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您的检索式：作者名="Thomas Kingsley"
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| 1 | Role of gut microbiota in cardiovascular diseases显示文摘The human gut is colonized by a community of microbiota,primarily bacteria,that exist in a symbiotic relationship with the host.Intestinal microbiota-host interactions play a critical role in the regulation of human physiology.Deleterious changes to the composition of gut microbiota,referred to as gut dysbiosis,has been linked to the development and progression of numerous diseases,including cardiovascular disease(CVD).Imbalances in host-microbial interaction impair homeostatic mechanisms that regulate health and can activate multiple pathways leading to CVD risk factor progression.Most CVD risk factors,including aging,obesity,dietary patterns,and a sedentary lifestyle,have been shown to induce gut dysbiosis.Dysbiosis is associated with intestinal inflammation and reduced integrity of the gut barrier,which in turn increases circulating levels of bacterial structural components and microbial metabolites,including trimethylamine-N-oxide and short-chain fatty acids,that may facilitate the development of CVD.This article reviews the normal function and composition of the gut microbiome,mechanisms leading to the leaky gut syndrome,its mechanistic link to CVD and potential novel therapeutic approaches aimed towards restoring gut microbiome and CVD prevention.As CVD is the leading cause of deaths globally,investigating the gut microbiota as a locus of intervention presents a novel and clinically relevant avenue for future research. | Marko Novakovic Amit Rout Thomas Kingsley Robert Kirchoff Amteshwar Singh Vipin Verma Ravi Kant Rahul Chaudhary | 2020 | World Journal of Cardiology2020，12，4： | 6 |
| 2 | ChIP ‐seq and transcriptome analysis of the OmpR regulon of S almonella enterica serovars T yphi and T yphimurium reveals accessory genes implicated in host colonization显示文摘 | Timothy T. Perkins Mark R. Davies Elizabeth J. Klemm Gary Rowley Thomas Wileman Keith James Thomas Keane Duncan Maskell Jay C. D. Hinton Gordon Dougan Robert A. Kingsley | 2012 | Molecular Microbiology2012，，3： | 1 |
| 3 | Reliability of individual valuations of public and private goods: Choice consistency, response time, and preference refinement显示文摘 | Thomas C. Brown David Kingsley George L. Peterson Nicholas E. Flores Andrea Clarke Andrej Birjulin | 2008 | Journal of Public Economics2008，，7： | 1 |
| 4 | Demystifying airline syncope显示文摘Syncope forms a major part of medical in-flight emergencies contributing one-infour in-flight medical events accounting to 70%of flight diversions.In such patients,it is important to elucidate the pathophysiology of syncope prior to diversion.Postural hypotension is the most common etiology of in-flight syncopal events.However,individuals without any underlying autonomic dysfunction can still experience syncope from hypoxia also known as airline syncope.Initial steps in managing such patients include positioning followed by the airway,breathing and circulation of resuscitation.These interventions need to be in close coordination with ground control to determine decision for flight diversion.Interventions which have been tried for prevention include mental challenge and increased salt and fluid intake.The current paper enhances the understanding of airline syncope by summarizing the associated pathophysiologic mechanisms and the management medical personnel can initiate with limited resources. | Thomas Kingsley Robert Kirchoff James S Newman Rahul Chaudhary | 2020 | World Journal of Cardiology2020，12，3： | 0 |
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