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| 1 | Irritable bowel syndrome: a disease still searching for pathogenesis, diagnosis and therapy显示文摘Irritable bowel syndrome(IBS) is the most frequently diagnosed functional gastrointestinal disorder in primary and secondary care. It is characterised by abdominal discomfort, pain and changes in bowel habits that can have a serious impact on the patient's quality of life. The pathophysiology of IBS is not yet completely clear. Genetic, immune, environmental, inflammatory, neurological and psychological factors, in addition to visceral hypersensitivity, can all play an important role, one that most likely involves the complex interactions between the gut and the brain(gut-brain axis). The diagnosis of IBS can only be made on the basis of the symptoms of the Rome Ⅲ criteria. Because the probability of organic disease in patients fulfilling the IBS criteria is very low, a careful medical history is critical and should pay particular attention to the possible comorbidities.Nevertheless, the severity of the patient's symptoms or concerns sometimes compels the physician to perform useless and/or expensive diagnostic tests, transforming IBS into a diagnosis of exclusion. The presence of alarming symptoms(fever, weight loss, rectal bleeding, significant changes in blood chemistry), the presence of palpable abdominal masses, any recent onset of symptoms in patient aged over 50 years, the presence of symptoms at night, and a familial history of celiac disease, colorectal cancer and/or inflammatory bowel diseases all warrant investigation. Treatment strategies are based on the nature and severity of the symptoms, the degree of functional impairment of the bowel habits, and the presence of psychosocial disorders. This review examines and discusses the pathophysiological aspects and the diagnostic and therapeutic approaches available for patients with symptoms possibly related to IBS, pointing out controversial issues and the strengths and weaknesses of the current knowledge. | Massimo Bellini Dario Gambaccini Cristina Stasi Maria Teresa Urbano Santino Marchi Paolo Usai-Satta | 2014 | World Journal of Gastroenterology2014，20，27： | 37 |
| 2 | SYBR GreenⅠ染料法定量PCR检测疟原虫感染及显示文摘目的评价一种可以快速定量检测疟原虫及虫种鉴别的荧光定量PCR法。方法将SYBR Green Ⅰ法与TaqMan探针法检测疟原虫进行比对,评价定量的准确性及方法的敏感度。以PCR-DNA测序法为金标准,评价SYBR Green Ⅰ法分型的准确性。结果两个方法的定量拷贝检测数无显著性差异(P>0.05)。SYBR Green Ⅰ法检测疟原虫的最低检测下限为1×102copy/mL至5×102copy/mL之间。与PCR-DNA测序法比较,SYBR Green Ⅰ法能准确的对感染的疟原虫虫种做准确的鉴定。结论 SYBR Green I染料法定量可同时进行人体疟原虫的定量检测和虫种鉴别,且成本低廉,操作简便快速,可以在疟疾的高发地区推广使用。 | 陈江涛 刘配芬 钟德善 潘雪峰 杨辉 杨立业 陆志为 杨惠钿 林敏 Santiago-m Monte-Nguba Juan Carlos Salas Ehapo Urbano Monsuy Eyi | 2013 | 分子诊断与治疗杂志2013，5，4： | 11 |
| 3 | G6PD缺陷症对恶性疟疾感染风险的影响显示文摘目的:观察葡萄糖-6-磷酸脱氢酶(G6PD)缺陷症不同表型对恶性疟原虫感染的影响。方法:采用横断面研究的方式,将2012年雨季到马拉博地区医院就诊的2 690名比奥克岛当地居民纳入研究。用显微镜镜检、荧光定量PCR结合熔解曲线法检测疟原虫。用荧光斑点法及PCR-DNA测序鉴定G6PD缺陷症。采用Logistic回归进行关联性分析。结果:该人群的G6PD缺陷症的总发生率为9.22%,基因型均为G6PD*A-(c.202 G>A/c.376 A>G)。G6PD缺陷症体现出强烈的疟疾保护作用(P<0.05);不同性别和表型的G6PD缺陷者中,只有男性半合子对疟疾有保护作用(P<0.05),而女性杂合子组与女性纯合子组均无统计学差异(P>0.05)。结论:G6PD缺陷症的男性半合子表型能够减低恶性疟疾感染的风险,但是其机制尚未明确,有待更深入的研究。 | 陈江涛 林敏 刘配芬 钟德善 谢东德 Santiago-m Monte-Nguba Juan Carlos Salas Ehapo Urbano Monsuy Eyi 杨立业 杨辉 詹小芬 杨惠钿 | 2014 | 实用医学杂志2014，30，21： | 4 |
| 4 | Hydroxytryptamine transporter gene-linked polymorphic region(5HTTLPR)is associated with delusions in Alzheimer’s disease显示文摘Background:Serotoninergic pathways underlying delusion symptoms in Alzheimer’s disease(AD)have not been fully clarified.5-Hydroxytryptamine transporter gene-linked polymorphic region(5-HTTLPR)is a variable number tandem repeats in the promoter region of serotonin transporter encoding-gene affecting transcription.Methods:We investigated the association of 5-HTTLPR with delusions in a total of 257 consecutive patients clinically diagnosed as AD according to the National Institute on Aging-Alzheimer’s Association criteria.All participants underwent a comprehensive evaluation with a standardized comprehensive geriatric assessment and Neuropsychiatric Inventory.Results:Delusion symptoms were observed in 171 patients(66.54%).In respect to AD patients without delusions,AD patients with delusions showed a low prevalence of S-plus carriers(5-HTTLPR-L/S+5-HTTLPR-S/S genotypes)[p<0.001;odds ratio(OR)=0.240,95% confidence interval(CI)=0.121–0.471].Logistic regression analysis adjusted for the apolipoprotein E polymorphism showed that in AD patients with delusions the presence of an 5-HTTLPR-S allele may reduce disease duration(p=0.005;OR=0.680,95% CI=0.522–0.886)and increase aberrant motor activity(p=0.013;OR=2.257,95% CI=1.195–4.260).The present findings suggested that 5-HTTLPR might be associated with delusions in AD.S-plus carriers might be associated with protective effect against delusions in AD.Conclusions:More studies on wider samples of high selected demented patients are needed to confirm our results.However,the present findings suggested that a genetic factor related to serotonin metabolism might exert a protective role on the clinical expression of neuropsychiatric clusters in AD with important implications regarding mechanisms underlying delusions and their possible treatment across the AD and dementia spectrum. | Grazia D’Onofrio Francesco Panza Daniele Sancarlo Michele Lauriola Mariangela P.Dagostino Giulia Paroni Madia Lozupone Antonio Mangiacotti Paola Bisceglia Carolina Gravina Maria Urbano Filomena Addante Francesco Paris Leandro Cascavilla Antonio Greco Davide Seripa | 2019 | Translational Neurodegeneration2019，8，1： | 2 |
| 5 | The impact of desirability and feasibility on entrepreneurial intentions: A structural equation model显示文摘 | Maribel Guerrero Josep Rialp David Urbano | 2008 | International Entrepreneurship and Management Journal2008，，1： | 2 |
| 6 | Electrochemical and spectroscopic study of interfacial interactions between chalcopyrite and typical flotation process reagents显示文摘Comparative voltammetry and differential double-layer capacitance studies were performed to evaluate interfacial interactions between cnalcopyrite(CuFeS_2) and n-isopropyl xanthate(X) in the presence of ammonium bisulfite/39wt%SO_2 and caustic starch at different pH values.Raman spectroscopy,Fourier transform infrared(FTIR) spectroscopy,contact angle measurements,and microflotation tests were used to establish the type and extent of xanthate adsorption as well as the species involved under different mineral surface conditions in this study.The results demonstrate that the species that favor a greater hydrophobicity of chalcopyrite are primarily CuX and S^0,whereas oxides and hydroxides of Cu and Fe as well as an excess of starch decrease the hydrophobicity.A conditioning of the mineral surface with ammonium bisulfite/39wt%SO_2 at pH 6 promotes the activation of surface and enhances the xanthate adsorption.However,this effect is diminished at pH ≥ 8,when an excess of starch is added during the preconditioning step. | Gustavo Urbano Isabel Lázaro Israel Rodríguez Juan Luis Reyes Roxana Larios Roel Cruz | 2016 | International Journal of Minerals,Metallurgy and Materials2016，23，2： | 2 |
| 7 | 赤道几内亚比奥科岛献血者的输血传播感染疾病血清流行学研究和风险因素评估显示文摘目的在比奥科岛上献血人群中开展一次输血传播感染疾病(transfusion—transmissibleinfections,TTIs)的血清流行病学调查。方法用金标法和ELISA对合格献血者血样进行4项输血传播感染疾病的检测,包括人类免疫缺陷病毒(HIV)、乙型肝型病毒(HBV)、丙型肝型病毒(HCV)、梅毒螺旋体(LUES),同时用多元回归分析方法评估TTIs疾病的相关危险因素。结果在2937名献血者中HIV、HBV、HCV和梅毒螺旋体的感染率分别为7.83%(95%CI:6.85~8.80)、10.01%(95%CI:8.92~11.10)、3.71%(95%CI:3.03~4.39)和21.52%(95%CI:20.02~23.00)。多重混合感染的阳性率是6.30%(95%CI:5.42~7.18)。同时发现女性献血者的HIV和梅毒感染阳性率明显高于男性献血者(HIV:AOR=I.50,95%CI:1.10-2.04,P=0.010;梅毒:AOR=1.27,95%CI:1.02~1.58,P=0.034)。岛上的未规划居住区是艾滋病、乙肝和梅毒感染的显著危险因素(HIV:AOR=I.66,95%CI:1.04~2.66,P=-0.033;HBV:AOR=I.78,95%CI:1.11~2.83,P=-0.016;梅毒:AOR=I.73,95%CI:1.26-2.37,P=-0.001)。结论比奥科岛的献血人群中输血传播感染的阳性率极高,当地政府和卫生部门应采取更有效的干预措施来提高血液安全。 | 谢东德 陈江涛 Urbano Monsuy Eyi Rocio Apicante Matesa Maximo Miko Ondo Obono Carlos Sala Ehapo 郑艳芬 詹小芬 杨辉 杨惠钿 杨立业 章光华 荆磊 林敏 | 2014 | 分子诊断与治疗杂志2014，6，1： | 2 |
| 8 | Update on pre-diabetes: Focus on diagnostic criteria and cardiovascular risk显示文摘Pre-diabetes, which is typically defined as blood glucose concentrations higher than normal but lower than thediabetes threshold, is a high-risk state for diabetes and cardiovascular disease development. As such, it represents three groups of individuals: Those with impaired fasting glucose(IFG), those with impaired glucose tolerance(IGT) and those with a glycated haemoglobin(HbA1c) between 39-46 mmol/mol. Several clinical trials have shown the important role of IFG, IGT and HbA1c -pre-diabetes as predictive tools for the risk of developing type 2 diabetes. Moreover, with regard to cardiovascular disease, pre-diabetes is associated with more advanced vascular damage compared with normoglycaemia, independently of confounding factors. In view of these observations, diagnosis of pre-diabetes is mandatory to prevent or delay the development of the disease and its complications; however, a number of previous studies reported that the concordance between pre-diabetes diagnoses made by IFG, IGT or HbA1c is scarce and there are conflicting data as to which of these methods best predicts cardiovascular disease. This review highlights recent studies and cur-rent controversies in the field. In consideration of the expected increased use of HbA1c as a screening tool to identify individuals with alteration of glycaemic homeo-stasis, we focused on the evidence regarding the ability of HbA1c as a diagnostic tool for pre-diabetes and as a useful marker in identifying patients who have an increased risk for cardiovascular disease. Finally, we reviewed the current evidence regarding non-traditional glycaemic biomarkers and their use as alternatives to or additions to traditional ones. | Antonino Di Pino Francesca Urbano Salvatore Piro Francesco Purrello Agata Maria Rabuazzo | 2016 | World Journal of Diabetes2016，7，18： | 2 |
| 9 | Economic, social and environmental impact of land consolidation in Galicia显示文摘 | Rafael Crecente Carlos Alvarez Urbano Fra | 2002 | Land Use Policy2002，，2： | 2 |
| 10 | Dendritic cells express tight junction proteins and penetrate gut epithelial monolayers to sample bacteria显示文摘 | Rescigno M Urbano M Valzasina B | 2001 | Nat Immunol2001，2，： | 1 |
| 11 | Effect of cryopreservation and single layer centrifugation on canine sperm DNA fragmentation assessed by the sperm chromatin dispersion test 显示文摘 | Urbano M Dorado J Ortiz I | 2013 | Anim Reprod Sci2013，143，14： | 1 |
| 12 | Intensity-modulated radiotherapy allows escalation of the radiationdose to the pelvic lymph nodes in patients with locally ad-vanced prostate cancer:preliminary results of a phase I doseescalation study 显示文摘 | Guerrero Urbano T Khoo V Staffurth J9et a/ | 2010 | Clin Oncol2010，22，3： | 1 |
| 13 | Accessibility in the European Union : theimpact of the trans-European road network 显示文摘 | Gutierrez J Urbano P | 1996 | Journal ofTransport Geography1996，4，1： | 1 |
| 14 | Study of spectral analytical data using fin- gerprints and scaledsimilarity measurements显示文摘 | M Urbano Cuadrado M D Luque de Castro M A Go mez-Nieto | 2005 | Anal Bioanal Chem2005，381，： | 1 |
| 15 | Forest fire spread models:the local quasi-equilibrium approach显示文摘 | Andre J C Urbano J M Viegas D X | 2006 | Combustion science and technology2006，178，12： | 1 |
| 16 | Dendritic cells express tight junction proteins and penetrate gut epithelial monolayers to sample bacteria显示文摘 | Reseigno M Urbano M Valazsiona B | 2001 | Nat Immunol2001，2，4： | 1 |
| 17 | Economic, social and environmenlal impact of land consohdation in Galicia 显示文摘 | Rafael Crecente Carlos Alvarez Urbano Fra | 2002 | Land Use Policy2002，2002，： | 1 |
| 18 | Refractional results of LASIK retreatment w ith w avefront-guided ablation versus standard ablation显示文摘 | Urbano AP NoséW | 2008 | Arq Bras Oftalm ol2008，71，5： | 1 |
| 19 | Identification of a potent and selective rlreceptor agonist potentiating NGF-induced neurite outgrowth in PC12 cells 显示文摘 | Rossi D Pedrali A Urbano M | 2011 | Bioorg Med Chem2011，19，21： | 1 |
| 20 | Removal of boron from geothermal water by a novel boron selective resin 显示文摘 | SANTANDER P RIVAS B L URBANO B F | 2013 | Desalination2013，310，： | 1 |
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