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| 1 | Inhibitory activities of extracts of Rumex dentatus, Commelina benghalensis, Ajuga bracteosa, Ziziphus mauritiana as well as their compounds of gallic acid and emodin against dengue virus显示文摘Objective: To investigate the inhibitory effects against dengue virus serotype 2(DENV-2) by five different fractions(extracted by methanol, ethanol, benzene, chloroform and n-hexane) of Rumex dentatus, Commelina benghalensis, Ajuga bracteosa and Ziziphus mauritiana, as well as their constituents(gallic acid, emodin, and isovanillic acid). Methods: All the samples were tested for cytotoxicity on baby hamster kidney cells by MTT assay and for anti-DENV-2 activity by plaque reduction neutralization assay using two DENV-2 doses(45 and 90 plaqueforming units or PFU). Results: All the samples except isovanillic acid exhibited significant prophylactic effects against DENV-2 infectivity(without cytotoxicity) when administered to cells before infection, but were not effective when given 6 h post-infection. The methanol extract of Rumex dentatus demonstrated the highest antiviral efficacy by inhibiting DENV-2 replication, with IC_(50) of 0.154 μg/mL and 0.234 μg/mL, when added before infection with 45 and 90 PFU of virus, respectively. Gallic acid also exhibited significant antiviral effects by prophylactic treatment prior to virus adsorption on cells, with IC_(50) of 0.191 μg/mL and 0.522 μg/mL at 45 and 90 PFU of DENV-2 infection, respectively. Conclusions: The highly potent activities of the extracts and constituent compounds of these plants against DENV-2 infectivity highlight their potential as targets for further research to identify novel antiviral agents against dengue. | Riffat Batool Ejaz Aziz Tariq Mahmood Benny KH Tan Vincent TK Chow | 2018 | Asian Pacific Journal of Tropical Medicine2018，11，4： | 3 |
| 2 | Complete cDNA sequence of chitin deacetylase from Gongronella butleri and its phylogenetic Analysis revealed clusters corresponding to taxonomic classification of fungi显示文摘 | Maw T Tan TK Khor E | 2002 | Journal of Bioscience and Bioengineering2002，93，4： | 1 |
| 3 | ASGS:an alternative splicing graph web service显示文摘 | Durgaprasad Bollina Lee Bernett TK Tan TW | 2006 | Nucleic Acids Res2006，34，： | 1 |
| 4 | Chitosanyield of zygomycetes at their optimum havesting time显示文摘 | Tan TK | 1996 | Carboydrate Polymers1996，30，4： | 1 |
| 5 | Impact of genetic and acquired alteration in cytochrome P450 sys tem on pharmacologic and clinical response to clopi dogrel显示文摘 | Ma TK Lam YY Tan VP | 2010 | PharmacolTher2010，125，2： | 1 |
| 6 | Antifimga 1 effects ofhydrogen p eroxide and peroxidase on spore germ ination andmy celial grow of Pseudocercospora species 显示文摘 | Joseph L M Tan TK W ong SM | 1998 | CanadianJournal of Botany1998，76，12： | 1 |
| 7 | Identification and mo- lecular phylogeny of Epulorhiza isolates from tropical orchids 显示文摘 | Ming MA Tan TK Wong SM | 2003 | Mycological Research2003，107，9： | 1 |
| 8 | Mining the gastric cancer secretome:identification of GRN as a potential diagnostic marker for early gastric cancer显示文摘 | Loei H Tan HT Lim TK | | 0，，03： | 1 |
| 9 | Coronary normograms and the coronary-aorta index: objective determinants of coronary artery dilatation 显示文摘 | Tan TH Wong KY Cheng TK | 2003 | Pediatr Cardiol2003，24，4： | 1 |
| 10 | Postoperative nausea and vomiting after craniotomy for tumor surgery:a comparison between awake craniotomy and general anesthesia显示文摘 | Manninen PH Tan TK | 2002 | J Clin Anesth2002，14，4： | 1 |
| 11 | Survery of epidural analgesia for labor显示文摘 | Tan Tk | 1998 | Ann Acad Med Singapore1998，27，： | 1 |
| 12 | Proteome analysis of butyrate-treated human colon cancer cells(HT-29) 显示文摘 | Tan S Seow TK Liang RC | 2002 | Int J Cancer2002，98，4： | 1 |
| 13 | On the role of VDAC in apoptosis: fact and fiction 显示文摘 | Rostovtseva TK Tan W Colombini M | 2005 | J Bioenerg Biomembr2005，37，3： | 1 |
| 14 | Coronary norrnograms and the coronaryaorta index : objective determinants of coronary ar- tery dilatation显示文摘 | Tan TH Wong KY Cheng TK | 2003 | Pediatr Cardiol2003，24，4： | 1 |
| 15 | Coronary normograms and the coronary-aorta index: objective determinants of coronary artery dilatation显示文摘 | Tan TH Wong KY Cheng TK | 2003 | Pediatr Cardiol2003，24，4： | 1 |
| 16 | Macrophage matrix metalloprotei-nase-9 mediates epithelial-mesenchymal transition in vitro in murinerenal tubular cells显示文摘 | Tan TK Zheng G Hsu TT | 2010 | Am J Pathol2010，176，3： | 1 |
| 17 | Impact of genetic and ac- quired alteration in cytochrome P450 system on pharmaco- logic and clinical response to clopidogrel 显示文摘 | MA TK LAM YY TAN YP | 2010 | Pharmacol T- her2010，125，2： | 1 |
| 18 | Roles of dbcAMP,IBMX and RA in As- pects of Neural Differentiatinn of Cord Blood Derived Mesenchymal- LikeStem Cells显示文摘 | Tio M Tan |tK le W | 2010 | PlosOne2010，5，2： | 1 |
| 19 | Impact of genetic and acquired alteration in cytochrome P450system on pharmaco-logic and clinical response to clopidogrel显示文摘 | Ma TK Lam YY Tan VP Kiernan TJ Yan BP | 2010 | Pharmacol Ther2010，125，2： | 1 |
| 20 | Mining the gastric cancer secretome: Identification of GRN as a potential diagnostic marker for early gastric cancer 显示文摘 | Loei H Tan HT Lim TK | 2012 | J Proteome Res2012，11，3： | 1 |
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