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| 1 | 来曲唑或克罗米芬治疗不孕后怀孕的911例新生儿中的先天性畸形分析显示文摘Objective: To evaluate the incidence of congenital malformations among offspring of mothers who conceived with clomiphene citrate(CC) or with letrozole treatment for infertility. Design: Retrospective study. Setting: 5 fertility centers in Canada. Patients: 911 newborns from women who conceived following CC or letrozole treatment. Interventions: Examination of medical files of both mother and newborn, and cross-checked with the parents by telephone calls. Main Outcome Measures: Identified major and minor congenital malformations, birth weight, age of the mother, and type of treatment that led to the conception. Results: Overall, congenital malformations and chromosomal abnormalities were found in 14 of 514 newborns in the letrozole group(2.4%) and in 19 of 397 newborns in the CC group(4.8%). The major malformation rate in the letrozole group was 1.2%(6/514) and in the CC group was 3.0%(12/397). One newborn in the letrozole group was found to have a ventricular septal defect(0.2%)-compared to 4 newborns in the CC group(1.0%). In addition, the rate of all congenital cardiac anomalies was significantly higher(P: 0.02) in the CC group(1.8%) compared to the letrozole group(0.2%). Conclusion: There was no difference in the overall rates of major and minor congenital malformations among newborns from mothers who conceived after letrozole or CC treatments. However, it appears that congenital cardiac anomaly is less frequent in the letrozole group. The concern that letrozole use for ovulation induction could be teratogenic is unfounded based on our data. | Tulandi T. Martin J. Al-Fadhli R. R.F. Casper 李跃萍 | 2006 | 世界核心医学期刊文摘(妇产科学分册)2006，0，10： | 2 |
| 2 | 子宫肌瘤栓塞失败的分析显示文摘Objective: To assess the outcomes of patients who underwent uterine fibroid embolization (UFE) and to evaluate factors associated with failure of UFE. Design: Retrospective study. Setting: University teaching hospital. Patient(s): Two hundred thirty-three consecutive patients who underwent UFE from November 1997 to February 2004. Intervention(s): Uterine fibroid embolizations were performed by three interventional radiologists using 355-500-μpolyvinyl alcohol particles. Main Outcome Measure(s): Hysterectomy rate, myomectomy rate, and repeat UFE rate. Result(s): With a mean follow-up of 13 months, a total of 22 patients underwent surgery after UFE (9.4%); 16 had hysterectomies (6.9%), and 6 had myomectomies (2.6%). This included 3 patients who underwent repeat UFE and subsequently required surgical intervention. The mean (±SEM) time interval between UFE and subsequent treatment was 12.5 ±2.0 months. Among patients who required surgery, 13 (59.1%) presented with recurrent menorrhagia, and 5 (22.7%) complained of persistent abdominal pain. Histopathologic examination revelead concomitant findings of adenomyosis in 25%of hysterectomy specimens. Patients who failed UFE were more likely to have had a previous myomectomy (13%vs 2.4%) and significant reduction in the uterine size 6 months after UFE (57.1%vs 25.2%). Conclusion(s): The overall failure rate of UFE is 9.4%. Failure is mainly due to persistent menorrhagia and abdominal pain. Shrinkage of the uterus after UFE does not necessarily correlate with long-term success of UFE. | Huang J.Y.J. Kafy S. Dugas A. T. Tulandi 李跃萍 | 2006 | 世界核心医学期刊文摘(妇产科学分册)2006，0，4： | 2 |
| 3 | 两种不同剂量来曲唑行超排卵的随机试验显示文摘Objective: The aim of this study was to evaluate the effects of either a 2.5-mg or a 5-mg daily dose of letrozole in women undergoing superovulation and intrauterine insemination (IUI). Design: Prospective randomized trial. Setting: Academic teaching hospital. Patient(s): Women < 40 years old, with patent fallopian tubes and infertility of > 1 year in duration. Intervention(s): Patients were randomized into either a 2.5-mg dose of letrozole (34 patients) or a 5-mg dose of letrozole (38 patients) daily for 5 days. When the leading follicle reached 18 mm in diameter, ovulation was triggered by an injection of hCG and IUI was performed 24 and 48 hours later. Main Outcome Measure(s): The number of follicles, endometrial thickness, and pregnancy rate. Result(s): Compared with those treated with 2.5 mg of letrozole, the total number of follicles was significantly higher in patients receiving 5 mg of letrozole. No difference in the endometrial thickness was found between the two groups. The pregnancy rate per cycle in patients receiving 5 mg of letrozole was statistically higher than in patients receiving 2.5 mg of letrozole (26.3%vs 5.9%, P < .05). No multiple pregnancies occurred. Conclusion(s): Compared with the daily dose of 2.5 mg, 5 mg of letrozole is associated with more follicles and a higher pregnancy rate. It appears that 5 mg daily for 5 days is a preferable letrozole dose for superovulation. | Al-Fadhli R. Sylvestre C. Buckett W. T. Tulandi 张旸 | 2006 | 世界核心医学期刊文摘(妇产科学分册)2006，0，4： | 1 |
| 4 | 间质妊娠:从生育外科协会登记处获得的结果 | Tulandi T. Al-JaroudiD. 马向东 | 2005 | 世界核心医学期刊文摘(妇产科学分册)2005，0，2： | 0 |
| 5 | 不孕症女性腹腔镜下行碘油和盐水输卵管灌注治疗的随机研究显示文摘Eighty- eight infertile patients undergoing laparoscopy were randomized to undergo chromopertubationwith lipiodol orwith normal saline. The cumulative probability of conception at 1, 3, and 6 months following laparoscopy was not statistically different between the lipiodol group (21% , 31% , and 43% , respectively) and the saline group (18% , 21% , and 33% , respectively). | Al-Fadhli R. Sylvestre C. Buckett W. Tulandi T. 马超 | 2006 | 世界核心医学期刊文摘(妇产科学分册)2006，2，6： | 0 |
| 6 | 卵巢皮样囊肿及子宫腺肌瘤中的神经纤维 | Al-FozanH. Bakare S. ChenM.-F. Tulandi T. 党慧敏 | 2005 | 世界核心医学期刊文摘(妇产科学分册)2005，0，2： | 0 |
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