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| 1 | The ruminal microbiome associated with methane emissions from ruminant livestock显示文摘Methane emissions from ruminant livestock contribute significantly to the large environmental footprint of agriculture.The rumen is the principal source of methane, and certain features of the microbiome are associated with low/high methane phenotypes. Despite their primary role in methanogenesis, the abundance of archaea has only a weak correlation with methane emissions from individual animals. The composition of the archaeal community appears to have a stronger effect, with animals harbouring the Methanobrevibacter gottschalki clade tending to be associated with greater methane emissions. Ciliate protozoa produce abundant H_2, the main substrate for methanogenesis in the rumen,and their removal(defaunation) results in an average 11% lower methane emissions in vivo, but the results are not consistent. Different protozoal genera seem to result in greater methane emissions, though community types(A, AB, B and O) did not differ. Within the bacteria, three different ‘ruminotypes' have been identified, two of which predispose animals to have lower methane emissions. The two low-methane ruminotypes are generally characterized by less abundant H_2-producing bacteria. A lower abundance of Proteobacteria and differences in certain Bacteroidetes and anaerobic fungi seem to be associated with high methane emissions. Rumen anaerobic fungi produce abundant H_2 and formate, and their abundance generally corresponds to the level of methane emissions. Thus, microbiome analysis is consistent with known pathways for H_2 production and methanogenesis, but not yet in a predictive manner. The production and utilisation of formate by the ruminal microbiota is poorly understood and may be a source of variability between animals. | Ilma Tapio Timothy J.Snelling Francesco Strozzi R.John Wallace | 2017 | Journal of Animal Science and Biotechnology2017，8，2： | 13 |
| 2 | Human Schistosome Infection and Allergic Sensitisation显示文摘 | Nadine Rujeni David W. Taylor Francisca Mutapi Maria Ilma Araujo | 2012 | Journal of Parasitology Research2012，，： | 1 |
| 3 | U reteric in ju ries:di agnosis,management,and ou tcome显示文摘 | AhmedMA GhaliMD Elfad ilMA | 1999 | J Trauma1999，46，1： | 1 |
| 4 | Modeling the IRI topside profile using scale heights fromground-based ionosonde measurements显示文摘 | Bodo W. Reinisch Xue-Qin Huang Anna Belehaki Jian-Kui Shi Man-Liars Zhang Ronald Ilma | 2004 | Advances in Space Research2004，，9： | 1 |
| 5 | Learning Process in NewProduct Development Teams and Effects on Product Success:A Socio-cognitive Perspective显示文摘 | AKGUN A E LUNN G S Y ILMA Z C | 2006 | Industrial Marketing Management2006，35，2： | 1 |
| 6 | Accuracy of Diagnostic Antibody Tests for Coeliac Disease in Children: Summary of an Evidence Report显示文摘 | Klaus Giersiepen Monika Lelgemann Nina Stuhldreher Luca Ronfani Steffen Husby Sibylle Koletzko Ilma R. Korponay-Szabó | 2012 | Journal of Pediatric Gastroenterology and Nutrition2012，，2： | 1 |
| 7 | Prediction of Clinical and Mucosal Severity of Coeliac Disease and Dermatitis Herpetiformis by Quantification of IgA/IgG Serum Antibodies to Tissue Transglutaminase显示文摘 | Ingrid Dahlbom Ilma R Korponay-Szabó Judit B Kovács Zsuzsanna Szalai Markku M?ki Tony Hansson | 2010 | Journal of Pediatric Gastroenterology and Nutrition2010，，2： | 1 |
| 8 | Increased Heat Shock Protein 72 Expression in Celiac Disease显示文摘 | Erna Sziksz Gábor Veres ádám Vannay ágnes Prókai Krisztina Gál Anna ónody Ilma Rita Korponay-Szabó Gy?rgy Reusz András Szabó Tivadar Tulassay András Arató Beáta Szebeni | 2010 | Journal of Pediatric Gastroenterology and Nutrition2010，，5： | 1 |
| 9 | Gluten-dependent Small Bowel Mucosal Transglutaminase 2–specific IgA Deposits in Overt and Mild Enteropathy Coeliac Disease显示文摘 | Outi Koskinen Pekka Collin Ilma Korponay-Szabo Teea Salmi Sari Iltanen Katri Haimila Jukka Partanen Markku M?ki Katri Kaukinen | 2008 | Journal of Pediatric Gastroenterology and Nutrition2008，，4： | 1 |
| 10 | Schistosoma mansoni infection modulates the immune response against allergic and auto-immune diseases显示文摘 | Mafia Ilma Araajo Bradford S Hoppe Manoel Medeiros Jr | 2004 | Mem Inst Oswaldo Cruz2004，99，5： | 1 |
| 11 | Small-bowel mucosal transglutaminase 2-specific IgA deposits in coeliac disease without villous atrophy: A prospective and randomized clinical study显示文摘 | Katri Kaukinen Markku Per?aho Pekka Collin Jukka Partanen Nina Woolley Tanja Kaartinen Tuula Nuutinen Tuula Halttunen Markku M?ki Ilma Korponay-Szabo | 2005 | Scandinavian Journal of Gastroenterology2005，，5： | 1 |
| 12 | Consumption of gluten with gluten-degrading enzyme by celiac patients: A pilot-study显示文摘AIM:To assesses the safety and efficacy of Aspergillus niger prolyl endoprotease(AN-PEP)to mitigate the im-munogenic effects of gluten in celiac patients.METHODS:Patients with initial diagnosis of celiac disease as confirmed by positive serology with subtotal or total villous atrophy on duodenal biopsies who adhere to a strict gluten-free diet(GFD)resulting in normalised antibodies and mucosal healing classified as Marsh 0 orⅠwere included.In a randomised double-blind placebo-controlled pilot study,patients consumed toast(approximately 7 g/d gluten)with AN-PEP for 2 wk(safety phase).After a 2-wk washout period with adherence of the usual GFD,14 patients were randomised to gluten intake with either AN-PEP or placebo for 2 wk(efficacy phase).Measurements at baseline included complaints,quality-of-life,serum antibodies,immunophenotyping of T-cells and duodenal mucosa immunohistology.Furthermore,serum and quality of life questionnaires were collected during and after the safety,washout and efficacy phase.Duodenal biopsies were collected after the safety phase and after the efficacy phase.A change in histological evaluation according to the modified Marsh classification was the primary endpoint.RESULTS:In total,16 adults were enrolled in the study.No serious adverse events occurred during the trial and no patients withdrew during the trial.The mean score for the gastrointestinal subcategory of the celiac disease quality(CDQ)was relatively high throughout the study,indicating that AN-PEP was well tolerated.In the efficacy phase,the CDQ scores of patients consuming gluten with placebo or gluten with AN-PEP did not significantly deteriorate and moreover no differences between the groups were observed.During the efficacy phase,neither the placebo nor the AN-PEP group developed significant antibody titers.The IgA-EM concentrations remained negative in both groups.Two patients were excluded from entering the efficacy phase as their mucosa showed an increase oftwo Marsh steps after the safety phase,yet with undetectable serum antibodies,while 14 patients were considered histologically stable on gluten with AN-PEP.Also after the efficacy phase,no significant deterioration was observed regarding immunohistological and flow cytometric evaluation in the group consuming placebo compared to the group receiving AN-PEP.Furthermore,IgA-tTG deposit staining increased after 2 wk of gluten compared to baseline in four out of seven patients on placebo.In the seven patients receiving AN-PEP,one patient showed increased and one showed decreased IgA-tTG deposits.CONCLUSION:AN-PEP appears to be well tolerated.However,the primary endpoint was not met due to lack of clinical deterioration upon placebo,impeding an effect of AN-PEP. | Greetje J Tack Jolanda MW van de Water Maaike J Bruins Engelina MC Kooy-Winkelaar Jeroen van Bergen Petra Bonnet Anita CE Vreugdenhil Ilma Korponay-Szabo Luppo Edens B Mary E von Blomberg Marco WJ Schreurs Chris J Mulder Frits Koning | 2013 | World Journal of Gastroenterology2013，19，35： | 1 |
| 13 | Measurement of the levels ofreticulated platelets after plateletpheresis to monitor activity of throm- bopoesis显示文摘 | Stohlawetz P Stiegler G J ilma B | 1998 | Transfu-sion1998，38，5： | 1 |
| 14 | Glycoprotein Ib polymorphisms influence platelet plug formation under high shear rates 显示文摘 | ILMA-STOHLAWETZ P HOMONCIK M J ILMA B | 2003 | Br J Haeroatol2003，120，4： | 1 |
| 15 | Polymorphic CAG and GGC Repeat Lengths in the Androgen Receptor Gene and Prostate Cancer Risk: Analysis of a Brazilian Population显示文摘 | Brasil Silva Neto Walter J. Koff Vanderlei Biolchi Cleber Brenner Karlo D. Biolo Poli Mara Spritzer Ilma S. Brum | 2008 | Cancer Investigation2008，，1： | 1 |
| 16 | Studies on Alkalophilic CGTase- Producing Bacteria and Effect of Starch on CGTase Activity 显示文摘 | Higuri Ilma Hiroko Silva Priscila Anunciacao Nascimento Againaldo Jose | 2004 | Brazilian Archives of Biology and Technology2004，47，： | 1 |
| 17 | yon Willehrand factor in cardiovascular disease: focus on acute coronary syndromes 显示文摘 | Spiel AO Gilbert JC ilma B | 2008 | Circulation2008，117，11： | 1 |
| 18 | Automated IMRT planning with regional optimization using planning scripts显示文摘 | Ilma Xhaferllari Eugene Wong Karl Bzdusek | 2013 | JOURNAL OF APPLIED CLINICAL MEDICAL PHYSICS2013，14，1： | 1 |
| 19 | Unconventional ligands and modulators of nicotinic receptors显示文摘 | Pereira E F H ilmas C Santos M D | 2002 | Journal of Neurobiology2002，53，： | 1 |
| 20 | Quality of life during and after inpatient stroke rehabilitation显示文摘 | W ilma M Hopman MA Jane Verner | 2003 | Stroke2003，34，3： | 1 |
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