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6篇 您的检索式：作者名="Thomas Gutsmann"

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		题名	作者	年代	出处	被引量
	1	The physicochemistry of endotoxins in relation to bioactivity显示文摘	Thomas Gutsmann Andra B. Schromm Klaus Brandenburg	2007	International Journal of Medical Microbiology2007，，5：	2
	2	Towards antibaeterial strategies:studies on the mechanisms of interaction between antibacterial pep- tides and model membranes 显示文摘	Andre Wiese Thomas Gutsmann Ulrich Seydel	2003	Jumal of Endotaxin Research2003，9，2：	1
	3	The physicochemistry of endotoxins in relation to bioactivity显示文摘	Thomas Gutsmann Andra B. Schromm Klaus Brandenburg	2007	International Journal of Medical Microbiology2007，，5：	1
	4	Giant bent core mesogens in the thread forming process of marine mussels显示文摘	Tue Hassenkam Thomas Gutsmann Herbert Waite J	2004	Biomacromolecules2004，5，4：	1
	5	Towards antibaeterial strategies:studies on the mechanisms of interaction between antibacterial peptides and model membranes显示文摘	Thomas Gutsmann Ulrich Seydel	2003	Jurnal of Endotaxin Research2003，9，2：	1
	6	ADAM10 sheddase activation is controlled by cell membrane asymmetry显示文摘Dysregulation of the disintegrin-metalloproteinase ADAM10 may contribute to the development of diseases including tumorigenesis and Alzheimer's disease.The mechanisms underlying ADAM10 sheddase activation are incompletely understood.Here,we show that transient exposure of the negatively charged phospholipid phosphatidylserine(PS)is necessarily required.The soluble PS headgroup was found to act as competitive inhibitor of substrate cleavage.Overexpression of the Ca2+-dependent phospholipid scramblase Anoctamin-6(AN06)led to increased PS externalization and substrate release.Transfection with a constitutively active form of AN06 resulted in maximum sheddase activity in the absence of any stimulus.Calcium-dependent ADAM10 activation could not be induced in lymphocytes of patients with Scott syndrome harbouring a missense mutation in AN06.A putative PS-binding motif was identified in the conserved stalk region.Replacement of this motif resulted in strong reduction of sheddase activity.In conjunction with the recently described 3D structure of the ADAM10 extracellular domain,a model is advanced to explain how surface-exposed PS triggers ADAM 10 sheddase function.	Florian Bleibaum Anselm Sommer Martin Veit Bjorn Rabe Jorg Andra Karl Kunzelmann Christian Nehls Wilmar Correa Thomas Gutsmann Joachim Grotzinger Sucharit Bhakdi Karina Reiss	2019	Journal of Molecular Cell Biology2019，11，11：	0

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