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| 1 | Real-world efficacy of daclatasvir and asunaprevir with respect to resistance-associated substitutions显示文摘AIM To investigate daclatasvir(DCV) and asunaprevir(ASV) efficacy in hepatitis C(HCV) patients, with respect to resistance-associated substitutions(RASs).METHODS A total of 392 HCV-infected patients from multiple centers were included in this study. We evaluated their clinical courses and sustained virologic responses(SVR) according to pretreatment factors(gender, age, history of interferon-based regimens, platelet counts, level of viremia, pretreatment NA5A:L31, and Y93 substitutions). We also analyzed the pretreatment and post-treatment major RASs of NS3:D168, NS5A:L31 and Y93 substitutions using a direct-sequencing method in 17 patients who were unable to achieve SVR at 12 wk after treatment completion(SVR12).RESULTS The overall SVR12 rate was 88.3%. Thirty-one patients discontinued treatment before 24 wk because of adverse events, 23 of whom achieved SVR12. There were no significant differences in SVR12 rates with respect to gender, age, history of interferon-based regimens, and platelet counts. The SVR12 rate in patients with viral loads of ≥ 6.0 log IU/m L was significantly lower than those with viral loads of < 6.0 log IU/m L(P < 0.001). The SVR12 rate in patients with Y93 substitution-positive was significantly lower than those with Y93 substitution-negative(P < 0.001). The L31 substitution-positive group showed a lower SVR12 rate than the L31 substitution-negative group, but the difference was not statistically significant. Seventeen patients who did not achieve SVR12 and had available pretreatment and post-treatment sera had additional RASs in NS3:D168, NS5:L31, and Y93 substitution at treatment failure.CONCLUSION Combination of DCV and ASV is associated with a high SVR rate. Baseline RASs should be thoroughly assessed to avoid additional RASs after treatment failure. | Hideki Fujii Atsushi Umemura Taichiro Nishikawa Kanji Yamaguchi Michihisa Moriguchi Hideki Nakamura Kohichiroh Yasui Masahito Minami Saiyu Tanaka Hiroki Ishikawa Hiroyuki Kimura Shiro Takami Yasuyuki Nagao Toshihide Shima Yoshito Itoh | 2017 | World Journal of Hepatology2017，9，25： | 3 |
| 2 | Structural Flexibility Enables Alternative Maturation, ARGONAUTE Sorting and Activities of miR168, a Global Gene Silencing Regulator in Plants显示文摘在优核质, RNase-III Dicer 经常生产长度 / 顺序 microRNA (miRNA ) 变体,叫的 isomiRs,由于 miRNA 先锋(pre-miRNAs ) 的内在的 structural/sequence 决定因素。在这研究,我们联合了学习 Arabidopsis miR168 的生物物理学,遗传和生物化学途径,中央植物 silencing 受动器蛋白质 ARGONAUTE1 (AGO1 ) 的关键反馈管理者。我们识别了在植物 pre-miR168 orthologs 之中保存的一个主题,它启用灵活内部基础配对的位于 \O 下面至少三种亚稳的结构的配置。这些配置支持与行动的特殊以前排序的性质和模式产生长度和结构的 isomiR168 变体的其他的、精确 Dicer 劈开事件。在这些 isomiR168s 之中,一与 22-nt 指南海滨双为 AGO10 展出惊人地优先的亲密关系,最靠近的 AGO1 paralog。22-nt miR168-AGO10 建筑群反对 AGO1 累积在 ? 经由及物的 RNAi 的部分,一个沉默扩大过程,维持 ? 适当 AGO1 细胞的动态平衡。而且,我们发现 tombusviral P19 silencing-suppressor 蛋白质在它的 isomiR168 货物之中为 22-nt 形式显示显著地更弱的亲密关系,从而支持调停 AGO1 的抗病毒的 silencing 的指导 AGO10 的抑制。一起拿,这些调查结果显示那结构的灵活性, pre-miRNAs 的一个以前俯看的性质,更加增加通用性和单个 MIRNA 基因,和病原体可能发展了的那一些的规章的潜力能力或机制篡夺这个性质。 | Taichiro Iki Antoine Cléry Nicolas G. Bologna Alexis Sarazin Christopher A. Brosnan Nathan Pumplin Frédéric H.T. Allain Olivier Voinnet | 2018 | Molecular Plant2018，11，8： | 2 |
| 3 | Cyclic loading behavior of EBF links constructed of ASTM A992 steel 显示文摘 | Taichiro Okazaki Michael D Engelhardt | 2007 | Journal of Constructional Steel Research2007，63，： | 1 |
| 4 | Toll-like re- ceptor expression in lupus peripheral blood mononuclear cells 显示文摘 | Kiyoshi Migita Taichiro Miyashita Yumi Maeda | 2007 | J Rheumato12007，34，3： | 1 |
| 5 | High prevalence of simian Tlymphotropic virus type L in wild Ethiopian baboons显示文摘 | Taichiro T Masahiro Y Makoto K | 2002 | J Virology2002，76，4： | 1 |
| 6 | XRF Analysis of Major and Trace Elements for Wide Compositional Ranges from Silicate to Carbonate Rocks Using Low Glass Beads 显示文摘 | Akiko G Taichiro H Tsukas O | 2002 | Japanese Magazine of Mineralogical and Petrological Sciences2002，31，： | 1 |
| 7 | Correlation between vascular endothelial growth factor and nonperfused areas in macular edema secondary to branch retinal vein occlusion显示文摘 | Masato Fujikawa Taichiro Miyake Sawada Ohji Kawamura Sawada Masashi Kakinoki | 2013 | Clinical Ophthalmology . 2013 (defa)2013，，： | 1 |
| 8 | Nonlinear finite-element analysis of critical gusset plates in the 1-35W bridge in Minnesota显示文摘 | Minmao Liao Taichiro Okazaki Roberto Ballarini | 2011 | Journal of Structural Engineering2011，137，1： | 1 |
| 9 | Compensatory glutamine metabolism promotes glioblastoma resistance to mTOR inhibitor treatment显示文摘 | Tanaka Kazuhiro Sasayama Takashi Irino Yasuhiro Takata Kumi Nagashima Hiroaki Satoh Naoko Kyotani Katsusuke Mizowaki Takashi Imahori Taichiro Ejima Yasuo Masui Kenta Gini Beatrice Yang Huijun Hosoda Kohkichi Sasaki Ryohei Mischel Paul S Ko | 2015 | Journal of Clinical Investigation2015，，4： | 1 |
| 10 | A study on collision buffer characteristic of sharp entrance angle bow structure 显示文摘 | Seiichiro Yagi Hideki Kumamoto Osamu Muragishi Yukichi Takaoka Taichiro Shimoda | 2009 | Marine Structures2009，22，： | 1 |
| 11 | Creep property measurements of welded joint of reduced-activation ferritic steel by the small-punch creep test显示文摘 | Shinichi K Taichiro K Yutaka K | 2009 | Materials Science and Engineering A2009，，： | 1 |
| 12 | Annular resonator with a cassegrain configuration显示文摘 | Jun-ichi Nishimae | 1997 | Applied Optics1997，36，24： | 1 |
| 13 | Annular resonator with a cassegrain configuration显示文摘 | Taichiro Tamida and Jun-ichi Nishimae | 1997 | Applied Op tics August1997，36，24： | 1 |
| 14 | Toll-like Receptor Expression in Lupus Peripheral Blood Mononuclear Cells显示文摘 | Kiyoshi M Taichiro M Yumi M | 2007 | J Rheumatol2007，34，： | 1 |
| 15 | Awareness and treatment of hypertension and hypercholesterolemia in Japanese workers: the highrisk and population strategy for occupational health promotion (HIPOP-OHP) study显示文摘 | Taichiro T Tomonori O Zentaro Y | 2007 | Hypertens Res2007，30，： | 1 |
| 16 | Cyclic loading behavior of EBF links constructed of ASTM A992 steel显示文摘 | Taichiro Okazaki Michael D. Engelhardt | 2006 | Journal of Constructional Steel Research2006，，6： | 1 |
| 17 | Stability requirements for beams inseismic steel moment frames显示文摘 | Taichiro 0 Liu D W | 2006 | Journal of Structural Engineering2006，132，9： | 1 |
| 18 | Percutaneous Bowel Drainage for Jaundice due to Afferent Loop Obstruction Following Pancreatoduodenectomy: Report of a Case显示文摘 | Shigeaki Moriura Yuichi Takayama Junichi Nagata Atsushi Akutagawa Atsushi Hirano Seiji Ishiguro Takatoshi Matsumoto Taichiro Sato | 1999 | Surgery Today1999，，10： | 1 |
| 19 | Experimental Investigation of Link-to-Column Connections in Eccentrically Braced Frames 显示文摘 | Taichiro Okazaki Engelhardt D | 2009 | Journal of Constructional Steel Research2009，65，7： | 1 |
| 20 | Collaboration between practice and research for development of steel construction in Japan 显示文摘 | Masayoshi Nakashima Mikiko Kato Taichiro Okazaki | 2004 | International Jourual of Steel Structures2004，4，4： | 1 |
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