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| 1 | Bone marrow-derived mesenchymal stem cells versus adipose-derived mesenchymal stem cells for peripheral nerve regeneration显示文摘Studies have confirmed that bone marrow-derived mesenchymal stem cells(MSCs) can be used for treatment of several nervous system diseases. However, isolation of bone marrow-derived MSCs(BMSCs) is an invasive and painful process and the yield is very low. Therefore, there is a need to search for other alterative stem cell sources. Adipose-derived MSCs(ADSCs) have phenotypic and gene expression profiles similar to those of BMSCs. The production of ADSCs is greater than that of BMSCs, and ADSCs proliferate faster than BMSCs. To compare the effects of venous grafts containing BMSCs or ADSCs on sciatic nerve injury, in this study, rats were randomly divided into four groups: sham(only sciatic nerve exposed), Matrigel(MG; sciatic nerve injury + intravenous transplantation of MG vehicle), ADSCs(sciatic nerve injury + intravenous MG containing ADSCs), and BMSCs(sciatic nerve injury + intravenous MG containing BMSCs) groups. Sciatic functional index was calculated to evaluate the function of injured sciatic nerve. Morphologic characteristics of nerves distal to the lesion were observed by toluidine blue staining. Spinal motor neurons labeled with Fluoro-Gold were quantitatively assessed. Compared with sham-operated rats, sciatic functional index was lower, the density of small-diameter fibers was significantly increased, and the number of motor neurons significantly decreased in rats with sciatic nerve injury. Neither ADSCs nor BMSCs significantly improved the sciatic nerve function of rats with sciatic nerve injury, increased fiber density, fiber diameters, axonal diameters, myelin sheath thickness, and G ratios(axonal diameter/fiber diameter ratios) in the sciatic nerve distal to the lesion site. There was no significant difference in the number of spinal motor neurons among ADSCs, BMSCs and MG groups. These results suggest that neither BMSCs nor ADSCs provide satisfactory results for peripheral nerve repair when using MG as the conductor for engraftment. | Marcela Fernandes Sandra Gomes Valente Rodrigo Guerra Sabongi Joao Baptista Gomes dos Santos Vilnei Mattioli Leite Henning Ulrich Arthur Andrade Nery Maria José da Silva Fernandes | 2018 | Neural Regeneration Research2018,13,1: | 10 |
| 2 | Separation of cellular and BOLD con- tributions to T2 u signal relaxation显示文摘 | Ulrich X Yablonskiy DA | 2015 | Magn Reson Meal2015,75,2: | 1 |
| 3 | The relationship of mo- tor skilts and social communicative skills in school-aged children with autismspectrum disorder显示文摘 | MacDonald M Lord C Ulrich DA | 2013 | Adapt Phys Ac- tiv Q2013,30,3: | 1 |
| 4 | Using real-time PCR to specifically detect Burkholderia mallei显示文摘 | Ulrich MP Norwood DA Christensenl DR | 2006 | J Medical Mierobiol2006,55,: | 1 |
| 5 | Using real - time PCR to specifically detectBurkholderia mallei 显示文摘 | Ulrich MP Norwood DA Christensen DR | 2006 | J Med Microbiol2006,55,5: | 1 |
| 6 | Treadmil training of infants with Down syndrome: evidence-based devel- opmental outcomes显示文摘 | Ulrich DA Ulrich BD Angulo-Kinzler RM | 2001 | Pediatrics2001,108,5: | 1 |
| 7 | Activity, selectivity and stability of metallosilicates containing molybdenum for the epoxidation of alkenes显示文摘 | Arnold Ulrich Da Cruz Rosenira Serpa | 2001 | J Mol Catal A:Chem2001,165,12: | 1 |
| 8 | Effects of intensi- ty of treadmill training on developmental outcomes and step- ping in infants with Down syndrome: a randomized trial显示文摘 | Ulrich DA Lloyd MC Tiernan CW | 2008 | Phys Ther2008,88,1: | 1 |
| 9 | Creative Activity and the Development of Consciousness:A Discussion With Piaget and Rudolf Steiner显示文摘This study aims to discuss the possibility of becoming conscious of certain aspects of one’s own existence through creative activity.The discussion involves Piagetian constructivism and Steiner’s ideas about human development and is justified by the contribution of creative activity to the development of autonomy,according to Piaget,and to the development of an ethical individuality,according to Steiner.The participation of adults in sessions of creative process,as well as the questions posed after this activity,asking for the relationships between what they created and their life,is evidence of practices favourable to increasing the grasping of consciousness of self and of the process of developing an ethical individuality. | Tania Stoltz Marcelo da Veiga Ulrich Weger | 2023 | Psychology Research2023,13,3: | 0 |