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5篇 您的检索式:作者名="Martin Veit"
    题名 作者 年代 出处 被引量
1High-resolution CCD camera for industrial imaging显示文摘MARTIN G J BLESSINGER K V VEITS C 1901SPIE1901,,:1
2High-resolution CCD camera for industrial imaging显示文摘MARTIN G J BLESSINGER KV VEITS C 1901SPIE1901,,:1
3Aberrant social and cerebral responding in a competitive reaction time paradigm in criminal psychopaths显示文摘Ralf Veit Martin Lotze Sven Sewing Heiner Missenhardt Tilman Gaber Niels Birbaumer 2009Neuroimage2009,,4:1
4SOX2 amplification is a common event in squamous cell carcinomas of different organ sites显示文摘Sebastian Maier Theresia Wilbertz Martin Braun Veit Scheble Markus Reischl Ralf Mikut Roopika Menon Pavel Nikolov Karen Petersen Christine Beschorner Holger Moch Christoph Kakies Chris Protzel Jürgen Bauer Alex Soltermann Falko Fend Annette Staebler Claud 2011Human Pathology2011,,8:1
5ADAM10 sheddase activation is controlled by cell membrane asymmetry显示文摘Dysregulation of the disintegrin-metalloproteinase ADAM10 may contribute to the development of diseases including tumorigenesis and Alzheimer's disease.The mechanisms underlying ADAM10 sheddase activation are incompletely understood.Here,we show that transient exposure of the negatively charged phospholipid phosphatidylserine(PS)is necessarily required.The soluble PS headgroup was found to act as competitive inhibitor of substrate cleavage.Overexpression of the Ca2+-dependent phospholipid scramblase Anoctamin-6(AN06)led to increased PS externalization and substrate release.Transfection with a constitutively active form of AN06 resulted in maximum sheddase activity in the absence of any stimulus.Calcium-dependent ADAM10 activation could not be induced in lymphocytes of patients with Scott syndrome harbouring a missense mutation in AN06.A putative PS-binding motif was identified in the conserved stalk region.Replacement of this motif resulted in strong reduction of sheddase activity.In conjunction with the recently described 3D structure of the ADAM10 extracellular domain,a model is advanced to explain how surface-exposed PS triggers ADAM 10 sheddase function.Florian Bleibaum Anselm Sommer Martin Veit Bjorn Rabe Jorg Andra Karl Kunzelmann Christian Nehls Wilmar Correa Thomas Gutsmann Joachim Grotzinger Sucharit Bhakdi Karina Reiss 2019Journal of Molecular Cell Biology2019,11,11:0
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