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| 1 | MicroRNAs as emerging biomarkers and therapeutic targets for pancreatic cancer显示文摘Despite tremendous efforts from scientists and clinicians worldwide, pancreatic adenocarcinoma(PDAC) remains a deadly disease due to the lack of early diagnostic tools and reliable therapeutic approaches. Consequently, a majority of patients(80%) display an advanced disease that results in a low resection rate leading to an overall median survival of less than 6 months. Accordingly, robust markers for the early diagnosis and prognosis of pancreatic cancer, or markers indicative of survival and/or metastatic disease are des-perately needed to help alleviate the dismal prognosis of this cancer. In addition, the discovery of new therapeutic targets is mandatory to design effective treatments. In this review, we will highlight the translational studies demonstrating that microRNAs may soon translate into clinical applications as long-awaited screening tools and therapeutic targets for PDAC. | Marion Gayral Sébastien Jo Naima Hanoun Alix Vignolle-Vidoni Hubert Lulka Yannick Delpu Aline Meulle Marlène Dufresne Marine Humeau Maёl Chalret du Rieu Barbara Bournet Janick Sèlves Rosine Guimbaud Nicolas Carrère Louis Buscail Jérome Torrisani Pierre Cordelier | 2014 | World Journal of Gastroenterology2014，20，32： | 4 |
| 2 | Role of endoscopic ultrasound in the molecular diagnosis of pancreatic cancer显示文摘Pancreatic ductal adenocarcinoma remains one of the most deadly types of tumor. Endoscopic ultrasoundguided fine-needle aspiration(EUS-FNA) is a safe, cost-effective, and accurate technique for evaluating and staging pancreatic tumors. However, EUS-FNA may be inconclusive or doubtful in up to 20% of cases. This review underlines the clinical interest of the molecular analysis of samples obtained by EUS-FNA in assessing diagnosis or prognosis of pancreatic cancer, especially in locally advanced tumors. On EUS-FNA materials DNA, mRNA and miRNA can be extracted, amplified, quantified and subjected to methylation assay. Kras mutation assay, improves diagnosis of pancreatic cancer. When facing to clinical and radiological presentations of pseudo-tumorous chronic pancreatitis, wildtype Kras is evocative of benignity. Conversely, in front of a pancreatic mass suspected of malignancy, a mutated Kras is highly evocative of pancreatic adenocarci-noma. This strategy can reduce false-negative diagnoses, avoids the delay of making decisions and reduces loss of surgical resectability. Similar approaches are conducted using analysis of miRNA expression as well as Mucin or markers of invasion(S100P, S100A6, PLAT or PLAU). Beyond the diagnosis approach, the prediction of response to treatment can be also investigated form biomarkers expression within EUS-FNA materials. | Barbara Bournet Marion Gayral Jérme Torrisani Janick Selves Pierre Cordelier Louis Buscail | 2014 | World Journal of Gastroenterology2014，20，31： | 3 |
| 3 | Endoscopic ultrasound-guided fine-needle aspiration biopsy coupled with KRAS mutation assay to distinguish pancreatic cancer from pseudotumoral chronic pancreatitis显示文摘 | B. Bournet A. Souque P. Senesse E. Assenat M. Barthet N. Lesavre A. Aubert D. O’Toole P. Hammel P. Levy P. Ruszniewski M. Bouisson J. Escourrou P. Cordelier L. Buscail | 2009 | Endoscopy2009，，06： | 2 |
| 4 | Analysis of Greenhouse Ventilation Efficiency based on Computational Fluid Dynamics显示文摘 | S.A. Ould Khaoua P.E. Bournet C. Migeon T. Boulard G. Chassériaux | 2006 | Biosystems Engineering2006，，1： | 2 |
| 5 | let-7MicroRNA transfer in pancreatic cancer-derived cells inhibits in vitro cell proliferation but fails to alter tumor progression显示文摘 | Torrisani J Bournet B du Rieu MC | 2009 | Hum Gene Ther2009，20，8： | 1 |
| 6 | Let-7 MicroRNA transfer in pancreatic cancer-derived cells inhibits in vitro cell proliferation but fails to alter tumor progressin显示文摘 | Torrisani J Bournet B du Rieu MC | | 0，，： | 1 |
| 7 | Interventional Endoscopic Ultrasound in Pancreatic Diseases显示文摘 | Louis Buscail Patrick Faure Barbara Bournet Janick Selves Jean Escourrou | 2006 | Pancreatology . 2006 (1-2)2006，，： | 1 |
| 8 | Endoscopic ultrasound and magnetic resonance cholangiopancreatography in patients with idiopathic acute pancreatitis显示文摘 | Thevenot A Bournet B Otal P | 2013 | Dig Dis Sci2013，58，8： | 1 |
| 9 | Gene expression signature of advanced pancreatic ductal adenocarcinoma using low density array on endoscopic ultrasound-guided fine needle aspiration samples显示文摘 | B. Bournet A. Pointreau A. Souque N. Oumouhou F. Muscari B. Lepage P. Senesse M. Barthet N. Lesavre P. Hammel P. Levy P. Ruszniewski P. Cordelier L. Buscail | 2012 | Pancreatology2012，，1： | 1 |
| 10 | Numerical prediction of the effect of vent arrangements on the ventilation and energy transfer in a multi-span glasshouse using a bi-band radiation model 显示文摘 | BOURNET P E KHAOUA S A O BOULARD T | 2007 | Biosystems Engineering2007，98，2： | 1 |
| 11 | Effect of roof and side opening combinations on the ventilation of a greenhouse using computer simulation显示文摘 | BOURNET P E KHAOUA S A O BOULARD T | 2007 | Transactions of the ASABE2007，50，1： | 1 |
| 12 | let-7 MicroRNA transfer in pancreatic cancer-derived cells inhibits in vitro cell proliferation but fails to alter tumor progression 显示文摘 | Torrisani J Bournet B du Rieu MC | 2009 | Hum Gene Ther2009，20，8： | 1 |
| 13 | let-7 Mi- croRNA transfer in pancreatic cancer-derived cells inhibits in vitro cell proliferation but fails to alter tumor progression显示文摘 | TOHRISANI J BOURNET B DU RIEU MC | 2009 | Hum Gene Ther2009，20，8： | 1 |
| 14 | Analysis of greenhouse ventilation efficiency based on computational fluid dynaraics显示文摘 | Ould Khaoua S A Bournet P E Migeon C | 2006 | Biosystcms Engineering2006，95，1： | 1 |
| 15 | Effect of ventilator configuration on the distributed climate of greenhouses: a review of experimental and CFD studies 显示文摘 | Bournet P E Boulard T | 2010 | Biosystems Engineering2010，74，2： | 1 |
| 16 | Analysis of greenhouse ventilation efficiency based on computational fluid dynamics 显示文摘 | Ould Khaoua S A Bournet P E Migeon C | 2006 | Biosystems Engineering2006，95，1： | 1 |
| 17 | Analysis of Greenhouse Ventilation Efficiency based on Computation Fluid Dynamics显示文摘 | Ould Khaoua S A Bournet P E Migeonet C | 2006 | Biosystems Engineering2006，95，1： | 1 |
| 18 | Anti-fog layer deposition onto polymer materials: a multi-step approach 显示文摘 | MAECHLER L BOURNET C S CHEEVALLIER P | 2011 | Plasma Chem Plasma Process- ing2011，31，1： | 1 |
| 19 | Numerical investigation of plunging density current显示文摘 | BOURNET P E DARTUS D TASSIN B | 1999 | Journal of Hydraulic Engi- neering1999，125，6： | 1 |
| 20 | Analy- sis of greenhouse ventilation efficiency based on computa- tional fluid dynamics 显示文摘 | Ould Khaoua S A Bournet P E Migeon C | 2006 | Biosystems Engineering2006，95，1： | 1 |
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