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| 1 | Mechanisms of hepatocellular carcinoma progression显示文摘Hepatocellular carcinoma(HCC) is the most common primary malignancy of the liver. It is the second leading cause of cancer-related deaths worldwide, with a very poor prognosis. In the United States, there has been only minimal improvement in the prognosis for HCC patients over the past 15 years. Details of the molecular mechanisms and other mechanisms of HCC progression remain unclear. Consequently, there is an urgent need for better understanding of these mechanisms. HCC is often diagnosed at advanced stages, and most patients will therefore need systemic therapy, with sorafenib being the most common at the present time. However, sorafenib therapy only minimally enhances patient survival. This review provides a summary of some of the known mechanisms that either cause HCC or contribute to its progression. Included in this review are the roles of viral hepatitis, non-viral hepatitis, chronic alcohol intake, genetic predisposition and congenital abnormalities, toxic exposures, and autoimmune diseases of the liver. Well-established molecular mechanisms of HCC progression such as epithelial-mesenchymal transition, tumor-stromal interactions and the tumor microenvironment, cancer stem cells, and senescence bypass are also discussed. Additionally, we discuss the roles of circulating tumor cells,immunomodulation, and neural regulation as potential new mechanisms of HCC progression. A better understanding of these mechanisms could have implications for the development of novel and more effective therapeutic and prognostic strategies, which are critically needed. | Olorunseun O Ogunwobi Trisheena Harricharran Jeannette Huaman Anna Galuza Oluwatoyin Odumuwagun Yin Tan Grace X Ma Minhhuyen T Nguyen | 2019 | World Journal of Gastroenterology2019，25，19： | 21 |
| 2 | Cyclooxygenase-2 polymorphisms and the risk of esophageal adeno-or squamous cell carcinoma显示文摘AIM:To determine whether-1195 A→G and/or-765 G→C polymorphisms in Cyclooxygenase-2(COX-2 ) may have a risk modifying effect on the development of esophageal carcinoma in a Dutch Caucasian population.METHODS:Two study groups were recruited, 252 patients with esophageal carcinoma and 240 healthy controls, matched for race, age, gender and recruiting area.DNA was isolated from whole blood and used for genotyping.PCR products were digested with restriction enzymes and products were analyzed by agarose gel electrophoresis.Odds ratios(OR) and 95% confldence intervals(CI) were estimated.RESULTS:The distribution of the-1195 A→G polymorphism was signif icantly different in esophageal cancer patients compared to controls.The-1195 GG genotype resulted in a higher risk of developing esophageal adenocarcinoma(OR = 3.85, 95% CI:1.45-10.3) compared with the-1195 AA genotype as a reference.The-765 G→C genotype distribution was not different between the two groups.The GG/ GG haplotype was present more often in esophageal adenocarcinoma patients than in controls(OR = 3.45, 95% CI:1.24-9.58;with AG/AG as a reference).The same trends were observed in patients with squamous cell carcinomas, however, the results did not reach statistical signif icance.CONCLUSION:Presence of the COX-2-1195 GG genotype and of the GG/GG haplotype may result in a higher risk of developing esophageal carcinoma. | Jón O Kristinsson Paul van Westerveld Rene HM te Morsche Hennie MJ Roelofs T Wobbes Ben JM Witteman Adriaan CITL Tan Martijn GH van Oijen Jan BMJ Jansen Wilbert HM Peters | 2009 | World Journal of Gastroenterology2009，15，28： | 11 |
| 3 | MiR-23b-3p induces the proliferation and metastasis of esophageal squamous cell carcinomas cells through the inhibition of EBF3显示文摘 | Jing Zhang Yan Zhang Xiaoping Tan Oing Zhang Chaoyong Liu Yali Zhang | 2018 | Acta Biochimica et Biophysica Sinica2018，50，6： | 4 |
| 4 | Dominance network structure across reproductive contexts in the cooperatively breeding cichlid fish Neolamprologus pulcher显示文摘 | Cody J. DEY Q.Y. Joanne TAN Constance M. O'CONNOR Adam R. REDDON J. Ryan CALDWELL Sigal BALSHINE | 2015 | Current Zoology2015，61，1： | 4 |
| 5 | 炎症、癫痫发作和癫痫发生:对人类疾病的探索显示文摘癫痫在历史上被认为是一种神经元信号异常传导的疾病,表现为癫痫发作。随着大量自身抗体的发现和对自身免疫性脑炎认识的不断加深,人们越来越重视先天性和适应性免疫系统在癫痫发作和癫痫发生中的作用。在不同的癫痫发作相关的神经炎症和自身免疫疾病中,不同程度观察到了致病性抗体、补体激活、CD8+细胞毒性T细胞和小胶质细胞激活。这些异常的免疫反应被认为会导致神经元信号传导破坏,产生急性症状性癫痫发作,并且在某些情况下,还会发展为长期的自身免疫性癫痫。虽然早期使用免疫调节疗法可以改善自身免疫性脑炎和自身免疫性癫痫的预后,但患者的识别和治疗方法的选择并不总是明确。本篇综述讨论了免疫系统的不同成分在各种形式的癫痫发作中的作用,包括自身免疫性脑炎、自身免疫性癫痫、Rasmussen脑炎、热性感染相关性癫痫综合征和新发难治性癫痫持续状态。尤其是讨论了在这些疾病中观察到的病理生理学和独特的细胞因子谱,及其与诊断、预后和治疗决策的联系。 | Tan TH Perucca P O'Brien TJ Kwan P 高凡凯(译) 李硕(译) 薛国芳(审) Mastura Monif | 2022 | 癫痫杂志2022，8，4： | 2 |
| 6 | J Power Sources显示文摘 | Matsuoka O Hiwara A Omi T Toriida M Hayashi T Tanaka C Saito Y Ishida T Tan H Ono S S Yamamoto S | 2002 | 108:1282002，108，： | 1 |
| 7 | Madelung syndrome with pubic involvement 显示文摘 | Tan O Erqen D | 2008 | Dermatol Surg2008，34，6： | 1 |
| 8 | Split-spectrum amplitude- decorrelatlon angiography with optical coherence tomography显示文摘 | Jia Y Tan O Tokayer J | 2012 | Opt xpress2012，20，4： | 1 |
| 9 | Large effects on body mass index and insulin resist- ance of fat mass and obesity associated gene (FTO) variants in patients with polycystic o- vary syndrome (PCOS) 显示文摘 | Tan S Scherag A Janssen O E | 2010 | BMC Med Gen- et2010，，11： | 1 |
| 10 | Electron microbeam analysis and scanning electron microscopy of soil-root interface显示文摘 | Tan K H Nopamornbodi O | 1981 | Soil Science1981，131，2： | 1 |
| 11 | Equilibria in second price auctions with participation costs显示文摘 | Tan G F Yilankay O | 2006 | Journal of Economic Theory2006，130，： | 1 |
| 12 | Hyperhomocysteinemia and impaired vasomotor function in type 2 diabetesmellitus显示文摘 | Tan KC O K Chow WS Ai VH | 2002 | Eur J Clin Invest2002，32，5： | 1 |
| 13 | Soft-tissue augmenta- tion of the middle and lower face using the deepithelial- ized submental flap显示文摘 | Tan O Atik B Parmaksizoglu D | 2007 | Plast Reconstr Surg2007，119，3： | 1 |
| 14 | Cerebellar neurodegeneration in the absence of microRNAs显示文摘 | Schaefer A O\'Carroll DON Tan CL | 2007 | Journal of Experimental Medicine2007，204，7： | 1 |
| 15 | Efficacy of anakinra in active ankylosing spondylitis : a clinical and magnetic resonance imaging study显示文摘 | Tan AL Marzo-Ortega H O' Connor P | 2004 | Ann Rheum Dis2004，63，9： | 1 |
| 16 | Expression of the GLT-1 subtypeof Na+-dependent glutamate transporter:pharmacological character-ization and lack of regulation by protein kinase C显示文摘 | Tan J Zelenaia O Correale D | 1999 | J PharmacolExp Ther1999，289，3： | 1 |
| 17 | Atmospheric mercury deposition in Guizhou, China显示文摘 | Tan H He J L Liang L Lazoff S Sommer J Xiao Z F Lindqvist O | 2000 | The Science of the Total Environment2000，259，13： | 1 |
| 18 | Sleep apnea and sleep disruption in obese patients显示文摘 | Vgontzas A N Tan T L Bixler E O | 1994 | Arch Intern Med1994，154，： | 1 |
| 19 | Hyperhomocysteinemia and impaired vasomotor function in type 2 diabetes mellitus显示文摘 | TAN K KARMIN O CHOW W S | 2002 | Eur J Clin Invest2002，32，： | 1 |
| 20 | Nanostructured oxides by highenergy ball milling technique:application as gas sensing materials显示文摘 | TAN O K CAO W HUA Y | 2004 | Solid State Ionics2004，172，： | 1 |
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