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| 1 | Nutrition and exercise in the management of liver cirrhosis显示文摘Liver cirrhosis(LC)patients often have protein-energy malnutrition(PEM)and decreased physical activity.These conditions often lead to sarcopenia,which is the loss of skeletal muscle volume and increased muscle weakness.Recent studies have demonstrated that PEM and sarcopenia are predictors for poor survival in LC patients.Nutrition and exercise management can improve PEM and sarcopenia in those patients.Nutrition management includes sufficient dietary intake and improved nutrient metabolism.With the current high prevalence of obesity,the number of obese LC patients has increased,and restriction of excessive caloric intake without the exacerbation of impaired nutrient metabolism is required for such patients.Branched chain amino acids are good candidates for supplemental nutrients for both obese and non-obese LC patients.Exercise management can increase skeletal muscle volume and strength and improve insulin resistance;however,nutritional status and LC complications should be assessed before an exercise management regimen is implemented in LC patients.The establishment of optimal exercise regimens for LC patients is currently required.In this review,we describe nutritional status and its clinical impact on the outcomes of LC patients and discuss general nutrition and exercise management in LC patients. | Nobuyuki Toshikuni Tomiyasu Arisawa Mikihiro Tsutsumi | 2014 | World Journal of Gastroenterology2014，20，23： | 20 |
| 2 | Clinical differences between alcoholic liver disease and nonalcoholic fatty liver disease显示文摘Alcoholic liver disease(ALD)and nonalcoholic fatty liver disease(NAFLD)are serious health problems worldwide.These two diseases have similar pathological spectra,ranging from simple hepatic steatosis to steatohepatitis,liver cirrhosis,and hepatocellular carcinoma.Although most subjects with excessive alcohol or food intake experience simple hepatic steatosis,a small percentage of individuals will develop progressive liver disease.Notably,both ALD and NAFLD are frequently accompanied by extrahepatic complications,including cardiovascular disease and malignancy.The survival of patients with ALD and NAFLD depends on various disease-associated conditions.This review delineates the clinical characteristics and outcomes of patients with ALD and NAFLD by comparing their epidemiology,the factors associated with disease susceptibility and progression,and the predictors and characteristics of outcomes.A comprehensive understanding of the characteristics and outcomes of ALD and NAFLD is imperative in the management of these chronic liver diseases. | Nobuyuki Toshikuni Mikihiro Tsutsumi Tomiyasu Arisawa | 2014 | World Journal of Gastroenterology2014，20，26： | 13 |
| 3 | Hepatitis C-related liver cirrhosis-strategies for the prevention of hepatic decompensation,hepatocarcinogenesis,and mortality显示文摘Liver cirrhosis(LC)is a critical stage of chronic liver disease,including that caused by hepatitis C virus(HCV).In the absence of antiviral therapy,67%-91%of patients with HCV-related LC patients die of liver-related causes,including hepatocellular carcinoma(HCC)and liver failure.Among the therapeutic strategies used to prevent liver-related complications in these patients is standard therapy with pegylated interferon and ribavirin,which induces a sustained virological response(SVR)in 25%of HCV genotype 1-infected patients and in 69% of patients infected with genotypes 2 and 3.SVR in patients with HCV-related LC has been associated with reduced rates of hepatic decompensation,HCC,and mortality.More recently developed direct-acting antiviral agents have shown excellent antiviral efficacy,with preliminary data demonstrating that an interferon-free regimen that includes these direct-acting antiviral agents achieved SVR in more than 50%of patients with HCV genotype 1 LC.Branched-chain amino acid supplementation,improvement of insulin resistance,and the use ofβ-blockers for portal hypertension may also reduce liverrelated complications.Here,we review advances in antiviral and adjunctive therapies for improved outcomes in patients with HCV-associated LC. | Nobuyuki Toshikuni Tomiyasu Arisawa Mikihiro Tsutsumi | 2014 | World Journal of Gastroenterology2014，20，11： | 10 |
| 4 | A hybrid multi-objective optimization method considering optimization problems in power distribution systems显示文摘Various kinds of new engineering technologies have been studied to realize the low-carbon and sustainable power supply systems all over the world.In actual implementation of these technologies,mostly,there are multiple objectives with trade off relationships among each other,and also various constraints in the achievement of these objectives.Therefore,it should be essential to solve multiobjective optimization problems effectively in the applications of these new technologies in power systems.This paper proposes an improved method to realize multiobjective optimization for critical challenges in advanced power systems.To realize that,in an optimal dispersed generation installation problem,that is,one of effective measures for low-carbon power systems,various optimization methods and their combination methods are evaluated and a hybrid method for evolutionary algorithms was developed.The method can provide improved results compared with other state-of-the-art multi-objective optimization methods. | Ken KURODA Hideki MAGORI Tomiyasu ICHIMURA Ryuichi YOKOYAMA | 2015 | Journal of Modern Power Systems and Clean Energy2015，3，1： | 5 |
| 5 | -449 C>G polymorphism of NFKB1 gene,coding nuclear factor-kappa-B,is associated with the susceptibility to ulcerative colitis显示文摘AIM:To clarify the association between a polymorphism-449 C>G(rs72696119) in 5'-UTR of NFKB1 with ulcerative colitis(UC).METHODS:The studied population comprised 639 subjects,including patients with UC(UC cases,n = 174) and subjects without UC(controls,n = 465).We employed polymerase chain reaction-single strand conformation polymorphism to detect the gene polymorphism.RESULTS:The rs72696119 G allele frequencies in controls and UC cases were 33.4% and 38.5%,respectively(P = 0.10).Genotype frequency of the GG homozygote in UC cases was significantly higher than that in controls(P = 0.017),and the GG homozygote was significantly associated with susceptibility to UC [odds ratio(OR),1.88;95%CI,1.13-3.14].In male subjects,the GG homozygote was associated with an increased risk for UC(OR,3.10;95%CI,1.47-6.54;P = 0.0053),whereas this association was not found in female subjects.In addition,the GG homozygote was significantly associated with the risk of non-continuous disease(OR,2.06;95%CI,1.12-3.79;P = 0.029),not having total colitis(OR,2.40;95%CI,1.09-3.80,P = 0.040),disease which developed before 20 years of age(OR,2.80;95%CI,1.07-7.32,P = 0.041),no hospitalization(OR,2.28;95%CI,1.29-4.05;P = 0.0090) and with a maximum of 8 or less on the UCDAI score(OR,2.45;95%CI,1.23-4.93;P = 0.022).CONCLUSION:Our results provide evidence that NFKB1 polymorphism rs72696119 was significantly associated with the development of UC.This polymorphism influences the susceptibility to and pathophysiological features of UC. | Ranji Hayashi Tomomitsu Tahara Tsukasa Yamaaki Takashi Saito Kazuhiro Matsunaga Nobuhiko Hayashi Atsushi Fukumura Kazuaki Ozaki Masakatsu Nakamura Hisakazu Shiroeda Mikihiro Tsutsumi Tomoyuki Shibata Tomiyasu Arisawa | 2012 | World Journal of Gastroenterology2012，18，47： | 2 |
| 6 | Effect of an extract of Ganoderma lucidum in men with lower urinary tract symptoms: a double-blind, placebo-controlled randomized and dose-ranging study显示文摘瞄准:进行一个双窗帘,控制安慰剂使随机化并且评估 Ganoderma 的摘录的安全和功效的变化剂量的学习易懂嗯(G。易懂嗯) 在有更低的泌尿道症状(LUTS ) 的人。方法:我们注册了男志愿者(≥ 50 年) 与一个国际前列腺症状分数(IPSS;问题 1-7 ) ≥ 5 并且前列腺特定的抗原(PSA ) 价值 <
4 ng/mL。志愿者被使随机化进一些安慰剂(n = 12 ) , G。易懂 0.6 mg 的 um (n = 12 ) , 6 mg (n = 12 ) 或 60 mg (n = 14 ) ,管理从前每日。功效在 IPSS 和山峰尿流动率(Q_( 最大)) 从基线作为一个变化被测量。前列腺体积和残余尿被 ultrasonography 估计,并且包括 PSA 层次,验血在基线并且在处理的结束被测量。结果:全面管理很好被容忍,没有主要不利效果。在在试验性的组之间的变化的大小的统计意义在星期被观察 4 和 8。没有变化被观察关于 Q_( 最大) ,残余尿,前列腺体积或 PSA 铺平。结论:G 的摘录。易懂嗯很好被容忍,在 IPSS 的改进被观察。G 的摘录的推荐剂量。易懂嗯是在有 LUTS 的人的 6 mg。 | Masanori Noguchi Tatsuyuki Kakuma Katsuro Tomiyasu Yoshiko Kurita Hiroko Kukihara Fumiko Konishi Shoichiro Kumamoto Kuniyoshi Shimizu Ryuichiro Kondo Kei Matsuoka | 2008 | Asian Journal of Andrology2008，10，4： | 2 |
| 7 | Randomized clinical trial of an ethanol extract of Ganoderma lucidum in men with lower urinary tract symptoms显示文摘瞄准:评估 Ganoderma 的一篇摘录的安全和功效易懂嗯那出现最强壮 5 α-reductase 在由一个双窗帘的 19 朵可食、药用的蘑菇的摘录之中的禁止的活动,控制安慰剂,使随机化并且在有更低的尿道症状(LUTS ) 的人的变化剂量的学习。方法:在这试用,我们随机分配了与 G 有 slight-to-moderate LUTS 到 12 星期处理的超过 49 年岁的 88 个人。易懂嗯摘录(6 mg 一次一天) 或安慰剂。主要结果措施是在国际前列腺症状分数(IPSS ) 和 uroflowmetry 的变量的变化。第二等的结果措施在前列腺尺寸包括了变化,剩余在 voiding,实验室价值和报导不利效果以后的尿体积。结果: G。易懂嗯对为改进全部的 IPSS, 2.1 个点在处理的目的减少的安慰剂有效、显著地优异(吝啬的差别, −1.18 点;95% 信心间隔, −1.74 到 −0.62;P <
0.0001 ) 。没有变化关于生活分数的质量被观察,山峰尿流动,吝啬的尿流动,剩余尿,前列腺体积,浆液前列腺特定的抗原或睾丸激素层次。全面处理很好没有严重不利效果被容忍。结论:G 的摘录。易懂嗯很好被容忍并且改进了 IPSS 分数。这些结果用 G 的摘录为长持续时间鼓励了植物治疗法的进一步的、大规模评估。易懂嗯在有 LUTS 的人上。 | Masanori Noguchi Tatsuyuki Kakuma Katsuro Tomiyasu Akira Yamada Kyogo Itoh Fumiko Konishi Shoichiro Kumamoto Kuniyoshi Shimizu Ryuichiro Kondo Kei Matsuoka | 2008 | Asian Journal of Andrology2008，10，5： | 2 |
| 8 | Gasification reaction of organic compounds catalyzed by RuO2 in supercritical water显示文摘 | Park K C Tomiyasu H | 2003 | Chem Commun2003，，6： | 1 |
| 9 | Regulations of ABCB1and ABCG2 expression through MAPK pathways in acute lymphoblastic leukemia cell lines显示文摘 | Tomiyasu H Watanabe M Sugita K | 2013 | Anticancer Res2013，33，12： | 1 |
| 10 | Iiiterleukin-10 inthe pathophysiology of inflammatory bowel disei ise : increasedserum concentrations during the recovery phase 显示文摘 | Mitsuyama K Tomiyasu N Takaki K | 2006 | MediatorsInflamm2006，2006，26： | 1 |
| 11 | Low serum bilirubinconcentration is associated with coronary artery calcification(CAC) 显示文摘 | Tanaka M Fukui M Tomiyasu K | 2009 | Atherosclerosis2009，206，1： | 1 |
| 12 | Cloning and Nucleotide Sequence of the Pullulanase Gene of Thermus thermophilus HB8 and Production of the Enzyme in Escherichia coli显示文摘 | Tomiyasu K Yato K Yasuda M Tonozuka T Ibuka A Sakai H | | 0，，09： | 1 |
| 13 | Computer simulation of a speckle in a synthetic aperture radar image pixel 显示文摘 | Tomiyasu K | 1983 | IEEE Transactions on Geoscience and Remote Sensing1983，，21： | 1 |
| 14 | Kinetics and mechanism of ozone decompositionin basic aqueous solution显示文摘 | TOMIYASU H FUKUTOMI H GORDON G | | 0，，19： | 1 |
| 15 | Mercury Contamination in the Yatsushiro Sea,South-western Japan:Spatial Variations of Mercury in Sediment显示文摘 | Tomiyasu T Nagano A Yonehara N | 2000 | The Science of the Total Environment2000，257，： | 1 |
| 16 | NMR Studies on Effects of Temperature, Pressure, and Fluorination on Structures and Dynamics of Alcohols in Liquid and Supercritical States显示文摘 | TSUKAHARA T HARADA M TOMIYASU H | 2008 | The Journal of Physical Chemistry A2008，112，40： | 1 |
| 17 | Kinetics and mechanism of ozone decomposition in basic aqueous solution 显示文摘 | TOMIYASU H FUKUTOMI H GORDON G | 1985 | Inorganic Chemistry1985，24，19： | 1 |
| 18 | Interleukin-10 in the pathophysiology of inilammatory bowel disease: increased serum concentrations during the recovery phase显示文摘 | Mitsuyama K Tomiyasu N Takaki K | 2006 | Mediators lnflamm2006，，6： | 1 |
| 19 | Efficacy of vascular endothelial growth factor in the treatment of experimental gastric injury显示文摘 | Matsui Y Mitsuyanma K Tomiyasu N | 2002 | Digestion2002，66，2： | 1 |
| 20 | Synthetic aperture radar imaging from an inclined geosynchronous orbit显示文摘 | Kiyo Tomiyasu | 1983 | IEEE Transactions on Geoscience and Remote Sensing1983，3，： | 1 |
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