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| 1 | Animal models of acute gastric mucosal injury: Macroscopic and microscopic evaluation显示文摘Acute gastric mucosal injury is a common disorder of the gastrointestinal tract and the search for new therapeutics is ongoing. The aim of this study is to update and expand the information related to the most widely used rat models of acute gastric ulcer, the ethanol‐induced ulcer and the indomethacin‐induced ulcer. These two models are compared in terms of macroscopic and microscopic features. Experimentally, ethanol was given orally in a single dose and indomethacin was subcutaneously injected into male Wistar rats. After ulcerative challenges, the stomachs were removed and visually inspected. Anti‐ulcerative drugs were used to validate the models. Histological analysis of the stomachs determined the microscopic score. The methodology used for model evaluation applied to macroscopic and microscopic gastric lesions. With these methods it was possible to induce lesions in the gastric mucosa. Microscopic evaluation permitted assessment of the inflammatory and apoptotic impact in the mucosa not observable by macroscopic evaluation. Groups of animals were treated with two standard drugs: sulcralfate suspension or lansoprazole solution. Both drugs reduced macroscopic and microscopic lesions, particularly the hemorrhagic ones. Both models induced acute gastric mucosal injury and no single evaluation method can address all the aspects of the pathology of gastric lesions. As a complement to macroscopic evaluation, microscopy appears to be a relevant tool to selectively identify specific aspects of the development of mucosal injury, quantify the extent of lesions, and contribute to an appropriate interpretation of results. The score systems established here offer a reliable method for testing antiulcer drugs. | Sandra Simoes Rui Lopes Maria Celeste Dias Campos Maria Joao Marruz Maria Eugenia Meirinhos da Cruz Luisa Corvo | 2019 | Animal Models and Experimental Medicine2019，2，2： | 7 |
| 2 | 扁平部玻璃体切除联合经巩膜缝线固定后房型人工晶状体移植的长期效果显示文摘PURPOSE: To investigate the long-term visual outcome and the complication rate following transscleral suture fixation of posterior chamber intraocular lenses (sutured PC-IOLs). DESIGN: A retrospective case-series descriptive study.METHODS: Records of patients who underwent combined pars plana vitrectomy and sutured PC-IOLs at Moorfields Eye Hospital and who had at least 12 months of follow-up were examined for recorded complications. RESULTS: Sixty-one eyes of 48 patients (33 males and 15 females) were identified and included in the analysis, with mean follow-up of 6 years. The mean final best-corrected visual acuity remained at preoperative levels (P=.211) and was largely determined by the underlying ocular pathology before sutured PC-IOL. Overall 30 of 61 (49%) eyes, two or more procedures were performed to reverse a significant peri-or postoperative complication. Breakage of polypropylene sutures was the main indication accounting for 17 of 30 (57%) of those reoperations. Subgroup analysis showed that younger patients were more likely to suffer the above complication (P=.009). The multivariate analysis also showed that longer follow-up was significantly associated with suture breakage (P=.014), with the mean time to breakage approximately 4 years after surgery. CONCLUSIONS: Long-term follow-up of patients undergoing sutured PC-IOLs appears to be associated with a high rate of postoperative complications and significant need for further surgery,which should be discussed during their informed consent process. | Vote B.J. Tranos P. Bunce C. L. Da Cruz 王静波 | 2006 | 世界核心医学期刊文摘(眼科学分册)2006，2，5： | 6 |
| 3 | Radiofrequency combined with immunomodulation for hepatocellular carcinoma: State of the art and innovations显示文摘Hepatocellular carcinoma(HCC)is the most common primary liver tumor and has been considered a very immunogenic tumor.The treatment with radiofrequency ablation(RFA)has been established as the standard ablative therapy for early HCC,and is currently recognized as the main ablative tool for HCC tumors<5 cm in size;however,progression and local recurrence remain the main disadvantages of this approach.To solve this clinical problem,recent efforts were concentrated on multimodal treatment,combining different strategies,including the combination of RFA and immunotherapy.This article reviewed the combination treatment of RFA with immunotherapy and found that this treatment strategy leads to an increased response of anti-tumor T cells,significantly reduces the risk of recurrence and improves survival rates compared to RFA alone.This review highlighted scientific evidence that supports the current recommendations for pre-clinical studies,and discuss the need for further research on this topic. | Adriano Carneiro da Costa Mikael Sodergren Kumar Jayant Fernando Santa Cruz Duncan Spalding Madhava Pai Nagy Habib | 2020 | World Journal of Gastroenterology2020，26，17： | 5 |
| 4 | Potential role of Limosilactobacillus fermentum as a probiotic with anti-diabetic properties: A review显示文摘Oxidative stress,inflammation,and gut microbiota impairments have been implicated in the development and maintenance of diabetes mellitus.Strategies capable of recovering the community of commensal gut microbiota and controlling diabetes mellitus have increased in recent years.Some lactobacilli strains have an antioxidant and anti-inflammatory system capable of protecting against oxidative stress,inflammation,and diabetes mellitus.Experimental studies and some clinical trials have demonstrated that Limosilactobacillus fermentum strains can beneficially modulate the host antioxidant and anti-inflammatory system,resulting in the amelioration of glucose homeostasis in diabetic conditions.This review presents and discusses the currently available studies on the identification of Limosilactobacillus fermentum strains with anti-diabetic properties,their sources,range of dosage,and the intervention time in experiments with animals and clinical trials.This review strives to serve as a relevant and well-cataloged reference of Limosilactobacillus fermentum strains capable of inducing anti-diabetic effects and promoting health benefits. | Diego Cabral Lacerda Paulo César Trindade da Costa Paula Brielle Pontes Lucas Alves Carneiro dos Santos JoséPatrocínio Ribeiro Cruz Neto Cristiane Cosmo Silva Luis Vanessa Polyana de Sousa Brito JoséLuiz de Brito Alves | 2022 | World Journal of Diabetes2022，13，9： | 3 |
| 5 | Role of Chitin and Chitinase/Chitinase-Like Proteins in Inflammation, Tissue Remodeling, and Injury显示文摘 | Chun Geun Lee Carla A. Da Silva Charles S. Dela Cruz Farida Ahangari Bing Ma Min-Jong Kang Chuan-Hua He Seyedtaghi Takyar Jack A. Elias | 2011 | Annual Review of Physiology2011，，： | 2 |
| 6 | Chemical and microbiological characterization of tinctures and microcapsules loaded with Brazilian red propolis extract显示文摘The aim of this study was to characterize tinctures and microcapsules loaded with an ethanol extract of red propolis through chemical, physicochemical and microbiological assays in order to establish quality control tools for nutraceutical preparations of red propolis. The markers(isoflavonoids, chalcones, pterocarpans,flavones, phenolic acids, terpenes and guttiferones) present in the tinctures A and B were identified and confirmed using LC/ESI/FTMS/Orbitrap. Four compositions(A, B, C and D) were prepared to contain B tincture of the red propolis with some pharmaceutical excipients and submitted to two drying processes, i. e.spray-drying and freeze-drying to obtain microcapsules loaded with the red propolis extract. The tinctures and microcapsules of the red propolis were submitted to the total flavonoid content and antioxidant activity tests.The antibacterial activity and minimum inhibitory concentration(MIC) were tested using Staphylococcus aureus ATCC 25293 and Pseudomonas aeruginosa ATCC 27853 strains. The tinctures and microcapsules presented high flavonoid quantities from 20.50 to 40.79 mg/100 mg of the microcapsules. The antioxidant activity and IC50 were determined for the tinctures A and B(IC50: 6.95 μg/m L and 7.48 μg/m L), the spray-dried microcapsules(IC50: 8.89–15.63 μg/m L) and the freeze-dried microcapsules(IC50: 11.83–23.36 μg/m L). The tinctures and microcapsules were proved to be bioactive against gram-positive and gram-negative bacteria with inhibition halos superior to 10 mm at concentration of 200 μg/m L and MIC values of 135.87–271.74 μg/m L using gram-positive strain and 271.74–543.48 μg/m L using gram-negative strain. The tinctures and microcapsules of the red propolis have a potential application for nutraceutical products. | Erika Tayse da Cruz Almeida Maria Cristina Delgado da Silva José Marcos dos Santos Oliveira Regianne Umeko Kamiya Rodolfo Elleson dos Santos Arruda Danilo Abreu Vieira Valdemir da Costa Silva Pierre Barnabé Escodro Irinaldo Diniz Basílio-Júnior Ticiano Gomes do Nascimento | 2017 | Journal of Pharmaceutical Analysis2017，7，5： | 2 |
| 7 | Odontoplasty associated with clinical crown lengthening in management of extensive crown destruction显示文摘 | da Cruz MK Martos J Silveira LF | 2012 | J Conserv Dent2012，15，1： | 1 |
| 8 | Quality Assurance Re- quirements in Produce Processing 显示文摘 | DA CRUZ G CENCI A & MAIA A | 2006 | Trends in Food Science & Technology2006，17，8： | 1 |
| 9 | Lactational response of cows fed condensed corn distillers solubles显示文摘 | Da Cruz C R M J Brouk D J Schingoethe | 2005 | ] Dairy Sci2005，88，： | 1 |
| 10 | Mel-CAM (CD146) expression in parotid mucoepidermoid carcinoma 显示文摘 | Pires FR Shih le M da Cruz Perez DE | 2003 | Oral Oncol2003，39，3： | 1 |
| 11 | MR imaging findings in Wernicke encephalopathy: nonalcoholics may be similar to alcoholics 显示文摘 | Hygino da Cruz LC Jr Domingues RC Vilanova I | 2010 | AJNR Am J Neuroradiol2010，31，6： | 1 |
| 12 | Prognostic factors in head and neck adenoid cystic carci- noma显示文摘 | Da Cruz Perez DE de Abreu Aires F Nobuko Nishimoto I | 2006 | Oral Oncol2006，42，： | 1 |
| 13 | Influence of light source and extended time of curing on microhardness and degree of conversion of different regions of a nanofilled composite resin 显示文摘 | Lima AF de Andrade KM da Cruz Alves LE | 2012 | Eur J Dent2012，6，2： | 1 |
| 14 | Urea- montmorillonite-extruded nanocomposites: A novel slow- release material 显示文摘 | PEREIRA E I MINUSS F B DA CRUZ C C T | 2012 | J Agric Food Chem2012，60，： | 1 |
| 15 | Blending PSO and ANN for optimal design of FSS filters with Koch Island patch elements 显示文摘 | Da F Silva P H Cruz R M S D' Assuncao A G | 2010 | IEEE Trans on Magnetics2010，46，8： | 1 |
| 16 | Salivary gland tumors in children and adolescents: a clinicopathologic and immunohistochemical study of fiftythree cases显示文摘 | da Cruz Perez DE Pires F R Alves F A | | Int J Pediatr Otorhinolaryngol 200 10，68，7： | 1 |
| 17 | PP1 inhibition by hbeta peptide as a potential pa- thological mechanism in hlzheimer's disease显示文摘 | Vint 6m AP Henriques AG da Cruz E Silva 0A | 2009 | Ne- urotoxicol Teratol2009，31，2： | 1 |
| 18 | Viability of probiotic microorganisms in cheese during production and storage:a review显示文摘 | Karimi R Mortazavian A M da Cruz A G | 2011 | Dairy Science & Technology2011，91，3： | 1 |
| 19 | Flooding effects on phosphorus dynamics in an Amazonian mangrove forest, Northern Brazil 显示文摘 | MENDOZA U N DA CRUZ C C MENEZES MP | 2012 | Plant and Soil2012，353，： | 1 |
| 20 | Inhibition of protein phosphatase 1 stimulates secretion of Alzheimer amyloid precursor protein显示文摘 | da Cruz e Silva EF da Cruz e Silva OA Zaia CT | 1995 | Mol Med1995，1，： | 1 |
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