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| 1 | MicroRNAs as emerging biomarkers and therapeutic targets for pancreatic cancer显示文摘Despite tremendous efforts from scientists and clinicians worldwide, pancreatic adenocarcinoma(PDAC) remains a deadly disease due to the lack of early diagnostic tools and reliable therapeutic approaches. Consequently, a majority of patients(80%) display an advanced disease that results in a low resection rate leading to an overall median survival of less than 6 months. Accordingly, robust markers for the early diagnosis and prognosis of pancreatic cancer, or markers indicative of survival and/or metastatic disease are des-perately needed to help alleviate the dismal prognosis of this cancer. In addition, the discovery of new therapeutic targets is mandatory to design effective treatments. In this review, we will highlight the translational studies demonstrating that microRNAs may soon translate into clinical applications as long-awaited screening tools and therapeutic targets for PDAC. | Marion Gayral Sébastien Jo Naima Hanoun Alix Vignolle-Vidoni Hubert Lulka Yannick Delpu Aline Meulle Marlène Dufresne Marine Humeau Maёl Chalret du Rieu Barbara Bournet Janick Sèlves Rosine Guimbaud Nicolas Carrère Louis Buscail Jérome Torrisani Pierre Cordelier | 2014 | World Journal of Gastroenterology2014，20，32： | 4 |
| 2 | Role of endoscopic ultrasound in the molecular diagnosis of pancreatic cancer显示文摘Pancreatic ductal adenocarcinoma remains one of the most deadly types of tumor. Endoscopic ultrasoundguided fine-needle aspiration(EUS-FNA) is a safe, cost-effective, and accurate technique for evaluating and staging pancreatic tumors. However, EUS-FNA may be inconclusive or doubtful in up to 20% of cases. This review underlines the clinical interest of the molecular analysis of samples obtained by EUS-FNA in assessing diagnosis or prognosis of pancreatic cancer, especially in locally advanced tumors. On EUS-FNA materials DNA, mRNA and miRNA can be extracted, amplified, quantified and subjected to methylation assay. Kras mutation assay, improves diagnosis of pancreatic cancer. When facing to clinical and radiological presentations of pseudo-tumorous chronic pancreatitis, wildtype Kras is evocative of benignity. Conversely, in front of a pancreatic mass suspected of malignancy, a mutated Kras is highly evocative of pancreatic adenocarci-noma. This strategy can reduce false-negative diagnoses, avoids the delay of making decisions and reduces loss of surgical resectability. Similar approaches are conducted using analysis of miRNA expression as well as Mucin or markers of invasion(S100P, S100A6, PLAT or PLAU). Beyond the diagnosis approach, the prediction of response to treatment can be also investigated form biomarkers expression within EUS-FNA materials. | Barbara Bournet Marion Gayral Jérme Torrisani Janick Selves Pierre Cordelier Louis Buscail | 2014 | World Journal of Gastroenterology2014，20，31： | 3 |
| 3 | MicroRNA-21 is induced early in pancreatic ductal adenocarcinoma precursor lesions 显示文摘 | du Rieu MC Torrisani J Selves J | 2010 | Clin Chem2010，56，4： | 1 |
| 4 | Histonedeacetylase inhibitor Trichostatin A induces global and gene-specific DNA demethylation in human cancer cell lines 显示文摘 | OU JN TORRISANI J UNTERBERGER A | 2007 | Biochem Pharmacol2007，73，9： | 1 |
| 5 | let-7MicroRNA transfer in pancreatic cancer-derived cells inhibits in vitro cell proliferation but fails to alter tumor progression显示文摘 | Torrisani J Bournet B du Rieu MC | 2009 | Hum Gene Ther2009，20，8： | 1 |
| 6 | MicroRNA-21 Is Induced Early in Pancreatic Ductal Adenocarcinoma Precursor Lesions显示文摘 | du Rieu Ma?l Chalret Torrisani Jér?me Selves Janick Al Saati Talal Souque Anny Dufresne Marlène Tsongalis Gregory J Suriawinata Arief A Carrére Nicolas Buscail Louis Cordelier Pierre | 2010 | Clinical Chemistry2010，，： | 1 |
| 7 | Let-7 MicroRNA transfer in pancreatic cancer-derived cells inhibits in vitro cell proliferation but fails to alter tumor progressin显示文摘 | Torrisani J Bournet B du Rieu MC | | 0，，： | 1 |
| 8 | Histone deacetylase inhibitor Trichostatin A induces global and gene-specific DNA demethylation in human cancer cell lines显示文摘 | Ou J Torrisani J Unterberger A | 2007 | Biochem Pharmacol2007，73，9： | 1 |
| 9 | MicroRNA-21 is induced early in pancreatic ductal adenocarcinoma precursor lesions显示文摘 | du Rieu MC Torrisani J Selves J | 2010 | Clin Chem2010，56，4： | 1 |
| 10 | Histone deacetylase inhibitor Trichostatin A induces global and gene - specific DNA demethylation in human cancer cell lines显示文摘 | OU J N TORRISANI J UNTERBERGER A | 2007 | Biochem Pharmacol2007，73，9： | 1 |
| 11 | miRNA in clinical practice : pancreatic cancer显示文摘 | Humeau M Torrisani J Cordelier P | 2013 | Clin Biochem2013，46，1011： | 1 |
| 12 | let-7 MicroRNA transfer in pancreatic cancer-derived cells inhibits in vitro cell proliferation but fails to alter tumor progression 显示文摘 | Torrisani J Bournet B du Rieu MC | 2009 | Hum Gene Ther2009，20，8： | 1 |
| 13 | microRNA-21 is induced early in pancreatic ductal adenocarcinoma precursor lesions显示文摘 | du Rieu MC Torrisani J Selves J | | 0，，04： | 1 |
| 14 | Genetic and Epigenetic Alterations in Pancreatic Carcinogenesis显示文摘 | Yannick Delpu Naima Hanoun Hubert Lulka Flavie Sicard Janick Selves Louis Buscail Jerome Torrisani Pierre Cordelier | 2011 | Current Genomics2011，，1： | 1 |
| 15 | New molecular targets in pancreatic cancer显示文摘 | Torrisani J Boumet B Cordelier P | 2008 | Bulletin du Cancer2008，95，： | 1 |
| 16 | MicroRNA-21 is in- duced early in pancreatic ductal adenocarcinoma precursor le- sions显示文摘 | du Rieu MC Torrisani J Selves J | 2010 | Clin Chem2010，56，4： | 1 |
| 17 | Micro RNA-21 is induced early in pancreatic ductal adenocarcinoma precursor lesions显示文摘 | du Rieu MC Torrisani J Selves J | 2010 | Clin Chem2010，56，4： | 1 |
| 18 | Histone deacety lase inhibitor Trichostatin A induces global and gene specific DNA demethylation in human cancer cell lines显示文摘 | Ou JN Torrisani J Unterberger A | 2007 | Biochem Pharmacol2007，73，： | 1 |
| 19 | Microrna-21 is inducedearly in pancreatic ductal adenocarcinoma precursor lesions显示文摘 | du Rieu MC Torrisani J Selves J | 2010 | Clin Chem2010，56，4： | 1 |
| 20 | miRNA in clinical practice: pancreatic cancer显示文摘 | HUMEAU M TORRISANI J CORDELIER P | 2013 | Clin Biochem2013，46，1011： | 1 |
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