine treatment on serum levels of cardiac biomarkers sST2, GDF-15, suPAR and H-FABP in patients with chronic heart failure显示文摘长期的心失败(CHF ) 代表住院和死亡的一个主要原因。最近的证据表演那新奇 biomarkers 象 tumorigenicity (sST2 ) 的可溶的抑制那样,生长区别 factor-15 (GDF-15 ) ,可溶的尿激 plasminogen 使活跃之物受体(suPAR ) 和心类型丰满的酸绑定蛋白质(H-FABP ) 被相关与煽动性并且在 CHF 病人的 ischemic 回答。在这研究,我们检验了禁止了 激活hyperpolarization 的周期的核苷酸门隧道的 Ivabradine 的效果( HCN 隧道,也叫的滑稽电流我 从而导致选择心率减小的 f ),和改进的心肌的氧在心脏的 biomarkers sST2 上供应, GDF-15 ,在在 Jena 的大学医院的 50 个 CHF 病人的 suPAR 和 H-FABP 。病人们基于 CHF 的病原学被划分成三个组:扩大心肌症(DCM, n=20 ) , ischemic 心肌症(ICM, n=20 ) 并且高血压的心肌症(HCM, n=10 ) 。病人是管理 Ivabradine (5 mg,为 3 个月的出价,和 7.5 mg 期望推进 3 个月) 。心血管的 biomarkers 的分析在基线以及在 3 月、 6 月的后续被执行。在 6 月的后续, GDF-15 层次显著地与基线层次(P=0.0215 ) 相比被减少,显示在心脏的改变的进步的减小。H-FABP 集中在与 ICM (1.89 对 3.24 g/mL ) 和 HCM 病人(1.89 对 3.80 g/mL ) 相比的 DCM 病人是显著地更低的,并且在 6 月的后续(P=0.0151 ) 上减少了。中部的层次仍然是的 suPAR 提高了,暗示主要进行中的煽动性的过程。是在 GDF-15 和 H-FABP 由重要减少证明层次,在室的改变的减小和无临床症状的局部缺血能被假定。然而,血液动力学的应力(sST2 ) 的标记和发炎(suPAR ) 没在 CHF 病人在 6 月 Ivabradine 治疗以后显示出变化或前进。进一步的研究是必要的验证这些新奇心血管的 biomarkers 的临床的适用性。 | Peter JIRAK Dzeneta FEJZIC Vera PAAR Bernhard WERNLY Rudin PISTULLI Ilonka ROHM Christian JUNG Uta C HOPPE P Christian SCHULZE Michael LICHTENAUER Atilla YILMAZ Daniel KRETZSCHMAR | 2018 | Acta Pharmacologica Sinica2018，39，7： | 31 |
| 2 | Signaling pathways for germ cell death in adult cynomolgus monkeys(Macaca fascicularis) induced by mild testicular hyperthermia and exol enous testosterone treatment显示文摘 | Jia, Y. Hikim, A.P.S. Lue,Y.H. Swerdloff, R.S. Vera,Y. Zhang,X. S. Hu, Z. Y. Li, Y. C. Liu, Y. X. Wang, C | 2007 | 南京医科大学学报(自然科学版)2007，27，10： | 10 |
| 3 | Expression of cyclooxygenase-2 is associated with p53 accumulation in premalignant and malignant gallbladder lesions显示文摘瞄准:在胆囊癌和它的先锋损害在表示和 p53 累积上检验在 cyclooxygenase-2 (COX-2 ) 之间的关系。方法:包括正常胆量 blader 上皮,发育异常(11 低档 dyplasia 和 16 高级发育异常) 的 27 个盒子和 27 腺癌的 14 个盒子的 68 件胆囊织物样品被免疫组织化学为 COX-2 表示和 p53 累积评估。在 COX-2 表示, p53 累积和 clinicopathological 特征之中的关系被分析。结果:COX-2 被表示在 14.3% 正常胆囊上皮, 70.3% 发育异常的 epite hlium,和 59.2% 腺癌。当划分了成低档和高级发育异常时, COX-2 在 5 是积极的(45.4%) 低档的盒子并且 14 (87.5%) 高级发育异常(P = 0.019 ) 。p53 的累积在 5 被检测(31.2%) 癌的高级发育异常并且在 13 的盒子(48.1%) 。没有 p53 累积在正常上皮或低档发育异常被发现。在表示上的 COX-2 在 18 中的 17 个被观察(94.4%) 有从没有 p53 累积的 50 个盒子的与 20 比较的 p53 累积(40.0%) 的盒子(P <
0.001 ) 。结论:在在正常上皮,低档发育异常和高级发育异常之中的 COX-2 表示的有效差量建议在 COX-2 的表示上,酶是在胆囊 carcinogenensis 的一个早事件。自从有 COX-2 表示的 p53 相互关联的累积,而且,在表示上的 COX-2 在高级发育异常和癌可能是的胆囊观察了部分由于 p53 的机能障碍。 | Mateja Legan Bo(s|ˇ)tjan Luzar Vera Ferlan Marolt Andrej C(o|¨)r | 2006 | World Journal of Gastroenterology2006，12，21： | 7 |
| 4 | Increased catabolism and decreased unsaturation of ganglioside in patients with inflammatory bowel disease显示文摘AIM: To investigate whether accelerated catabolism of ganglioside and decreased ganglioside content contribute to the etiology of pro-inflammatory intestinal disease. METHODS: Intestinal mucosa from terminal ileum or colon was obtained from patients with ulcerative colitis or inflammatory Crohn's disease(n = 11) undergoing bowel resection and compared to control samples of normal intestine from patients with benign colon polyps(n = 6) and colorectal cancer(n = 12) in this observational case-control study. Gangliosides and phospholipids of intestinal mucosa were characterized by class and ceramide or fatty acid composition using liquid chromatography triple-quad mass spectrometry. Content and composition of ganglioside classes GM1, GM3, GD3, GD1 a, GT1 and GT3 were compared among subject groups. Content and composition of phospholipid classes phosphatidylcholine(PC) and phosphatidylethanolamine were compared among subject groups. Unsaturation index of individual ganglioside and phospholipid classes was computed and compared among subject groups. Ganglioside catabolism enzymes beta-hexosaminidase A(HEXA) and sialidase-3(NEU3) were measured in intestinal mucosa using western blot and compared among subject groups. RESULTS: Relative GM3 ganglioside content was 2-fold higher(P < 0.05) in intestine from patients with inflammatory bowel disease(IBD) compared to control intestine. The quantity of GM3 and ratio of GM3/GD3 was also higher in IBD intestine than control tissue(P < 0.05). Control intestine exhibited 3-fold higher(P < 0.01) relative GD1 a ganglioside content than IBD intestine. GD3 and GD1 a species of ganglioside containing three unsaturated bonds were present in control intestine, but were not detected in IBD intestine. The relative content of PC containing more than two unsaturated bonds was 30% lower in IBD intestine than control intestine(P < 0.05). The relative content of HEXA in IBD intestine was increased 1.7-fold(P < 0.05) and NEU3 was increased 8.3-fold(P < 0.01) compared to normal intestine. Intestinal mucosa in IBD is characterized by increased GM3 content, decreased GD1 a, and a reduction in polyunsaturated fatty acid constituents in GD3, GD1 a and PC.CONCLUSION: This study suggests a new paradigm by proposing that IBD occurs as a consequence of increased metabolism of specific gangliosides. | John J Miklavcic Glen K Shoemaker Vera C Mazurak M Tom Clandinin Tasha DL Hart Kareena L Schnabl Gordon M Lees Bodil MK Larsen Oliver F Bathe Alan BR Thomson M Tom Clandinin | 2015 | World Journal of Gastroenterology2015，21，35： | 3 |
| 5 | Novel role of STAT3 in microglia-dependent neuroinflammation after experimental subarachnoid haemorrhage显示文摘Background and purpose Signal transducer and activator of transcription 3(STAT3)may contribute to the proinflammation in the central nervous system diseases by modulating the microglial responses.Thus,this study was intended to investigate the effect of STAT3 on microglia-dependent neuroinflammation and functional outcome after experimental subarachnoid haemorrhage(SAH).Methods The SAH model was established by endovascular perforation in the mouse.Real-time PCR(RtPCR)and western blot were used to examine the dynamic STAT3 signalling pathway responses after SAH.To clarify the role of the STAT3 signalling pathway in the microglia-dependent neuroinflammation after SAH,the microglia-specific STAT3 knockout(KO)mice were generated by the Cre-LoxP system.The neurological functions were assessed by Catwalk and Morris water maze tests.Neuronal loss after SAH was determined by immunohistochemistry staining.Microglial polarisation status after STAT3 KO was then examined by RtPCR and immunofluorescence.Results The STAT3 and Janus kinase-signal transducer 2 activated immediately with the upregulation and phosphorylation after SAH.Downstream factors and related mediators altered dynamically and accordingly.Microglial STAT3 deletion ameliorated the neurological impairment and alleviated the early neuronal loss after SAH.To investigate the underlying mechanism,we examined the microglial reaction after STAT3 KO.STAT3 deletion reversed the increase of microglia after SAH.Loss of STAT3 triggered the early morphological changes of microglia and primed microglia from M1 to M2 polarisation.Functionally,microglial STAT3 deletion suppressed the SAH-induced proinflammation and promoted the anti-inflammation in the early phase.Conclusions STAT3 is closely related to the microglial polarisation transition and modulation of microglia-dependent neuroinflammation.Microglial STAT3 deletion improved neurological function and neuronal survival probably through promoting M2 polarisation and anti-inflammatory responses after SAH.STAT3 may serve as a promising therapeutic target to alleviate early brain injury after SAH. | Zhiyuan Vera Zheng Junfan Chen Hao Lyu Sin Yu Erica Lam Gang Lu Wai Yee Chan George K C Wong | 2022 | Stroke & Vascular Neurology2022，7，1： | 3 |
| 6 | 表面活性剂对S.sobrinus 6715在实验性获得性膜粘附影响的体外研究显示文摘通过细菌对羟磷灰石(HA)表面形成的实验性获得性膜粘附的实验模式,比较了5种表面活性剂(surfaceactiveagents,简称SAA)对S.sobrinus6715粘附的影响。结果表明,所实验的5种SAA对S.sobrinus6715对原位形成的葡聚糖的粘附无明显影响,而阳离子含氟表面活性剂ZonylFSC在0.1%~0.2%浓度时对粘附的菌细胞有明显的解吸作用。 | 刘天佳 Vera,C | 1994 | 华西口腔医学杂志1994，12，1： | 2 |
| 7 | Phase Ⅰ and pharmacokinetic study of etaracizumab (Abegrin) , a humanized monoclonal antibody against alphavbeta3 integrin receptor, in patients with advanced solid tumors显示文摘 | Delbaldo C Raymond E Vera K | 2008 | Invest New Drugs2008，26，1： | 1 |
| 8 | Deriving simulation models from bond graphs with algebraic loops显示文摘 | Felez J Vera C | 2000 | Journal of Franklin Institute2000，，337： | 1 |
| 9 | Characteristics of communityacquired pneumonia in patients with chronic obstrtive pulmonary disease显示文摘 | Pifarre R Falquera M Vieente de vera C | 2007 | Respir Med2007，，： | 1 |
| 10 | Generation of DNA profiles from fabrics without DNA extraction 显示文摘 | Adrian L Vera P Yuvaneswari C S | 2010 | Forensic Sci Int(Genetics)2010，4，： | 1 |
| 11 | Pt/SO2- -ZrO2 catalysts prepared from Pt organometallic compounds 显示文摘 | VERA C R PIECK C L SHIMIZU K | 2002 | Applied Catalysis A: General2002，232，12： | 1 |
| 12 | Deriving Simulation Models from Bond Graphs with Algebraic Loops-The Extension to Multibond Graph Systems显示文摘 | Cacho R Felez J Vera C | 2000 | Journal of The Franklin Institute2000，337，4： | 1 |
| 13 | Eft'eels of vhlual realily immersion anti attdiovisual distraction techniques fbr patients with pruritus 显示文摘 | Vera I Florella M Sarale C el al | 2009 | lain fes Ma mg2009，14，4： | 1 |
| 14 | Safety,pharmacokinetic,and antitumor activity of SU11248,a novel oral multitarget tyrosine kinase inhibitor,in patients with cancer显示文摘 | Faivre S Delbaldo C Vera K | 2006 | J Clin Oncol2006，24，1： | 1 |
| 15 | Safety, pharmacokinetic, and antitumor activity of SUl1248, a novel oral multitarget tyrosine kinase inhibitor,in patients with cancer显示文摘 | FAIVRE S DELBALDO C VERA K | 2006 | J ClinOnco12006，24，1： | 1 |
| 16 | Phase I and pharmacokinetic study of etaracizumab (Abegrin), a humanized monoclonal antibody against alphavbeta3 integrin receptor, in patients with advanced solid tumors, Invest 显示文摘 | Delbaldo C Raymond E Vera K | 2008 | New Drugs2008，26，： | 1 |
| 17 | Determination of partition and diffusion coefficients of components of two rubber adhesives in different multilayer materials显示文摘 | Nerin C Gaspar J Vera P | 2013 | International Journal of Adhesion and Adhesives2013，40，： | 1 |
| 18 | Bond Graph Assisted Models for Hydro-Pneumatic Suspensions in Crane Vehicles 显示文摘 | FELEZ J VERA C | 1987 | Vehicle System Dynamics1987，16，56： | 1 |
| 19 | Experimental investigation of smouldering in biomass 显示文摘 | Carvalho E R Gurgel Veras C A CarvalhoJr J A | 2002 | Biomass and Bioenergy2002，22，4： | 1 |
| 20 | Effects of virtual reality immersion and audiovisual distraction techniques for patients with pruritus显示文摘 | Vera L Florella M Sarale C et a1 | 2009 | Pain Res Manag2009，14，4： | 1 |
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