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| 1 | Matrix metalloproteinases contribute to kidney fibrosis in chronic kidney diseases显示文摘Matrix metalloproteinases(MMPs) are members of the neutral proteinase family. They were previously thought to be anti-fibrotic because of their ability to degrade and remodel of extracellular matrix. However, recent studies have shown that MMPs are implicated in initiation and progression of kidney fibrosis through tubular cell epithelial–mesenchymal transition(EMT) as well as activation of resident fibroblasts, endothelial-mesenchymal transition(Endo MT) and pericyte-myofibroblast transdifferentiation. Interstitial macrophage infiltration has also been shown to correlate with the severity of kidney fibrosis in various chronic kidney diseases. MMPs secreted by macrophages, especially MMP-9, hasbeen shown by us to be profibrotic by induction of tubular cells EMT. EMT is mainly induced by transforming growth factor-β(TGF-β). However, MMP-9 was found by us and others to be up-regulated by TGF-β1 in kidney tubular epithelial cells and secreted by activated macrophages, resulting in EMT and ultimately kidney fibrosis. Therefore, MMP-9 may serve as a potential therapeutic target to prevent kidney fibrosis in chronic kidney disease. This review, by a particular focus on EMT, seeks to provide a comprehensive understanding of MMPs, especially MMP-9, in kidney fibrosis. | Hong Zhao Yanting Dong Xinrui Tian Thian Kui Tan Zhuola Liu Ye Zhao Yun Zhang David CH Harris Guoping Zheng | 2013 | World Journal of Nephrology2013，2，3： | 21 |
| 2 | Hydrodeoxygenation of Phenolic Model Compounds over MoS2 Catalysts with Different Structures显示文摘不同结构的几 MoS2 催化剂,准备了由在铵Keptamolyb日期( AHM )和铝 naphthenate ( MoNaph )的 situ 分解,并且由 MoS2 脱落( TDM ),被赌注描绘,X光检查衍射( XRD ),精力散X光检查( EDX )和传播电子显微镜学( TEM )。分析证明那 MoS2 结构依赖于准备过程。催化剂的活动被用在氢并且温度从 320 鈥 ? 70qC 的 2.8 MPa 操作的一个批压热器反应堆测量酚, 4-methylphenol 和 4-methoxyphenol 的 hydrodeoxygenation (HDO ) 决定。由比较变换,催化剂的反应顺序是:AHM > TDM-D > MoNaph > 热 > MoS2 粉末 > TDM-W。另外, HDO 变换上的反应温度的效果以可逆反应动力学的平衡被解释。为酉分的混合物的 HDO 的主要产品被煤气的层析 / 团 spectrometry (GC/MS ) 识别。结果证明产品分发和 HDO 选择与反应温度被相关。二条平行反应线路,直接 hydrogenolysis 和联合 hydrogenation-hydrogenolysis,被产品分发的分析证实。高温度为酚和 4-methoxyphenol 的 HDO 在加氢上赞成了 hydrogenolysis,而为 4-methylphenol 颠倒是真的。 | 杨运泉 罗和安 童刚生 Kevin J. Smith TYE Ching Thian | 2008 | Chinese Journal of Chemical Engineering2008，16，5： | 18 |
| 3 | Polymorphisms of MTHFR and susceptibility to oesophageal adenocarcinoma in a Caucasian United Kingdom population显示文摘AIM:To identify if methylene tetra-hydrofolatereductase(MTHFR)C677T polymorphisms are associated with oesophageal adenocarcnomas in a Caucasian population and to test whether folic acid and homocysteine levels are linked with cancer risk.METHODS:A case control study comprising of 58 non cancer and 48 cancer patients,MTHFR C667T genotyping was made and serum folate,homocysteine and vitamin B12 levels were made.Tumour stage,differentiation and survival was recorded.A P value of less than0.05 was taken to be significant.Theχ2 used to compare discrete variables and the Mantel-Cox was used to compare survival.A P value less than 0.05 was deemed to be significant.RESULTS:MTHFR polymorphisms is associated with an increased risk of several cancers.A link between MTHFR C677T polymorphisms and oesophageal squamous cell carcinoma and gastric cardia adenocarcinoma has been demonstrated in at risk Chinese populations.In a Western European population the role of the MTHFR gene has not previously been investigated in the setting of oesophageal adenocarcinoma.No association between folic acid levels and cancer patients was found.The unstable MTHFR 667 TT genotype occurred in 11%cancers and 7%controls,but statistical significance was not reached,homocysteine levels and folic acid levels were not affected,cancer patients with TT genotype displayed a trend for a shorter survival 7 mo vs 20 mo.Serum vitamin B12 levels were higher in the cancer group.The MTHFR 667 TT genotype is much lower than previous population studies.CONCLUSION:We conclude that serum folic acid and MTHFR polymorphisms are not associated with an increased risk of oesophageal adenocarcinoma,although cancers with unstable TT genotype may indicate a more aggressive disease course. | Richard Keld Manyi Thian Chia Hau Jamil Sajid Narveen Kumar Yeng Ang | 2014 | World Journal of Gastroenterology2014，20，34： | 8 |
| 4 | Reducing Vulnerability of Water Resources of Canadian Prairies to Potential Droughts and Possible Climatic Warming显示文摘 | Thian Yew Gan | 2000 | Water Resources Management2000，，2： | 2 |
| 5 | Effects of debinding parameters on powder injection molded Ti-6Al-4V/HA composite parts显示文摘 | Thian E S | 2001 | Advanced Powder Technol2001，12，3： | 1 |
| 6 | The response of osteoblasts to nanoerystalline silicon -substituted hydroxyapatite thin films 显示文摘 | Thian ES Huang J Best SM | 2006 | Biomaterials2006，27，13： | 1 |
| 7 | Effects of debinding parameters on powder injection molded Ti-6Al-4V/HA composite parts显示文摘 | E.S. Thian N.H. Loh K.A. Khor S.B. Tor | 2001 | Advanced Powder Technology2001，，3： | 1 |
| 8 | Atypical enhencement pattern of hepatocellular carcinoma with portal vein thrombosis on multiphasic CT显示文摘 | Yee Liang Thian Albert SC Low Pierce KH Chow | 2011 | Ann Acad Med Singapore2011，40，： | 1 |
| 9 | Influence of nanohydroxyapatite patterns deposited by electrohydrodynamic spraying on osteoblast response显示文摘 | Thian ES Huang J Ahmad Z | | 0，，01： | 1 |
| 10 | Analysis and design of class-E3F and transmission-line class-E3F2 power amplifiers 显示文摘 | THIAN M FUSCO V F | 2011 | IEEE Transac- tions on Circuits and Systems2011，58，5： | 1 |
| 11 | Long non-coding RNA expression profiles predict clinical phenotypes in glioma显示文摘 | Xiaoqin Zhang Stella Sun Jenny Kan Suen Pu Anderson Chun On Tsang Derek Lee Venus On Ying Man Wai Man Lui Stanley Thian Sze Wong Gilberto Ka Kit Leung | 2012 | Neurobiology of Disease2012，，1： | 1 |
| 12 | Application of wavelet empirical orthogonal function analysis to investigate the nonstationary character of Ethiopian rainfall and its teleconnection to nonstationary global sea surface temperature variations for 1900–1998显示文摘 | Mohamed Helmy Elsanabary Thian Yew Gan Davison Mwale | 2014 | Int. J. Climatol2014，，： | 1 |
| 13 | Bioceramics:past,presentandforthefuture显示文摘 | BestSM PorterAE ThianES etal | 2008 | JEurCeramSoc2008，28，7： | 1 |
| 14 | Atypical enhancementpattern of hepatocellular carcinoma with portal veinthrombosison multiphasic CT 显示文摘 | Thian YL Low AS Chow PK | 2011 | Ann Acad Med Singapore2011，40，10： | 1 |
| 15 | Influence of MoS2 catalyst morphology on the hydrodeoxygenation of phenols 显示文摘 | Yun Quan Yang Ching Thian Tye Kevin J Smith | 2008 | Catalysis Communications2008，9，6： | 1 |
| 16 | Maguetron co-sputtered silicon-containing hydroxyapatite thin films-an in vitro study显示文摘 | Thian ES Huang J Best SM | 2005 | Biomaterials2005，26，16： | 1 |
| 17 | Processing of biocomposite Ti-6Al-4V/HA powder显示文摘 | Thian E S Loh N H Khor K A | 2003 | Journal of Materials Science Letters2003，22，： | 1 |
| 18 | Collagen-hyaluronic acid scaffolds for adipose tissue engineering显示文摘 | Davidenko N Campbell J J Thian ES | 2010 | Acta Biomater2010，6，10： | 1 |
| 19 | Identification of pyruvate kinase type M2 as potential oncoprotein in squamous cell carcinoma of tongue through microRNA profiling显示文摘 | Thian‐SzeWong Xiao‐BingLiu AmbroseChung‐Wai Ho AnthonyPo‐Wing Yuen RaymondWai‐Man Ng WilliamIgnace Wei | 2008 | Int J Cancer2008，，2： | 1 |
| 20 | Reducing vulnerability of water resources of Canadian prairies to potential droughts and possible climatic warming 显示文摘 | Thian Y G | 2000 | Water Resources Management2000，14，： | 1 |
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