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| 1 | Treatment with dimethyl fumarate ameliorates liver ischemia/reperfusion injury显示文摘AIM To investigate the hypothesis that treatment with dimethyl fumarate(D MF) mayame liorate liver ischemia/reperfusion injury(I/RI).METHODS Rats were divided into 3 groups: sham, control(CTL), and DMF. DMF(25 mg/kg, twice/d) was orally administered for 2 d before the procedure. The CTL and DMF rats were subjected to ischemia for 1 h and reperfusion for 2 h. The serum alanine aminotransferase(ALT) and malondialdehyde(MDA) levels, adenosine triphosphate(ATP), NO × metabolites, anti-oxidant enzyme expression level, antiinflammatory effect, and anti-apoptotic effect were determined.RESULTS Histological tissue damage was significantly reduced in the DMF group(Suzuki scores: sham: 0 ± 0; CTL: 9.3± 0.5; DMF: 2.5 ± 1.2; sham vs CTL, P < 0.0001; CTL vs DMF, P < 0.0001). This effect was associated with significantly lower serum ALT(DMF 5026 ± 2305 U/L vs CTL 10592 ± 1152 U/L, P = 0.04) and MDA(DMF 18.2 ± 1.4 μmol/L vs CTL 26.0 ± 1.0 μmol/L, P = 0.0009). DMF effectively improved the ATP content(DMF 20.3 ± 0.4 nmol/mg vs CTL 18.3 ± 0.6 nmol/mg, P = 0.02), myeloperoxidase activity(DMF 7.8 ± 0.4 m U/m L vs CTL 6.0 ± 0.5 m U/m L, P = 0.01) and level of endothelial nitric oxide synthase expression(DMF 0.38 ± 0.05-fold vs 0.17 ± 0.06-fold, P = 0.02). The higher expression levels of anti-oxidant enzymes(catalase and glutamatecysteine ligase modifier subunit and lower levels of key inflammatory mediators(nuclear factor-kappa B and cyclooxygenase-2 were confirmed in the DMF group.CONCLUSION DMF improved the liver function and the anti-oxidant and inflammation status following I/RI. Treatment with DMF could be a promising strategy in patients with liver I/RI. | Chie Takasu Nosratola D Vaziri Shiri Li Lourdes Robles Kelly Vo Mizuki Takasu Christine Pham Seyed H Farzaneh Mitsuo Shimada Michael J Stamos Hirohito Ichii | 2017 | World Journal of Gastroenterology2017，23，25： | 3 |
| 2 | Inhibition of ileal Na +/bile acid cotransporter by S-8921 reduces serum cholesterol and prevents atherosclerosis in rabbits显示文摘 | Higaki J Hara S Takasu N | 1998 | Artheroscl Thromb Vascular Biol1998，18，8： | 1 |
| 3 | Comparison of LV mass and volume measurements derived from electron beam tomography using cine ima- ging and angiographic imaging显示文摘 | Mao S Takasu J Child J | 2003 | Cardiovasc Imaging2003，19，： | 1 |
| 4 | Valvular and thoracic aortic calcium as a marker of the extent and severity of angiographic coronary artery disease显示文摘 | Yamamoto H Shavelle D Takasu J | 2003 | Am Heart J2003，146，1： | 1 |
| 5 | Valvular and thoracic aortic calcium as a marker of the extent and severity of angiographic coronary artery disease显示文摘 | YAMAMOTO H SHAVELLE D TAKASU J | 2003 | Am HeartJ2003，146，1： | 1 |
| 6 | Valvular andthoraeic aortic calcium as a marker of the extent and severity of angiographie coronary artery disease显示文摘 | Yamamoto H Shavelle D Takasu J | 2003 | ArnHeart J2003，146，1： | 1 |
| 7 | Expansion rate of thoracic aortic aneurysms and influencing factors 显示文摘 | Masuda Y Takanashi K Takasu J | 1992 | Chest1992，102，2： | 1 |
| 8 | ^40Ar/^39Ar Ages of the High-p/T Metamorphic Rocks of the Hei- longjiang Complex in the Jiamusi Massif, Northeast- ern China显示文摘 | Li W M Takasu A Liu Y J | 2009 | Journal of Mineralogical and Petro- logical Sciences2009，104，： | 1 |
| 9 | Relationship between common carotid intima-media thickness and thoracic aortic calcification:the Multi-Ethnic Study of Atherosclerosis 显示文摘 | Takasu J Budoff MJ Katz R | 2010 | Atherosclerosis2010，209，1： | 1 |
| 10 | Hashinoto' s thyrodidist: TGA, TPO-Ab,TRAb and recovery from hypothyroidism显示文摘 | Takasu N Yoshimura Noh J | 2008 | Expert Rev Clin Immunol2008，4，2： | 1 |
| 11 | Pericardial fat accumulation in men as a risk factor for coronary artery disease 显示文摘 | Taguchi R Takasu J Itani Y | 2001 | Atherosclerosis2001，157，1： | 1 |
| 12 | Importance of adult food sources to host searching of the larval parasitoid Microplitis croceipes显示文摘 | Takasu K Lewis W J | 1995 | Biological Control1995，5，： | 1 |
| 13 | Importance of adult food sources to host searching of the larval parasitoid Microplitis croceipes显示文摘 | Takasu K Lewis W J | 1995 | Biological Control1995，5，： | 1 |
| 14 | Valvular and thoracic aortic calcium as a marker of the extent and severity of angiographie coronary artery disease显示文摘 | Yamamoto H Shavelle D Takasu J | 2003 | Am Heart J2003，146，1： | 1 |
| 15 | Valvular and thoracic arotic calcium as a marker of the exent and severity of angiofraghic coronary ar- tery disease显示文摘 | Yamamoto H Shavelle D Takasu J | 2003 | Am Heart J2003，146，1： | 1 |
| 16 | CGC perpendicular recording media with CoCrPt-SiO2 alloy as granular layer显示文摘 | SONOBE Y THAM K K WU L UMEZAWA T TAKASU C DUMAYA J A H ONOUE T LEO P LIAU M | 2006 | IEEE Trans Magn2006，42，10： | 1 |
| 17 | Hashimoto′s thyroiditis:TGAb,TPOAb,TRAb and recovery from hypothyroidism显示文摘 | Takasu N Yoshimura Noh J | | 0，，： | 1 |
| 18 | Importance of adult food sources to host searching of the larval parasitoid Microplitis croceipes显示文摘 | Takasu K Lewis W J | 1995 | Biological Control1995，5，1： | 1 |
| 19 | Pericardial fat accumulation in men as a risk factor for coronary artery disease显示文摘 | Taguchi R Takasu J Itani I | 2001 | J Atherosclerosis2001，157，： | 1 |
| 20 | Apoptosis and perturbation of cell cycle progression in an acidic environment after hyperthermia显示文摘 | Takasu T Lyons JC Park H J | 1998 | Cancer Res1998，58，12： | 1 |
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