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| 1 | Dyslipidemia management in primary prevention of cardiovascular disease:Current guidelines and strategies显示文摘Cardiovascular disease is the leading cause of death in the United States. In 2010, the Centers for Disease Control and Prevention estimated that $444 billion was spent on cardiovascular diseases alone, about $1 of every $6 spent on health care. As life expectancy continues to increase, this annual cost will also increase, making costeffective primary prevention of cardiovascular disease highly desirable. Because of its role in development of atherosclerosis and clinical events, dyslipidemia management is a high priority in cardiovascular prevention. Multiple major dyslipidemia guidelines have been published around the world recently, four of them by independent organizations in the United States alone. They share the goal of providing clinical guidance on optimal dyslipidemia management, but guidelines differ in their emphasis on pharmacotherapy, stratification of groups, emphasis on lifestyle modification, and use of a fixed target or percentage reduction in low density lipoprotein cholesterol. This review summarizes eight major guidelines for dyslipidemia management and considers the basis for their recommendations. Our primary aim is to enhance understanding of dyslipidemia management guidelines in patient care for primary prevention of future cardiovascular risk. | Aditya D Hendrani Tolulope Adesiyun Renato Quispe Steven R Jones Neil J Stone Roger S Blumenthal Seth S Martin | 2016 | World Journal of Cardiology2016，8，2： | 5 |
| 2 | Perception and Practice of Emergency Contraception among Female Undergraduates of the University of Ibadan, Nigeria显示文摘Objective To assess perception and level of proper utilization of emergency contraception (EC) among female undergraduates. Methods Cross-sectional questionnaire study was performed on 383 female under- graduates in Nigeria in June 2006. Data analysis was with χ-square test and logistic regressions (P<0.05). Results One hundred and five (48.2%) had been sexually exposed. Only 32 (30.5%) used regular contraception. Seventy-three (24.3%) female undergraduates were aware of EC. Only 29 (7.6%) had used EC before. Most would not use emergency contraceptive drugs in future due to lack of awareness (64.8%), and fear for future fertility and of drugs being injurious to health. Use of EC was associated with awareness of correct interval for use (OR=9.1; 95%CI: 2.1-39.9). Conclusion There is poor knowledge about EC and poor use, while significant need remains. Most knowledge was acquired from peers and inaccurate. Peer educators are important and professionals’ knowledge needs improvement. | Folasade Adenike Bello Oladapo Olayemi Adeniran Olubukola Fawole Olayinka Oladunjoye Ogunbode Tolulope Sobukunola Olubukola Adeponle Adesina Christopher Aimakhu Michael Abiola Okunlola | 2009 | Journal of Reproduction and Contraception2009，20，2： | 4 |
| 3 | Antimalarial potential of kolaviron,a biflavonoid from Garcinia kola seeds,against Plasmodium berghei infection in Swiss albino mice显示文摘Objective:To investigate the antimalarial potential of kolaviron(KV),a biflavonoid fraction from Garcinia kola seeds,against Plasmodium berghei(P.berghei)infection in Swiss albino mice.Methods:The study consists of seven groups of ten mice each.Groups I,II and III were normal mice that received com oil.KV1 and chloroquine(CQ),respectively.Groups IV,V,ⅥandⅦwere infected mice that received corn oil.CQ,KYI and KV2.respectively.CQ.KY1 and KV2were given at 10-,100-and 200-mg/kg daily,respectively for three consecutive days.Results:Administration of KV1 and KV2 significantly(P<0.05)suppressed P.berghei-infection in the mice by 85%and 90%.respectively,while CQ produced 87%suppression relative to untreated infected group after the fifth day of treatment.Also,KV2 significantly(P<0.05)increased the mean survival time of the infected mice by 175%.The biflavonoid prevented a drastic reduction in HCV from day4 of treatment,indicating its efficacy in ameliorating anaemia.Significant(P<0.05)oxidative stress assessed by the elevation of serum and hepatic malondialdehydewere observed in unlrealed P.berghei-infected mice.Specifically,senum and hepatic malondialdehyde levels increased by93%and 78%,resjiectively in the unlrealed infecled mice.Furlhennore,antioxidant indices,viz;superoxide dismutase.catalase,glutathione-s-transferasc.glualhione peroxidase and reduced gluathione decreased significantly(P<0.05)in the tissues of untreated P.berghei-infected mice.KV significantly(P<0.05)ameliorated the P.berghei-induced decrease in antioxidant status of the infected mice.Conclusions:This study shows that kolaviron,especially at 200 mg/kg,has high antimalarial activities in P.berghei-infected mice,in addition to its known antioxidant properties. | Adaramoyc Oluwatosin Akinpelu Tolulope Kosoko Ayokulchin Okoric Patricia Kehinde Aderemi Falade Catherine Ademowo Olusegun | 2014 | Asian Pacific Journal of Tropical Medicine2014，7，2： | 2 |
| 4 | Urogenital schistosomiasis and associated determinant factors among senior high school students in the Dutsin-Ma and Safana Local Government Areas of Katsina State, Nigeria显示文摘Background:Human schistosomiasis is a chronic parasitic disease of poverty caused by the cercariae of digenetic trematodes of the genus Schistosoma.The disease is a major source of morbidity and mortality in 77 low-and middle-income countries in the tropics where 700 million people are at risk.In a bid to provide relevant epidemiological information to boost control of urogenital schistosomiasis at the state level in Nigeria,we conducted this study with the aim of investigating the disease’s prevalence and intensity,and the determinant factors responsible for its endemicity.Methods:Data on risk factors were obtained from a total of 645 students aged 12─25 years using well-designed questionnaires.Samples were collected between 09:45 and 14:00 in universal bottles.Each10μl centrifuged sample was examined for the eggs of S.haematobium using Motic®(Binocular)Light Microscope(model S-10-P)with a x10 objective.Average infection intensity was recorded as number of eggs per 10 ml of urine sample.Survey data were entered into Microsoft Excel 2010 and analyzed using Epi Info™7.Associations among variables were determined using the chi square test and bivariate and multivariate logistic regressions.Results:Prevalence of urogenital schistosomiasis was 30.54%among the study population,with a mean infection intensity of 30.27 eggs/10 ml of urine.Prevalence and average intensity were higher in males(28.37%and 32.21 eggs/10 ml of urine respectively)than in females(2.17%and 5 eggs/10 ml of urine respectively).Water contact activities(χ^(2)=29.031,P=0.0000),sex(male)[χ^(2)=109.82;P<0.0001],location(Dutsin─Ma)[χ^(2)=7.19;P=0.0073],age group 18-20(χ^(2)=4.819,P=0.0281),altitude(531─560 m)[χ^(2)=6.84,p=0.0089],fathers doing other brown─collar jobs(χ^(2)=8.449,P=0.0037)and mothers’occupation(χ^(2)=9.470,P=0.0021)were found to be significantly associated with urogenital schistosomiasis.Boys were six times more likely to be infected with the cercariae of S.haematobium compared to girls[AOR(95%CI):6.34(4.89─8.22)].Conclusions:Dutsin-Ma and Safana were classified as moderate-risk Local Government Areas for urogenital schistosomiasis.The strong association between the disease and mother’s occupation is of utmost importance and suggests a promising control measure:that is,directing health education as well as grassroots mass chemotherapeutic intervention with praziquantel at mothers.A good network including treated pipe-borne water,drainage system,and sewage disposal facilities available should be improved upon.Molluscicides should be provided at highly subsidized rate to help control the disease. | Tolulope Ebenezer Atalabi Umar Lawal Francis Omowonuola Akinluyi | 2016 | Infectious Diseases of Poverty2016，5，1： | 2 |
| 5 | Females have fewer complications and lower mortality following trauma than similarly injured males: A risk adjusted analysis of adults in the National Trauma Data Bank显示文摘 | Adil H. Haider Joseph G. Crompton Tolulope Oyetunji Kent A. Stevens David T. Efron Alicia N. Kieninger David C. Chang Edward E. Cornwell Elliott R. Haut | 2009 | Surgery2009，，2： | 1 |
| 6 | Identification of microRNAs and other small regulatory RNAs using cDNA library sequencing显示文摘 | Markus Hafner Pablo Landgraf Janos Ludwig Amanda Rice Tolulope Ojo Carolina Lin Daniel Holoch Cindy Lim Thomas Tuschl | 2007 | Methods2007，，1： | 1 |
| 7 | Interconnections between governance and socioeconomic conditions:Understanding the challenges in sub-Saharan Africa显示文摘Given that challenges on the issue of socioeconomic development faced by countries in sub-Saharan Africa(SSA)have been identified as critical to strengthening the inherent link between governance and socioeconomic conditions,this study examines the interconnections between governance and socioeconomic conditions in SSA.With a focus on 25 countries in SSA between 2005 and 2019,we conduct the analysis based on the Panel-Corrected Standard Error and System Generalized Method of Moments estimations and panel causality tests.The results show that SSA does not seem to have the means of effective governance to spur improved socioeconomic conditions.Moreover,the pervasiveness of institutional problems in many countries of SSA has been responsible for the poor socioeconomic conditions in the region.Likewise,governance quality and socioeconomic conditions are found to influence each other.An improvement in socioeconomic conditions could result in better governance quality.On the other hand,governance quality is viewed as a vital ingredient in achieving needed socioeconomic development outcomes.Thus,it is suggested that there is a need for countries in SSA to streamline governing systems toward engendering improved well-being.The introduction and implementation of transformative policies through effective governance are also necessary for ensuring critical structural changes and increasing social service provision.Overall,there should be a proactive identification of ineffective policies and procedures by policymakers to enhance meaningful impacts in the region. | Fisayo FAGBEMI Geraldine Ejiaka NZERIBE Tolulope Temilola OSINUBI Simplice ASONGU | 2021 | Regional Sustainability2021，2，4： | 1 |
| 8 | Knowledge, attitude, and practice of HIV/AIDS-related stigma and discrimination reduction among nursing students in southwest Nigeria显示文摘 | Adekunbi Farotimi Chinomso Nwozichi Tolulope Ojediran | 2015 | Iranian Journal of Nursing and Midwifery Research2015，，6： | 1 |
| 9 | The role of herbivore- and plant-related experiences in intraspecific host preference of a relatively specialized parasitoid显示文摘Parasitoids use odor cues from infested plants and herbivore hosts to locate their hosts. Specialist parasitoids of generalist herbivores are predicted to rely more on herbivorederived cues than plant-derived cues. Microplitis croceipes (Cresson)(Hymenoptera: Braconidae) is a relatively specialized larval endoparasitoid of Heliothis virescens (F.)(Lepidoptera: Noctuidae), which is a generalist herbivore on several crops including cotton and soybean. Using M. croceipes/H. virescens as a model system, we tested the following predictions about specialist parasitoids of generalist herbivores:(i) naive parasitoids will show innate responses to herbivore-emitted kairomones, regardless of host plant identity and (ii) herbivore-related experience will have a greater influence on intraspecific oviposition preference than plant-related experience. Inexperienced (naive) female M. croceipes did not discriminate between cotton-fed and soybean-fed H. virescens in oviposition choice tests, supporting our first prediction. Oviposition experience alone with either host group influenced subsequent oviposition preference while experience with infested plants alone did not elicit preference in M. croceipes, supporting our second prediction. Furthermore, associative learning of oviposition with host-damaged plants facilitated host location. I terestingly, naive parasitoids attacked more soybeathan cotton-fed host larvae in two-choice tests when a background of host-infested cotton odor was supplied, and vice versa. This suggests that plant volatiles may have created an olfactory contrast effect. We discussed ecological significance of the results and concluded that both plant- and herbivore-related experiences play important role in parasitoid host foraging. | Tolulope Morawo Henry Fadamiro | 2019 | Insect Science2019，26，2： | 1 |
| 10 | Laparoscopic Appendectomy in Children with Complicated Appendicitis: Ethnic Disparity Amid Changing Trend显示文摘 | Tolulope A. Oyetunji Benedict C. Nwomeh Sharon K. Ong’uti Dani O. Gonzalez Edward E. Cornwell Terrence M. Fullum | 2011 | Journal of Surgical Research2011，，1： | 1 |
| 11 | A Study on Microstructural and Mechanical Properties of a Stir Cast Al(SiC-Mg-TiFe)Composite显示文摘Development of metal matrix composite is becoming widespread in most engineering applications where excellent mechanical properties are required.Mechanical and microstructural properties of aluminium reinforced with silicon carbide was investigated.Ingot of aluminium was melted in a furnace at temperature ranging between 650-700℃.Ferrotitanium and silicon carbide were preheated in a muffle furnace before addition to molten aluminium in a crucible furnace.Fixed proportions of magnesium,ferrotitanium and varying proportions of silicon carbide were utilized as reinforcements.Stirring was carried out manually for a minimum of 10 mins after the addition of each weight percent of silicon carbide.Resulting as-cast samples were sectioned for various mechanical and microstructural analysis.Microstructural studies from optical microscopy and scanning electron microscopy(SEM)showed the dispersion of reinforcements in the aluminium matrix.Mechanical properties which includes hardness and tensile strength of fabricated composites were observed to increase,while XRD analysis showed various phases formed from reaction between the matrix and reinforcements. | Samuel Olukayode Akinwamide Serge Mudinga Lemika Babatunde Abiodun Obadele Ojo Jeremiah Akinribide Bolanle Tolulope Abe Peter Apata Olubambi | 2019 | Fluid Dynamics & Materials Processing2019，15，1： | 1 |
| 12 | A framework for e-commerce implementation: Nigeria a case study显示文摘 | Charles K Ayodele A Tolulope F I | 2008 | Journal of Internet Banking and Commerce2008，13，2： | 1 |
| 13 | Affine processes under parameter uncertainty显示文摘We develop a one-dimensional notion of affine processes under parameter uncertainty,which we call nonlinear affine processes.This is done as follows:given a setof parameters for the process,we construct a corresponding nonlinear expectation on the path space of continuous processes.By a general dynamic programming principle,we link this nonlinear expectation to a variational form of the Kolmogorov equation,where the generator of a single affine process is replaced by the supremum over all corresponding generators of affine processes with parameters in.This nonlinear affine process yields a tractable model for Knightian uncertainty,especially for modelling interest rates under ambiguity.We then develop an appropriate Ito formula,the respective term-structure equations,and study the nonlinear versions of the Vasiˇcek and the Cox–Ingersoll–Ross(CIR)model.Thereafter,we introduce the nonlinear Vasicek–CIR model.This model is particularly suitable for modelling interest rates when one does not want to restrict the state space a priori and hence this approach solves the modelling issue arising with negative interest rates. | Tolulope Fadina Ariel Neufeld Thorsten Schmidt | 2019 | Probability, Uncertainty and Quantitative Risk2019，4，1： | 1 |
| 14 | Pediatric Negative Appendectomy Rate: Trend, Predictors, and Differentials显示文摘 | Tolulope A. Oyetunji Sharon K. Ong’uti Oluwaseyi B. Bolorunduro Edward E. Cornwell Benedict C. Nwomeh | 2012 | Journal of Surgical Research2012，，1： | 1 |
| 15 | Synthesis, optical properties, crystal structures and phase behaviour of symmetric, conjugated ethynylarene-based rigid rods with terminal carboxylate groups显示文摘 | Tolulope M Fasina Jonathan C Collings Jacqueline M Burke | 2005 | J Mater Chem2005，15，： | 1 |
| 16 | Improving multi access interference suppression in optical CDMA by using all-optical signal processing显示文摘 | Tolulope B Osadola Siti K Idfis Ivan Glesk | 2013 | Telfor Journal2013，5，1： | 1 |
| 17 | Assessment of the impact of climate change on the occurrences of malaria,pneumonia,meningitis,and cholera in Lokoja City,Nigeria显示文摘This study examined the impact of climate change on the occurrence of malaria,pneumonia,meningitis,and cholera in Lokoja City,Nigeria,with the aim of investigating the spatial distribution and prevalence of the four kinds of diseases as well as the coping strategies of people in the area.We collected the rainfall and temperature data of Lokoja City during 2000-2020 from the National Aeronautics and Space Administration(NASA),and the medical records data of the four kinds of diseases from the Kogi State Ministry of Health.We also conducted a semi-structured questionnaire of 250 residents,who have experienced one of these diseases,to investigate their coping strategies with these diseases.The Pearson correlation and multiple regression analysis were used to research the relationship between the climate parameters and cases of diseases.The result showed annual variations in climatic parameters with R^(2)values of 0.0557,0.0009,and 0.4915 for rainfall,maximum temperature,and minimum temperature,respectively.A positive and significant relationship were observed between maximum temperature and malaria(r=0.80),rainfall and malaria(r=0.54),minimum temperature and meningitis(r=0.64),as well as rainfall and cholera(r=0.66)at P<0.05 level.For the regression analysis R^(2)=0.71,0.50,and 0.52 for malaria,cholera,and meningitis,respectively at P<0.05 level.During 2000-2020,cases of malaria were highest in Ward A with 15,422,while 715 cases of pneumonia were highest in Kupa North Ward.In Ward A,3787 cases of cholera were recorded to be the highest,while cases of meningitis were highest in Kupa North Ward with 2383 cases.Investigation revealed that malaria is more common in the wet season,while cholera and meningitis cases were highest in the dry season.The study revealed that the most practiced coping strategy is the use of medications by about 90%of the respondents.More studies are recommended in the study area to establish a causal link between climate change and disease occurrence,and intervention from government in form of prevention and control programmes should be vigorously implemented. | Isaac Ayo OLUWATIMILEHIN Joseph Omojesu AKERELE Tolulope Adedoyin OLADEJI Mojisola Hannah OMOGBEHIN Godwin ATAI | 2022 | Regional Sustainability2022，3，4： | 1 |
| 18 | Thyroid hormone resistance 显示文摘 | Tolulope 00lateju Mark PJ Vanderpump | 2006 | Ann Clin Biochem2006，43，6： | 1 |
| 19 | Negative appendectomy: a 10-year review of a nationally representative sample显示文摘 | Shiva A. Seetahal Oluwaseyi B. Bolorunduro Trishanna C. Sookdeo Tolulope A. Oyetunji Wendy R. Greene Wayne Frederick Edward E. Cornwell David C. Chang Suryanarayana M. Siram | 2011 | The American Journal of Surgery2011，，4： | 1 |
| 20 | Ethylacetate extract of red onion(Allium cepa L.)tunic affects hemodynamic parameters in rats显示文摘The effects of ethylacetate extract of red onion(Allium cepa)tunic(ACTE)on some hemodynamic and biochemical parameters were evaluated in normotensive albino rats.Blood pressure parameters were determined in anaesthetized rats orally administered ACTE(10-,20-,or 40 mg/kg)or ramipril(1 mg/kg)once daily for 14 days.Respectively,10-,20-,or 40 mg/kg ACTE produced significant(P<0.01),dose-dependent fall in systolic blood pressure,SBP(21%,27%,33%),diastolic blood pressure,DBP(6%,10%,16%),pulse pressure,PP(42%,49%,56%),mean arterial blood pressure,MAPB(13%,18%,23%)and heart rate,HR(4%,5%,7%).The highest effective dose(40 mg/kg)compared well with ramipril(1 mg/kg)with regards to SBP(41%),DBP(19%),PP(70%),MABP(29%)and HR(10%).Similar trends(decreases)were recorded for 40 mg/kg ACTE and ramipril,respectively,as regards the activities of serum enzymes:creatine kinase(60%and 65%),ALT(18%and 14%)and ALP(28%and 16%).HPLC fingerprints of the flavonoid-rich ACTE revealed that flavonols:quercetin,quercitrin,isoquercitrin,rutin and kaempferol are the active flavonoids.The results demonstrate the hypotensive effect of A.cepa tunic flavonoids initiating further investigation of their individual or synergistic contribution(s)to the observed effects. | Olanrewaju Sam Olayeriju Mary Tolulope Olaleye Olamide Olajusi Crown Kayode Komolafe Aline Augusti Boligon Margareth Linde Athayde Akintunde Afolabi Akindahunsi | 2015 | Food Science and Human Wellness2015，4，3： | 1 |
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