|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Interacting with Text:The Role of Dialogue in Learning to Read and Write显示文摘English language teachers in China are expressing growing interest in the model of language provided by systemic functional linguistics and genre theory. This paper offers further insights into the methods developed in this framework,for teaching reading and writing in school and academic contexts. These methods involve carefully planned interactions between teachers and students,that enable all students in a class to successfully practise skills in academic reading and writing. The paper outlines the models of language and language learning that underpin the methods,and illustrates the kinds of classroom interactions used for writing and reading. It concludes with a discussion of the implications of these methods for language teaching in China. | J. R. Martin David Rose | 2007 | 中国外语2007，4，5： | 23 |
| 2 | 微波预处理对秸秆厌氧消化影响的研究显示文摘以秸秆为研究对象,比较不同的微波强度预处理作用下对秸秆厌氧消化产气特性的影响,研究日产气量、pH值、甲烷气体浓度及生物降解率4个参数的变化趋势,结果表明:微波预处理对秸秆厌氧消化有明显效果,平均日产气量由未被预处理的6.21mL/gVS上升到8.16mL/gVS,上升了31.33%,达到最大日产气量时间由原来的第12d,提前至第2~第7d不等,最大日产气量由原来的23.43mL/gVS上升到43.49mL/gVS;在360~900W范围内,微波强度越大,反应的pH值下降越快,秸秆厌氧消化最大日产气量越提前;经过微波预处理的甲烷浓度平均浓度由原来的50%提高至62%左右,其生物能范围也由未处理前的17.58MJ/m^3提高至23.46MJ/m^3,物降解率由未预处理的44.12%,提高至71.55%。 | 冯磊 李润东 Bernhard Raninger Martin J. Gehring | 2009 | 环境工程学报2009，3，8： | 17 |
| 3 | First report of a novel abluminal groove filled biodegradable polymer rapamycin-eluting stent in de novo coronary artery disease: results of the first in man FIREHAWK trial显示文摘 | QIAN Jie XU Bo Alexandra J. Lansky YANG Yue-jin QIAO Shu-bin WU Yong-jian CHEN Jue HU Feng-huan YANG Wei-xian Gary S. Mintz Martin B. Leon GAO Run-lin | 2012 | Chinese Medical Journal2012，，6： | 14 |
| 4 | The Metabolic Response of Arabidopsis Roots to Oxidative Stress is Distinct from that of Heterotrophic Cells in Culture and Highlights a Complex Relationship between the Levels of Transcripts, Metabolites, and Flux显示文摘新陈代谢的调整是一重要,但是糟糕理解,到氧化应力的植物的反应的部分。在以前的研究(巴斯斯特等, 2007 ) ,在到由甲蔡醌的氧化应力的正式就职的文化的 Arabidopsis 房间的新陈代谢的反应被描绘。紧急情况幸存策略在 anabolism 的主要新陈代谢大部分在哪个是下面调整的赞成被揭开分解代谢并且抗氧化剂新陈代谢。在整个植物纸巾的反应可能是不同的,我们因此调查了 Arabidopsis 根的反应到甲蔡醌处理,分析有主要以及第二等的新陈代谢的焦点的 transcriptome, metabolome 和关键新陈代谢的流动。用氧化还原作用敏感的 GFP,甲蔡醌引起氧化还原作用不安,这也被显示出,不是就在线粒体,而且在根的 cytosol 和质体。在里面开始的 30 ? 处理的 min,反应类似于房间文化:在 TCA 周期和氨基酸生合成的代谢物有减少, transcriptomic 反应被 DNA 规章的蛋白质的起来规定统治。在 2 和 6 以后 ? 处理的 h,根的反应对房间文化不同。代谢物层次没仍然保持沮丧,但是相反恢复并且在 pyruvate 的情况中,一些氨基酸和脂肪族的 glucosinolates 在控制层次上面显示出稳定的增加。然而,在中央碳新陈代谢的流动的主要变化都没被观察,新陈代谢的抄本主要独立于相应代谢物变化了。一起,结果建议根纸巾能在氧化抑制以后恢复新陈代谢的活动并且为 glycolysis 和氧化戊糖磷酸盐小径加亮潜在地重要的角色。 | Martin Lehmann Markus Schwarzlander Toshihiro Obata Supaart Sirikantaramas Meike Burow Carl Erik Olsen Takayuki Tohge Mark D. Fricker Birger Lindberg Moiler Alisdair R. Fernie Lee J. Sweetlove Miriam Laxa | 2009 | Molecular Plant2009，2，3： | 8 |
| 5 | Efficacy and safety of FIREHAWK abluminal groove filled biodegradable polymer sirolimus-eluting stents for the treatment of long coronary lesions: nine-month angiographic and one-year clinical results from TARGET I trial lona cohort显示文摘 | XU Bo GAO Run-lin ZHANG Rui-yan WANG Hai-chang LI Zhan-quan YANG Yue-jin MA Chang-sheng HAN Ya-ling Alexandra J. Lansky HUO Yong LI Wei Martin B. Leon | 2013 | Chinese Medical Journal2013，，6： | 8 |
| 6 | 中国东南部福州花岗质杂岩的岩石学和地球化学显示文摘中国东南部福州复式岩体主要由两个岩套构成:(1)钙碱性岩套(丹阳岩体、福州岩体)侵位于约105—100Ma前(Rb-Sr年龄)。这些花岗岩显示了有斜长石和角闪石分离的分异作用。Sr和Nd同位素证据说明老地壳物质在岩浆形成中起了重要作用。(2)碱性岩套(魁岐岩体、笔架山岩体)侵位于90Ma前。这个岩套主要由超溶线过碱性花岗岩组成。这些过碱性花岗岩的岩浆分异作用很微弱,特征是稀土含量高。Sr和Nd同位素资料表明,在岩浆形成过程中地壳物质带入未起重要作用。 由岩石成因研究可见,福州复式岩体是逐渐连续侵位于地壳上部。钙碱性岩套是侵位于俯冲带的典型岩套,而碱性岩套则与较大的地壳深断裂有关。 | Martin H. Bonin B. Didier J. 江博明 Lameyre J. 裘愉卓 王一先 | 1991 | 地球化学1991，20，2： | 7 |
| 7 | Hijacking antibody-induced CTLA-4 lysosomal degradation for safer and more effective cancer immunotherapy显示文摘It remains unclear why the clinically used anti-CTLA-4 antibodies, popularly called checkpoint inhibitors, have severe immunotherapy-related adverse effects (irAEs) and yet suboptimal cancer immunotherapeutic effects (CITE). Here we report that while irAE-prone Ipilimumab and TremeIgG1 rapidly direct cell surface CTLA-4 for lysosomal degradation, the non-irAE-prone antibodies we generated, HL12 or HL32, dissociate from CTLA-4 after endocytosis and allow CTLA-4 recycling to cell surface by the LRBA-dependent mechanism. Disrupting CTLA-4 recycling results in robust CTLA-4 downregulation by all anti-CTLA-4 antibodies and confers toxicity to a non-irAE-prone anti-CTLA-4 mAb. Conversely, increasing the pH sensitivity of TremeIgG1 by introducing designed tyrosine-to-histidine mutations prevents antibody-triggered lysosomal CTLA-4 downregulation and dramatically attenuates irAE. Surprisingly, by avoiding CTLA-4 downregulation and due to their increased bioavailability, pH-sensitive anti-CTLA-4 antibodies are more effective in intratumor regulatory T-cell depletion and rejection of large established tumors. Our data establish a new paradigm for cancer research that allows for abrogating irAE while increasing CITE of anti-CTLA-4 antibodies. | Yan Zhang Xuexiang Du Mingyue Liu Fei Tang Peng Zhang Chunxia Ai James K. Fields Eric J. Sundberg Olga S. Latinovic Martin Devenport Pan Zheng Yang Liu | 2019 | Cell Research2019，29，8： | 6 |
| 8 | Mitochondria in Apoptosis: Bcl-2 Family Members and Mitochondrial Dynamics显示文摘 | Jean-Claude Martinou Richard J. Youle | 2011 | Developmental Cell2011，，1： | 6 |
| 9 | 炎症和老化在年龄相关性黄斑变性和葡萄膜黑色素瘤中的作用显示文摘许多眼科疾病在中老年人群中的患病率高于其他年龄组,随着全球老龄化社会的到来,眼科医师面临着年龄相关性眼病疾病谱迅速扩大的挑战,加强年龄相关性眼病的预防对于中老年人的健康有着重要意义。因此,了解年龄相关性黄斑变性(AMD)、青光眼和葡萄膜黑色素瘤易在老年人中发病的原因至关重要。我们先前的动物实验研究表明,正常的老化过程伴随着炎症反应,这种反应增加了眼部疾病发病的风险,而加重炎症反应的环境因素是吸烟。目前已发现炎症参与AMD的发病和进展,并且可能在青光眼、葡萄膜黑色素瘤的病理过程中发挥作用,巨噬细胞和淋巴细胞增加了肿瘤转移的风险。一些实验研究也表明,巨噬细胞在脉络膜/视网膜炎症、眼内肿瘤等疾病中发挥关键作用。巨噬细胞分为M1型和M2型,前者刺激特异性免疫反应,后者可刺激血管的生成。在机体老化过程中,M1型的功能可以向M2型转化,从而可能促进AMD和肿瘤的进展。深入研究巨噬细胞的特性有助于老化过程的干预和年龄相关性眼病的预防。 | Martine J. Jager L. Ho L. V. Ly | 2013 | 中华实验眼科杂志2013，31，1： | 5 |
| 10 | Accuracy details in realistic CFD modeling of an industrial centrifugal pump in direct and reverse modes显示文摘Numerical computation of the flowfield inside a pump is herein used as a numerical laboratory, subject to the limitations of modeling assumptions and to experimental verification. A numerical computation of the flow inside a real industrial centrifugal pump is performed that includes a very sophisticated geometry. Conversely to other computations, in this test case no simplification of the geometry was introduced. Numerical computations are obtained using Spalart-Allmaras turbulence model. A detailed analysis of the turbulent flowstructure is performed for the design point and two off design conditions. Additional computations were performed in order to compare the numerical and experimental pump characteristics; these were obtained under normalized testing conditions. Further computations are presented for the pump working in reverse turbine mode (PAT). Detailed analyses of the flow allow a comparison of the internal flow losses when the pump is operating in direct and reverse mode. This is also useful to help in the selection of an adequate pump geometry that can work in both modes with best efficiency. | J.C. Páscoa F. J. Silva J.S. Pinheiro D.J. Martins | 2010 | Journal of Thermal Science2010，19，6： | 5 |
| 11 | Risk factors for post-ERCP pancreatitis: A prospective, multicenter study显示文摘 | Martin L. Freeman James A. DiSario Douglas B. Nelson M.Brian Fennerty John G. Lee David J. Bjorkman Carol S. Overby Johannes Aas Michael E. Ryan Gary S. Bochna Michael J. Shaw Harry W. Snady Robert V. Erickson Joseph P. Moore Joseph P. Roel | 2001 | Gastrointestinal Endoscopy2001，，4： | 5 |
| 12 | The Early-Middle Pleistocene Transition: characterization and proposed guide for the defining boundary显示文摘 | Martin J. Head Brad Pillans Sarah A. Farquhar | 2008 | Episodes2008，31，2： | 5 |
| 13 | IKKβ Links Inflammation and Tumorigenesis in a Mouse Model of Colitis-Associated Cancer显示文摘 | Florian R. Greten Lars Eckmann Tim F. Greten Jin Mo Park Zhi-Wei Li Laurence J. Egan Martin F. Kagnoff Michael Karin | 2004 | Cell2004，，3： | 4 |
| 14 | Angiographic Patterns of In-Stent Restenosis: Classification and Implications for Long-Term Outcome显示文摘 | Roxana Mehran George Dangas Andrea S. Abizaid Gary S. Mintz Alexandra J. Lansky Lowell F. Satler Augusto D. Pichard Kenneth M. Kent Gregg W. Stone Martin B. Leon | 1999 | Circulation1999，，18： | 4 |
| 15 | 消融的冰川:加拿大班夫国家公园亚高山带鲍湖中持久性有机氯的主要来源显示文摘有机氯杀虫剂和多氯联苯(PCB)是环境中普遍而稳固的化合物。现已查明,由于它们从温暖的地区逐渐蒸发出来,并在较冷的地区凝聚下来,因而它们富集在寒冷的环境中。在本研究中,我们的结果是,消融的冰川供给阿尔伯达亚高山带湖泊中的有机氯输入量为50%~97%,而提供的水量为73%。对氚的分析结果表明,在夏季的中、晚期,至少10%的冰川消融物是在1950~1970年期间沉积下来的,这期间它受到有机氯更多的污染。这一发现表明,气候变暖可能会使消融的冰川成为日益增多的淡水污染物来源。由于有机物贫乏的冰川粘土对多氯联苯这样的疏水化合物的吸附能力有限,因此冰川水流带来的有机氯大多呈溶解状态。 | Jules M. Blais David W. Schindler Derek C. G. Muir Martin Sharp David Donald MelissaLafrenière Eric Braekevelt William M. J. Strachan 周立志 | 2001 | AMBIO-人类环境杂志2001，30，7： | 4 |
| 16 | Histological grading and staging of chronic hepatitis显示文摘 | Kamal Ishak Amelia Baptista Leonardo Bianchi Francesco Callea Jan De Groote Fred Gudat Helmut Denk Valeer Desmet Gerhard Korb Roderick N.M. MacSween M.James Phillips Bernard G. Portmann Hemming Poulsen Peter J. Scheuer Martin Schmid Heribert Thaler | 1995 | Journal of Hepatology1995，，6： | 4 |
| 17 | Histological grading and staging of chronic hepatitis显示文摘 | Kamal Ishak Amelia Baptista Leonardo Bianchi Francesco Callea Jan De Groote Fred Gudat Helmut Denk Valeer Desmet Gerhard Korb Roderick N.M. MacSween M.James Phillips Bernard G. Portmann Hemming Poulsen Peter J. Scheuer Martin Schmid Heribert Thaler | 1995 | Journal of Hepatology1995，，6： | 4 |
| 18 | Helicobacter pylori in Health and Disease显示文摘 | Timothy L. Cover Martin J. Blaser | 2009 | Gastroenterology2009，，6： | 4 |
| 19 | 检测凝血酶原前体蛋白判断维生素K营养状况显示文摘至今尚无理想指标评价机体的Vit K营养状况,当Vit K缺乏或使用拮抗剂时,血清中检测到一组蛋白质,并称之为Vit K缺乏或Vit K拮抗剂诱生蛋白(proteins induced by Vitamin K absence or antagonism,简称PIVKA),其中凝血酶原前体蛋白(PIVKA-Ⅱ)变化最明显,目前国际上已把PIVKA-Ⅱ作为生化水平反映机体Vit K营养状况最敏感的指标。我们使用PIVKA-Ⅱ的单克隆抗体(mAb)率先在国内建立了PIVKA-Ⅱ检测的ELISA法,以推动我国Vit K营养问题的研究。 1 材料和方法 1.1 材料 正常新生儿34例。 | 张会丰 王丽芳 范士英 Julia Harvey Martin J. Shearer | 2000 | 世界华人消化杂志2000，8，3： | 4 |
| 20 | New Technologies,Tools and Approaches for Improving Crop Breeding显示文摘Introduction Most crops were first domesticated about 13 000 to 11 000 years ago.Humans are dependent on crops for survival,and from the beginnings of agriculture have been energetically involved in developing crops that better serve their | Parry, Martin A. J. Wang, Jiankang Luis Araus, Jose | 2012 | Journal of Integrative Plant Biology2012，54，4： | 4 |
您所在的机构暂未开通此部分的功能，请联系管理员