维普期刊资源整合服务平台（V6.5）

维普中文期刊产品整合服务

3篇 您的检索式：作者名="Tommaso Colangelo"

选中清除导出查看参考文献查看引证文献引用追踪共1页首页上一页第1页下一页末页 /1 跳转

		题名	作者	年代	出处	被引量
	1	emerging role of the β-catenin-PPARγ axis in the pathogenesis of colorectal cancer显示文摘Multiple lines of evidence indicate that Wnt/β-catenin signaling plays a fundamental role in colorectal cancer(CRC)initiation and progression.Recent genome-wide data have confirmed that in CRC this pathway is one of the most frequently modified by genetic or epigenetic alterations affecting almost 90%of Wnt/β-catenin gene members.A major challenge is thus learning how the corrupted coordination of this pathway is tied to other signalings to enhance cell growth.Peroxisome proliferator activated receptorγ(PPARγ)is emerging as a growth-limiting and differentiation-promoting factor.In tumorigenesis it exerts a tumor suppressor role and is potentially linked with the Wnt/β-catenin pathway.Based on these results,the identification of new selective PPARγmodulators with inhibitory effects on the Wnt/β-catenin pathway is becoming an interesting perspective.Should,in fact,these molecules display such properties,new research avenues would be opened aimed at developing new molecular targeted drugs.Herein,we review the basic principles and present new hypotheses underlying the crosstalk between Wnt/β-catenin and PPARγsignaling.Furthermore,we discuss the advances in our understanding as to how their altered regulation can culminate in colon cancer and the efforts aimed at designing novel PPARγagonists endowed with Wnt/β-catenin inhibitory effects to be used as therapeutic and/or preventive agents.	Lina Sabatino Massimo Pancione Carolina Votino Tommaso Colangelo Angelo Lupo Ettore Novellino Antonio Lavecchia Vittorio Colantuoni	2014	World Journal of Gastroenterology2014，20，23：	8
	2	MicroRNA-130b Promotes Tumor Development and Is Associated with Poor Prognosis in Colorectal Cancer显示文摘	Tommaso Colangelo Alessandra Fucci Carolina Votino Lina Sabatino Massimo Pancione Carmelo Laudanna Monica Binaschi Mario Bigioni Carlo Alberto Maggi Domenico Parente Nicola Forte Vittorio Colantuoni	2013	Neoplasia2013，，：	1
	3	Peroxisome proliferator-activated receptor γ-mediated induction of microRNA-145 opposes tumor phenotype in colorectal cancer显示文摘	Anna Panza Carolina Votino Annamaria Gentile Maria Rosaria Valvano Tommaso Colangelo Massimo Pancione Giuseppe Merla Angelo Andriulli Lina Sabatino Manlio Vinciguerra Gianluigi Mazzoccoli Vittorio Colantuoni Ada Piepoli	2014	BBA - Molecular Cell Research2014，，：	1

返回顶部每页显示：

共1页首页上一页第1页下一页末页 /1 跳转

goolge学术搜索-维普

网站首页 | 关于我们 | 联系我们 | 产品服务 | 客服中心 | 广告服务 | 版权声明 | 网站联盟 | 友情链接 | 售卡网点

版权所有© 渝B2-20050021-1　渝公网安备 50019002500403号　违法和不良信息举报中心

互联网出版许可证新出网证(渝)字10号全国400电话 - 免长途话费