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| 1 | Lung epithelial cell-derived IL-25 negatively regulates LPS-induced exosome release from macrophages显示文摘Background: Acute lung injury(ALI) is a major component of multiple organ dysfunction syndrome(MODS) following pulmonary and systemic infection. Alveolar macrophages(AMφ) are at the center of ALI pathogenesis. Emerging evidence has shown that cell-cell interactions in the lungs play an important regulatory role in the development of acute lung inflammation. However, the underneath mechanisms remain poorly addressed. In this study, we explore a novel function of lung epithelial cells(LEPCs) in regulating the release of exosomes from AMφ following LPS stimulation.Methods: For the in vivo experiments, C57 BL/6 wildtype(WT) mice were treated with lipopolysaccharide(LPS)(2 mg/kg) in 0.2 ml of saline via intratracheal aerosol administration. Bronchoalveolar lavage fluid was collected at 0–24 h after LPS treatment, and exosomes derived from AMφ were measured. For the in vitro studies, LEPCs and bone marrowderived Mφ(BMDM) were isolated from WT or TLR4-/-mice and were then cocultured in the Transwell? system. After coculture for 0–24 h, the BMDM and supernatant were harvested for the measurement of exosomes and cytokines.Results: We demonstrate that LPS induces macrophages(Mφ) to release exosomes, which are then internalized by neighboring Mφ to promote TNF-α expression. The secreted interleukin(IL)-25 from LEPCs downregulates Rab27 a and Rab27 b expression in Mφ, resulting in suppressed exosome release and thereby attenuating exosome-induced TNF-α expression and secretion.Conclusion: These findings reveal a previously unidentified crosstalk pathway between LEPCs and Mφ that negatively regulates the inflammatory responses of Mφ to LPS. Modulating IL-25 signaling and targeting exosome release may present a new therapeutic strategy for the treatment of ALI. | Zhi-Gang Li Melanie J. Scott Tomasz Brzóska Prithu Sundd Yue-Hua Li Timothy R. Billiar Mark A. Wilson Ping Wang Jie Fan | 2018 | Military Medical Research2018，5，4： | 5 |
| 2 | Update on Cardiovascular Implantable Electronic Device Infections and Their Management: A Scientific Statement From the American Heart Association显示文摘 | Larry M. Baddour Andrew E. Epstein Christopher C. Erickson Bradley P. Knight Matthew E. Levison Peter B. Lockhart Frederick A. Masoudi Eric J. Okum Walter R. Wilson Lee B. Beerman Ann F. Bolger N A. Mark Estes Michael Gewitz Jane W. Newburger Eleanor B. S | 2010 | Circulation2010，，3： | 4 |
| 3 | 卒中一级预防指南美国心脏协会/美国卒中协会对医疗专业人员的声明显示文摘这份更新版指南旨在为既往无卒中或短暂性脑缺血发作史的人群提供适时的综合性卒中预防循证建议,包括危险因素控制、头颈部动脉粥样硬化性疾病的干预方法以及预防血栓形成和血栓栓塞性卒中的抗栓治疗。此外,本指南还提供了针对遗传和药理学检测以及在其他特殊情况下(包括镰状细胞疾病和卵圆孔未闭)进行卒中预防的建议。 | James F. Meschia Cheryl Bushnell Bernadette Boden-Albala Lynne T. Braun Dawn M. Bravata Seemant Chaturvedi Mark A. Creager Robert H. Eckel Mitchell S.V. Elkind Myriam Fornage Larry B Goldstein Steven M. Greenberg Susanna E. Horvath Costantino Iadecola Edward C. Jauch Wesley S. Moore John A. Wilson 李迪 高一鹭 陈政弘 霍晓川 孙海欣 孙冬玲 茹小娟 江滨 | 2015 | 国际脑血管病杂志2015，23，6： | 4 |
| 4 | Ethnicity and nonalcoholic fatty liver disease显示文摘 | Kiran Bambha Patricia Belt Maria Abraham Laura A. Wilson Mark Pabst Linda Ferrell Aynur Unalp‐Arida Nathan Bass | 2012 | Hepatology2012，，： | 2 |
| 5 | Colitis and Intestinal Inflammation in IL10 ?/? Mice Results From IL-13Rα2–Mediated Attenuation of IL-13 Activity显示文摘 | Mark S. Wilson Thirumalai R. Ramalingam Aymeric Rivollier Kevin Shenderov Margaret M. Mentink–Kane Satish K. Madala Allen W. Cheever David Artis Brian L. Kelsall Thomas A. Wynn | 2011 | Gastroenterology2011，，1： | 2 |
| 6 | Evolution in the Management of Hepatic Trauma: A 25-Year Perspective显示文摘 | J. David Richardson Glen A. Franklin James K. Lukan Eddy H. Carrillo David A. Spain Frank B. Miller Mark A. Wilson Hiram C. Polk Lewis M. Flint | 2000 | Annals of Surgery2000，，3： | 2 |
| 7 | The Roles of Social Support and Self-Efficacy in Physical Health’s Impact on Depressive and Anxiety Symptoms in Older Adults显示文摘 | Amber L. Paukert Jeremy W. Pettit Mark E. Kunik Nancy Wilson Diane M. Novy Howard M. Rhoades Anthony J. Greisinger Oscar A. Wehmanen Melinda A. Stanley | 2010 | Journal of Clinical Psychology in Medical Settings2010，，4： | 1 |
| 8 | Kidney Disease as a Risk Factor for Development of Cardiovascular Disease: A Statement From the American Heart Association Councils on Kidney in Cardiovascular Disease, High Blood Pressure Research, Clinical Cardiology, and Epidemiology and Prevention显示文摘 | Mark J. Sarnak Andrew S. Levey Anton C. Schoolwerth Josef Coresh Bruce Culleton L. Lee Hamm Peter A. McCullough Bertram L. Kasiske Ellie Kelepouris Michael J. Klag Patrick Parfrey Marc Pfeffer Leopoldo Raij David J. Spinosa Peter W. Wilson | 2003 | Circulation: Journal of the American Heart Association2003，，17： | 1 |
| 9 | Tips for Teachers of Evidence-based Medicine: Making Sense of Diagnostic Test Results Using Likelihood Ratios显示文摘 | W. Scott Richardson MD Mark C. Wilson MD MPH Sheri A. Keitz MD PhD Peter C. Wyer MD | 2008 | Journal of General Internal Medicine2008，，1： | 1 |
| 10 | Reduced Endoglin Activity Limits Cardiac Fibrosis and Improves Survival in Heart Failure显示文摘 | Navin K. Kapur Szuhuei Wilson Adil A. Yunis Xiaoying Qiao Emily Mackey Vikram Paruchuri Corey Baker Mark J. Aronovitz S. Ananth Karumanchi Michelle Letarte David A. Kass Michael E. Mendelsohn Richard H. Karas | | Circulation0，，： | 1 |
| 11 | Kidney Disease as a Risk Factor for Development of Cardiovascular Disease: A Statement From the American Heart Association Councils on Kidney in Cardiovascular Disease, High Blood Pressure Research, Clinical Cardiology, and Epidemiology and Prevention显示文摘 | Mark J. Sarnak Andrew S. Levey Anton C. Schoolwerth Josef Coresh Bruce Culleton L. Lee Hamm Peter A. McCullough Bertram L. Kasiske Ellie Kelepouris Michael J. Klag Patrick Parfrey Marc Pfeffer Leopoldo Raij David J. Spinosa Peter W. Wilson | 2003 | Circulation: Journal of the American Heart Association2003，，17： | 1 |
| 12 | A lightweight transducer platform for use in stationary shallow water horizontal-aspect acoustic surveys显示文摘 | Kevin M. Boswell Mark W. Miller Charles A. Wilson | 2007 | Fisheries Research2007，，3： | 1 |
| 13 | Kidney Disease as a Risk Factor for Development of Cardiovascular Disease: A Statement From the American Heart Association Councils on Kidney in Cardiovascular Disease, High Blood Pressure Research, Clinical Cardiology, and Epidemiology and Prevention显示文摘 | Mark J. Sarnak Andrew S. Levey Anton C. Schoolwerth Josef Coresh Bruce Culleton L. Lee Hamm Peter A. McCullough Bertram L. Kasiske Ellie Kelepouris Michael J. Klag Patrick Parfrey Marc Pfeffer Leopoldo Raij David J. Spinosa Peter W. Wilson | 2003 | Hypertension: Journal of the American Heart Association2003，，5： | 1 |
| 14 | Caregiver Outcomes of Partners in Dementia Care: Effect of a Care Coordination Program for Veterans with Dementia and Their Family Members and Friends显示文摘 | David M. Bass Katherine S. Judge A. Lynn Snow Nancy L. Wilson Robert Morgan Wendy J. Looman Catherine A. McCarthy Katie Maslow Jennifer A. Moye Ronda Randazzo Maurilio Garcia‐Maldonado Richard Elbein Germaine Odenheimer Mark E. Kunik | 2013 | J Am Geriatr Soc2013，，8： | 1 |
| 15 | Randomized Double-Blind Assessment of the ONSET and OFFSET of the Antiplatelet Effects of Ticagrelor Versus Clopidogrel in Patients With Stable Coronary Artery Disease: The ONSET/OFFSET Study显示文摘 | Paul A. Gurbel Kevin P. Bliden Kathleen Butler Udaya S. Tantry Tania Gesheff Cheryl Wei Renli Teng Mark J. Antonino Shankar B. Patil Arun Karunakaran Dean J. Kereiakes Cordel Parris Drew Purdy Vance Wilson Gary S. Ledley Robert F. Storey | 2009 | Circulation2009，，25： | 1 |
| 16 | Self-Emulsifying Drug Delivery Systems: Formulation and Biopharmaceutic Evaluation of an Investigational Lipophilic Compound显示文摘 | Susan A. Charman William N. Charman Mark C. Rogge Terry D. Wilson Frank J. Dutko Colin W. Pouton | 1992 | Pharmaceutical Research1992，，1： | 1 |
| 17 | Subtotal Parathyroidectomy in Renal Failure: Still Needed after All These Years显示文摘 | P. Anthony Decker Eric P. Cohen Kara M. DoffekB.S. Blake A. Ashley Mary E. Bienemann Yong Ran Zhu Mark E. Adams Stuart D. Wilson Michael J. Demeure | 2001 | World Journal of Surgery2001，，6： | 1 |
| 18 | Does the Literature Support Double-Row Suture Anchor Fixation for Arthroscopic Rotator Cuff Repair? A Systematic Review Comparing Double-Row and Single-Row Suture Anchor Configuration显示文摘 | Shane J. Nho Mark A. Slabaugh Shane T. Seroyer Robert C. Grumet Joseph B. Wilson Nikhil N. Verma Anthony A. Romeo Bernard R. Bach | 2009 | Arthroscopy: The Journal of Arthroscopic and Related Surgery2009，，11： | 1 |
| 19 | Development of a method for the determination of glycine in human cerebrospinal fluid using pre-column derivatization and LC–MS/MS显示文摘 | Sarah F. Wilson Christopher A. James Xiaochun Zhu Mike T. Davis Mark J. Rose | 2011 | Journal of Pharmaceutical and Biomedical Analysis2011，，2： | 1 |
| 20 | Univariate and multivariate analyses of preoperative factors influencing symptomatic outcomes of transoral fundoplication显示文摘 | Reginald C. W. Bell Mark A. Fox William E. Barnes Peter G. Mavrelis Robert W. Sewell Bart J. Carter Glenn M. Ihde Karim S. Trad David Dargis Kevin M. Hoddinott Katherine D. Freeman Tanja Gunsberger Mark G. Hausmann Brian DaCosta Gill Erik Wilson | 2014 | Surgical Endoscopy2014，，： | 1 |
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