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| 1 | Dysfunctional stem and progenitor cells impair fracture healing with age显示文摘Successful fracture healing requires the simultaneous regeneration of both the bone and vasculature;mesenchymal stem cells (MSCs) are directed to replace the bone tissue, while endothelial progenitor cells (EPCs) form the new vasculature that supplies blood to the fracture site. In the elderly, the healing process is slowed, partly due to decreased regenerative function of these stem and progenitor cells. MSCs from older individuals are impaired with regard to cell number, proliferative capacity, ability to migrate, and osteochondrogenic differentiation potential. The proliferation, migration and function of EPCs are also compromised with advanced age. Although the reasons for cellular dysfunction with age are complex and multidimensional, reduced expression of growth factors, accumulation of oxidative damage from reactive oxygen species, and altered signaling of the Sirtuin-1 pathway are contributing factors to aging at the cellular level of both MSCs and EPCs. Because of these geriatric-specific issues, effective treatment for fracture repair may require new therapeutic techniques to restore cellular function. Some suggested directions for potential treatments include cellular therapies, pharmacological agents, treatments targeting age-related molecular mechanisms, and physical therapeutics. Advanced age is the primary risk factor for a fracture, due to the low bone mass and inferior bone quality associated with aging;a better understanding of the dysfunctional behavior of the aging cell will provide a foundation for new treatments to decrease healing time and reduce the development of complications during the extended recovery from fracture healing in the elderly. | Diane R Wagner Sonali Karnik Zachary J Gunderson Jeffery J Nielsen Alanna Fennimore Hunter J Promer Jonathan W Lowery M Terry Loghmani Philip S Low Todd O McKinley Melissa A Kacena Matthias Clauss Jiliang Li | 2019 | World Journal of Stem Cells2019，11，6： | 3 |
| 2 | Advanced Irrigation Engineering: Precision and Precise显示文摘 | Terry A. Howell Steven R. EveR Susan A. O' Shaughnessy Paul D. Colaizzi Prasanna H. Gowda | 2012 | Journal of Agricultural Science and Technology(A)2012，2，1： | 3 |
| 3 | Rapid detection of Listeria monocytogenes in food using culture enrichment combined with real-time PCR显示文摘 | Justin O’Grady Margaret Ruttledge Sara Sedano-Balbás Terry J. Smith Thomas Barry Majella Maher | 2008 | Food Microbiology2008，，1： | 2 |
| 4 | In situ production of Fe-TiC composite by reactions in liquid iron alloys显示文摘 | Terry B S Chinymakobvu O S | 1991 | J Mater Lett1991，，10： | 1 |
| 5 | Adeno-associated virus vector-mediated minidystrophin gene therapy improves dystrophic muscle contractile function in mdx mice显示文摘 | Jon Watchko Terry O Day Bing Wang | 2002 | Human Gene Therapy2002，10，： | 1 |
| 6 | Natural product as a source of agrochenicals and leads for chemical synthesis显示文摘 | PILLMOOR B O WRIGHT K TERRY S A | 1993 | Pesticide Sci1993，39，： | 1 |
| 7 | Natural products as a source of agrochemicals and leads for chemical synthesis显示文摘 | Pillmoor B O Wright K Terry S A | 1993 | Pestic Sci1993，39，： | 1 |
| 8 | Inflammatory Bowel Disease in African American Children Compared With Other Racial/Ethnic Groups in a Multicenter Registry显示文摘 | Jolanda M. White Siobhán O’Connor Harland S. Winter Melvin B. Heyman Barbara S. Kirschner George D. Ferry Stanley A. Cohen Robert N. Baldassano Terry Smith Traci Clemons Benjamin D. Gold | 2008 | Clinical Gastroenterology and Hepatology2008，，12： | 1 |
| 9 | In Situ Production of Fe-TiC Composites by Reaction in Liquid Iron Alloys显示文摘 | Chimyamakobvu O S | 1991 | J Mater Sci Lett1991，，： | 1 |
| 10 | In situ production of Fe-TiC composites by reactions in liquid iron alloys 显示文摘 | Terry B S Chinyamakobvu O S | 1991 | Journal of Materials Science Letters1991，，10： | 1 |
| 11 | The Theory of Planned Behav- ior: The Effects of Perceived Behavioral Control and Self-efficacy显示文摘 | Terry D J O'Leary J E | 1995 | British Journal of Social Psychology1995，34，2： | 1 |
| 12 | Anatomical form de- fines color: Function, form, and aesthetics显示文摘 | Terry DA Geller W Tric O | 2002 | Pract Proced Aesthet Dent2002，14，1： | 1 |
| 13 | Phytoremediation of Mercury and Organomercurials in Chloroplast Transgenic Plants: Enhanced Root Uptake, Translocation to Shoots, and Volatilization 显示文摘 | HUSSEIN H S RUIZ O N TERRY N | 2007 | Environmental Science and Technology2007，41，24： | 1 |
| 14 | In situ production of Fe/TiC composites by reaction in liquid iron alloy显示文摘 | Terry B S Chinyamakobvu O S | 1991 | J Mater Lett1991，10，： | 1 |
| 15 | Natural Product as a source of agrochenicals and leads for chemical synthesis显示文摘 | Pillmoor B O Wright K Terry S A | 1993 | Pesticide Sci1993，39，： | 1 |
| 16 | Carotid intimal-media thickness as a surrogate for cardiovascular disease erents in trials of HMG-CoA reductase inhibitors显示文摘 | Espeland MA O'lesry DH Terry JG | | 0，，01： | 1 |
| 17 | Carbothermic Reduction of Ilmenite and Rutile as Means of Production of Iron Based Ti ( O, C) Metal Matrix Composites 显示文摘 | TERRY B S CHINYAMAKOBVU O | 1997 | Materials Sciences Technology1997，，7： | 1 |
| 18 | In situ production of Fe-TiC composites by reactions in liquid iron alloys 显示文摘 | Terry B S Chinyamakobvu O S | 1991 | J Mater Sci Lett1991，，10： | 1 |
| 19 | Synthesis of iron aluminide under thermal explosion condition显示文摘 | Chinyamacobvu O S | 1991 | J Mater Sci Lett1991，10，4： | 1 |
| 20 | CPR quality improvement during in-hospital cardiac arrest using a real-time audiovisual feedback system显示文摘 | Benjamin S. Abella Dana P. Edelson Salem Kim Elizabeth Retzer Helge Myklebust Anne M. Barry Nicholas O’Hearn Terry L. Vanden Hoek Lance B. Becker | 2006 | Resuscitation2006，，1： | 1 |
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