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| 1 | Estimating steatosis and fibrosis: Comparison of acoustic structure quantification with established techniques显示文摘AIM:To compare ultrasound-based acoustic structure quantification(ASQ) with established non-invasive techniques for grading and staging fatty liver disease.METHODS:Type 2 diabetic patients at risk of nonalcoholic fatty liver disease(n = 50) and healthy volunteers(n = 20) were evaluated using laboratory analysis and anthropometric measurements, transient elastography(TE), controlled attenuation parameter(CAP), proton magnetic resonance spectroscopy(1H-MRS; only available for the diabetic cohort), and ASQ.ASQ parameters mode, average and focal disturbance(FD) ratio were compared with:(1) the extent of liver fibrosis estimated from TE and nonalcoholic fatty liver disease(NAFLD) fibrosis scores; and(2) the amount of steatosis, which was classified according to CAP values.RESULTS:Forty-seven diabetic patients(age 67.0±8.6 years;body mass index 29.4±4.5 kg/m2)with reliable CAP measurements and all controls(age 26.5±3.2 years;body mass index 22.0±2.7 kg/m2)were included in the analysis.All ASQ parameters showed differences between healthy controls and diabetic patients(P<0.001,respectively).The ASQ FD ratio(logarithmic)correlated with the CAP(r=-0.81,P<0.001)and 1H-MRS(r=-0.43,P=0.004)results.The FD ratio[CAP<250 d B/m:107(102-109),CAP between 250 and 300 d B/m:106(102-114);CAP between 300 and 350 d B/m:105(100-112),CAP≥350 d B/m:102(99-108)]as well as mode and average parameters,were reduced in cases with advanced steatosis(ANOVA P<0.05).However,none of the ASQ parameters showed a significant difference in patients with advanced fibrosis,as determined by TE and the NAFLD fibrosis score(P>0.08,respectively).CONCLUSION:ASQ parameters correlate with steatosis,but not with fibrosis in fatty liver disease.Steatosis estimation with ASQ should be further evaluated in biopsy-controlled studies. | Thomas Karlas Joachim Berger Nikita Garnov Franziska Lindner Harald Busse Nicolas Linder Alexander Schaudinn Bettina Relke Rima Chakaroun Michael Trltzsch Johannes Wiegand Volker Keim | 2015 | World Journal of Gastroenterology2015，21，16： | 9 |
| 2 | Acoustic radiation force impulse imaging (ARFI) for non-invasive detection of liver fibrosis: examination standards and evaluation of interlobe differences in healthy subjects and chronic liver disease显示文摘 | Thomas Karlas Cornelia Pfrepper Johannes Wiegand Christian Wittekind Marie Neuschulz Joachim M?ssner Thomas Berg Michael Tr?ltzsch Volker Keim | 2011 | Scandinavian Journal of Gastroenterology2011，，12： | 4 |
| 3 | Non-invasive evaluation of hepatic manifestation in Wilson disease with transient elastography, ARFI, and different fibrosis scores显示文摘 | Thomas Karlas Maria Hempel Michael Tr?ltzsch Dominik Huster Peter Günther Hannelore Tenckhoff Joachim M?ssner Thomas Berg Volker Keim Johannes Wiegand | 2012 | Scandinavian Journal of Gastroenterology2012，，11： | 2 |
| 4 | The Yersinia Ser/Thr protein kinase YpkA/YopO directly interacts with the small GTPases RhoA and Rac-1显示文摘 | Corinna Barz Thomas N Abahji Konrad Trülzsch Jürgen Heesemann | 2000 | FEBS Letters2000，，： | 1 |
| 5 | Tackling antibiotic resistance显示文摘 | Bush K Courvalin P Dantas G Davies J Eisenstein B Huovinen P Jacoby GA Kishony R Kreiswirth BN Kutter E Lerner SA Levy S Lewis K Lomovskaya O Miller JH Mobashery S Piddock LJ Projan S Thomas CM Tomasz A Tulkens PM Walsh TR Watson JD Witkowski J Witte W Wr | | 0，，： | 1 |
| 6 | Constraint-dependent twin variant distribution in Ni 2 MnGa single crystal, polycrystals and thin film: An EBSD study显示文摘 | N. Scheerbaum Y.W. Lai T. Leisegang M. Thomas J. Liu K. Khlopkov J. McCord S. F?hler R. Tr?ger D.C. Meyer L. Schultz O. Gutfleisch | 2010 | Acta Materialia2010，，14： | 1 |
| 7 | Elidernoilogie assessment of chronic atrial fibrillation and risk of stroke: The Framingham study显示文摘 | Wolf PA Dawber TR Thomas HE | 1978 | Neurology1978，28，： | 1 |
| 8 | Collagen gene expression in rat left ventri- cle: interactive effect of age and exercise training 显示文摘 | Thomas DP Zimmerman SD Hansen TR | 2000 | J Appl Physiol2000，89，4： | 1 |
| 9 | Epidemiologic assessment of chronic atrial fibrillation and risk of stroke:the Framingham study显示文摘 | Wolf PA Dawber TR Thomas HE Jr | | 0，，： | 1 |
| 10 | Gait analysis and functional outcomes following ankle arthrodesis for isolated ankle arthritis显示文摘 | THOMAS R DANIELS TR PARKER K | 2006 | J Bone Joint Surg Am2006，88，3： | 1 |
| 11 | Successful treatment of extensively drug-resistant Pseudomonas aeruginosa osteomyelitis using a colistin- and tobramycin-impregnated PMMA spacer显示文摘 | Jochen Krajewski Stefanie M. Bode-B?ger Uwe Tr?ger Jens Martens-Lobenhoffer Thomas Mulrooney Hagen Mittelst?dt Martin Russlies Rainer Kirchner Johannes K.-M. Knobloch | 2014 | International Journal of Antimicrobial Agents2014，，： | 1 |
| 12 | How long should patients take medications for postmenopausal osteoporosis显示文摘 | Briot K Trémollières F Thomas T | 2007 | Joint Bone Spine2007，74，1： | 1 |
| 13 | Protective effects of a cyclic nitrone antioxidant in animal models of endotoxic shock and chronic bacteremia显示文摘 | French JF Thomas CE Downs TR | 1994 | Cric Shock1994，43，： | 1 |
| 14 | Ankle arthritis显示文摘 | Thomas RH Daniels TR | 2003 | J Bone Joint Surg Am2003，85，5： | 1 |
| 15 | Functional analysis of TRAIL recepters using monoclonal antibodies显示文摘 | Thoma SG Charles TR Pam JS | 1999 | J Immunol1999，162，： | 1 |
| 16 | Effects of omega-3 fatty acid supplementation and exercise on low-density lipoprotein and high-density lipoprotein subfractions 显示文摘 | Thomas TR Smith BK Donahue OM | 2004 | Metabolism2004，53，6： | 1 |
| 17 | Metabolic responses as- sociated with four modes of prolonged exercise显示文摘 | Thomas TR Feiock CW Araujo J | 1989 | Journal of Sports Medicine and Physical Fitness1989，29，1： | 1 |
| 18 | Gaitanalysis and functional outcomes following ankle arthrodesis for isolated ankle arthritis 显示文摘 | Thomas R Daniels TR Parker K | 2006 | J Bone Joint Surg Am2006，88，： | 1 |
| 19 | Functional outcome of the foot and ankle after free fibular graft显示文摘 | Daniels TR Thomas R Bell TH | 2005 | Foot Ankle Int2005，26，8： | 1 |
| 20 | Epidemiologic assessment of chronic atrial fibrillation and risk of stroke: the Framingham Study显示文摘 | Wolf PA Dawber TR Thomas HE Jr | 1978 | Neurology1978，28，10： | 1 |
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