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| 1 | N-Acetyltransferase 2 genetic polymorphisms and risk of colorectal cancer显示文摘AIM:To investigate the possible association between meat intake,cigarette smoking and N-acetyltransferase 2 (NAT2) genetic polymorphisms on colorectal cancer (CRC) risk.METHODS:Patients with CRC were matched for gender and age to healthy controls.Meat intake and cigarette smoking were assessed using a specific frequency questionnaire.DNA was extracted from peripheral blood and the genotypes of the polymorphism were assessed by polymerase chain reaction-restriction fragment length polymorphism.Five NAT2 alleles were studied (WT,M1,M2,M3 and M4) using specific digestion enzymes.RESULTS:A total of 147 patients with colorectal cancer (76 women and 90 men with colon cancer) and 212 controls were studied.The mean age of the two groups was 62 years.More than half the subjects (59.8% in the case group and 51.9% in the control group) were NAT2 slow acetylators.The odds ratio for colorectal cancer was 1.38 (95% CI:0.90-2.12) in slow acetylators.Although the number of women was small (n=76 in the case group),the cancer risk was found to be lower in intermediate (W/Mx) acetylators [odds ratio (OR):0.55,95% confidence interval (95% CI):0.29-1.02].This difference was not observed in men (OR:0.56,95% CI:0.16-2.00).Among NAT2 fast acetylators (W/W or W/Mx),meat consumption more than 3 times a week increased the risk of colorectal cancer (OR:2.05,95% CI:1.01-4.16).In contrast,cigarette smoking increased the risk of CRC among slow acetylators (OR:1.97,95% CI:1.02-3.79).CONCLUSION:The risk of CRC was higher among fast acetylators who reported a higher meat intake.Slow NAT2 acetylation was associated with an increased risk of CRC. | Tiago Donizetti da Silva Aledson Vitor Felipe Jacqueline Miranda de Lima Celina Tizuko Fujiyama Oshima Nora Manoukian Forones | 2011 | World Journal of Gastroenterology2011，17，6： | 3 |
| 2 | Ki-67 as a prognostic marker in colorectal cancer but not in gastric cancer显示文摘 | Oshima CT Iriya K Forones NM | 2005 | Neoplasma2005，52，5： | 1 |
| 3 | Ki-67 as a prognostic marker in colorectal cancer but not in gastric cancer显示文摘 | Oshima C Iriya A Forones NM | 2005 | Neoplasma2005，52，5： | 1 |
| 4 | Cyclin D1G870A polymorphism in Brazilian Colorectal Cancer Patients显示文摘 | Forones N M Lima JMd Souza LG d etal | 2008 | J Gastrointest Canc2008，39，14： | 1 |
| 5 | Serum levels of interleukin - z and tumour necrosis factor - alpha correlate to tumor progression in gastric cancer 显示文摘 | Forones NM Mandowsky SV Lourenco LG | 2001 | Hepatogastroenterology2001，48，40： | 1 |
| 6 | Ki - 67 as a prognostic marker in colorectal cancer but not in gastric cancer 显示文摘 | Oshima CT Iriya K Forones NM | 2005 | Neoplasma2005，52，5： | 1 |
| 7 | Cell proliferation and apoptosis in gastric cancer and intestinal metaplasis显示文摘 | Forones NM Carvalho AP Giannotti-Filho O | 2005 | Arq Gastroenterol2005，42，1： | 1 |
| 8 | Ki-67 as a prognostic marker in colorectal cancer but not in gastric cancer显示文摘 | Oshima CT Iriya K Forones NM | 2005 | Neoplasma2005，52，5： | 1 |
| 9 | Correlation analysis of c-myc, p21WAF/CIP1, p53, C-erbB-2 and COX-2 proteins in esophageal squamous cell carcinoma 显示文摘 | Gomes TS Noguti J Forones NM | 2013 | Pathol Res Pract2013，209，1： | 1 |
| 10 | MMR deficiency may lead to a high immunogenicity and then an improvement in anti-PD‐1 efficacy for metastatic colorectal cancer显示文摘 | Pedro Nazareth Aguiar Hakaru Tadokoro Nora Manoukian Forones Ramon Andrade de Mello | 2015 | Immunotherapy2015，，0： | 1 |
| 11 | Determination of proliferative activity using ki67 and expression of p53 in colorectal cancer 显示文摘 | Forones NM Oshima C Nanogaki S | 1999 | Arq Gastroenterol1999，36，： | 1 |
| 12 | Determination of proliferative activity using Ki - 67 and expression of p53 in colorectal cancer显示文摘 | Forones NM Oshima C Nanogaki S | 1999 | Arg Gastroenterol1999，36，3： | 1 |
| 13 | Immunoexpression of cyclooxygenase-1 and -2 in ulcerative colitis 显示文摘 | Paiotti A P Artigiani N R Forones N M | 2007 | Brazil Journal of Medicine Biology Research2007，40，： | 1 |
| 14 | Ki-67 as a prognostic marker in colorectal cancer but not in gastric cancer显示文摘 | OSHIMA C T IRIYA K FORONES N M | 2005 | Neoplasma2005，52，5： | 1 |
| 15 | CEA and CA19-9 as prognostic indexes in colorectal cancer显示文摘 | Forones NM Tanaka M | | 0，，26： | 1 |
| 16 | Laminin concentration in ascites of patients with hepatic cirrhosis and peritoneal carcinomatosis 显示文摘 | Catarino RM Lopes JD Forones NM | 2005 | Braz J Med Biol Res2005，38，2： | 1 |
| 17 | Depression and anxiety in colorectal cancer patients 显示文摘 | Medeiros M Oshima CT Forones N M | 2010 | J Gastrointest Cancer2010，41，3： | 1 |
| 18 | Ki67 as a prognostic marker in colorectal cancer but not in gastric cancer显示文摘 | Oshima CT Iriya K Forones NM | 2005 | Neoplasma2005，52，5： | 1 |
| 19 | Determination of proliferative activity using Ki67 and expression of P53 in colorectal cancer显示文摘 | Forones NM Oshima C Nanogaki S | 1999 | Arq Gastroenterol1999，36，： | 1 |
| 20 | Ki-67 as a prognostic marker in colo-rectal cancer but not in gastric cancer 显示文摘 | Oshima CTJriya K Forones NM | 2005 | Neoplasma2005，52，5： | 1 |
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