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| 1 | Effect of longer battery life on small bowel capsule endoscopy显示文摘AIM:To determine if longer battery life improves capsule endoscopy(CE) completion rates.METHODS:A retrospective study was performed at a tertiary,university-affiliated hospital in Vancouver,Canada.Patients who underwent CE with either PillCamTM SB2 or SB2 U between 01/2010 and 12/2013 were considered for inclusion.SB2 and SB2 U share identical physical dimensions but differ in their battery lives(8 h vs 12 h).Exclusion criteria included history of gastric or small bowel surgery,endoscopic placement of CE,interrupted view of major landmarks due to technical difficulty or significant amount of debris,and repeat CE using same system.Basic demographics,comorbidities,medications,baseline bowel habits,and previous surgeries were reviewed.Timing of major landmarks in CE were recorded,and used to calculate gastric transit time,small bowel transit time,and total recording time.A complete CE study was defined as visualization of cecum.Transit times and completion rates were compared.RESULTS:Four hundred and eight patients,including 208(51.0%) males,were included for analysis.The mean age was 55.5 ± 19.3 years.The most common indication for CE was gastrointestinal bleeding(n =254,62.3%),followed by inflammatory bowel disease(n =86,21.1%).There was no difference in gastric transit times(group difference 0.90,95%CI:0.72-1.13,P =0.352) and small bowel transit times(group difference 1.07,95%CI:0.95-1.19,P =0.261) between SB2 U and SB2,but total recording time was about 14% longer in the SB2 U group(95%CI:10%-18%,P < 0.001) and there was a corresponding trend toward higher completion rate(88.2% vs 93.2%,OR =1.78,95%CI 0.88-3.63,P =0.111).There was no statistically significant difference in the rates of positive findings(OR =0.98,95%CI:0.64-1.51,P =0.918).CONCLUSION:Extending the operating time of CE may be a simple method to improve completion rate although it does not affect the rate of positive findings. | George Ou Neal Shahidi Cherry Galorport Oliver Takach Terry Lee Robert Enns | 2015 | World Journal of Gastroenterology2015，21，9： | 13 |
| 2 | Predictors of disease severity in ulcerative colitis patients from Southwestern Ontario显示文摘AIM:To understand the demographic characteristics of patients in Southwestern Ontario,Canada with ulcerative colitis(UC)in order to predict disease severity. METHODS:Records from 1996 to 2001 were exam- ined to create a database of UC patients seen in the London Health Sciences Centre South Street Hospital Inflammatory Bowel Disease Clinic.To be included, patients'charts were required to have information of their disease presentation and a minimum of 5 years of follow-up.Charts were reviewed using standardized data collection forms.Disease severity was generated during the chart review process,and non-endoscopic Mayo Score criteria were collected into a composite. RESULTS:One hundred and two consecutive patients'data were entered into the database.Demographic analyses revealed that 51%of the patients were male, the mean age at diagnosis was 39 years,13.7%had a first degree relative with inflammatory bowel disease (IBD),61.8%were nonsmokers and 24.5%were ex-smokers.In 22.5%of patients the disease was limited to the rectum,in 21.6%disease was limited to the sigmoid colon,in 22.5%disease was limited to the left colon,and 32.4%of patients had pancolitis. Standard multiple regression analysis which regressed a composite of physician global assessment of disease severity,average number of bowel movements,and average amount of blood in bowel movements on year of diagnosis and age at time of diagnosis was significant,R 2=0.306,F(7,74)=4.66,P<0.01. Delay from symptoms to diagnosis of UC,gender, family history of IBD,smoking status and disease severity at the time of diagnosis didnot significantly predict the composite measure. CONCLUSION:UC severity is associated with younger age at diagnosis and year of diagnosis in a longitudinal cohort of UC patients,and may identify prognostic UC indicators. | Lee S Roth Nilesh Chande Terry Ponich Maya L Roth James Gregor | 2010 | World Journal of Gastroenterology2010，16，2： | 4 |
| 3 | Discovering small molecules as Wnt inhibitors that promote heart regeneration and injury repair显示文摘There are intense interests in discovering pro regenerative medicine leads that can promote cardiac differentiation and regeneration,as well as repair damaged heart tissues.We have combined zebrafish embryo-based screens with cardiomyogenesis assays to discover selective small molecules that modulate heart development and regeneration with minimal adverse effects.Two related compounds with novel structures,named as Cardiomogen 1 and 2(CDMG1 and CDMG2),were identified for their capacity to promote myocardial hyperplasia through expansion of the cardiac progenitor cell population.We find that Cardiomogen acts as a Wnt inhibitor by targeting p-catenin and reducing Tcf/Lef-mediated transcription in cultured cells.CDMG treatment of amputated zebrafish hearts reduces nuclear p-catenin in injured heart tissue,increases cardiomyocyte(CM)proliferation,and expedites wound healing,thus accelerating cardiac muscle regeneration.Importantly,Cardiomogen can alleviate the functional deterioration of mammalian hearts after myocardial infarction.Injured hearts exposed to CDMG1 display increased newly formed CMs and reduced fibrotic scar tissue,which are in part attributable to the^-catenin reduction.Our findings indicate Cardiomogen as a Wnt inhibitor in enhancing injury-induced CM proliferation and heart regeneration,highlighting the values of embryo-based small molecule screens in discovery of effective and safe medicine leads. | Shuying Xie Wenbin Fu Guangju Yu Xueli Hu Kaa Seng Lai Xiangwen Peng Yating Zhou Xuejiao Zhu Ptamen Christov Leah Sawyer Terri T.Ni Gary A.Sulikowski Zhongzhou Yang Ethan Lee Chunyu Zeng Wei E.Wang Tao P.Zhong | 2020 | Journal of Molecular Cell Biology2020，12，1： | 4 |
| 4 | FOCUS: Future of fecal calprotectin utility study in inflammatory bowel disease显示文摘AIM To evaluate the perspective of gastroenterologists regarding the impact of fecal calprotectin(FC) on the management of patients with inflammatory bowel disease(IBD).METHODS Patients with known IBD or symptoms suggestive of IBD for whom the physician identified that FC would be clinically useful were recruited. Physicians completed an online 'pre survey' outlining their rationale for the test. After receipt of the test results, the physicians completed an online 'post survey' to portray their perceived impact of the test result on patient management. Clinical outcomes for a subset of patients with follow-up data available beyond the completion of the 'post survey' were collected and analyzed.RESULTS Of 373 test kits distributed, 290 were returned, resulting in 279 fully completed surveys. One hundred and ninety patients were known to have IBD; 147(77%) with Crohn's Disease, 43(21%) Ulcerative Colitis and 5(2%) IBD unclassified. Indications for FC testing included: 90(32.2%) to differentiate a new diagnosis of IBD from Irritable Bowel Syndrome(IBS), 85(30.5%) to distinguish symptoms of IBS from IBD in those known to have IBD and 104(37.2%) as an objective measure of inflammation. FC levels resulted in a change in management 51.3%(143/279) of the time which included a significant reduction in the number of colonoscopies(118) performed(P < 0.001). Overall, 97.5%(272/279) of the time, the physicians found the test sufficiently useful that they would order it again in similar situations. Follow-up data was available for 172 patients with further support for the clinical utility of FC provided.CONCLUSION The FC test effected a change in management 51.3% of the time and receipt of the result was associated with a reduction in the number of colonoscopies performed. | Greg Rosenfeld Astrid-Jane Greenup Andrew Round Oliver Takach Lawrence Halparin Abid Saadeddin Jin Kee Ho Terry Lee Robert Enns Brian Bressler | 2016 | World Journal of Gastroenterology2016，22，36： | 2 |
| 5 | The role of endoscopy in the management of obscure GI bleeding显示文摘 | Laurel Fisher Mary Lee Krinsky Michelle A. Anderson Vasundhara Appalaneni Subhas Banerjee Tamir Ben-Menachem Brooks D. Cash G. Anton Decker Robert D. Fanelli Cindy Friis Norio Fukami M. Edwyn Harrison Steven O. Ikenberry Rajeev Jain Terry Jue Khalid Khan | 2010 | Gastrointestinal Endoscopy2010，，3： | 2 |
| 6 | Nonalcoholic fatty liver disease is associated with coronary artery calcification显示文摘 | Donghee Kim Su‐Yeon Choi Eun Ha Park Whal Lee Jin Hwa Kang Won Kim Yoon Jun Kim Jung‐Hwan Yoon Sook Hyang Jeong Dong Ho Lee Hyo‐suk Lee Joseph Larson Terry M. Therneau W. Ray Kim | 2012 | Hepatology2012，，2： | 2 |
| 7 | Oxidative Stress and Matrix Metalloproteinase-9 in Acute Ischemic Stroke: The Biomarker Evaluation for Antioxidant Therapies in Stroke (BEAT-Stroke) Study显示文摘 | Peter J. Kelly Jason D. Morrow MingMing Ning Walter Koroshetz Eng H. Lo Erin Terry Ginger L. Milne Jane Hubbard Hang Lee Elizabeth Stevenson Megan Lederer Karen L Furie | 2008 | Stroke2008，，1： | 2 |
| 8 | Ultraconserved Regions Encoding ncRNAs Are Altered in Human Leukemias and Carcinomas显示文摘 | George A. Calin Chang-gong Liu Manuela Ferracin Terry Hyslop Riccardo Spizzo Cinzia Sevignani Muller Fabbri Amelia Cimmino Eun Joo Lee Sylwia E. Wojcik Masayoshi Shimizu Esmerina Tili Simona Rossi Cristian Taccioli Flavia Pichiorri Xiuping Liu Simona Zupo | 2007 | Cancer Cell2007，，3： | 1 |
| 9 | High- thrust-high-specific impulse gasdynamic fusion propulsion system显示文摘 | Terry Kammash Lee Myoung-Jae Poston David I | 1997 | Journal of Propulsion and Power1997，13，3： | 1 |
| 10 | Qscore: an algorithm for evaluating SEQUEST database search results显示文摘 | Roger E Moore Mary K Young Terry D Lee | 2002 | Journal of the American Society for Mass Spectrometry2002，13，4： | 1 |
| 11 | The efficacy of corticos- teroids in postparotidectomy facial nerve paresis显示文摘 | LEE K J FEE WE JR TERRIS DJ | 2002 | Laryngoscope2002，112，11： | 1 |
| 12 | Incidence, Risk Factors, and Impact of Severe Neutropenia After Hyperthermic Intraperitoneal Mitomycin C显示文摘 | Laura A. Lambert Terri S. Armstrong J. Jack Lee Suyu Liu Matthew H. G. Katz Cathy Eng Robert A. Wolff Melissa L. Tortorice Pier Tansey Santiago Gonzalez-Moreno Donald H. Lambert Paul F. Mansfield | 2009 | Annals of Surgical Oncology2009，，： | 1 |
| 13 | Design of ultrasonically-activatable nanoparticles using low boiling point perfluorocarbons显示文摘 | Paul S. Sheeran Samantha H. Luois Lee B. Mullin Terry O. Matsunaga Paul A. Dayton | 2012 | Biomaterials2012，，11： | 1 |
| 14 | LT-IIc, a new member of the type II heat-labile enterotoxin family, exhibits potent immunomodulatory properties that are different from those induced by LT-IIa or LT-IIb显示文摘 | Hesham F. Nawar Christopher J. Greene Chang Hoon Lee Lorrie M. Mandell George Hajishengallis Terry D. Connell | 2010 | Vaccine2010，，4： | 1 |
| 15 | Australian IPO underpricing in the short-and long-run显示文摘 | PHILIP STEPHEN TAYLOR TERRY WALTER | 1996 | Journal of Banking and Finance1996，，20： | 1 |
| 16 | Lin28B increases fetal hemoglobin and regulates BCL11A expression in human erythroid tissues显示文摘 | Jaira F de Vasconcellos Terry Lee Y Joan Yuan | | 0，，： | 1 |
| 17 | Repair of palatal bone defects using osteogenically differentiated fat-derived stem cells显示文摘 | Conejero JA Lee JA Parrett BM Terry M Wear-Maggitti K Grant RT Breitbart AS | | 0，，3： | 1 |
| 18 | Malaria in the Republic of Korea, 1993-2007. Variables Related to Re-emergence and Persistence of Plasmodium vivax Among Korean Populations and U.S. Forces in Korea显示文摘 | Kim Heung-Chul Pacha Laura A Lee Won-Ja Lee Jong-Koo Gaydos Joel C Sames William J Lee Hee-Choon S Bradley Kent Jeung Gi-Gon Tobler Steven K Klein Terry A | 2009 | Military Medicine2009，，7： | 1 |
| 19 | Competition and disruption in a dynamic urban supply chain显示文摘 | Terry L. Friesz Ilsoo Lee Cheng-Chang Lin | 2011 | Transportation Research Part B2011，，8： | 1 |
| 20 | The production of Al-Ti-B grain refining master alloys显示文摘 | LEE M S TERRY B S GRIEVESON P | 2003 | Scandinavian Journal of Met-allurgy2003，32，5： | 1 |
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