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| 1 | Distinct Defects in Spine Formation or Pruning in Two Gene Duplication Mouse Models of Autism显示文摘Autism spectrum disorder(ASD) encompasses a complex set of developmental neurological disorders,characterized by de?cits in social communication and excessive repetitive behaviors. In recent years, ASD is increasingly being considered as a disease of the synapse.One main type of genetic aberration leading to ASD is gene duplication, and several mouse models have been generated mimicking these mutations. Here, we studied the effects of MECP2 duplication and human chromosome15q11-13 duplication on synaptic development and neural circuit wiring in the mouse sensory cortices. We showed that mice carrying MECP2 duplication had speci?c defects in spine pruning, while the 15q11-13 duplication mouse model had impaired spine formation. Our results demonstrate that spine pathology varies signi?cantly between autism models and that distinct aspects of neural circuit development may be targeted in different ASD mutations.Our results further underscore the importance of gene dosage in normal development and function of the brain. | Miao Wang Huiping Li Toru Takumi Zilong Qiu Xiu Xu Xiang Yu Wen-Jie Bian | 2017 | Neuroscience Bulletin2017，33，2： | 5 |
| 2 | Successful resection of metachronous para-aortic, Virchow lymph node and liver metastatic recurrence of rectal cancer显示文摘A 66-year-old female presented with the main complaint of defecation trouble and abdominal distention. With diagnosis of rectal cancer, c SS, c N0, c H0, c P0, c M0 c Stage Ⅱ, Hartmann's operation with D3 lymph node dissection was performed and a para-aortic lymph node and a disseminated node near the primary tumor were resected. Histological examination showed moderately differentiated adenocarcinoma, p SS, p N3, p H0, p P1, p M1(para-aortic lymph node, dissemination) f Stage Ⅳ. After the operation, the patient received chemotherapy with FOLFIRI regimen. After 12 cycles of FOLFIRI regimen, computed tomography(CT) detected an 11 mm of liver metastasis in the posteroinferior segment of right hepatic lobe. With diagnosis of liver metastatic recurrence, we performed partial hepatectomy. Histological examination revealed moderately differentiated adenocarcinoma as a metastatic rectal cancer with cut end microscopically positive. After the second operation, the patient received chemotherapy with TS1 alone for 2 years. Ten months after the break, CT detected a 20 mm of paraaortic lymph node metastasis and a 10 mm of lymph node metastasis at the hepato-duodenal ligament. With diagnosis of lymph node metastatic recurrences, we performed lymph node dissection. Histological examination revealed moderately differentiated adenocarcinoma as metastatic rectal cancer in paraaortic and hepato-duodenal ligament areas. After the third operation, we started chemotherapy with modified FOLFOX6 regimen. After 2 cycles of modified FOLFOX6 regimen, due to the onset of neutropenia and liver dysfunction, we switched to capecitabine aloneand continued it for 6 mo and then stopped. Eleven months after the break, CT detected two swelling 12 mm of lymph nodes at the left supraclavicular region. With diagnosis of Virchow lymph node metastatic recurrence, we started chemotherapy with capecitabine plus bevacizumab regimen. Due to the onset of neutropenia and hand foot syndrome(Grade 3), we managed to continue capecitabine administration with extension of interval period and dose reduction. After 2 years and 2 mo from starting capecitabine plus bevacizumab regimen, Virchow lymph nodes had slowly grown up to 17 mm. Because no recurrence had been detected besides Virchow lymph nodes for this follow up period, considering the side effects and quality of life, surgical resection was selected. We performed left supraclavicular lymph node dissection. Histological examination revealed moderately differentiated adenocarcinoma as a metastatic rectal cancer. After the fourth operation, the patient selected follow up without chemotherapy. Now we follow up her without recurrence and keep her quality of life high. | Nobuyoshi Takeshita Toru Fukunaga Masayuki Kimura Yuji Sugamoto Kentaro Tasaki Isamu Hoshino Takumi Ota Tetsuro Maruyama Tomohide Tamachi Takashi Hosokawa Yo Asai Hisahiro Matsubara | 2015 | World Journal of Gastroenterology2015，21，44： | 4 |
| 3 | Autism spectrum disorder model mice: Focus on copy number variation and epigenetics显示文摘Autism spectrum disorder(ASD) is gathering concerns in socially developed countries. ASD is a neuropsychiatric disorder of genetic origin with high prevalence of 1%–2%. The patients with ASD characteristically show impaired social skills. Today, many genetic studies identify numerous susceptible genes and genetic loci associated with ASD. Although some genetic factors can lead to abnormal brain function linked to ASD phenotypes, the pathogenic mechanism of ASD is still unclear. Here, we discuss a new mouse model for ASD as an advanced tool to understand the mechanism of ASD. | Nobuhiro NAKAI Susumu OTSUKA Jihwan MYUNG Toru TAKUMI | 2015 | Science China(Life Sciences)2015，58，10： | 4 |
| 4 | The antiapoptotic protein Bcl-xL negatively regulates the bone-resorbing activity of osteoclasts in mice显示文摘 | Iwasawa Mitsuyasu Miyazaki Tsuyoshi Nagase Yuichi Akiyama Toru Kadono Yuho Nakamura Masaki Oshima Yasushi Yasui Tetsuro Matsumoto Takumi Nakamura Takashi Kato Shigeaki Hennighausen Lothar Nakamura Kozo Tanaka Sakae | 2009 | Journal of Clinical Investigation2009，，10： | 1 |
| 5 | Estrogen upregulates nitric oxide synthase expression in cultured rat hepatic sinusoidal endothelial cells显示文摘 | Masaharu Sakamoto Takato Ueno Toru Nakamura Osamu Hashimoto Ryuichiro Sakata Motoaki Kin Riko Ogata Takumi Kawaguchi Takuji Torimura Michio Sata | 2001 | Journal of Hepatology2001，，6： | 1 |
| 6 | Autocrine motility factor enhances hepatoma cell invasion across the basement membrane through activation of β1 integrins显示文摘 | Takuji Torimura Takato Ueno Motoaki Kin Riko Harada Toru Nakamura Takumi Kawaguchi Masaru Harada Ryukichi Kumashiro Hideomi Watanabe Raz Avraham Michio Sata | 2001 | Hepatology2001，，1： | 1 |
| 7 | Percutaneous Transluminal Pulmonary Angioplasty for Central-Type Chronic Thromboembolic Pulmonary Hypertension显示文摘 | Haruhisa Ishiguro Masaharu Kataoka Takumi Inami Ryoji Yanagisawa Nobuhiko Shimura Hiroki Taguchi Hideyasu Kohshoh Hideaki Yoshino Toru Satoh | 2013 | JACC: Cardiovascular Interventions2013，，11： | 1 |
| 8 | Pulmonary Edema Predictive Scoring Index (PEPSI), a New Index to Predict Risk of Reperfusion Pulmonary Edema and Improvement of Hemodynamics in Percutaneous Transluminal Pulmonary Angioplasty显示文摘 | Takumi Inami Masaharu Kataoka Nobuhiko Shimura Haruhisa Ishiguro Ryoji Yanagisawa Hiroki Taguchi Keiichi Fukuda Hideaki Yoshino Toru Satoh | 2013 | JACC: Cardiovascular Interventions2013，，7： | 1 |
| 9 | Percutaneous Transluminal Pulmonary Angioplasty for the Treatment of Chronic Thromboembolic Pulmonary Hypertension显示文摘 | Masaharu Kataoka Takumi Inami Kentaro Hayashida Nobuhiko Shimura Haruhisa Ishiguro Takayuki Abe Yuichi Tamura Motomi Ando Keiichi Fukuda Hideaki Yoshino Toru Satoh | 2012 | Circulation: Cardiovascular Interventions2012，，6： | 1 |
| 10 | Neoculin, a taste-modifying sweet protein, accumulates in ripening fruits of cultivated Curculigo latifolia显示文摘 | Satoshi Okubo Tomiko Asakura Kazue Okubo Kazutoshi Abe Takumi Misaka Toru Akita Keiko Abe | 2008 | Journal of Plant Physiology2008，，18： | 1 |
| 11 | Feasibility study of cyclodextrins as active pharmaceutical ingredients for the treatment of GM1-gangliosidosis显示文摘GM1-gangliosidosis is a rare lysosomal storage disorder characterized clinically by a wide range of variable neurovisceral,ophthalmological and dysmorphic features. Without enough functionalβ-galactosidase, GM1-gangliosides cannot be degraded in lysosomes, and accumulate to toxic levels in many tissues and organs, particularly in the brain. In spite of several approaches for the treatment of GM1-gangliosidosis. | Yuki Maeda Keiichi Motoyama Taishi Higashi Yuka Horikoshi Toru Takeo Naomi Nakagata Yuki Kurauchi Hiroshi Katsuki Yuki Kondo Yoichi Ishitsuka Tetsumi Irie Takumi Erad Hidetoshi Arima | 2016 | Asian Journal of Pharmaceutical Sciences2016，11，1： | 0 |
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