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| 1 | Screening and identification of mimotopes of the major shrimp allergen tropomyosin using one-bead-one- compound peptide libraries显示文摘one-bead-one-compound (OBOC ) 组合的肽图书馆是一个强大的工具识别 ligand 和受体相互作用。这里,我们使用了 OBOC 图书馆技术识别对主要贝壳变应原 tropomyosin 的免疫球蛋白 E (IgE ) epitopes 特定的 mimotopes。有 8-12 氨基酸残余的 OBOC 肽图书馆为 tropomyosin 的 IgE mimotopes 与贝壳过敏症从病人与浆液样品被屏蔽。25 mimotopes 从屏蔽被识别,他们到 tropomyosin 特定的 IgE 的有约束力的反应被肽 ELISA 证实。这些 mimotopes 能基于顺序相同被划分成七簇,并且由聚类的 mimotopes 的 EpiSearch 印射的 epitope 被执行描绘并且证实 mimotopes 的有效性。五从六预言的 epitopes 被发现与 tropomyosin 的以前识别的 epitopes 重叠。为了推进,证实 mimotopes 的模仿潜力, BALB/c 老鼠被使免疫, mimotopes 结合了到锁眼恋栈者 hemocyanin 和 assayed 让他们的能力导致 tropomyosin 特定的抗体。那收到的 mimotope 免疫被发现有 tropomyosin 特定的免疫球蛋白 G 的提高的水平的 BALB/c 老鼠,然而并非收到了无关的 mimotope 的老鼠。这研究用整个 sera 开创 OBOC 图书馆的成功的申请屏蔽并且识别多重虾变应原 mimotopes 并且验证他们在 vitro 使用的模仿潜力,在 vivo,并且在 silico 方法。 | Nicki YH Leung Christine YY Wai Marco HK Ho Ruiwu Liu Kit S Lam Jin Jun Wang Shang An Shu Ka Hou Chu Patrick SC Leung | 2017 | Cellular & Molecular Immunology2017，14，3： | 6 |
| 2 | The correlation among obesity,apnea-hypopnea index,and tonsil size in children显示文摘 | Lam YY Chan EY Ng DK | 2006 | Chest2006，130，6： | 1 |
| 3 | The Correlation Among Obesity, Apnea-Hypopnea Index, and Tonsil Size in Children 显示文摘 | Lam YY Chan EY Ng DK | 2006 | Chest2006，130，6： | 1 |
| 4 | Prognostic value of neutrophil/ lymphocyte ratio in patients with ST-elevated myocardial infarction undergoing primary coronary intervention : a prospective, multicenter study 显示文摘 | Kaya MG Akpek M Lam YY | 2013 | Int J Cardio12013，168，2： | 1 |
| 5 | Effect of left ventricular lead concordance to the delayed contraction segment on echocardiographic and clinical outcomes after cardiac resynchronization therapy显示文摘 | Fung JW Lam YY Zhang Q | 2009 | J Cardiovasc Electrophysiol2009，20，5： | 1 |
| 6 | Identification of a no- vel missense mutation (G149E) in the glucose-6-phosphate translocase gene in a Chinese family with glycogen storage disease type lb显示文摘 | Lam CW Tong SF Lam YY | 1999 | Hum Mutat Online Report1999，，： | 1 |
| 7 | A new left atrial appendage occluder(Lifetech LAmbre Device)for stroke prevention in AF显示文摘 | Lam YY | 2013 | Cardiovasc Revasc Med2013，14，： | 1 |
| 8 | Obstructive sleep apnoea syndrome and obesity in children 显示文摘 | Ng DK Lam YY Kwok KL | 2004 | Hong Kong Med J2004，10，1： | 1 |
| 9 | Alternatives to chronic warfarin therapy for the prevention of stroke in patientswith atrial fibrillation显示文摘 | Lam YY Ma TK Yan BP | 2011 | Int J Car- diol2011，150，1： | 1 |
| 10 | The correlation among obesity,apnea-hypopnea index,and tonsil size in children显示文摘 | Lam YY Chan EY Ng DK | 2006 | Chest2006，130，6： | 1 |
| 11 | Impact of genetic and acquired alteration in cytochrome P450 sys tem on pharmacologic and clinical response to clopi dogrel显示文摘 | Ma TK Lam YY Tan VP | 2010 | PharmacolTher2010，125，2： | 1 |
| 12 | Intravenous leiomyomatosis:computed tomography diagnosis显示文摘 | Wong YY Chu WC Lam WW | 2006 | Hong Kong Med J2006，12，3： | 1 |
| 13 | Combination of arsenic trioxide and chemotherapy in small cell lung cancer显示文摘 | ZHENG CY LAM SK LI YY | 2013 | Lung Cancer2013，82，2： | 1 |
| 14 | Alternatives to chronic warfarin therapy for the prevention of stroke in patients with atrial fibrillation显示文摘 | Lam YY Ma TK Yan BP | 2011 | International Journal of Cardiology2011，150，1： | 1 |
| 15 | Comparison of outcomes of primary scleral-fixated versus primary anterior chamber intraocular lens implantation in complicated cataract surgeries显示文摘 | Kwong YY Yuen HK Lam RF | 2007 | Ophthalmology2007，114，1： | 1 |
| 16 | Left atrial appendage exclusion:state-of-the-art显示文摘 | Cruz-Gonzalez I Yan BP Lam YY | 2010 | Catheter Cardiovasc Interv2010，75，5： | 1 |
| 17 | Relation of neutrophil/lym- phocyte ratio to coronary flow to in-hospital major adverse cardiac events in patients with ST-elevated myocardial infarction undergo- ing primary coronary intervention显示文摘 | Akpek M Kaya MG Lam YY | 2012 | Am J Cardiol2012，110，5： | 1 |
| 18 | Effects of phacoemulsification versus combined phacotrabeculectomy on drainage angle status in primary angle closure glaucoma (PACG)显示文摘 | Tham CC Leung DY Kwong YY Li FC LaiJS Lam DS | 2010 | J Glaucoma2010，19，2： | 1 |
| 19 | Left atrial appendage closure with AMPLATZER cardiac plug for stroke prevention in atrial fibrillation: initial Asia-Pacific experience显示文摘 | Lam YY Yip GW Yu CM | 2012 | Catheter Cardiovasc Interv2012，79，5： | 1 |
| 20 | Effect of left ventricular lead concordance to the delayed contraction segment on echocardiographic and clinical outcomes after cardiac resynchronization therapy显示文摘 | Fung JW Lam YY Zhang Q | 2009 | J Cardiovasc Electrophysiol2009，20，5： | 1 |
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