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| 1 | Differential diagnosis in patients with suspected bile acid synthesis defects显示文摘AIM: To investigate the clinical presentations associated with bile acid synthesis defects and to describe identification of individual disorders and diagnostic pitfalls. METHODS: We describe semiquantitative determination of 16 urinary bile acid metabolites by electrospray ionization-tandem mass spectrometry. Sample preparation was performed by solid-phase extraction. The total analysis time was 2 min per sample. We determined bile acid metabolites in 363 patients with suspected defects in bile acid metabolism. RESULTS: Abnormal bile acid metabolites were found in 36 patients. Two patients had bile acid synthesis defects but presented with atypical presentations. In 2 other patients who were later shown to be affected by biliary atresia and cystic fibrosis the profile of bile acid metabolites was initially suggestive of a bile acid synthesis defect. Three adult patients suffered from cerebrotendinous xanthomatosis. Nineteen patients had peroxisomal disorders, and 10 patients had cholestatic hepatopathy of other cause. CONCLUSION: Screening for urinary cholanoids should be done in every infant with cholestatic hepatopathy as well as in children with progressive neurological disease to provide specific therapy. | Dorothea Haas Hongying Gan-Schreier Claus-Dieter Langhans Tilman Rohrer Guido Engelmann Maura Heverin David W Russell Peter T Clayton Georg F Hoffmann Jürgen G Okun | 2012 | World Journal of Gastroenterology2012，18，10： | 2 |
| 2 | Plant succession and gopher disturbance along an experimental gradient显示文摘 | David Tilman | 1983 | Oecologia1983，，3： | 1 |
| 3 | Agricultural sustainability and intensive production practices 显示文摘 | David Tilman Kenneth G Cassman Pamela A Matson | 2002 | Nature2002，418，： | 1 |
| 4 | 3D printing of patient-specific implants for osteochondral defects: workflow for an MRI-guided zonal design显示文摘Magnetic resonance imaging(MRI)is a common clinical practice to visualize defects and to distinguish different tissue types and pathologies in the human body.So far,MRI data have not been used to model and generate a patient-specific design of multilayered tissue substitutes in the case of interfacial defects.For orthopedic cases that require highly individual surgical treatment,implant fabrication by additive manufacturing holds great potential.Extrusion-based techniques like 3D plot-ting allow the spatially defined application of several materials,as well as implementation of bioprinting strategies.With the example of a typical multi-zonal osteochondral defect in an osteochondritis dissecans(OCD)patient,this study aimed to close the technological gap between MRI analysis and the additive manufacturing process of an implant based on dif-ferent biomaterial inks.A workflow was developed which covers the processing steps of MRI-based defect identification,segmentation,modeling,implant design adjustment,and implant generation.A model implant was fabricated based on two biomaterial inks with clinically relevant properties that would allow for bioprinting,the direct embedding of a patient’s own cells in the printing process.As demonstrated by the geometric compatibility of the designed and fabricated model implant in a stereolithography(SLA)model of lesioned femoral condyles,a novel versatile CAD/CAM workflow was successfully established that opens up new perspectives for the treatment of multi-zonal(osteochondral)defects. | David Kilian Philipp Sembdner Henriette Bretschneider Tilman Ahlfeld Lydia Mika Jörg Lützner Stefan Holtzhausen Anja Lode Ralph Stelzer Michael Gelinsky | 2021 | Bio-Design and Manufacturing2021，4，4： | 1 |
| 5 | Diversity, productivity and temporal stability in the economices of humans and nature 显示文摘 | David Tilman Stephen Polasky Clarence Lehman | 2005 | Journal of Environmental Economics and management2005，49，： | 1 |
| 6 | 玻璃游戏 上海儿童玻璃博物馆2.0显示文摘众打造的当代艺术与设计博物馆。由玻璃工作车间改造而成的博物馆占地2320 m2,为儿童设计的内容结合探索性的参观体验,鼓励孩子们进行独立自主的学习。博物馆的展览在多个层面吸引观众,与其开展互动,而且所有展品都由一个寻宝游戏串联,邀请观众们在空间中寻找线索。互动性十足的博物馆让孩子们主导参观体验,探索更多他们感兴趣的主题,并积极主动学习关于玻璃、环境、科学、技术、艺术、设计与人类文明的知识。多媒体与数字内容在展览设计中扮演着重要的角色,包含镜子迷宫、声音装置、追踪动态的互动展项以及探讨与玻璃相关的各种主题视频。 | 无 Tilman Thürmer(设计) Francesca Inchingolo(设计) David Keohane(设计) María Fernanda González Prendes(设计) 陈怡君(设计) 文思宁(设计) | 2021 | 室内设计与装修2021，，9： | 1 |
| 7 | Toward Clinical X-ray Phase-Contrast CT: Demonstration of Enhanced Soft-Tissue Contrast in Human Specimen显示文摘 | Tilman Donath Franz Pfeiffer Oliver Bunk Christian Grünzweig Eckhard Hempel Stefan Popescu Peter Vock Christian David | 2010 | Investigative Radiology2010，，： | 1 |
| 8 | Plant diversity increases resistance to invasion in the absence of covarying extrinsic factors显示文摘 | Naeem Shahid Knops Johannes MH Tilman David | 2000 | Oikos2000，91，1： | 1 |
| 9 | The influ- ence of functional diversity and composition on ecosystem processes 显示文摘 | Tilman D Johannes knops David wedin | 1997 | Science1997，277，29： | 1 |
| 10 | Carbon and nitrogen cycling during old-field succession: Constraints on plant and microbial biomass显示文摘 | Donald R. Zak David F. Grigal Scott Gleeson David Tilman | 1990 | Biogeochemistry1990，，2： | 1 |
| 11 | Beneficial Biofuels-The Food, Energy, and Environment Trilemma显示文摘 | David Tilman Robert Socolow etal | 2009 | SCIENCE2009，，325： | 1 |
| 12 | Land clearing and the biofuel carbon debt显示文摘 | Joseph Fargione Jason Hill David Tilman | 2008 | Science2008，319，5867： | 1 |
| 13 | Environmental, economic, and energetic costs and benefits of biodiesel and ethanol biofuels显示文摘 | Jason Hill Erik Nelson David Tilman | 2006 | Proceedings of the National Academy of Sciences of the United States of America2006，103，11： | 1 |
| 14 | Dynamic and static views of succession: Testing the descriptive power of the chronosequence approach显示文摘 | Bryan L. Foster David Tilman | 2000 | Plant Ecology2000，，1： | 1 |
| 15 | Global food de- mand and the sustainable intensification of agriculture显示文摘 | David Tilman Christian Balzer Jason Hill | 2011 | PNAS2011，108，20： | 1 |
| 16 | 生态学的试验方法——强度和概念性问题显示文摘生态学的研究需要综合方法.即观察性的、实验性的、理论性的方法。本文讨论了生态学实验方法的必要性和可行性,井比较了短期实验和长期实验的利弊。本文讨论了田间实验的概念性问题、间接作用问题、环境变化、综合稳定平衡和立地历史等. | David Tilman 王向宏 | 1992 | 国土与自然资源研究1992，，S1： | 0 |
| 17 | Evaluation of different crosslinking methods in altering the properties of extrusion-printed chitosan-basedmulti-material hydrogel composites显示文摘Three-dimensional printing technologies exhibit tremendous potential in the advancing fields of tissue engineering and regenerative medicine due to the precise spatial control over depositing the biomaterial.Despite their widespread utilization and numerous advantages,the development of suitable novel biomaterials for extrusion-based 3D printing of scaffolds that support cell attachment,proliferation,and vascularization remains a challenge.Multi-material composite hydrogels present incredible potential in this field.Thus,in this work,a multi-material composite hydrogel with a promising formulation of chitosan/gelatin functionalized with egg white was developed,which provides good printability and shape fidelity.In addition,a series of comparative analyses of different crosslinking agents and processes based on tripolyphosphate(TPP),genipin(GP),and glutaraldehyde(GTA)were investigated and compared to select the ideal crosslinking strategy to enhance the physicochemical and biological properties of the fabricated scaffolds.All of the results indicate that the composite hydrogel and the resulting scaffolds utilizing TPP crosslinking have great potential in tissue engineering,especially for supporting neo-vessel growth into the scaffold and promoting angiogenesis within engineered tissues. | Suihong Liu Haiguang Zhang Tilman Ahlfeld David Kilian Yakui Liu Michael Gelinsky Qingxi Hu | 2023 | Bio-Design and Manufacturing2023，6，2： | 0 |
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