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| 1 | QTL mapping of resistance to sheath blight in maize(Zea mays L.)显示文摘The genetic linkage map has been constructed with 125 SSR markers based on BC1:2 population consisting of 322 lines derived from the combination of (CML270×478) ×CML270 in maize (Zea mays L.), covering 1939.0 cM of maize genome. The average mapping distance was about 15.5 cM. Three major QTLs of the relative resistant index of re- sistance to maize sheath blight (Rhizoctonia solani) had been located on chromosomes 1, 7 by composite interval mapping (CIM). 7 QTLs of the plant height have been located on chromosomes 3, 4, 5, 6. Five QTLs of ear height have been located on chromosomes 3, 4, 6. The resistance to the sheath blight is shown to be not relative to plant height and ear height genetically. Inbred line CML270 was used for mo- lecular assisted selection and cloning the genes. | YANGHua YANGJunpinx RONGTingzhao TANJun QIUZhenggao | 2005 | Chinese Science Bulletin2005，50，8： | 3 |
| 2 | Upregulation of SIRT1 by 17β-estradiol depends on ubiquitin-proteasome degradation of PPAR-γ mediated by NEDD4-1显示文摘17β-estradiol (E2) treatment of cells results in an upregulation of SIRT1 and a down-regulation of PPARγ. The decrease in PPARγ expression is mediated by increased degradation of PPARγ. Here we report that PPARγ is ubiquitinated by HECT E3 ubiquitin ligase NEDD4-1 and degraded, along with PPARγ, in response to E2 stimulation. The PPARγ interacts with ubiquitin ligase NEDD4-1 through a conserved PPXY-WW binding motif. The WW3 domain in NEDD4-1 is critical for binding to PPARΓ. NEDD4-1 overexpression leads to PPARγ ubiquitination and reduced expression of PPARγ. Conversely, knockdown of NEDD4-1 by specific siRNAs abolishes PPARΓ ubiquitination. These data indicate that NEDD4-1 is the E3 ubiquitin ligase responsible for PPARγ ubiquitination. Here, we show that NEDD4-1 delays cellular senescence by degrading PPARΓ expression. Taken together, our data show that E2 could upregulate SIRT1 expression via promoting the PPARΓ ubiquitination-proteasome degradation pathway to delay the process of cell senescence. | Limin Han Pan Wang Ganye Zhao Hui Wang Meng Wang Jun Chen Tanjun Tong | 2013 | Protein & Cell2013，4，4： | 3 |
| 3 | Senescence Delay of Human Diploid Fibroblast Induced by Anti-sense P16INK4a Expression显示文摘 | Jianming Duan Zongyu Zhang and Tanjun Tong | 2001 | J Biol Chem2001，276，48： | 1 |
| 4 | UpconversionwhitephotoluminescenceandferroelectricpropertyforEr3+GTm3+GYb3+ triGcodoped Bi4Ti3O12 thinfilm显示文摘 | SunLina TanJun BaDechun etal | 2014 | ActaMetallurgicaSinica2014，50，： | 1 |
| 5 | Advances in the research on p38 kinase显示文摘 | Cai Jiaxin Tong Tanjun | 1993 | Progress in Physiological Sciences1993，24，2： | 1 |
| 6 | The molecular basis of Chinese herbs(Astragali and Angelica)on increasing serum albumin synthesis in nephritic rats显示文摘 | Li Liying Chen Menghua Tong Tanjun | | 0，，01： | 1 |
| 7 | The molecular basis of Cllinese herbs(Astragali and Angelica)on increasing serum albumin synthesis in nephritic rats显示文摘 | kiying Li Menghua chen Tanjun Tong et aI | 1998 | Nephrology1998，4，1： | 1 |
| 8 | 显示文摘 | MaYao(马矗) ZhouZhangjian(周张健) TanJun(谈军)eta1 | 2011 | 稀有金属材料与工程2011，40，1： | 1 |
| 9 | The molecular basis of Chinese herbs(Astragali and Angelica)on increasing serum albumin synthesis in nephritic rats显示文摘 | Liying Li Menghua chen Tanjun Tong | 1998 | Nephrology1998，4，1： | 1 |
| 10 | 显示文摘 | QuDandan(屈丹丹) ZhouZhangjian(周张健) TanJun(谈军) | 2011 | 北京科技大学学报2011，33，： | 1 |
| 11 | The molecular ba- sis of Chinese herbs( Astragali and Angelica) on increasing ser- um albumin synthesis in nephrotic rats 显示文摘 | Liying Li Menghua Chen Tanjun Tong | 1998 | NePhrology1998，4，56： | 1 |
| 12 | Mitochondrion-processed TERC regulates senescence without affecting telomerase activities显示文摘Mitochondrial dysfunctions play major roles in ageing.How mitochondrial stresses invoke downstream responses and how specificity of the signaling is achieved, however, remains unclear. We have previously discovered that the RNA component of Telomerase TERC is imported into mitochondria, processed to a shorter form TERC-53, and then exported back to the cytosol. Cytosolic TERC-53 levels respond to mitochondrial functions, but have no direct effect on these functions, suggesting that cytosolic TERC-53 functions downstream of mitochondria as a signal of mitochondrial functions. Here, we show that cytosolic TERC-53 plays a regulatory role on cellular senescence and is involved in cognition decline in 10 months old mice, independent of its telomerase function. Manipulation of cytosolic TERC-53 levels affects cellular senescence and cognition decline in 10 months old mouse hippocampi without affecting telomerase activity, and most importantly, affects cellular senescence in terc^-/- cells. These findings uncover a senescence-related regulatory pathway with a non-coding RNA as the signal in mammals. | Qian Zheng Peipei Liu Ge Gao Jiapei Yuan Pengfeng Wang Jinliang Huang Leiming Xie Xinping Lu Fan Di Tanjun Tong Jun Chen Zhi Lu Jisong Guan Geng Wang | 2019 | Protein & Cell2019，10，9： | 0 |
| 13 | Effect of Si and Nb on the solidification mode of a Cr-Ni-Mn-Naustenitic hydrogen-resistant steels显示文摘 | TANJun WANGYe 等 | 2002 | 电子显微学报2002，21，5： | 0 |
| 14 | Effect of the Flanking Sequence Architecture of Translation Initiation AUG Codon on Gene Expression Level in Rice显示文摘The relationship between the codon usage bias, gene expression level and the AUG context(from -20 to +6 positions relative to the initiator AUG codon) was examined in 541unigene sequences of rice. A significant correlation for CAI values (codon adaptationindex) was observed at five nucleotide positions (-19, -18, -9, -4, +5), eight (-19, -18,-14, -9, -6, -4, -1, +5) for CPP (codon preference parameter), and seven (-18, -16, -15,-9, -7, -1, +6) for mRNA abundance in the flanking sequence of the initiator AUG codonrespectively, but a significantly positive correlation for both CAI and CPP at twopositions (-4 and +5), indicating that both those positions are evolutionally under thenatural selection constraint at the translational level. By site-directed mutagenesis atseven specific positions (-18, -16, -15, -9, -7, -1 and +6) for allergenic protein thathad the highest mRNA abundance in this study, its expression level decreased dramatically63.3 and 72.5% respectively, indicating the importance of those 7 positions for geneexpression. A highly positive correlation (r=0.625, P<0.01) between AUGCAI and GCcontent in the flanking sequence of the initiator AUG codon showed a more effectivehigher GC content on translation initiation efficiency. The strong preference for G orC at those 8 positions (-6, -5, -3, -2, -1, +4, +5 and +6) in the AUG context suggestedthat an important factor in modulation of the translation efficiency, as well assynonymous codon usage bias, particularly in highly expressed genes. | LIUQing-po TANJun XUEQing-zhong | 2004 | Agricultural Sciences in China2004，3，6： | 0 |
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