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| 1 | Xylanase, protease and superdosing phytase interactions in broiler performance, carcass yield and digesta transit time显示文摘The interaction of xylanase, protease and superdosing(1,500 FTU/kg) phytase in a 2×2×2 factorial arrangement was studied in broilers fed sorghum-based diets. A total of 2,800 one-day-old unsexed Ross308 chicks were housed in 56 pens with 50 birds per pen, with or without inclusion of xylanase, protease and phytase, totaling 8 treatments and 7 replicates per treatment. Body weight(BW) and feed intake(FI)were measured at 21 and 42 days of age, and mortality corrected feed conversion ratio(FCR) was calculated for each period and cumulatively. Tibia ash and carcass yield were determined in 2 birds per replicate at 21 and 42 days of age, respectively. Digesta transit time was determined at 21, 28, 35 and 42 days of age using 5 birds per replicate. Results showed that superdosing phytase increased BW and FI at42 days of age(P < 0.05) and xylanase improved FCR(P < 0.05). Xylanase and phytase also positively influenced carcass yield and breast weight, respectively. Overall, inclusion of superdosing phytase increased transit time when included in a diet containing xylanase, and no change with protease inclusion. In conclusion, the beneficial effects of xylanase, protease and superdosing phytase in broiler performance were not additive. This limitation is likely not related to the lack of efficacy of any one of the individual enzymes but to a limitation of the bird to respond additively to successive additions of enzymes. | Tiago T.dos Santos Helen V.Masey O'Neill Gemma González-Ortiz Daniel Camacho-Fernández Carlos López-Coello | 2017 | Animal Nutrition2017，，2： | 2 |
| 2 | Income-based environmental responsibility显示文摘 | Alexandra Marques Jo?o Rodrigues Manfred Lenzen Tiago Domingos | 2012 | Ecological Economics2012，，： | 1 |
| 3 | Exhaled nitric oxide levels and blood eosinophil counts independently associate with wheeze and asthma events in National Health and Nutrition Examination Survey subjects显示文摘 | Andrei Malinovschi Jo?o A. Fonseca Tiago Jacinto Kjell Alving Christer Janson | 2013 | The Journal of Allergy and Clinical Immunology2013，，4： | 1 |
| 4 | Control of stomatal aperture and carbon uptake by deficit irrigation in two grapevine cultivars显示文摘 | Claudia R. de Souza Jo?o P. Maroco Tiago P. dos Santos M. Lucília Rodrigues Carlos Lopes Jo?o S. Pereira M. Manuela Chaves | 2004 | Agriculture Ecosystems and Environment2004，，2： | 1 |
| 5 | Transvesical thoracoscopy: A natural orifice translumenal endoscopic approach for thoracic surgery显示文摘 | Estêv?o Lima Tiago Henriques-Coelho Carla Rolanda José M. Pêgo David Silva José L. Carvalho Jorge Correia-Pinto | 2007 | Surgical Endoscopy2007，，6： | 1 |
| 6 | Mechanical properties of adobe bricks in ancient constructions显示文摘 | Dora Silveira Humberto Varum Aníbal Costa Tiago Martins Henrique Pereira Jo?o Almeida | 2011 | Construction and Building Materials2011，，1： | 1 |
| 7 | Designing an indicator of environmental responsibility显示文摘 | Jo?o Rodrigues Tiago Domingos Stefan Giljum Fran?ois Schneider | 2005 | Ecological Economics2005，，3： | 1 |
| 8 | Direct-acting antivirals for chronic hepatitis C treatment: The experience of two tertiary university centers in Brazil显示文摘BACKGROUND Hepatitis C virus(HCV)treatment has undergone major changes in recent years.Previous interferon-based therapies have been replaced by oral direct-acting antivirals(DAA)regimens,with high sustained virologic response(SVR)rates,and a lower incidence of adverse events(AEs).AIM To evaluate the efficacy and safety of DAAs for HCV treatment in subjects from two tertiary university centers in Brazil.METHODS This is a multicenter retrospective cohort study of 532 patients with chronic hepatitis C(CHC),undergoing treatment with interferon-free regimens from November 2015 to November 2019.The therapeutic regimen was defined by the current Brazilian guidelines for HCV management at the time of treatment.Demographic,anthropometric,clinical,and laboratory variables were evaluated.SVRs were assessed at 12 to 24 wk after therapy by intention-to-treat(ITT),and modified ITT(m-ITT)analysis.AEs and serious adverse events(SAEs)were registered.In the statistical analysis,a P value of<0.05 was considered significant.RESULTS The mean age was 56.88 years,with 415(78.5%)being HCV genotype 1,followed by genotype 3(20.1%).Moreover,306(57.5%)subjects had cirrhosis,and a third of them had decompensated cirrhosis.Sofosbuvir(SOF)plus daclatasvir±ribavirin was the most frequently used treatment(66.9%),followed by SOF plus simeprevir(21.2%).The overall ITT SVR was 92.6%(493/532),while the m-ITT SVR was 96.8%(493/509).Variables associated with treatment failure via ITT evaluation were hepatic encephalopathy(OR:4.320;95%CI:1.920-9.721,P=0.0004),presence of esophageal varices(OR:2.381;95%CI:1.137-4.988,P=0.0215),previous portal hypertensive bleeding(OR:2.756;95%CI:1.173-6.471,P=0.02),higher model for end-stage liver disease scores(OR:1.143,95%CI:1.060–1.233,P=0.0005),lower serum albumin levels(OR:0.528,95%CI:0.322-0.867,P=0.0115),higher serum creatinine(OR:1.117,95%CI:1.056-1.312,P=0.0033),and international normalized ratio(INR)levels(OR:5.542,95%CI:2.023-15.182,P=0.0009).AEs were reported in 41.1%(211/514)of patients,and SAEs in 3.7%.The female gender,higher body mass index,esophageal varices,higher INR values,and longer treatment duration were independently associated with AE occurrence.CONCLUSION Treatment with oral DAAs attains a high SVR rate,with fewer SAEs in a real-life cohort of subjects with CHC,from two tertiary university centers in Brazil. | Mariana Sandoval Lourenço Patricia Momoyo Y Zitelli Marlone Cunha-Silva Arthur Ivan N Oliveira Cláudia P Oliveira Tiago Sevá-Pereira Flair JoséCarrilho Mario G Pessoa Daniel F Mazo | 2022 | World Journal of Hepatology2022，14，1： | 1 |
| 9 | Extending the understanding of mobile banking adoption:When UTAUT meets TTF and ITM显示文摘 | Tiago O Miguel F Manoj A T | 2014 | International Journal of Information Management2014，34，： | 1 |
| 10 | The explanatory power of symbolic similarity in case-based reasoning显示文摘 | Enric Plaza Eva Armengol San Tiago O | 2005 | Artificial Intelligence Review2005，24，： | 1 |
| 11 | Acute Improvement in Insulin Resistance After Laparoscopic Roux-en-Y Gastric Bypass: Is 3 Days Enough to Correct Insulin Metabolism?显示文摘 | Gil Faria John Preto Eduardo Lima Costa Jo?o Tiago Guimar?es Concei??o Calhau António Taveira-Gomes | 2013 | Obesity Surgery2013，，1： | 1 |
| 12 | Is It Possible to Predict the Presence of Intestinal Angioectasias?显示文摘 | Tiago Cúrdia Gon?alves Joana Magalh?es Pedro Boal Carvalho Maria Jo?o Moreira Bruno Rosa José Cotter Spiros D. Ladas | 2014 | Diagnostic and Therapeutic Endoscopy2014，，： | 1 |
| 13 | Aerobic exercise reduces oxidative stress and improves vascular changes of small mesenteric and coronary arteries in hypertension显示文摘 | Fernanda R Roque Ana M Briones Ana B García‐Redondo María Galán Sonia Martínez‐Revelles Maria S Avenda?o Victoria Cachofeiro Tiago Fernandes Dalton V Vassallo Edilamar M Oliveira Mercedes Salaices | 2013 | Br J Pharmacol2013，，3： | 1 |
| 14 | Association between the C3435T single-nucleotide polymorphism of multidrugresistance 1 gene and risk of gastric cancer显示文摘 | Juliana Oliveira Aledson Felipe Paula Chang Celia Pimenta Tiago Silva Jo?o Massud Nora Forones | 2012 | Molecular Medicine Reports2012，，2： | 1 |
| 15 | Use of hybrid chitosan membranes and human mesenchymal stem cells from the Wharton jelly of umbilical cord for promoting nerve regeneration in an axonotmesis rat model显示文摘Many studies have been dedicated to the development of scaffolds for improving post-traumatic nerve regeneration. The goal of this study was to assess the effect on nerve regeneration, associating a hybrid chitosan membrane with non-differentiated human mesenchymal stem cells isolated from Wharton's jelly of umbilical cord, in peripheral nerve reconstruction after crush injury. Chromosome analysis on human mesenchymal stem cell line from Wharton's jelly was carried out and no structural alterations were found in metaphase. Chitosan membranes were previously tested in vitro, to assess their ability in supporting human mesenchymal stem cell survival, expansion, and differentiation. For the in vivo testing, Sasco Sprague adult rats were divided in 4 groups of 6 or 7 animals each:Group 1, sciatic axonotmesis injury without any other intervention (Group 1-Crush); Group 2, the axonotmesis lesion of 3 mm was infiltrated with a suspension of 1 250-1 500 human mesenchymal stem cells (total volume of 50 μL) (Group 2-CrushCell); Group 3, axonotmesis lesion of 3 mm was enwrapped with a chitosan type III membrane covered with a monolayer of non-differentiated human mesenchymal stem cells (Group 3-CrushChitIIICell) and Group 4, axonotmesis lesion of 3 mm was enwrapped with a chitosan type III membrane (Group 4-CrushChitIII). Motor and sensory functional recovery was evaluated throughout a healing period of 12 weeks using sciatic functional index, static sciatic index, extensor postural thrust, and withdrawal reflex latency. Stereological analysis was carried out on regenerated nerve fibers. Results showed that infiltration of human mesenchymal stem cells, or the combination of chitosan membrane enwrapment and human mesenchymal stem cell enrichment after nerve crush injury provide a slight advantage to post-traumatic nerve regeneration. Results obtained with chitosan type III membrane alone confirmed that they significantly improve post-traumatic axonal regrowth and may represent a very promising clinical tool in peripheral nerve reconstructive surgery. Yet, umbilical cord human mesenchymal stem cells, that can be expanded in culture and induced toform several different types of cells, may prove, in future experiments, to be a new source of cells for cell therapy, including targets such as peripheral nerve and muscle. | Andrea Gärtner Tiago Pereira Maria Joāo Simōes Paulo AS Armada-da-Silva Miguel L França Rosa Sousa Simone Bompasso Stefania Raimondo Yuki Shirosaki Yuri Nakamura Satoshi Hayakawa Akiyoshi Osakah Beatriz Porto Ana Lúcia Luís Artur SP Varejāo Ana Colette Maurício | 2012 | Neural Regeneration Research2012，7，29： | 1 |
| 16 | Consumer and producer environmental responsibility: Comparing two approaches显示文摘 | Jo?o Rodrigues Tiago Domingos | 2007 | Ecological Economics2007，，2： | 1 |
| 17 | Antioxidant activity of methanolic extract of Bombax ceiba 显示文摘 | Tiago O V Ataa S Elsayed A | 2009 | Redox Rep2009，，14： | 1 |
| 18 | Epigenetic regulation of TP53 is involved in prostate cancer radioresistance and DNA damage response signaling显示文摘External beam radiotherapy(RT)is a leading first-line therapy for prostate cancer(PCa),and,in recent years,significant advances have been accomplished.However,RT resistance can arise and result in long-term recurrence or disease progression in the worst-case scenario.Thus,making crucial the discovery of new targets for PCa radiosensitization.Herein,we generated a radioresistant PCa cell line,and found p53 to be highly expressed in radioresistant PCa cells,as well as in PCa patients with recurrent/disease progression submitted to RT.Mechanism dissection revealed that RT could promote p53 expression via epigenetic modulation.Specifically,a decrease of H3K27me3 occupancy at TP53 gene promoter,due to increased KDM6B activity,was observed in radioresistant PCa cells.Furthermore,p53 is essential for efficient DNA damage signaling response and cell recovery upon stress induction by prolonged fractionated irradiation.Remarkably,KDM6B inhibition by GSK-J4 significantly decreased p53 expression,consequently attenuating the radioresistant phenotype of PCa cells and hampering in vivo 3D tumor formation.Overall,this work contributes to improve the understanding of p53 as a mediator of signaling transduction in DNA damage repair,as well as the impact of epigenetic targeting for PCa radiosensitization. | Catarina Macedo-Silva Vera Miranda-Gonçalves Nuno Tiago Tavares Daniela Barros-Silva Joana Lencart João Lobo Ângelo Oliveira Margareta PCorreia Lucia Altucci Carmen Jerónimo | 2023 | Signal Transduction and Targeted Therapy2023，8，11： | 0 |
| 19 | Uncovering the uncertainty: Risk factors and clinical relevance of P1 lesions on small bowel capsule endoscopy of anemic patients显示文摘AIM To identify risk factors for P1 lesions on small bowel capsule endoscopy(SBCE) and to describe the natural history of anemic patients with such type of lesions.METHODS One hundred patients were consecutively selected for a case-control analysis performed between 37 cases with P1 lesions and 63 controls with negative SBCE. Age, gender, comorbidities and regular medication were collected. Rebleeding, further investigational studies and death were also analyzed during the follow-up.RESULTS No significant differences on gender, median age or Charlson index were found between groups. Although no differences were found on the use of proton pump inhibitors, acetylsalicylic acid, anticoagulants or antiplatelet agents, the use of non-steroidal antiinflammatory drugs(NSAID) was associated with a higher risk of P1 lesions(OR = 12.00, 95%CI: 1.38-104.1). From the 87 patients followed at our center, 39 were submitted to additional studies for investigation of iron-deficiency anemia(IDA), and this was significantly more common in those patients with no findings on SBCE(53.7% vs 30.3%, P = 0.033). A total of 29 patients had at least one rebleeding or IDA recurrence episode and 9 patients died of non-anemia related causes but no differences were found between cases and controls.CONCLUSION P1 lesions are commonly found in patients with IDA submitted to SBCE. The use of NSAID seems to be a risk factor for P1 lesions. The outcomes of patients with P1 lesions do not differ significantly from those with P0 lesions or normal SBCE. | Tiago Cúrdia Gon?alves Mara Barbosa Bruno Rosa Maria Jo?o Moreira José Cotter | 2016 | World Journal of Gastroenterology2016，22，38： | 0 |
| 20 | Vertical stratification of bat assemblages in flooded and unflooded Amazonian forests显示文摘Tropical rainforests usually have multiple strata that results in a vertical stratification of ecological opportunities foranimals. We investigated if this stratification influences the way bats use the vertical space in flooded and unflooded forests of theCentral Amazon. Using mist-nets set in the canopy (17 to 35 m high) and in the understorey (0 to 3 m high) we sampled four sitesin upland unflooded forests (terra firme), three in forests seasonally flooded by nutrient-rich water (varzea), and three in forestsseasonally flooded by nutrient-poor water (igapo). Using rarefaction curves we found that species richness in the understorey andcanopy were very similar. An ordination analysis clearly separated the bat assemblages of the canopy from those of the understorey inboth flooded and unflooded habitats. Gleaning carnivores were clearly associated with the understorey, whereas frugivores wereabundant in both strata. Of the frugivores, Carollinae and some Stenodermatinae were understorey specialists, but several Stenodermatinaemostly used the canopy. The first group mainly includes species that, in general, feed on fruits of understorey shrubs,whereas the second group feed on figs and other canopy fruits. We conclude that vertical stratification in bat communities occurseven within forests with lower canopy heights, such as Amazonian seasonally flooded forests, and that the vertical distribution ofbat species is closely related to their diet and foraging behaviour. | Maria Joo Ramos PEREIRA Joo Tiago MARQUES Jorge M.PALMEIRIM | 2010 | Current Zoology2010，56，4： | 0 |
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