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| 1 | Retrospective study on mixed neuroendocrine non-neuroendocrine neoplasms from five European centres显示文摘BACKGROUND Mixed neuroendocrine non-neuroendocrine neoplasm(MiNEN)is a rare diagnosis,mainly encountered in the gastro-entero-pancreatic tract.There is limited knowledge of its epidemiology,prognosis and biology,and the best management for affected patients is still to be defined.AIM To investigate clinical-pathological characteristics,treatment modalities and survival outcomes of a retrospective cohort of patients with a diagnosis of MiNEN.METHODS Consecutive patients with a histologically proven diagnosis of MiNEN were identified at 5 European centres.Patient data were retrospectively collected from medical records.Pathological samples were reviewed to ascertain compliance with the 2017 World Health Organisation definition of MiNEN.Tumour responses to systemic treatment were assessed according to the Response Evaluation Criteria in Solid Tumours 1.1.Kaplan-Meier analysis was applied to estimate survival outcomes.Associations between clinical-pathological characteristics and survival outcomes were explored using Log-rank test for equality of survivors functions(univariate)and Cox-regression analysis(multivariable).RESULTS Sixty-nine consecutive patients identified;Median age at diagnosis:64 years.Males:63.8%.Localised disease(curable):53.6%.Commonest sites of origin:colon-rectum(43.5%)and oesophagus/oesophagogastric junction(15.9%).The neuroendocrine component was;predominant in 58.6%,poorly differentiated in 86.3%,and large cell in 81.25%,of cases analysed.Most distant metastases analysed(73.4%)were occupied only by a poorly differentiated neuroendocrine component.Ninety-four percent of patients with localised disease underwent curative surgery;53%also received perioperative treatment,most often in line with protocols for adenocarcinomas from the same sites of origin.Chemotherapy was offered to most patients(68.1%)with advanced disease,and followed protocols for pure neuroendocrine carcinomas or adenocarcinomas in equal proportion.In localised cases,median recurrence free survival(RFS);14.0 months(95%CI:9.2-24.4),and median overall survival(OS):28.6 months(95%CI:18.3-41.1).On univariate analysis,receipt of perioperative treatment(vs surgery alone)did not improve RFS(P=0.375),or OS(P=0.240).In advanced cases,median progression free survival(PFS);5.6 months(95%CI:4.4-7.4),and median OS;9.0 months(95%CI:5.2-13.4).On univariate analysis,receipt of palliative active treatment(vs best supportive care)prolonged PFS and OS(both,P<0.001).CONCLUSION MiNEN is most commonly driven by a poorly differentiated neuroendocrine component,and has poor prognosis.Advances in its biological understanding are needed to identify effective treatments and improve patient outcomes. | Melissa Frizziero Xin Wang Bipasha Chakrabarty Alexa Childs Tu V Luong Thomas Walter Mohid S Khan Meleri Morgan Adam Christian Mona Elshafie Tahir Shah Annamaria Minicozzi Wasat Mansoor Tim Meyer Angela Lamarca Richard A Hubner Juan W Valle Mairéad G McNamara | 2019 | World Journal of Gastroenterology2019，25，39： | 13 |
| 2 | Muscle function, physical performance and body composition changes in men with prostate cancer undergoing androgen deprivation therapy显示文摘前列腺癌症(PCa ) 是在有雄激素剥夺治疗(ADT ) 的人的最普通的内脏的恶意压制睾丸激素生产和因此肿瘤生长的比较喜欢的治疗。尽管有它在阴沉的睾丸激素的有效性, ADT 包括肌肉质量,减少的肌肉力量,在物理性能的减少,更早的疲劳和生活的衰退质量的损失与副作用被联系。这评论在肌肉力量,物理功能和身体作文与变化的一个焦点报导文学的调查,由于短期、长期的 ADT。在这些区域的研究是稀少的,特别控制得好的、未来的使随机化的试用。为有与不收到 ADT 的 PCa 象病人一样与 ADT 对待的 PCa 的人和匹配年龄的健康的人的代表性、纵的数据(多达 2 年) 被介绍什么时候可得到。基于有限纵的数据,肌肉功能上的 ADT 的不利效果,物理性能和身体作文立即在 ADT 的发作以后发生并且趋于随着时间的过去坚持并且变得更坏。锻练训练为为锻练节目设计减轻这些变化和起始的指南因为有 PCa 的人被运动药的美国学院出版了是一只保险箱和有效干预。在学习持续时间,研究的类型和象自从诊断,癌症阶段和 comorbidities 的时间那样的另外的病人特定的变量的不同都可以影响对健康,物理表演和死亡的 ADT 的影响的理解。 | Thomas W Storet Renee Miciek Thomas G Travison | 2012 | Asian Journal of Andrology2012，14，2： | 7 |
| 3 | Nat Genet:单基因突变导致过敏性皮炎的发生显示文摘最近,研究者们鉴定出了一类导致神经性皮炎发生的关键基因突变:CARDll。来自美国NIH过敏与传染病研究所的研究者们通过对四个没有血缘关系的患病家庭进行分析,发现了这一导致疾病产生的基因、 | Chi A Ma, Yuan Zhang, Michael A Weinreich, Jonathan J Lyons, Celeste G Nelson, Thomas DiMaggio, Kelly D Stone, Joshua D Milner Jeffrey R Stinson, Elisa Ruffo, Batsukh Dorjbal, Swadhinya Arjunaraja, Kelsey Voss, Andrew L Snow Jordan K Abbott, Pia J Hauk, Paul R Reynolds, Erwin W Gelfand Elisa Ruffo Salomé Glauzy, Natsuko Yamakawa, Eric Meffre Jennifer Stoddard, Julie Niemela, Sergio D Rosenzweig Yu Zhang, Helen F Matthews Joshua J McElwee Nina Jones Alejandro Palma, Matías Oleastro, Emma Prieto, Andrea R Bernasconi, Geronimo Dubra, Silvia Danielian, Jonathan Zaiat, Marcelo A Marti Brian Kim Megan A Cooper Neil Romberg | 2017 | 现代生物医学进展2017，17，27： | 3 |
| 4 | Diagnostic accuracy of tests for Helicobacter pylori in an Alaska Native population显示文摘AIM:To evaluate the accuracy of two non-invasivetests in a population of Alaska Native persons. Highrates of Helico bacter pylori(H. pylori) infection,H. pylori treatment failure,and gastric cancer in this population necessitate documentation of infection status atmultiple time points over a patient's life.METHODS:In 280 patients undergoing endoscopy,H. pylori was diagnosed by culture,histology,rapidurease test,13C urea breath test(UBT) ,and immuno-globulin G antibodies to H. pylori in serum. The performances of 13C-UBT and antibody test were compared to a gold standard defined by a positive H. pylori testby culture or,in case of a negative culture result,bypositive histology and a positive rapid urease test.RESULTS:The sensitivity and specificity of the 13C-UBT were 93% and 88%,respectively,relative to thegold standard. The antibody test had an equivalents ensitivity of 93% with a reduced specificity of 68%.The false positive results for the antibody test were as-sociated with previous treatment for an H. pylori infection [relative risk(RR) = 2.8]. High levels of antibodiesto H. pylori were associated with chronic gastritis and male gender,while high scores in the 13C-UBT testwere associated with older age and with the H. pyloribacteria load on histological examination(RR = 4.4) .CONCLUSION:The 13C-UBT out performed the anti-body test for H. pylori and could be used when a non-invasive test is clinically necessary to document treatment out come or when monitoring for reinfection. | Dana L Bruden Michael G Bruce Karen M Miernyk Julie Morris Debby Hurlburt Thomas W Hennessy Helen Peters Frank Sacco Alan J Parkinson Brian J McMahon | 2011 | World Journal of Gastroenterology2011，17，42： | 3 |
| 5 | 22-gauge core vs 22-gauge aspiration needle for endoscopic ultrasound-guided sampling of abdominal masses显示文摘AIM To compare the aspiration needle(AN) and core biopsy needle(PC) in endoscopic ultrasound-guided fine needle aspiration(EUS-FNA) of abdominal masses.METHODS Consecutive patients referred for EUS-FNA were included in this prospective single-center trial. Each patient underwent a puncture of the lesion with both standard 22-gauge(G) AN(Echo Tip Ultra; Cook Medical, Bloomington, Indiana, United States) and the novel 22 G PC(Echo Tip Pro Core; Cook Medical, Bloomington, Indiana, United States) in a randomized fashion; histology was attempted in the PC group only. The main study endpoint was the overall diagnostic accuracy, including the contribution of histology to the final diagnosis. Secondary outcome measures included material adequacy, number of needle passes, and complications.RESULTS Fifty six consecutive patients(29 men; mean age 68 years) with pancreatic lesions(n = 38), lymphadenopathy(n = 13), submucosal tumors(n = 4), or others lesions(n = 1) underwent EUS-FNA using both of the needles in a randomized order. AN and PC reached similar overall results for diagnostic accuracy(AN: 88.9 vs PC: 96.1, P = 0.25), specimen adequacy(AN: 96.4% vs PC: 91.1%, P = 0.38), mean number of passes(AN: 1.5 vs PC: 1.7, P = 0.14), mean cellularity score(AN: 1.7 vs PC: 1.1, P = 0.058), and complications(none). A diagnosis on the basis of histology was achieved in the PC group in 36(64.3%) patients, and in 2 of those as the sole modality. In patients with available histology the mean cellularity score was higher for AN(AN: 1.7 vs PC: 1.0, P = 0.034); no other differences were of statistical significance.CONCLUSION Both needles achieved high overall diagnostic yields and similar performance characteristics for cytological diagnosis; histological analysis was only possible in 2/3 of cases with the new needle. | William Sterlacci Athanasios D Sioulas Lothar Veits Pervin G?nüllü Guido Schachschal Stefan Groth Mario Anders Christos K Kontos Theodoros Topalidis Andrea Hinsch Michael Vieth Thomas R?sch Ulrike W Denzer | 2016 | World Journal of Gastroenterology2016，22，39： | 2 |
| 6 | Intra-and inter-specific mitochondrial DNA sequences divergence in salmo:rainbow,steelhead,and cutthroat trouts显示文摘 | Wilson G M Thomas W K Beckenbach A T | 1985 | Can J Zool1985，，63： | 2 |
| 7 | On Transmission Congestion and Pricing显示文摘 | Thomas W G | 1999 | IEEE Tansactions on Power Systems1999，14，1： | 1 |
| 8 | IL-18 Stimulates the proliferation and IFN-γ release of CD4^+ T cells in the chicken: conservation of a Th1-Like system in a noumamalian Species 显示文摘 | Thomas W G Schneider K Schacear B | 2003 | Immunol2003，171，： | 1 |
| 9 | Large deformations of thin-walled circular tubes under transverse loading 显示文摘 | Thomas S G Reid S R Johnson W | 1976 | International Journal of Mechanical Sciences1976，18，6： | 1 |
| 10 | Lignin and carbohydrate alteration in particle-size separates of an oxisol under tropical pastures following native savanna 显示文摘 | GUGGENBERGER G ZECH W and THOMAS R J | 1995 | Soil Biology and Biochemistry1995，27，12： | 1 |
| 11 | Characterization of the high-molecular weight fructan isolated from garlic (Allium Sativum L)显示文摘 | Baumgartner S Thomas G D Praznik W | 2000 | Carbohydrate Research2000，328，： | 1 |
| 12 | Electrospinning and dtabilization of gfully hydrolrzed poly(viny alcohol)fibers显示文摘 | YAO LI THOMAS W H ANTHONY G E | 2003 | Chem Mater2003，15，： | 1 |
| 13 | Experimental approach and tech- niques for the evaluation of wet flue gas desulfurization scrubber fluid mechanics显示文摘 | Thomas W S Wadie F G | 1994 | Chemical Engineering Science1994，49，24： | 1 |
| 14 | The renin - angiotensin system and cancer: old dog, new tricks显示文摘 | GEORGE A J THOMAS W G HANNAN R D | 2010 | Nat Rev Cancer2010，10，11： | 1 |
| 15 | The Phase Transformations in Starch During Gelatiniza- tion:a Liquid Crystalline Approach 显示文摘 | THOMAS A W MICHAEL J G BEMARD U K | 2000 | CarbohydrateResearch2000，328，2： | 1 |
| 16 | Tackling antibiotic resistance显示文摘 | Bush K Courvalin P Dantas G Davies J Eisenstein B Huovinen P Jacoby GA Kishony R Kreiswirth BN Kutter E Lerner SA Levy S Lewis K Lomovskaya O Miller JH Mobashery S Piddock LJ Projan S Thomas CM Tomasz A Tulkens PM Walsh TR Watson JD Witkowski J Witte W Wr | | 0，，： | 1 |
| 17 | Chemical sen- sors based on amplifying fluorescent conjugated poly- mers显示文摘 | Thomas m S W Joly G D Swager T M | 2007 | Chem Rev2007，107，4： | 1 |
| 18 | Refined model for analysis of plates on elastic foundations显示文摘 | VALLABHAN C A G THOMAS S W DAS Y C | 1990 | Journal of Engineering Mechanics1990，117，12： | 1 |
| 19 | Influence of conservationtillage on soil properties显示文摘 | BLEVINS R L SMITH M S THOMAS G W | 1983 | Soil Water Conserve1983，38，： | 1 |
| 20 | Does empowerment always work: Understanding the role of intrinsic motivation and personal interpretation显示文摘 | Thomas K W Tymon W G | 1994 | Journal of Management Systems1994，6，2： | 1 |
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