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| 1 | Curcumin protects PC12 cells against 1-methyl-4-phenylpyridinium ion-induced apoptosis by bcl-2-mitochondria-ROS-iNOS pathway.显示文摘 | Chert J Tang XQ Zhi JL Cui Y Yu HM Tang EH Sun SN Feng JQ Chen PX Chen J | 2006 | 中国生物学文摘2006，20，10： | 16 |
| 2 | Edible Bird's Nest Attenuates Menopause-Related Bone Degeneration in Rats via Increasing Bone Estrogen-Receptor Expression显示文摘Objective:To investigate the mechanistic basis for the attenuation of bone degeneration by edible bird's nest(EBN)in ovariectomized rats.Methods:Forty-two female Sprage-Dawley rats were randomized into 7 groups(6 in each group).The ovariectomized(OVX)and OVX+6%,3%,and 1.5%EBN and OVX+estrogen groups were given standard rat chow alone,standard rat chow+6%,3%,and 1.5%EBN,or standard rat chow+estrogen therapy(0.2mg/kg per day),respectively.The sham-operation group was surgically opened without removing the ovaries.The control group did not have any surgical intervention.After 12 weeks of intervention,blood samples were taken for serum estrogen,osteocalcin,and osteoprotegerin,as well as the measurement of magnesium,calcium abd zinc concentrations.While femurs were removed from the surrounding muscles to measure bone mass density using the X-ray edge detection technique,then collected for histology and estrogen receptor(ER)immunohistochemistry.Results:Ovariectomy altered serum estrogen levels resulting in increased food intake and weight gain,while estrogen and EBN supplementation attenuated these changes.Ovariectomy also reduced bone ER expression and density,and the production of osteopcalcin and osteorotegerin,which are important pro-osteoplastic hormones that promote bone mineraliztion and density.Conversely,estrogen and EBN increased serum estrogen levels leading to increased bone ER expression,pro-osteoplastic hormone production and bone density(all P<0.05).Conclusion:EBN could be used as a safe alternative to hormone replacement therapys for managing menopausal complications like bone degeneration. | HOU Zhi-ping TANG Shi-ying Jl Hai-ru HE Pei-yuan LI Yu-hong DONG Xian-ling DU Meng-nan Ismail Maznah HE Wen-jing | 2021 | Chinese Journal of Integrative Medicine2021，27，4： | 6 |
| 3 | Tojapride Reverses Esophageal Epithelial Inflammatory Responses on Reflux Esophagitis Model Rats显示文摘Objective To investigate the mechanism of Tojapride,a Chinese herbal formula extract,on strengthening the barrier function of esophageal epithelium in rats with reflux esophagitis(RE).Methods Ten out of 85 SD rats were randomly selected as the sham group(n10),and 75 rats were developed a reflux esophagitis model(RE)by the esophageal and duodenal side-to-side anastomosis.Fifty successful modeling rats were divided into different medicated groups through a random number table including the model,low-,medium-,and high-dose of Tojapride as well as omeprazole groups(n10).Three doses of Tojapride[5.73,11.46,22.92 g/(kg•d)]and omeprazole[4.17 mg/(kg•d)]were administrated intragastrically twice daily for 3 weeks.And the rats in the sham and model groups were administered 10 mL/kg distilled water.Gastric fluid was collected and the supernatant was kept to measure for volume,pH value and acidity.Esophageal tissues were isolated to monitor the morphological changes through hematoxylin-eosin(HE)staining,and esophageal epithelial ultrastructure was observed by transmission electron microscopy.The expressions of nuclear factor kappa-light-chain-enhancer of activated B cells p65(NF-KBp65),κB kinase beta(IKKß),occludin,and zonula occludens-1(ZO-1)in the esophageal tissues were measured by immunohistochemistry and Western blot,respectively.Results The gastric pH value in the model group was significantly lower than the sham group(P<0.05).Compared with the model group,gastric pH value in the omeprazole and medium-dose of Tojapride groups were significantly higher(P<0.05).A large area of ulceration was found on the esophageal mucosa from the model rats,while varying degrees of congestion and partially visible erosion was observed in the remaining groups.Remarkable increase in cell gap width and decrease in desmosome count was seen in RE rats and the effect was reversed by Tojapride treatment.Compared with the sham group,the IKKßlevels were significantly higher in the model group(P<0.05).However,the IKKßlevels were down-regulated after treatment by all doses of Tojapride(P<0.01 or P<0.05).The occluding and ZO-1 levels decreased in the model group compared with the sham group(Ps0.01 or Ps0.05),while both indices were significantly up-regulated in the Tojapride-treated groups(P<0.01 or P<0.05).Conclusions Tojapride could improve the pathological conditions of esophageal epithelium in RE rats.The underlying mechanisms may involve in down-regulating the IKKßexpression and elevating ZO-1 and occludin expression,thereby alleviating the inflammation of the esophagus and strengthening the barrier function of the esophageal epithelium. | YIN Xiao-lan ZHONG Linda LIN Cheng-yuan SHI Xiao-shuang ZHANG Jiao CHEN Zheng-yi CHE Hui MA Xiang-xue TIAN Ya-xin DUAN Yuan-zhi LU Lin Jl Hai-jie ZHAO Ying-pan TANG Xu-dong WANG Feng-yun | 2021 | Chinese Journal of Integrative Medicine2021，27，8： | 4 |
| 4 | Characteristics of air quality in Tianjin during the Spring Festival period of 2015显示文摘To better understand the characteristics of air quality and the relationship between the chemical composition evolution and source variation,an intensive atmospheric campaign was conducted in Tianjin,a megacity of the North China Plain,from 10 February to 6 March 2015.There were 20 days exceeding the threshold value of secondary Chinese Ambient Air Quality Standards for PM2.5(75 μg m-3,daily average over 24 h)during the study period.Five air pollution episodes were selected for investigation.During the pre-holiday pollution episode,NH^+_4,NO^-_3,and SO^(2-)_4 were more abundant,indicating that air pollution was caused by motor vehicle exhaust emissions and coal consumption under unfavorable meteorological conditions.During Chinese Lunar New Year's Eve,widespread use of fireworks resulted in extremely high aerosol concentrations.Firework displays caused increases in K+ and also enrichment of SO^(2-)_4 relative to NO^-_3.The holiday pollution episode was caused by regional transport,characterized by abundant SO^(2-)_4 and NH^+_4.In addition,the aging processes of the particles from fireworks discharge played an important role in the formation of NO-3and SO^(2-)_4.The Lantern Festival episode was characterized by a transition from the enrichment of K+ to secondary inorganic ions(NO^-_3,SO^(2-)_4,and NH^+_4).The results of this study are useful for a detailed understanding of the variation in atmospheric compositions and sources caused by anthropogenic activity,and highlight the importance of controlling intensive fireworks discharge. | TANG Miao Jl Dong-Sheng GAO Wen-Kang YU Zhong-Wang CHEN Kui CAO Wan | 2016 | Atmospheric and Oceanic Science Letters2016，9，1： | 4 |
| 5 | 非甾体抗炎药应用中,环氧合酶2、不对称二甲基精氨酸与心血管危害的关系显示文摘已有大规模、安慰剂对照试验确定了非甾体类抗炎药(nonsteroidal anti—inflammatory drugs,NSAIDs)具有心血管危害性:这归因于环氧合酶2(cyclooxygenase,COX-2)的心脏保护产物受到抑制,尤其是前列环素(prostacyclin,PG12)。NSAID降低心脏保护作用的另一种机制可能是通过增强肾脏中甲基精氨酸的形成来限制一氧化氮在整个脉管系统中的作用。 | Ricciotti E Castro C Tang SY Briggs WTE West JA Malik D Rhoades SD Meng H Li X Lahens NF Sparks JA Karlson EW Weljie AM Griffin JL FitzGerald GA6 刘青 叶鹏 | 2018 | 中华高血压杂志2018，26，9： | 3 |
| 6 | Hypertension prevalence, awareness, treatment, control, and associated factors in adults in southern China显示文摘 | Ma WJ Tang JL Zhang YH | 2012 | Am J Hypertens2012，25，5： | 1 |
| 7 | Ellagic acid inhibits human pancreatic cancer growth in Balb c nude mice显示文摘 | Zhao M Tang SN Marsh JL | 2013 | Cancer Lett2013，337，2： | 1 |
| 8 | Philadelphia chromosome-positive acute lymphoblastic leukemia in Taiwan显示文摘 | Ko BS Tang JL Tsai W | 2001 | Ann ematol2001，80，9： | 1 |
| 9 | Treatment outcome and pattern of failure in 77 patients with sinonasal natural killer/T-cell or T-cell lymphoma显示文摘 | Li CC Tien HF Tang JL | 2004 | Cancer2004，100，2： | 1 |
| 10 | Acupuncture for stroke rehabilitation显示文摘 | Wu HM Tang JL Lin XP | 2006 | Cochrane Database Syst Rev2006，，00： | 1 |
| 11 | What is the optimal body mass ifldex for Chinese people?显示文摘 | Zhu S Ma X Tang JL | 2011 | CMAJ2011，183，6： | 1 |
| 12 | MicroRNA 345, a methylation- sensitive microRNA is involved in cell proliferation and invasion in human colorectal cancer显示文摘 | Tang JT Wang JL Du W | 2011 | Carcinogenesis2011，32，8： | 1 |
| 13 | Clinical implications of the SETBP1 mutation in patients with primary myelodysplastic syndrome and its stability during disease progression 显示文摘 | Hou HA Kuo YY Tang JL | 2014 | Am J Hematnl2014，89，2： | 1 |
| 14 | Nucleophosmin mutations in de novo acute myeloid leukemia:the age-dependent incidences and the stability during disease evolution显示文摘 | Chou WC Tang JL Lin LI | 2006 | Cancer Res2006，66，： | 1 |
| 15 | Combinatorial modulation of galP and glk gene expression for improved alternative glucose utilization显示文摘 | Lu J Tang JL Liu Y | | 0，，06： | 1 |
| 16 | Treatment outcome and pattern of failure in 77 patients with sinonasal natural killer/T-cell or T- cell lymphoma显示文摘 | Li CC Tien HF Tang JL | 2004 | Cancer2004，100，2： | 1 |
| 17 | Minimally differentiated acute myeloid leukemia in Taiwan: predominantly occurs in children less than 3 years and adults between 51 and 70 years显示文摘 | Huang SY Tang JL Jou ST | 1999 | Leukemia1999，13，10： | 1 |
| 18 | Effect of the neuroprotective agent riluzole on intracellular Ca2+ levels in IMB32 neuroblastoma cells 显示文摘 | Wang JL Lee KC Tang KY | 2001 | Arch Toxicol2001，75，： | 1 |
| 19 | Identification of viral microRNAs expressed in human sacral ganglia latently infected with herpes simplex virus 2显示文摘 | Umbach JL Wang K Tang S | | 0，，： | 1 |
| 20 | Epithelial-mesenchymal transdifferentiation of renal tubular epithelial cells induced by urinary proteins requires the activation of PKC-α and 131 isozymes显示文摘 | Tang R Yang C Tao JL | 2011 | Cell Biol Int2011，35，9： | 1 |
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