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| 1 | CTGF, intestinal stellate cells and carcinoid fi brogenesis显示文摘AIM: To investigate the role of small intestinal carcinoid tumor-derived fibrotic mediators, TGFβ1 and CTGF, in the mediation of fi brosis via activation of an 'intestinal' stellate cell. METHODS: GI carcinoid tumors were collected for Q RT-PCR analysis of CTGF and TGFβ1. Markers of stellate cell desmoplasia were identified in peritoneal fibrosis by immunohistochemistry and stellate cells cultured from fresh resected fibrotic tissue. CTGF and TGFβ1 were evaluated using quantitative tissue array profi ling (AQUA analysis) in a GI carcinoid tissue microarray (TMA) with immunostaining and correlated with clinical and histologically documented fi brosis. Serum CTGF was analyzed using a sandwich ELISA assay. RESULTS: Message levels of both CTGF and TGFβ1 in SI carcinoid tumors were signifi cantly increased (> 2-fold, P < 0.05) versus normal mucosa and gastric (non-f ibrotic) carcinoids. Activated stellate cells and markers of stellate cell-mediated fi brosis (vimentin, desmin) were identifi ed in histological fibrosis. An intestinal stellate cell was immunocytochemically and biochemically characterized and its TGFβ1 (10-7M) initiated CTGF transcription response (> 3-fold, P < 0.05) demonstrated. In SI carcinoid tumor patients with documented fi brosis, TMA analysis demonstrated higher CTGF immunostaining (AQUA Score: 92 ± 8; P <0.05), as well as elevated TGFβ1 (90.6 ± 4.4, P < 0.05). Plasma CTGF (normal 12.5 ± 2.6 ng/mL) was increased in SI carcinoid tumor patients (31 ± 10 ng/mL, P < 0.05) compared to non-fi brotic GI carcinoids (< 15 ng/mL).CONCLUSION: SI carcinoid tumor fibrosis is a CTGF/ TGFβ1-mediated stellate cell-driven fibrotic response. The delineation of the biology of fibrosis will facilitate diagnosis and enable development of agents to obviate its local and systemic complications. | M Kidd IM Modlin MD Shapiro RL Camp SM Mane W Usinger JR Murren | 2007 | World Journal of Gastroenterology2007，13，39： | 5 |
| 2 | Accumulation of NH2-terminal fragment of connective tissue growth factor in the vitreous of patients with proliferative diabetic retinopathy显示文摘 | Hinton DR Spee C He S Weitz S Usinger W LaBree L | 2004 | Diabetes Care2004，27，3： | 1 |
| 3 | Cooperative interactionof CTGF and TGF - beta in animal models of fibrotic disease显示文摘 | WANG Q USINGER W NICHOLS B | 2011 | Fi-brogenesis Tissue Repair2011，4，1： | 1 |
| 4 | N-terminal connective tissue growth factor is a marker of the fibrotic phenotype in scleroderma显示文摘 | USINGER W LEASK A | 2005 | QJM2005，98，7： | 1 |
| 5 | Cooperative interaction of CTGF and TGF-βin animal models of fibrotic disease显示文摘 | Wang Q Usinger W Nichols B | 2011 | Fibrogenesis Tissue Repair2011，4，1： | 1 |
| 6 | Long cores from small lakesrecovering up to 100 mlong lake sediment sequences with a high-precision rodoperated piston corer (Usinger-corer) 显示文摘 | Mingram J Negendank J E W Brauer A Berger D Hendrich A Kohler M Usinger H | 2006 | Journal of Paleolimnology2006，37，4： | 1 |
| 7 | Cooperative interaction of CTGF and TGF-13 in animal models of fibrotic disease显示文摘 | Wang Q Usinger W Nichols B | 2011 | Fibro- genesis Tissue Repair2011，4，1： | 1 |
| 8 | Cooperative interaction of CTGF and TGF-βin animal models of fibrotic disease显示文摘 | Wang Q Usinger W Nichols B | 2011 | Fibrogenesis Tissue Repair2011，4，1： | 1 |
| 9 | N-terminal connective tissue growth factor is a marker of the fibrotic phenotype in scleroderma显示文摘 | Dziadzio M Usinger W Leask A | 2005 | QJM2005，98，7： | 1 |
| 10 | Cooperative interaction of CTGF and TGF - fi in animal models of fibrotic disease 显示文摘 | Wang Q Usinger W Nichols B | 2011 | Fibrogenesis Tissue Repair2011，4，1： | 1 |
| 11 | Connec- tive tissue growth factor and susceptibility to renal and vascular disease risk in type 1 diabetes 显示文摘 | Jaffa A A Usinger W R McHenry M B | 2008 | Clin Endocri- nol Metab2008，93，5： | 1 |
| 12 | Cooperative inter- action of CTGF and TGF-显示文摘 | WANG Q USINGER W NICHOLS B | 2011 | Fibrogenesis Tissue Repair2011，4，1： | 1 |
| 13 | Cooperative interaction of CTGF and TGF-β in animal models of fibrotic disease显示文摘 | Wang Q Usinger W Nichols B | 2011 | Fibrogenesis Tissue Repair2011，4，4： | 1 |
| 14 | Cooperative interaction of CTGF and TGF-β in animal models of fibrotic disease显示文摘 | Wang Q Usinger W Nichols B | | 0，，01： | 1 |
| 15 | Connective tissue growth factor and susceptibility to renal and vascu- lar disease risk in type 1 diabetes显示文摘 | Jaffa A A Usinger W R Jaffa M A | 2008 | Clin Endocrinol Metab2008，93，5： | 1 |
| 16 | Cooperative interaction of CTGF and TGF-β in animal models of fibrotic disease显示文摘 | Wang Q Usinger W Nichols B | | 0，，01： | 1 |
| 17 | Cooperative inter- action of CTGF and TGF-显示文摘 | WANG Q USINGER W NICHOLS B | 2011 | Fibrogcnesis Tissue Repair2011，4，1： | 1 |
| 18 | N-terminal connective tissue growth factor is a marker of the fibrotic phenotype in scleroderma显示文摘 | Dziadzio M Usinger W Leask A Abraham D Black CM Denton C | 2005 | QJM2005，98，7： | 1 |
| 19 | Cooperative interaction of CTGF and TGF-β in animal models of fibrotic disease 显示文摘 | Wang Q Usinger W Nichols B | 2011 | Fibrogenesis Tissue Repair2011，4，1： | 1 |
| 20 | N-terminal connective tissue growth factor is a marker of the fibrotic phenotype in scleroderma显示文摘 | Dziadzio M Usinger W Leask A Abraham D Black CM Denton C | 2005 | QJM2005，98，7： | 1 |
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