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| 1 | Fatty liver in hepatitis C patients post-sustained virological response with direct-acting antivirals显示文摘AIM To determine steatosis and fibrosis prevalence in hepatitis C patients after a sustained virological response achieved with direct-acting antivirals.METHODS Transient elastography with controlled attenuation parameter(CAP) was used to assess hepatic steatosis post-sustained virological response(SVR);the CAP technology was not available in the United States at study initiation.Liver stiffness/fibrosis was measured before and 47 wk after treatment completion.Patients with genotype 3 and patients with cirrhosis were excluded.RESULTS One hundred and one patients were included in the study.Post-SVR there were decreases from baseline in alanine aminotransferase(ALT)(63.1 to 17.8 U/L),aspartate aminotransferase(51.8 to 21.5 U/L) and fibrosis score(7.4 to 6.1 k Pa)(P < 0.05).Post-SVR,48 patients(47.5%) had steatosis on CAP;of these,6.25% had advanced fibrosis.Patients with steatosis had higher body mass index(29.0 vs 26.1 kg/m2),glucose(107.8 vs 96.6 mg/d L),ALT(20.4 vs 15.3 mg/d L),CAP score(296.3 vs 212.4 d B/m) and fibrosis score(7.0 vs 5.3 k Pa);P < 0.05.Interestingly,compared to baseline,both patients with and without steatosis had change in fibrosis score post-SVR(7.7 k Pa vs 7.0 k Pa and 7.0 k Pa vs 5.3 k Pa);alternatively,(P < 0.05) and therefore patients with steatosis continued to have clinically significant stiffness(≥ 7 k Pa).CONCLUSION Fatty liver is very common in hepatitis C virus(HCV) patients post-SVR.These patients continue to have elevated mean fibrosis score(≥ 7 k Pa) compared to those without fatty liver;some have advanced fibrosis.Long term follow up is needed to assess steatosis and fibrosis in HCV patients post-SVR. | Mazen Noureddin Micaela M Wong Tsuyoshi Todo Shelly C Lu Arun J Sanyal Edward A Mena | 2018 | World Journal of Gastroenterology2018，24，11： | 6 |
| 2 | Cloning and expression of two carbonyl reductase-like 20 beta-hydroxysteroid dehydrogenase cDNAs in ovarian follicles of rainbow trout (Oncorhynchus mykiss) 显示文摘 | Guan G Tanaka M Todo T | 1999 | Biochem Biophys Res Commun1999，255，： | 1 |
| 3 | Treatment of severe intraventricular hemorrhage by intraventricular infusion of urekinase 显示文摘 | Todo T Usui M Takakura K | 1991 | Neurosurg1991，74，1： | 1 |
| 4 | A systematic nerve-sparin- gradical hysterectomy technique in invasive cervical cancer for preserving postsurgical bladder function 显示文摘 | Sakuragi N Todo Y Kudo M | 2005 | Int J Gynecol Cancer2005，15，2： | 1 |
| 5 | Effects of implant diameter, insertion depth, and loading angle on stress/strain fields in implant/jawbone systems finite element analysis 显示文摘 | Oian L Todo M Matsushita Y | 2008 | Int J Oral Maxillofac Implants2008，24，5： | 1 |
| 6 | A systematic nerve-sparing radical hysterectomy technique in invasive cervical cancer for preserving postsurgical bladder function 显示文摘 | Sakuragi N Todo Y Kudo M | 2005 | Int J Gynecol Cancer2005，15，2： | 1 |
| 7 | Treatment of severe intraventricular hemorrhage by intraventricular infusion of urokinase显示文摘 | Todo T Usui M Takakura K | 1991 | J Neurosurg1991，74，： | 1 |
| 8 | Survival effect of para -aortic lyrnphadenectomy in endometrial cancer (SEPAL study) : a retrospective cohort analysis 显示文摘 | Todo Y Kato H Kaneuehi M | 2010 | Lancet2010，375，9721： | 1 |
| 9 | Treatment of severe intraven-tricular hemorhage by intraventricular infusion of urokinase 显示文摘 | Todo T Usui M Takakura K | 2011 | J Neuro- surg2011，74，1： | 1 |
| 10 | The novel antioxidant edaravone: from bench to bedside显示文摘 | WATANABE T TAHARA M TODO S | 2008 | Cardiovasc Ther2008，26，2： | 1 |
| 11 | Treatment of severe intraventricular hemorrhage by intraventricular Infusion of urokinase 显示文摘 | Todo T Usti M Takakura K | 1991 | J Neurosurg1991，74，： | 1 |
| 12 | Treatment of severe intraventrieular hemorrange by intraventriclar infusion of urokinase显示文摘 | Todo T Usai M Takakura K | 1991 | J Neurosurg1991，74，1： | 1 |
| 13 | A systenmtic nerve-sparing radical hysterectomy technique in invasive cervical cancer for preserving post- surgical bladder function 显示文摘 | Sakuragi N Todo Y Kudo M | 2005 | Gynecol Cancer2005，15，2： | 1 |
| 14 | A systematic nerve-sparing radical hysterectomy technique in invasive cervical cancer for preserving postsurgical bladder function显示文摘 | Sakuragi N Todo Y Kudo M | 2005 | Int J Gynecol Cancer2005，15，2： | 1 |
| 15 | Treatment of severe intraventricular hemorrhage by intraventricular infusion of urokinase显示文摘 | Todo T Usvi M Takakvra K | 1991 | J Neurosurg1991，74，1： | 1 |
| 16 | Treatment of severe intraventricular hemorrhage by intraventricular infusion ofurokinasse显示文摘 | Todo T Usui M Takakura K | 1991 | Neurosurg1991，74，： | 1 |
| 17 | A case of pure-type ovarian squamous cell carcinoma for which combination chemotherapy consisting of paclitaxel and carboplatin was not effective显示文摘 | TODO Y MINOBE S SASAKI M | 2005 | Gynecologic Oncology2005，97，1： | 1 |
| 18 | Treatment of severe intraventricu|ar hemorrhage by intraventricular infusion of urokinase 显示文摘 | Todo T Usui M Takakura K | 1991 | J Neurosury1991，74，1： | 1 |
| 19 | Assessment of five-year experience with abdominal organ cluster transplantation显示文摘 | Alessiani M Tzakis A Todo S | 1995 | J Am Coll Surg1995，180，： | 1 |
| 20 | Treatment of Severe Intraventricular Hemorrhage by Intraventrilar Infufsion of Urokinasse 显示文摘 | Todo T Usui M Takakura K | 1991 | J Neurosurg1991，74，： | 1 |
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