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| 1 | Personalized surgical management of colorectal cancer in elderly population显示文摘Colorectal cancer(CRC)in the elderly is extremely common but only a few clinicians are familiar with the complexity of issues which present in the geriatric population.In this phase of the life cycle,treatment is frequently suboptimal.Despite the fact that,nowadays,older people tend to be healthier than in previous generations,surgical undertreatment is frequently encountered.On the other hand,surgical overtreatment in the vulnerable or frail patient can lead to unacceptable postoperative outcomes with high mortality or persistent disability.Unfortunately,due to the geriatric patient being traditionally excluded from randomized controlled trials for a variety of factors(heterogeneity,frailty,etc.),there is a dearth of evidence-based clinical guidelines for the management of these patients.The objective of this review was to summarize the most relevant clinical studies available in order to assist clinicians in the management of CRC in the elderly.More than in any other patient group,both surgical and non-surgical management strategies should be carefully individualized in the elderly population affected by CRC.Although cure and sphincter preservation are the primary goals,many other variables need to be taken into account,such as maintenance of cognitive status,independence,life expectancy and quality of life. | Giampaolo Ugolini Federico Ghignone Davide Zattoni Giacomo Veronese Isacco Montroni | 2014 | World Journal of Gastroenterology2014，20，14： | 5 |
| 2 | New insights into the cell-and tissue-specificity of glucocorticoid actions显示文摘Glucocorticoids(GCs)are endogenous hormones that are crucial for the homeostasis of the organism and adaptation to the external environment.Because of their anti-inflammatory effects,synthetic GCs are also extensively used in clinical practice.However,almost all cells in the body are sensitive to GC regulation.As a result,these mediators have pleiotropic effects,which may be undesirable or detrimental to human health.Here,we summarize the recent findings that contribute to deciphering the molecular mechanisms downstream of glucocorticoid receptor activation.We also discuss the complex role of GCs in infectious diseases such as sepsis and COVID-19,in which the balance between pathogen elimination and protection against excessive inflammation and immunopathology needs to be tightly regulated.An understanding of the cell type-and context-specific actions of GCs from the molecular to the organismal level would help to optimize their therapeutic use. | Linda Quatrini Sophie Ugolini | 2021 | Cellular & Molecular Immunology2021，18，2： | 5 |
| 3 | How to select elderly colorectal cancer patients for surgery: a pilot study in an Italian academic medical center显示文摘Objective: Cancer is one of the most common diagnoses in elderly patients. Of all types of abdominal cancer, colorectal cancer(CRC) is undoubtedly the most frequent. Median age at diagnosis is approximately 70 years old worldwide. Due to the multiple comorbidities affecting elderly people, frailty evaluation is very important in order to avoid over- or undertreatment. This pilot study was designed to investigate the variables capable of predicting the long-term risk of mortality and living situation after surgery for CRC.Methods: Patients with 70 years old and older undergoing elective surgery for CRC were prospectively enrolled in the study. The patients were preoperatively screened using 11 internationally-validated-frailty-assessment tests. The endpoints of the study were long-term mortality and living situation. The data were analyzed using univariate Cox proportional-hazard regression analysis to verify the predictive value of score indices in order to identify possible risk factors.Results: Forty-six patients were studied. The median follow-up time after surgery was 4.6 years(range, 2.9-5.7 years) and no patients were lost to follow-up. The overall mortality rate was 39%. Four of the patients who survived(4/28, 14%) lost their functional autonomy. The preoperative impaired Timed Up and Go(TUG), Eastern Cooperative Group Performance Status(ECOG PS), Instrumental Activities of Daily Living(IADLs), Vulnerable Elders Survey(VES-13) scoring systems were significantly associated with increased long term mortality risk.Conclusion: Simplified frailty-assessing tools should be routinely used in elderly cancer patients before treatment in order to stratify patient risk. The TUG, ECOG-PS, IADLs and VES-13 scoring systems are potentially able to predict long-term mortality and disability. Additional studies will be needed to confirm the preliminary data in order to improve management strategies for oncogeriatric surgical patients. | Giampaolo Ugolini Francesco Pasini Federico Ghignone Davide Zattoni Maria Letizia Bacchi Reggiani Daniele Parlanti Isacco Montroni | 2015 | Cancer Biology & Medicine2015，12，4： | 4 |
| 4 | miR-1254 and miR-574-5p: serum-based microRNA biomarkers for early-stage non-small cell lung cancer显示文摘 | Foss K M Sima C Ugolini D | 2011 | J Thorac Oneol2011，6，： | 1 |
| 5 | Unilateral renal artery stenosis:Perfusion patterns with electron-beam dynamic CT-preliminary experience显示文摘 | Paul JF Ugolini P Sapoval M | 2001 | Radiology2001，221，1： | 1 |
| 6 | Systemic Risk in European Sovereign Debt Markets:A CoVaR-Copula Approach显示文摘 | Reboredo J C Ugolini A | 2015 | Journal of International Money and Finance2015，51，12： | 1 |
| 7 | Unilateral renal artery stenosis: perfusion patterns with electron-beam dynamic CT- preliminary experience 显示文摘 | Paul JF Ugolini P Sapoval M | 2001 | Radiology2001，221，1： | 1 |
| 8 | Minimally invasive video-assisted thyroidectomy for benign thyroid disease: an evidence-based review 显示文摘 | Miccoli P Minuto MN Ugolini C | 2008 | World J Surg2008，32，7： | 1 |
| 9 | TLR3 deficiency in patients with herpes simplex encephalitis显示文摘 | Zhang SY Jouanguy E Ugolini S | 2007 | Science2007，317，5844： | 1 |
| 10 | Weekly paclitaxel in elderly patients (aged>or=70 years) with advanced non-smalleell lung cancer:an alternative choice? Results of a phase II study显示文摘 | Rossi D Dennetta D Ugolini M | 2008 | Clin Lung Cancer2008，9，5： | 1 |
| 11 | Association of BRAF V600E mutation with poor clinicopathological outcomes in 500 consecutive cases of papillary thyroid carcinoma显示文摘 | Lupi C Giannini R Ugolini C | 2007 | J ClinEndocrinolMetab2007，92，11： | 1 |
| 12 | Association of BRAF V600E mutation with poor clinicopathological outcomes in 500 consecutive cases of papillary thyroid carcinoma 显示文摘 | Lupi C Giannini R Ugolini C | 2007 | J Clin Endocrinol Metab2007，92，11： | 1 |
| 13 | BRAF(V600E) mutation and outcome of patients with papillary thyroid carcinoma: a 15-year median follow-up study显示文摘 | Elisei R Ugolini C Viola D | 2008 | J Clin Endocrinol Metab2008，93，10： | 1 |
| 14 | Minimally invasive videoassisted thyroidectomy for benign thyroid disease : an evidence-based review 显示文摘 | Miccoli P Minuto MN Ugolini C | 2008 | World J Surg2008，32，7： | 1 |
| 15 | Alzheimer-like neurodegeneration in aged antinerve growth factor transgenic mice 显示文摘 | Capsoni S Ugolini G Comparini A | 2000 | Proc Natl Acad Sci USA2000，97，12： | 1 |
| 16 | Fas / tumor necrosis factor receptor death signaling is required for axotomy-induced death of motoneurons in vivo显示文摘 | Ugolini G Raoul C Ferri A | | 0，，： | 1 |
| 17 | Chemical and photochemical degradation of polycyclic aromatic hydrocarbons in the atmosphere显示文摘 | Valerio F Bottino P Ugolini D | 1984 | Science of Total Environment1984，40，1： | 1 |
| 18 | Role of soluble organics in the soil processes of Apodzol, Central Cascades 显示文摘 | Dawson H J Ugolini F C Hrutfiord B F | 1978 | Soil Sci1978，126，： | 1 |
| 19 | TLR3 deficiency in pa- tients with herpes simplex encephalitis 显示文摘 | Zhang SY Jouanguy E Ugolini S | 2007 | Science2007，317，5844： | 1 |
| 20 | TLR3 deficiency in patients with herpes simplex encephalitis 显示文摘 | Zhang SY Jouanguy E Ugolini S | 2007 | Science2007，317，5844： | 1 |
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