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| 1 | Adiponectin deficiency enhances colorectal carcinogenesis and liver tumor formation induced by azoxymethane in mice显示文摘AIM:To investigate the causal relationship between hypoadiponectinemia and colorectal carcinogenesis in in vivo experimental model,and to determine the con-tribution of adiponectin defi ciency to colorectal cancer development and proliferation.METHODS:We examined the influence of adiponectin defi ciency on colorectal carcinogenesis induced by the administration of azoxymethane(AOM)(7.5 mg/kg,in-traperitoneal injection once a week for 8 wk),by using adiponectin-knockout(KO) mice.RESULTS:At 53 wk after the fi rst AOM treatment,KOmice developed larger and histologically more progres-sive colorectal tumors with greater frequency com-pared with wild-type(WT) mice,although the tumor incidence was not different between WT and KO mice.KO mice showed increased cell proliferation of colorec-tal tumor cells,which correlated with the expression levels of cyclooxygenase-2(COX-2) in the colorectal tumors.In addition,KO mice showed higher incidence and frequency of liver tumors after AOM treatment.Thirteen percent of WT mice developed liver tumors,and these WT mice had only a single tumor.In contrast,50% of KO mice developed liver tumors,and 58% of these KO mice had multiple tumors.CONCLUSION:Adiponectin deficiency enhances colorectal carcinogenesis and liver tumor formation induced by AOM in mice.This study strongly suggests that hypoadiponectinemia could be involved in the pathogenesis for colorectal cancer and liver tumor in human subjects. | Tamao Nishihara Miyako Baba Morihiro Matsuda Masahiro Inoue Yasuko Nishizawa Atsunori Fukuhara Hiroshi Araki Shinji Kihara Tohru Funahashi Shinji Tamura Norio Hayashi Hiroyasu Iishi Iichiro Shimomura | 2008 | World Journal of Gastroenterology2008，14，42： | 12 |
| 2 | Effect of Adiponectin on Murine Colitis Induced by Dextran Sulfate Sodium显示文摘 | Tamao Nishihara Morihiro Matsuda Hiroshi Araki Kazuya Oshima Shinji Kihara Tohru Funahashi Iichiro Shimomura | 2006 | Gastroenterology2006，，3： | 2 |
| 3 | Nitrogen removal efficiencies and microbial communities in full-scale IFAS and MBBR municipal wastewater treatment plants at high COD:N ratio显示文摘The relative locations of AOB,NOB,and DNB were examined for three different kinds of carriers in two types of hybrid bioflm process configurations:integrated fixed-film activated sludge(IFAS)and moving bed bioflm reactor(MBBR)processes.IFAS water resource recovery facilities(WRRFs)used Anodkainess^TM K1 carriers(KC)at Broomfield,Colorado,USA and polypropylene resin crriers(R)at Fukuok,Japa,whic MBBR WRFS used KC crier at South Adams Couty,Colorado,USA and sponge carriers(SC)at Saga,Japan.Influent COD to N ratios ranged from 8:1 to 15:1.The COD and BOD removal efficiencies were high(96%-98%);NH^+4-N and TN removal efficiencies were more varied at 72%98%and 64%-77%,respectively.The extent of TN removal was higher at high SRT,high COD:N ratio and low DO concentration in the anoxic tank.In IFAS,RC with high specific surface area.(SSA)maintained higher AOB population than KC.Sponge carriers with high SSA maintained higher overall bacteria population than KC in MBBR systems.However,the DNB were not more abundant in high SSA crriers.The diversity of AOB,NOB,and DNB was fairly similar in different carriers.Nitrosomonas sp.dominated over Nitrosospira sp.while denitrifying bacteria included Rhodobacter sp.,Sulfuritalea sp.,.Rubrivivax sp:Paracoccus sp..and Pseudomonas sp.The results from this work suggest that high SRT,high.COD:N ratio,low DO concentration in anoxic tanks,and carriers with greater surface area may be recommended for high COD,BOD and TN removal in WRRFs with IFAS and MBBR systerms. | Supaporn Phanwilai Naluporn Kangwannarakul Pongsak(Lek)Noophan Tamao Kasahara Akihiko Terada Junko Munakata-Marr Linda Ann Figueroa | 2020 | Frontiers of Environmental Science & Engineering2020，14，6： | 2 |
| 4 | Toxicity oIf pufferfish takifugu rubripes cultured in netcages at sea or aquaria on land显示文摘 | Noguchi Tamao Arakawa Osamu Takatani Tomohiro | 2006 | Comparative Biochemistry and Physiology Part D:Genomics and Proteomics2006，1，1： | 1 |
| 5 | Optically active 2,2'-bis(diphenylphosphinomethyl)-1,1'-binaphthyl:A new chiral bidentate phosphine ligand for transition-metal complex catalyzed asymmetric reactions显示文摘 | Tamao K Yamamoto H Masumoto H | 1977 | Tetrahedron Lett1977，18，： | 1 |
| 6 | A surface analytical approach to the structure of starch granules 显示文摘 | Tamao H Seiko N Keiji K | 2003 | The Japanese Society of Applied Glycoscience2003，50，： | 1 |
| 7 | The first observation of electroluminescence from di(2-naphthyl) disilene, an Si= Si double bond-containing n-conjugated compound显示文摘 | Tamao K Kobayashi M Matsuo T | 2012 | Chem Commun2012，48，： | 1 |
| 8 | Deposition of gold nanoparticles on carbons for aerobic glucose oxidation显示文摘 | Hiroko Okatsu Naoto Kinoshita Tomoki Akita Tamao Ishida Masatake Haruta | 2009 | Applied Catalysis A General2009，，1： | 1 |
| 9 | X-ray photoelectron spectroscopic study on the goethites with variations in crystallinity and morphology: their effects on surface hydroxyl concentration显示文摘 | Takuya Echigo Tamao Hatta Seiko Nemoto Shigeru Takizawa | 2012 | Physics and Chemistry of Minerals2012，，9： | 1 |
| 10 | Direct deposition of gold nanoparticles onto polymer beads and glucose oxidation with H 2 O 2显示文摘 | Tamao Ishida Kyoko Kuroda Naoto Kinoshita Wataru Minagawa Masatake Haruta | 2008 | Journal of Colloid And Interface Science2008，，1： | 1 |
| 11 | Immunoenzymatic visualization of tetrodotoxin (TTX) in Cephalothrix species (Nemertea: Anopla: Palaeonemertea: Cephalotrichidae) and Planocera reticulata (Platyhelminthes: Turbellaria: Polycladida: Planoceridae)显示文摘 | Mohosena Begum Tanu Yahia Mahmud Osamu Arakawa Tomohiro Takatani Hiroshi Kajihara Kentaro Kawatsu Yonekazu Hamano Manabu Asakawa Keisuke Miyazawa Tamao Noguchi | 2004 | Toxicon2004，，5： | 1 |
| 12 | Novel method of gene transfer in birds: Intracytoplasmic sperm injection for green fluorescent protein expression in quail blastoderms显示文摘 | Shusei M Soichi T Tamao O | 2010 | Biol Reprod2010，18，： | 1 |
| 13 | A colorimetric and ratiometric fluorescent chemosensor with three emission changes:Fluoride ion sensing by a triarylborane-porphyrin conjugate显示文摘 | Kubo Y Yamamoto M Ikeda M Takeuchi M Shinkai S Yamaguchi S Tamao K | 2003 | Angewandte Chemie-International Edition2003，42，18： | 1 |
| 14 | Sex-specific and left-right asymmetric expression pattern of Bmp7 in the gonad of normal and sex-reversed chicken embryos 显示文摘 | Anshin H Masafumi K Tamao O | 2005 | Develop Growth Differ2005，47，： | 1 |
| 15 | 显示文摘 | Yamaguchi S Jin R Z Tamao K | 1999 | J Am Chem Soc1999，121，： | 1 |
| 16 | Colorimetric fluoride ion sensing by boron-containing pi-electron systems显示文摘 | Yamaguchi S Akiyama S Tamao K | 2001 | Journal of the American Chemical Society2001，123，11： | 1 |
| 17 | 显示文摘 | Yamaguchi S Jin R Z Tamao K J | 1998 | Organometal Chem1998，559，12： | 1 |
| 18 | 显示文摘 | Tamao K Kobayashi K Ito Y | 1992 | Synlett1992，，： | 1 |
| 19 | TTX accumulation in pufferfish显示文摘 | Tamao N | 2006 | Comparative Biochemistry and Physiology2006，1，： | 1 |
| 20 | 显示文摘 | Tamao K Yamaguchi S Shiro M | 1994 | J Am Chem Soc1994，116，11： | 1 |
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