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| 1 | CTGF, intestinal stellate cells and carcinoid fi brogenesis显示文摘AIM: To investigate the role of small intestinal carcinoid tumor-derived fibrotic mediators, TGFβ1 and CTGF, in the mediation of fi brosis via activation of an 'intestinal' stellate cell. METHODS: GI carcinoid tumors were collected for Q RT-PCR analysis of CTGF and TGFβ1. Markers of stellate cell desmoplasia were identified in peritoneal fibrosis by immunohistochemistry and stellate cells cultured from fresh resected fibrotic tissue. CTGF and TGFβ1 were evaluated using quantitative tissue array profi ling (AQUA analysis) in a GI carcinoid tissue microarray (TMA) with immunostaining and correlated with clinical and histologically documented fi brosis. Serum CTGF was analyzed using a sandwich ELISA assay. RESULTS: Message levels of both CTGF and TGFβ1 in SI carcinoid tumors were signifi cantly increased (> 2-fold, P < 0.05) versus normal mucosa and gastric (non-f ibrotic) carcinoids. Activated stellate cells and markers of stellate cell-mediated fi brosis (vimentin, desmin) were identifi ed in histological fibrosis. An intestinal stellate cell was immunocytochemically and biochemically characterized and its TGFβ1 (10-7M) initiated CTGF transcription response (> 3-fold, P < 0.05) demonstrated. In SI carcinoid tumor patients with documented fi brosis, TMA analysis demonstrated higher CTGF immunostaining (AQUA Score: 92 ± 8; P <0.05), as well as elevated TGFβ1 (90.6 ± 4.4, P < 0.05). Plasma CTGF (normal 12.5 ± 2.6 ng/mL) was increased in SI carcinoid tumor patients (31 ± 10 ng/mL, P < 0.05) compared to non-fi brotic GI carcinoids (< 15 ng/mL).CONCLUSION: SI carcinoid tumor fibrosis is a CTGF/ TGFβ1-mediated stellate cell-driven fibrotic response. The delineation of the biology of fibrosis will facilitate diagnosis and enable development of agents to obviate its local and systemic complications. | M Kidd IM Modlin MD Shapiro RL Camp SM Mane W Usinger JR Murren | 2007 | World Journal of Gastroenterology2007，13，39： | 5 |
| 2 | Accumulation of NH2-terminal fragment of connective tissue growth factor in the vitreous of patients with proliferative diabetic retinopathy显示文摘 | Hinton DR Spee C He S Weitz S Usinger W LaBree L | 2004 | Diabetes Care2004，27，3： | 1 |
| 3 | Importance of the duodenal passage and pouch volume after total gastrectomy and reconstruction with Ulm pouch:prospective randomized clinical study显示文摘 | Schwarz A Buchler M Usinger K | 1996 | World J Surg1996，20，1： | 1 |
| 4 | Cooperative interactionof CTGF and TGF - beta in animal models of fibrotic disease显示文摘 | WANG Q USINGER W NICHOLS B | 2011 | Fi-brogenesis Tissue Repair2011，4，1： | 1 |
| 5 | Importance of the duodenalpassage and pouch volume after total gastrectomy and reconstructionwith the Ulm pouch:prospective randomized clinical study显示文摘 | Schwarz A Buchler M Usinger K | 1996 | World J Surg1996，20，1： | 1 |
| 6 | Importance of the duodenal:passage and pouch volume after total gastrectomy and reconstruction with the ulm pouch:prospective randomized clinical study显示文摘 | Schwarz A Buchler M Usinger K | 1996 | World J Surg1996，20，： | 1 |
| 7 | coliβ-galactosidase显示文摘 | Farquhar D Pan BF Sakurai M Suicide gene therapy usingE | 2002 | Cancer Chemother Pharmacol2002，50，： | 1 |
| 8 | Head Neck Oncol显示文摘 | Yokoyama J Ohba S Ito S et al Impact of lymphatic chemotherapy targeting metastatic lymph nodes in patients with tongue cancer (cT3N2bM0) using intra-arterial chemotherapy | | 0，，02： | 1 |
| 9 | Int J Radiat Oncol Biol Phys显示文摘 | Mitsudo K Koizumi T Iida M et al Thermochemoradiation therapy using superselective intra - arterial infusion via superficial temporal and occipital arteries for oral cancer with N3 cervical lymph node metastases | | 0，，05： | 1 |
| 10 | The antihypertensive effect of fermented milk in individuals with prehypertension or borderline hypertension显示文摘 | Usinger L Jensen LT Flambard B | 2010 | J Hum Hypertens2010，24，： | 1 |
| 11 | Accuracy of multi- slice computed tomography for measurement of left ventricu- lar ejection fraction compared with cardiac magnetic reso- nance imaging and two-dimensional transthoracic echocardio- graphy:a systematic review and meta-analysis显示文摘 | Asferg C Usinger L Kristensen T S | 2012 | Eur J Ra- diol2012，81，5： | 1 |
| 12 | 查看详情显示文摘 | T. Kodama N. Kataoka N. Wada G.Cincotti X.Wang T.Miyazaki and K.Kitayama High-Security 2.5 Gbps Polarization Multiplexed 256-Ary OCDM Using a Single Multi-Port Encoder/Decoder | | 0，，20： | 1 |
| 13 | N-terminal connective tissue growth factor is a marker of the fibrotic phenotype in scleroderma显示文摘 | USINGER W LEASK A | 2005 | QJM2005，98，7： | 1 |
| 14 | Pharmacological effects of Hoe 249:a new potential antidepressant显示文摘 | Alpermann HG Schacht U Usinger P Hock FJ | 1992 | Drug Dev Res1992，25，4： | 1 |
| 15 | Options and impli- cations of replacing HCFCs with natural refrigerants in China 显示文摘 | D Colbourne V Hasse J Usinger | 2007 | International Symposium on ODS Phase - out and Technol- ogy Development of HCFCs Substitution2007，12，： | 1 |
| 16 | Cooperative interaction of CTGF and TGF-βin animal models of fibrotic disease显示文摘 | Wang Q Usinger W Nichols B | 2011 | Fibrogenesis Tissue Repair2011，4，1： | 1 |
| 17 | Accuracy of multi-slice computed tomography for measurement of left ventricular ejection fraction compared with cardiac magnetic resonance imaging and two-dimensional transthoracic echocardiography: a systematic review and recta-analysis 显示文摘 | Asferg C Usinger L Kristensen TS | 2012 | Eur J Radiol2012，81，： | 1 |
| 18 | Long cores from small lakesrecovering up to 100 mlong lake sediment sequences with a high-precision rodoperated piston corer (Usinger-corer) 显示文摘 | Mingram J Negendank J E W Brauer A Berger D Hendrich A Kohler M Usinger H | 2006 | Journal of Paleolimnology2006，37，4： | 1 |
| 19 | Importance of the duodenal passage and pouch volume after total gastrectomy and reconstruction with the Ulm pouch: prospective randomized clinical study显示文摘 | Schwarz A Btichler M Usinger K | 1996 | World J Surg1996，20，： | 1 |
| 20 | Importance of the duodenal passage and pouch volume after total gastrectomy and reconstruction with the Ulm pouch: prospective randomized clinical study显示文摘 | Schwarz A B ti chler M Usinger K | 1996 | World J Surg1996，20，1： | 1 |
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