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| 1 | Relationship of cystatin C with coronary artery disease and its severity显示文摘 | Yusuf C. Doganer Umit Aydogan Aydogan Aydogdu Mustafa Aparci Halil Akbulut Polat Nerkiz Turker Turker Tuncer Cayci Cem Barcin Kenan Saglam | 2013 | Coronary Artery Disease2013，，2： | 2 |
| 2 | Investigation of possible risk factors in the development of seasonal allergic conjunctivitis显示文摘AIM: To analyze the possible risk factors in the development of seasonal allergic conjunctivitis(SAC) through an evaluation of skin allergy tests and data obtained from questionnaires.METHODS: The study included a total of 75 SAC patients and 71 control subjects without SAC diagnosis who were admitted to the Abant Izzet Baysal University Medical Faculty Ophthalmology Clinic between March 2016 and December 2016. Skin prick tests were performed for all participants. Serum levels of total IgE and 25-OH vitamin D were also measured. In the tear, total IgE levels were measured. Moreover, possible risk factors for the onset of SAC(smoking, paracetamol exposure, vitamin D supplementation and environmental factors etc.) were examined for all patients by both prenatal and postnatal aspects.RESULTS: The patients with SAC were found to have a history of maternal paracetamol exposure during the prenatal period. Likewise, in the same patient group, the duration of postnatal vitamin D supplementation was shorter(P<0.001). However, no significant correlation was found between SAC and maternal antibiotic exposure, maternal smoking, the mode of delivery and birth weight, as well as presence of pets. Moreover, patients with SAC were more likely to have asthma, allergic rhinitis and oral allergy syndrome. We have also found that SAC patients' mothers and siblings were more likely to have allergic conjunctivitis. Likewise, their fathers were more likely to have allergic rhinitis. CONCLUSION: Prenatal maternal paracetamol exposure and shorter duration of vitamin D supplementation in the postnatal period may play a role in development of SAC. Therefore prevention of unnecessary gestational paracetamol intake and vitamin D supplementation during infancy could potentially reduce the onset and development of SAC. | Umit Dogan Sümeyra Agca | 2018 | International Journal of Ophthalmology(English edition)2018，11，9： | 1 |
| 3 | Sustained virological response based on the week 4 response in hepatitis C virus genotype 1 patients treated with peginterferons α-2a and α-2b, plus ribavirin显示文摘 | Umit B. Dogan Mustafa S. Akin Serkan Yalaki | 2013 | European Journal of Gastroenterology & Hepatology2013，，11： | 1 |
| 4 | Five Percent Weight Lost in the First Month of Intragastric Balloon Treatment May Be a Predictor for Long-Term Weight Maintenance显示文摘 | Umit Bilge Dogan Yuksel Gumurdulu Mustafa Salih Akin Serkan Yalaki | 2013 | Obesity Surgery2013，，7： | 1 |
| 5 | The comparison of the efficacy of pegylated interferon α-2a and α-2b in chronic hepatitis C patients with genotype 1显示文摘 | Umit B. Dogan Ayse Atabay Mustafa S. Akin Serkan Yalaki | 2013 | European Journal of Gastroenterology & Hepatology2013，，9： | 1 |
| 6 | Effect of nepafenac 0.1% on retinal thickness after cataract surgery in patients without risk factors for cystoid macular edema显示文摘AIM:To evaluate the effect of topical preoperative nepafenac 0.1%treatment on postoperative macular edema using optical coherence tomography(OCT)after uncomplicated cataract surgery.METHODS:Ninety eyes of 90 patients without any risk factors were included in the study.The patients were assigned to three groups:group 1,treated with topical prednisolone acetate 1%;group 2,treated with topical nepafenac 0.1%in addition to prednisolone acetate(1%);and group 3,those who started receiving nepafenac 0.1%treatment 3 d prior to surgery and continued the treatment postoperatively in addition to prednisolone acetate(1%).Central retinal thickness(CRT)and macular volume values were recorded using OCT at weeks 3 and 6.RESULTS:The increases in macular volume in the central 1 mm area after 3 and 6 wk were significantly lower in patients who used prophylactic topical nepafenac preoperatively(group 3)compared with those in group 1(P=0.028 and 0.008,respectively).No significant differences in the increase in macular volume and CRT were noted between groups 2 and 3(P>0.05).In group 1,the increases in macular volume in the central 3 mm area at weeks 3 and 6 were significantly higher than that in group 2 and 3(3rd week,P=0.004;6th week,P=0.005).CONCLUSION:Nepafenac 0.1%treatment in addition to topical steroids after uncomplicated cataract surgery reduce the increase in macular volume in the early postoperative period. | Asena Keles Sahin Ahmet Sahap Kükner Fatih Ulas Umit Dogan | 2020 | International Journal of Ophthalmology(English edition)2020，13，12： | 0 |
| 7 | Experimental analysis on the nonlinear behavior of DC barrier discharge plasmas显示文摘Nonlinear behavior of glow discharge plasmas is experimentally investigated.The glow is generated between a barrier semiconductor electrode,Chromium doped namely Gallium Arsenide(Ga As:Cr),as a cathode and an Indium–Tin Oxide(ITO) coated glass electrode as an anode,in reverse bias.The planar nature of electrodes provides symmetry in spatial geometry.The discharge behaves oscillatory in the time domain,with single and sometimes multiperiodicities in plasma current and voltage characteristics.In this paper,harmonic frequency generation and transition to chaotic behavior is investigated.The observed current–voltage characteristics of the discharge are discussed in detail. | Dogan MANSUROGLU Ilker Umit UZUN-KAYMAK | 2017 | Plasma Science and Technology2017，19，1： | 0 |
| 8 | Impact of adjuvant treatment modalities on survival outcomes in curatively resected pancreatic and periampullary adenocarcinoma显示文摘Background: We examined the impact of adjuvant modalities on resected pancreatic and periampullary adenocarcinoma(PAC).Methods: A total of 563 patients who were curatively resected for PAC were retrospectively analyzed between 2003 and 2013.Results: Of 563 patients, 472 received adjuvant chemotherapy(CT) alone, chemoradiotherapy(CRT) alone, and chemoradiotherapy plus chemotherapy(CRT-CT) were analyzed. Of the 472 patients, 231 were given CRT-CT, 26 were given CRT, and 215 were given CT. The median recurrence-free survival(RFS) and overall survival(OS) were 12 and 19 months, respectively. When CT and CRT-CT groups were compared, there was no significant difference with respect to both RFS and OS, and also there was no difference in RFS and OS among CRT-CT, CT and CRT groups. To further investigate the impact of radiation on subgroups, patients were stratified according to lymph node status and resection margins. In node-positive patients, both RFS and OS were significantly longer in CRT-CT than CT. In contrast, there was no significant differencebetween groups when patients with node-negative disease or patients with or without positive surgical margins were considered.Conclusions: Addition of radiation to CT has a survival benefit in patients with node-positive disease following pancreatic resection. | Nedim Turan Mustafa Benekli Olcun Umit Unal ?lkay Tugba Unek Didem Tastekin Faysal Dane Efnan Alg?n Sukran Ulger Tulay Eren Turkan Ozturk Topcu Esma Turkmen Nalan Akgül Babacan Gulnihal Tufan Zuhat Urakci Basak Oven Ustaalioglu Ozlem Sonmez Uysal Ozlem Balvan Ercelep Burcu Yapar Taskoylu Asude Aksoy Mustafa Canhoroz Umut Demirci Erkan Dogan Veli Berk Ozan Balakan Ahmet ?iyar Ekinci Mukremin Uysal ?brahim Petekkaya Sel?uk Cemil Ozturk ?nder Tonyal? Bülent ?etin Mehmet Naci Aldemir Kaan Helvac? Nuriye Ozdemir ?lhan Oztop Ugur Coskun Aytug Uner Ahmet Ozet Suleyman Buyukberber | 2015 | Chinese Journal of Cancer Research2015，27，4： | 0 |
| 9 | Alanine aminotransferase normalization at week 8 predicts viral response during hepatitis C treatment显示文摘AIM:To investigate alanine aminotransferase(ALT)and sustained virological response(SVR)in chronic hepatitis C(CHC)during peginterferon-ribavirin treatment.METHODS:One hundred and fifty-one genotype 1CHC patients underwent treatment for 48 wk with peginterferon and ribavirin,and were retrospectively divided into two groups as having a rapid virological response(RVR)(Group 1,n=52)and not having an RVR(Group 2,n=99).We also subdivided each group into two according to the initial ALT level being high(Group1h and Group 2h)or normal(Group 1n and Group 2n).HCV RNA and ALT levels were measured at baseline;at 4,12,24 and 48 wk during the treatment period;and at 24 wk follow-up.ALT levels were also obtained at 8 wk.According to the results of ALT,patients were enrolled in either the follow-up abnormal or follow-up normalized ALT groups at each interval.Patients with high and normal ALT levels were compared for each interval in terms of SVR.RESULTS:The SVR rates were 83%vs 40%(P=0.000),82%vs 84%(P=0.830),and 37%vs 44%(P=0.466)when comparing Group 1 with 2,1h with1n,and 2h with 2n,respectively.In Group 2h,the SVR rates were 34%vs 40%(P=0.701),11%vs 52%(P=0.004),12%vs 50%(P=0.007),7%vs 50%(P=0.003),6%vs 53%(P=0.001),and 0%vs 64%(P=0.000)when comparing patients with high and normalized ALT levels at week 4,8,12,24,48 and 72,respectively.The multiple logistic regression analysis revealed that RVR(OR=7.05;95%CI:3.1-16.05,P=0.000),complete early virological response(cEVR)(OR=17.55;95%CI:6.32-48.76,P=0.000),normalization of ALT at8 wk(OR=3.04;95%CI:1.31-7.06,P=0.008),and at 12 wk(OR=4.21;95%CI:1.65-10.76,P=0.002)were identified as independent significant predictive factors for SVR.CONCLUSION:Normalization of ALT at 8 wk may predict viral response during peginterferon-ribavirin treatment in genotype-1 CHC patients especially without RVR. | Umit Bilge Dogan Mustafa Salih Akin Serkan Yalaki | 2013 | World Journal of Gastroenterology2013，19，46： | 0 |
| 10 | 在试验性的糖尿病的 3 个层次建模的网膜的 VEGF, TNF,和 caspase 上的 intravitreal bevacizumab 和 intravitreal fasudil 的效果的比较显示文摘AIM: To evaluate the influence of an intravitreal injection of bevacizumab and fasudil on the retinal vascular endothelial growth factor(VEGF),tumor necrosis factor alpha(TNFα),and caspase 3 levels in a diabetic rabbit model. · METHODS: The study included 6 healthy rabbits(Group 1),6 rabbits with experimentally induced diabetes mellitus(DM)(Group 2),7 rabbits with experimentally induced DM to which intravitreal bevacizumab was administered(Group 3),and 7 rabbits with experimentally induced DM to which intravitreal fasudil was administered(Group 4). An intravitreal injection of 1.25mg/50μL bevacizumab in the right eye of rabbits in Group 3 and an intravitreal injection of 0.0064mg/50μL fasudil in the right eye of rabbits in Group 4 were administered on day 21 after the induction of DM. The studied eyes of the rabbits were enucleated three days after the intravitreal injection. The TNFα,VEGF,and caspase 3 levels were determined using the ELISA method. · RESULTS: There was a statistically significant difference in the VEGF and caspase 3 levels between groups(P =0.005 and P =0.013,respectively),but the TNF α level did not differ significantly between groups(P = 0.792). It was found that VEGF levels were significantly lower in Group 1 and Group 3 than in Group 2 using the Mann-Whitney U test with the Bonferroni correction(P = 0.004 for both comparison). There was no statistically significant difference between other groups with regard to VEGF levels(the P value ranged between 0.015 and 0.886). Although the P values of the caspase 3 levels were 0.015 for Group 1 and Group 4,0.038 for Group 2and Group 3,and 0.018 for Group 3 and Group 4,these P values remained above the threshold P value of 0.0083,which was the statistically significant level for post hoc tests. ·CONCLUSION: An intravitreal injection of bevacizumab decreased both the VEGF level,which plays a role in angiogenesis,and the caspase 3 level,which plays a role in apoptosis. Although not as effective as bevacizumab,fasudil had a beneficial effect on the VEGF levels but significantly increased the caspase 3 levels. | Fatih Celik Fatih Ulas Zeynep Gunes Ozunal Tulin Firat Serdal Celebi Umit Dogan | 2014 | International Journal of Ophthalmology(English edition)2014，7，1： | 0 |
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