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| 1 | Root-Specific Transcript Profiling of Contrasting Rice Genotypes in Response to Salinity Stress显示文摘提高的咸度强加渗透并且离子毒性在生活上强调房间并且要求大量的回答以便启用植物幸存。在在米饭( Oryza sativa )介绍抄本层次的更早的工作上造 FL478 射击,盐容忍的 indica recombinant 生来的线,和 IR29 ,盐敏感的栽培变种,抄本层次在这二就职的根以及在二另外的盐容忍的 indica 遗传型的根被比较, landrace Pokkali 和 recombinant 生来的线 IR63731 。这研究的目的是比较抄本在敏感并且容忍的线以便多半识别基因涉及工厂咸度忍耐,而非响应咸度本身。有到咸度忍耐的已知的连接的几个基因家庭的抄本侧面被描述(例如 HKT, NHX ) 。通过他们的盐应答,抄本层次,或 chromosomal 地点识别的一套基因的通常认为的功能(即在为咸度忍耐的 QTL 下面) 也被讨论。最后,在 FL478 的 Saltol 区域的父母起源进一步被调查。总的来说,介绍的数据集看起来柔韧,这个系统能为涉及咸度忍耐的新奇基因的发现提供可靠策略,似乎可能。 | Olivier Cotsaftis Darren Plett Alexander A.T. Johnson Harkamal Walia Clyde Wilson Abdelbagi M. Ismail Timothy J. Close Mark Tester Ute Baumann | 2011 | Molecular Plant2011，4，1： | 14 |
| 2 | Lung epithelial cell-derived IL-25 negatively regulates LPS-induced exosome release from macrophages显示文摘Background: Acute lung injury(ALI) is a major component of multiple organ dysfunction syndrome(MODS) following pulmonary and systemic infection. Alveolar macrophages(AMφ) are at the center of ALI pathogenesis. Emerging evidence has shown that cell-cell interactions in the lungs play an important regulatory role in the development of acute lung inflammation. However, the underneath mechanisms remain poorly addressed. In this study, we explore a novel function of lung epithelial cells(LEPCs) in regulating the release of exosomes from AMφ following LPS stimulation.Methods: For the in vivo experiments, C57 BL/6 wildtype(WT) mice were treated with lipopolysaccharide(LPS)(2 mg/kg) in 0.2 ml of saline via intratracheal aerosol administration. Bronchoalveolar lavage fluid was collected at 0–24 h after LPS treatment, and exosomes derived from AMφ were measured. For the in vitro studies, LEPCs and bone marrowderived Mφ(BMDM) were isolated from WT or TLR4-/-mice and were then cocultured in the Transwell? system. After coculture for 0–24 h, the BMDM and supernatant were harvested for the measurement of exosomes and cytokines.Results: We demonstrate that LPS induces macrophages(Mφ) to release exosomes, which are then internalized by neighboring Mφ to promote TNF-α expression. The secreted interleukin(IL)-25 from LEPCs downregulates Rab27 a and Rab27 b expression in Mφ, resulting in suppressed exosome release and thereby attenuating exosome-induced TNF-α expression and secretion.Conclusion: These findings reveal a previously unidentified crosstalk pathway between LEPCs and Mφ that negatively regulates the inflammatory responses of Mφ to LPS. Modulating IL-25 signaling and targeting exosome release may present a new therapeutic strategy for the treatment of ALI. | Zhi-Gang Li Melanie J. Scott Tomasz Brzóska Prithu Sundd Yue-Hua Li Timothy R. Billiar Mark A. Wilson Ping Wang Jie Fan | 2018 | Military Medical Research2018，5，4： | 5 |
| 3 | Ribozymes and the mechanisms that underlie RNA catalysis显示文摘Ribozymes 是普遍的,并且在房间催化一些极其重要的反应。最机械学地掉进二个班之一,用任何一个金属离子或一般酸硷的催化作用。nucleolytic ribozymes 掉进后者班,主要用 nucleobases。这些的一个子集使用加腺嘌酸基础的 guanine 的联合催化劈开反应。新 ribozymes 仍然在常规间隔正在被发现,我们能在 ribozymes 的潜在的存在上推测在 phosphoryl 转移反应以外催化化学,也许使用小分子的辅酶。 | Timothy J. Wilson Yijin Liu David M. J. Lilley | 2016 | Frontiers of Chemical Science and Engineering2016，10，2： | 2 |
| 4 | Bad riddance or good rubbish? Ownership and not loss aversion causes the endowment effect显示文摘 | Carey K. Morewedge Lisa L. Shu Daniel T. Gilbert Timothy D. Wilson | 2009 | Journal of Experimental Social Psychology2009，，4： | 1 |
| 5 | Affective Forecasting显示文摘 | Timothy D Wilson | 2003 | Advances in Experimental Social Psychology2003，，： | 1 |
| 6 | Prospective assessment of lymphatic dissemination in endometrial cancer: A paradigm shift in surgical staging显示文摘 | Andrea Mariani Sean C. Dowdy William A. Cliby Bobbie S. Gostout Monica B. Jones Timothy O. Wilson Karl C. Podratz | 2008 | Gynecologic Oncology2008，，1： | 1 |
| 7 | Cost Control and Revenue Generation: The Case of Public-housing Companies' Experiences in Sweden 显示文摘 | Lars Lindbergh Claes-Goran Larsson Timothy Wilson | 2004 | Regional Studies2004，，10： | 1 |
| 8 | Enabling advanced mirror blank design through modern optical fabrication technology显示文摘 | TIMOTHY WiLSON VICTOR GENDERG | 1994 | SPIE1994，1994，： | 1 |
| 9 | Robust cardiomyocyte differentiation from human pluripotent stem cells via temporal modulation of canonical Wnt signaling显示文摘 | Xiaojun Lian Cheston Hsiao Gisela Wilson Kexian Zhu Laurie B. Hazeltine Samira M. Azarin Kunil K. Raval Jianhua Zhang Timothy J. Kamp Sean P. Palecek | 2012 | Proceedings of the National Academy of Sciences2012，，27： | 1 |
| 10 | Patients with prior TURP undergoing robot-assisted laparoscopic radical prostatectomy have higher positive surgical margin rates显示文摘 | Lance Hampton Rebecca A. Nelson Roger Satterthwaite Timothy Wilson Laura Crocitto | 2008 | Journal of Robotic Surgery2008，，4： | 1 |
| 11 | Ileitis in Ulcerative Colitis: Is It a Backwash?显示文摘 | Ayman S. Abdelrazeq M.S. F.R.C.S. F.R.C.S.I. Timothy R. Wilson M.R.C.S. Derek L. Leitch M.R.C.P. M.R.C.Path. Jonathan N. Lund D.M. F.R.C.S. Stephen H. Leveson M.D. F.R.C.S | 2005 | Diseases of the Colon & Rectum2005，，11： | 1 |
| 12 | Survival and Functional Outcome After Surgical Resection of Intramedullary Spinal Cord Metastases显示文摘 | David A. Wilson David J. Fusco Timothy D. Uschold Robert F. Spetzler Steve W. Chang | 2012 | World Neurosurgery2012，，2： | 1 |
| 13 | Internetworked after-sales service显示文摘 | Zackariasson Peter Timothy L Wilson | 2004 | Industrial Marketing Management2004，，33： | 1 |
| 14 | Extracellular Matrix Promotes Highly Efficient Cardiac Differentiation of Human Pluripotent Stem Cells: The Matrix Sandwich Method显示文摘 | Jianhua Zhang Matthew Klos Gisela F. Wilson Amanda M. Herman Xiaojun Lian Kunil K. Raval Matthew R. Barron Luqia Hou Andrew G. Soerens Junying Yu Sean P. Palecek Gary E. Lyons James A. Thomson Todd J. Herron José Jalife Timothy J. Kamp | 2012 | Circulation Research2012，，： | 1 |
| 15 | Colon-specific delivery of a probiotic-derived soluble protein ameliorates intestinal inflammation in mice through an EGFR-dependent mechanism显示文摘 | Yan Fang Cao Hanwei Cover Timothy L Washington M Kay Shi Yan Liu LinShu Chaturvedi Rupesh Peek Richard M Wilson Keith T Polk D Brent | 2011 | Journal of Clinical Investigation2011，，6： | 1 |
| 16 | Bad riddance or good rubbish? Ownership and not loss aversion causes the endowment effect显示文摘 | Carey K. Morewedge Lisa L. Shu Daniel T. Gilbert Timothy D. Wilson | 2009 | Journal of Experimental Social Psychology2009，，4： | 1 |
| 17 | Robust cardiomyocyte differentiation from human pluripotent stem cells via temporal modulation of canonical Wnt signaling显示文摘 | Xiaojun Lian Cheston Hsiao Gisela Wilson Kexian Zhu Laurie B. Hazeltine Samira M. Azarin Kunil K. Raval Jianhua Zhang Timothy J. Kamp Sean P. Palecek | 2012 | Proceedings of the National Academy of Sciences2012，，： | 1 |
| 18 | Systematic Review and Meta-analysis of Studies Reporting Potency Rates After Robot-assisted Radical Prostatectomy 显示文摘 | Vincenzo Ficarra Giacomo Novara Thomas E. Ahlering Anthony Costello James A. Eastham Markus Graefen Giorgio Guazzoni Mani Menon Alexandre Mottrie Vipul R. Patel Henk Van der Poel Raymond C. Rosen Ashutosh K. Tewari Timothy G. Wilson Filiberto Zattoni Fran | 2012 | European Urology2012，，3： | 1 |
| 19 | Genome-wide transcriptional analysis of salinity stressed japonica and indica rice genotypes during panicle initiation stage显示文摘 | Harkamal Walia Clyde Wilson Linghe Zeng Abdelbagi M. Ismail Pascal Condamine Timothy J. Close | 2007 | Plant Molecular Biology2007，，5： | 1 |
| 20 | Distributed whole city water level measurements from the Carlisle 2005 urban flood event and comparison with hydraulic model simulations显示文摘 | Jeffrey C. Neal Paul D. Bates Timothy J. Fewtrell Neil M. Hunter Matthew D. Wilson Matthew S. Horritt | 2009 | Journal of Hydrology2009，，1： | 1 |
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