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| 1 | Mixed adenoneuroendocrine carcinoma of gastrointestinal tract: Report of two cases显示文摘Mixed adenoneuroendocrine carcinoma(MANEC) is a rare tumor of the gastrointestinal tract that consists of a dual adenocarcinomatous and neuroendocrine differentiation, each component representing at least 30% of the tumor. To date, only seven cases have been reported in the cecum, and less than 40 in the stomach. Our first case was diagnosed in a 74-years-old female as a polypoid lesion of the cecum with direct invasion in the transverse colon, without lymph node metastases. The second case was diagnosed in the stomach of a 46-years-old male as a polypoid tumor of the antral region that invaded the pancreas and presented metastases in 22 regional lymph nodes. The metastatic tissue was represented by the glandular component. In both cases, the tumor consisted of a moderately-differentiated tubular adenocarcinoma(with mucinous component in Case 1) intermingled with neuroendocrine carcinoma. Ki67 index was lower than 20% in Case 1, respectively higher than 20% in Case 2. The neuroendocrine component was marked by synaptophysin and neuron specific enolase, being negative for Keratins 7/20. The neuroendocrine component represented 60% in Case 1, and 40% in Case 2, respectively. The glandular components were marked by carcinoembryonic antigen, maspin and keratin 20/7(Case 1/2). Both cases were proved to be microsatellite stable. Independently by the localization and tumor stage, MANECs appear to be highly malignant tumors, with high risk for distant metastases. The aggressiveness seems to depend on the endocrine component, independent of its proportion. The neuroendocrine component could be a dedifferentiated adenocarcinoma with a neuroendocrine phenotype. | Simona Gurzu Zoltan Kadar Tivadar Bara Tivadar Jr. Bara Adrian Tamasi Leonard Azamfirei Ioan Jung | 2015 | World Journal of Gastroenterology2015，21，4： | 14 |
| 2 | Single skip metastasis in sentinel lymph node: In an early gastric cancer显示文摘Lymph node status is considered a key prognostic and predictive factor in patients with gastric cancer(GC).Although there is a practical approach to the intraoperative detection of sentinel lymph nodes(SLNs),such a procedure is not included in the European surgical protocol.In this report,we present a practical approach to SLN mapping in a representative case with early gastric cancer(EGC).A 74-year-old female was hospitalized with an endoscopically observed,superficially ulcerated tumor located in the antral region.Subtotal gastrectomy with D2 lymphadenectomy and SLN mapping was performed by injecting methylene blue dye into the peritumoral submucosal layer.An incidentally detected blue-stained lymph node located along the middle colic artery was also removed.This was detected 40 min after injection of the methylene blue.Histopathologic examination showed a p T1b-staged well-differentiated HER-2-negative adenocarcinoma.All of the 41 LNs located at the first,third,and fifth station of the regional LN compartments were found to be free of tumor cells.The only lymph node with metastasis was located along the middle colicartery and was considered a non-regional lymph node.This incidentally identified skip metastasis indicated stage Ⅳ GC.A classic chemotherapy regimen was given,and no recurrences were observed six months after surgery.In this representative case,low-cost SLN mapping,with a longer intraoperative waiting time,totally changed the stage of the tumor in a patient with EGC. | Tivadar Jr Bara Simona Gurzu Ioan Jung Zoltan Kadar Haruhiko Sugimura Tivadar Bara | 2015 | World Journal of Gastroenterology2015，21，33： | 8 |
| 3 | Paradoxical expression pattern of the epithelial mesenchymal transition-related biomarkers CD44, SLUG, N-cadherin and VSIG1/Glycoprotein A34 in gastrointestinal stromal tumors显示文摘AIM To evaluate the immunohistochemical(IHC) expression of five biomarkers, commonly involved in epithelial mesenchymal/mesenchymal epithelial transition(EMT/MET), in gastrointestinal stromal tumors(GISTs). METHODS In 80 consecutive GISTs the IHC examinations were performed using the EMT-related antibodies E-cadherin,N-cadherin, SLUG, V-set and immunoglobulin domain containing 1(VSIG1) and CD44. RESULTS The positivity rate was 88.75% for SLUG, 83.75% for VSIG1, 36.25% for CD44 and 10% for N-cadherin. No correlation was noted between the examined markers and clinicopathological parameters. Nuclear positivity for SLUG and VSIG1 was observed in all cases with distant metastasis. The extra-gastrointestinal stromal tumors(e-GISTs) expressed nuclear positivity for VSIG1 and SLUG, with infrequent positivity for N-cadherin and CD44. The low overall survival was mainly dependent on VSIG1 negativity(P = 0.01) and nuclear positivity for SLUG and/or CD44. CONCLUSION GIST aggressivity may be induced by nuclear upregulation of SLUG and loss or cytoplasm-to-nuclear translocation of VSIG1. SLUG and VSIG1 may act as activated nuclear transcription factors. The CD44, but not N-cadherin, might also have an independent prognostic value in these tumors. The role of the EMT/MET-related transcription factors in the evolution of GISTs, should be revisited with a larger dataset. This is the first study exploring the IHC pattern of VSIG1 in GISTs. | Attila Kovecsi Simona Gurzu Zoltan Szentirmay Zsolt Kovacs Tivadar Jr Bara Ioan Jung | 2017 | World Journal of Gastrointestinal Oncology2017，9，11： | 2 |
| 4 | Food, ethics and aesthetics 显示文摘 | Blanka Tivadar Breda Luthar | 2005 | Appetite2005，44，： | 1 |
| 5 | Comparative high-performance liquid chromatography enantioseparations on polysaccharide based chiral stationary phases prepared by coating totally porous and core-shell silica particles显示文摘 | Ketevan Lomsadze George Jibuti Tivadar Farkas | 2012 | Chromatography A2012，1234，： | 1 |
| 6 | Treatment of venous thromboembolism with the oral thrombin inhibitor,ximelagatran显示文摘 | Harenberg J Ingrid J Tivadar F | 2002 | Isr Med Assoc J2002，4，11： | 1 |
| 7 | Characterization of clay-based K catalysts and their application in Friedel-Crafts alkylation of aromatics显示文摘 | TIVADAR C SANDOR B FRANCOIS F | 1995 | Applied Catalysis A:General1995，132，： | 1 |
| 8 | Preparation andcharacterization of photochromic poly (methyl methacry-late) and ethyl cellulose nanocapsules containing a spiro-oxazine dye显示文摘 | Tivadar F Olivia V Margit K | 2011 | Journal of Photochemistry and Photobiol-ogy A: Chemistry2011，，222： | 1 |
| 9 | Synthesis of 5-(2-chloroalkyl)-2,2-dimethyl-1,3-dioxane-4,6-diones显示文摘 | Gyorgy T Tivadar T Ildiko B | 2002 | Synth Commun2002，23，： | 1 |
| 10 | Benzylation of Aromatics on Lon-Exchanged Clays显示文摘 | Tivadar C S (C)ndor B Francois F | | 0，，： | 1 |
| 11 | Influence of H 2 S on the hydrogenation activity of relevant transition metal sulfides显示文摘 | Guernalec Nadège Cseri Tivadar Raybaud Pascal Geantet Christophe Vrinat Michel | 2004 | Catalysis Today2004，，1： | 1 |
| 12 | Rapid and Reproducible Extraction of Acylamide in French Fries Using a Single Solid-Phase Sorbent 显示文摘 | Liming Peng Tivadar Farkas Lawrece Loo | 2003 | Torrance: American Laboratory2003，，10： | 1 |
| 13 | 面向便携设备的LED驱动器显示文摘如今的移动电话和PDA用户对背光和显示色彩的要求越来越高.设计人员可能期望消费者会根据产品的技术特点选择购买,然而移动电话和PDA用户看重的却往往是产品的外在特色,如特别的色彩或声音等.此类外在特色将成为下一代移动电话和PDA产品的卖点,也是产品能否在市场上取得成功的关键. | Tivadar Szabo DeAnn Wright | 2003 | 世界电子元器件2003，，11： | 1 |
| 14 | Increased Heat Shock Protein 72 Expression in Celiac Disease显示文摘 | Erna Sziksz Gábor Veres ádám Vannay ágnes Prókai Krisztina Gál Anna ónody Ilma Rita Korponay-Szabó Gy?rgy Reusz András Szabó Tivadar Tulassay András Arató Beáta Szebeni | 2010 | Journal of Pediatric Gastroenterology and Nutrition2010，，5： | 1 |
| 15 | Preparation and characterization of photochromic poly (methyl methacrylate) and ethyl cellulose nanocapsules containing a spirooxazine dye 显示文摘 | Tivadar Feczk6 Olivia Varga Margit KovOcs | 2011 | Journal of Photochemistry and Photobiology A : Chemistry2011，222，1： | 1 |
| 16 | Improvement of fatigue resistance of spirooxazine in ethyl cellulose and Poly ( methyl methaerylate ) nanopartieles usinghindered amine light stabilizer显示文摘 | TIVADAR F MARGIT K BOJANA V J | 2012 | Journal of Photochemistry and Photobiology A : Chemistry2012，，247： | 1 |
| 17 | Influence of H 2 S on the hydrogenation activity of relevant transition metal sulfides显示文摘 | Guernalec Nadège Cseri Tivadar Raybaud Pascal Geantet Christophe Vrinat Michel | 2004 | Catalysis Today2004，，1： | 1 |
| 18 | Interaction of arylsulfatases A and B with maspin: A possible explanation for dysregulation of tumor cell metabolism and invasive potential of colorectal cancer显示文摘BACKGROUND Although it has been shown that arylsulfatases are lost in colorectal cancer(CRC)cell lines,their exact role in the carcinogenesis and behavior of this cancer was not elucidated.No data about the correlation between serum and immunohistochemical(IHC)level of arylsulfatases(ARSA,ARSB)in patients with CRC were published yet.AIM To evaluate the possible prognostic value of ARSA and/or ARSB in CRC,at circulating and protein levels.METHODS The present study included 45 consecutive patients who were prospectively diagnosed with CRC.For IHC stains(protein expression)ARSA,ARSB and maspin expression were quantified.For these markers,cytoplasmic expression was taken into account.For gene expression study,circulating mRNA was isolated from all patients,before surgery.A group of 45 healthy patients without inflammatory or tumor pathologies was used as control group.Reverse transcription and Taqman Gene Expression Array were used for ARSB gene expression.RESULTS The preoperative circulating RNA level of the ARSB gene was significantly decreased in patients with CRC(RQ<1),compared with the control group(RQ>1).A more significant decrease(RQ<0.5)occurred in ulcero-infiltrative maspinpositive adenocarcinomas,with a higher degree of tumor budding,diagnosed in locally advanced stages(pT3/4).ARSA/maspin immunopositivity indicated a higher risk for lymph node metastasis,while triple positivity for maspin/ARSA/ARSB and ARSB gene expression level<0.5 were indicators of CRC aggressive behavior,independent of lymph node status.CONCLUSION The significant independent negative prognostic factors of CRC are the ulceroinfiltrative aspect,high budding degree,triple positivity for maspin,ARSA and ARSB,and low ARSB gene expression. | Zsolt Kovacs Ioan Jung Krisztina Szalman Laura Banias Tivadar Jr Bara Simona Gurzu | 2019 | World Journal of Clinical Cases2019，7，23： | 1 |
| 19 | Preparation and Characterization of Ethylcellulose-based Microcapsules for Sustaining Release of a Model Fragrance 显示文摘 | TIVADAR FECZK VANJA KOKOL BOJANA VONCINA | 2010 | Macromolecular Research2010，，7： | 1 |
| 20 | Cloud computing technology applied in healtheare for developing large scale flexi- ble solutions 显示文摘 | LUPSE O S VIDA M STOICU - TIVADAR L | 2012 | Studies in health tech- nology and informalics2012，174，： | 1 |
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